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  • Published In : Apr 2024
  • Code : CMI6883
  • Pages :175
  • Formats :
      Excel and PDF
  • Industry : Pharmaceutical

Market Size and Trends

The liposome drug delivery market is estimated to be valued at USD 5,482.2 Mn in 2024 and is expected to reach USD 9,935.6 Mn by 2031, exhibiting a compound annual growth rate (CAGR) of 8.9% from 2024 to 2031.

Liposome Drug Delivery Market Key Factors

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The liposome drug delivery market is expected to witness lucrative growth over the forecast period. This is mainly attributed to increasing demand for advanced drug delivery systems and targeted drug delivery. Liposomes have emerged as a viable drug carrier due to their ability to encapsulate both hydrophilic and hydrophobic drug molecules and release them in a controlled manner. These liposomal formulations enhance drug solubility, bioavailability, and stability while reducing toxicity. Using liposomes as drug carriers helps minimize side effects and overcome multi-drug resistance associated with conventional chemotherapy. Several liposomal drugs have been approved for cancer treatment and many more are in clinical trial stages, indicating robust growth opportunities over the coming years.

Rising Incidences of Chronic Diseases

The increasing prevalence of chronic diseases across the globe has significantly boosted demand for more effective drug delivery systems. Conventional drug delivery methods often face challenges in efficiently delivering medications to the target sites for many chronic health conditions. Liposomes present a promising solution given their unique properties to encapsulate both hydrophobic and hydrophilic drug molecules and transport them across biological membranes. Chronic diseases such as cancer, cardiovascular ailments, and neurological disorders are posing a huge burden on individuals and healthcare systems. It is estimated that over 50% of adults in developed nations suffer from at least one chronic disease. These diseases usually require long-term or even lifetime treatment often comprising multiple drugs. Ensuring compliance and delivering the right dose of drugs to affected tissues can be challenging with conventional delivery methods. Liposomes address this need by allowing targeted and controlled release of encapsulated drugs. Their nanoparticle size facilitates penetration through biological barriers like cell membranes. Functionalization of liposomes with ligands permits active targeting to diseased sites. Controlled release kinetics via stimuli-responsive mechanisms prevents premature drug leakage.

Market Concentration and Competitive Landscape

Liposome Drug Delivery Market Concentration By Players

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Emerging Therapies

The constant flow of new molecular entities and therapeutic modalities is opening up sweeping opportunities for innovative drug delivery strategies. Several cutting-edge therapies, such as gene therapy, immunotherapy, and tissue engineering, are highlighting the indispensable role of effective delivery systems. While formidable in potential, these new treatment paradigms also present complex formulation and administration puzzles that demand ingenious solutions. Liposomes here offer a uniquely qualified delivery platform ready to power the next generation medical innovations. Groundbreaking technologies to alter cellular physiology, eradicate diseases, and repair tissues are transforming healthcare outlooks. Gene therapies for inherited disorders, cell therapies for regenerative medicine, and cytokine-based immunotherapies for cancer possess immense lifesaving capabilities. However, their clinical translation requires overcoming large molecular

Liposome Drug Delivery Market Key Takeaways From Lead Analyst

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Market Challenges – High Costs of Development

The liposome drug delivery market faces several challenges. The high cost of development acts as a deterrent for smaller pharmaceutical companies. Additionally, the instability of liposomes during storage and circulation poses regulatory hurdles. Their large size limits their use for targeting certain organs. Drug leakage during circulation also reduces the amount of drug reaching the target site.

Market Opportunities – Ongoing Research to Enhance Stability

The liposome drug delivery market also presents multiple opportunities. The ability of liposomes to encapsulate both hydrophobic and hydrophilic drugs expands the range of treatable diseases. Ongoing research to enhance stability, modify surface properties for effective targeting, and introduce triggered release could help address current challenges. New application areas like gene therapy offer scope for further innovation. 

Liposome Drug Delivery Market By Product

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Insights, By Product: Targeted Delivery Drives Growth of Liposomal Doxorubicin

The product segment includes liposomal paclitaxel, liposomal doxorubicin, liposomal amphotericin B, and others. The liposomal doxorubicin segment is estimated to hold 36.1% share of the market in 2024 owing to its targeted delivery capabilities. Doxorubicin is an effective chemotherapy drug but its use is limited by dose-dependent cardiac toxicity. Encapsulating doxorubicin inside a liposome allows it to be delivered directly to tumor sites while avoiding healthy tissues. This targeted delivery significantly reduces toxicity compared to conventional doxorubicin. Liposomal doxorubicin's encapsulation protects the drug from degradation until it reaches the tumor. Once there, the drug payload is released inside cancer cells through degradation of the liposome membrane. This prolonged circulation time and controlled release at tumor sites maximizes doxorubicin concentrations where they are needed most. The targeted delivery greatly enhances the therapeutic index of doxorubicin and allows effective treatment at doses that otherwise could not be tolerated. 

Insights, By Technology: Stealth Technology Leads in Drug Shielding

The technology segment includes stealth liposome technology, non-PEGylated liposome technology, and DepoFoam liposome technology. The stealth liposome technology sub-segment is expected to hold 42.7% of the market share in 2024 owing to its superior drug encapsulation abilities. Stealth liposomes modify the membrane with hydrophilic polymers like PEG to reduce uptake by the mononuclear phagocyte system. This “masks” the liposome from the immune system, increasing circulation time up to 72 hours versus a few minutes for conventional liposomes. The longer circulation duration gives stealth liposomes greater opportunity to accumulate selectively at tumor sites versus healthy tissues. It also allows for release of higher concentrations of the drug payload intracellularly over an extended period versus a single burst. This passive targeting via the enhanced permeability and retention effect maximizes drug accumulation precisely where needed.

Insights, By Indication: Growth in Ambulatory Surgeries Boosts Demand

The indication segment includes fungal diseases, pain management, cancer therapeutics, and others. The cancer therapeutics sub-segment is expected to account for 53.7% of the market share in 2024. This dominant position stems from the high incidence and prevalence of various types of cancer worldwide. Cancer accounts for nearly one in six deaths globally, with over 20 million new cases and 10 million cancer deaths reported each year. The growing cancer burden can be attributed to several factors such as aging populations, changing lifestyles resulting in obesity and lack of physical activity, and exposure to carcinogens such as tobacco smoke. While advancements in early detection and treatment have helped push up survival rates for certain cancer types, there remains an immense unmet need for developing more effective and targeted therapies. It is here that liposome drug delivery demonstrates considerable promise. By encapsulating anti-cancer drugs in liposomes, these nanocarriers can selectively deliver higher concentrations of medication to tumor sites while avoiding healthy tissues. This results in improved efficacy and fewer side effects for patients undergoing chemotherapy. Some examples of liposomal cancer medications that have witnessed success include Doxil, Liposomal Daunorubicin, and others. 

Regional Insights

Liposome Drug Delivery Market Regional Insights

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North America remains the dominant region in the global liposome drug delivery market and is anticipated to hold 41.7% of the market share in 2024. North America has established itself as the leading regional market for liposome drug delivery. The major factor driving its prominence is the strong presence of leading pharmaceutical and biotechnology companies in the U.S. and Canada. American companies like Gilead Sciences, Jazz Pharmaceuticals, and Acrotech Biopharma have been pioneering the research and development of novel liposomal drugs for critical therapies like cancer. Supportive regulatory environment provided by U.S. Food and drug Administration has encouraged clinical trials and approvals of many liposomal formulations over the past decade. Additionally, high healthcare spending, and availability of advanced medical facilities have enabled faster adoption of innovative liposomal drugs. Leading U.S.-based pharmaceutical companies also actively engage in contract manufacturing and licensing deals to cater liposomal drugs globally.

The Asia Pacific region, primarily driven by China and India, is emerging as the fastest growing regional market. Both the countries have witnessed significant growth in their pharmaceutical industries over the last few years. Many domestic Chinese and Indian companies are now engaged in the development and manufacturing of generic liposomal drugs. Growing expertise in areas like nanotechnology and pharmaceutical production has boosted their capabilities. Low manufacturing and labor costs provide Asia Pacific companies a competitive edge in the global liposome drug delivery market. Several leading multinational pharmaceutical companies have also established manufacturing bases in China and contract local players for supply of liposomal drugs worldwide. Rising income levels and expanding medical insurance coverage are increasing access to innovative therapies in major Asian countries. Their governments also support local R&D through funding and relaxed regulatory norms to encourage drug innovation. 

Market Report Scope

Liposome Drug Delivery Market Report Coverage

Report Coverage Details
Base Year: 2023 Market Size in 2024: US$ 5,482.2 Mn
Historical Data for: 2019 To 2023 Forecast Period: 2024 To 2031
Forecast Period 2024 to 2031 CAGR: 8.9% 2031 Value Projection: US$ 9,935.6 Mn
Geographies covered:
  • North America: U.S. and Canada
  • Latin America: Brazil, Argentina, Mexico, and Rest of Latin America
  • Europe: Germany, U.K., Spain, France, Italy, Russia, and Rest of Europe
  • Asia Pacific: China, India, Japan, Australia, South Korea, ASEAN, and Rest of Asia Pacific
  • Middle East: GCC Countries, Israel, and Rest of Middle East
  • Africa: South Africa, North Africa, and Central Africa
Segments covered:
  • By Product: Liposomal Paclitaxel , Liposomal Doxorubicin , Liposomal Amphotericin B , and Others
  • By Technology: Stealth Liposome Technology , Non-PEGylated Liposome Technology , and DepoFoam Liposome Technology
  • By Indication: Fungal Diseases , Pain Management , Cancer Therapeutics , and Others
  • By End User: Hospitals , Clinics , Research Laboratories , and Others 
Companies covered:

Gilead Sciences, Inc., Luye Pharma Group, Ipsen Biopharmaceuticals, Inc., Pacira Pharmaceuticals, Inc., Acuitas Therapeutics, LIPOSOMA B.V., Takeda Pharmaceutical Company Limited, Taiwan Liposome Company, Ltd., Endo International, and Jazz Pharmaceuticals plc

Growth Drivers:
  • Emerging Therapies
  • Rising Incidences of Chronic Diseases 
Restraints & Challenges:
  • Lack of Alternative Targeting Approaches
  • High Costs of Development

Key Developments

  • On February 13, 2024, Ipsen Biopharmaceuticals, Inc., a global biopharmaceutical company, announced that the U.S. Food and Drug Administration (FDA) has approved irinotecan liposome (Onivyde) for the first-line treatment of metastatic pancreatic adenocarcinoma
  • In March 2021, Jazz Pharmaceuticals plc, a pharmaceutical company, announced that the U.S. Food and Drug Administration (FDA) approved a revised label for Vyxeos (daunorubicin and cytarabine) to include a new indication to treat newly-diagnosed therapy-related acute myeloid leukemia (t-AML) or AML with myelodysplasia-related changes (AML-MRC) in pediatric patients aged one year and older. Vyxeos is a liposomal combination of daunorubicin, an anthracycline topoisomerase inhibitor, and cytarabine, a nucleoside metabolic inhibitor.
  • *Definition: Liposomes are lipid vesicles that have revolutionized drug delivery by enhancing the stability of therapeutic compounds, improving biodistribution to target sites, and minimizing systemic toxicity. These nanocarriers can encapsulate both lipophilic and hydrophilic compounds, making them versatile for drug delivery applications. They are used for a wide range of therapeutic compounds, gene therapy, and bioactive agents, with modifications constantly being explored to enhance efficacy and reduce toxicity.

Market Segmentation

  •  Product Insights (Revenue, USD Mn, 2019 - 2031)
    • Liposomal Paclitaxel
    • Lsiposomal Doxorubicin
    • Liposomal Amphotericin B
    • Others
  •  Technology Insights (Revenue, USD Mn, 2019 - 2031)
    • Stealth Liposome Technology
    • Non-PEGylated Liposome Technology
    • DepoFoam Liposome Technology
  •  Indication Insights (Revenue, USD Mn, 2019 - 2031)
    • Fungal Diseases
    • Pain Management
    • Cancer Therapeutics
    • Others
  •  End User Insights (Revenue, USD Mn, 2019 - 2031)
    • Hospitals
    • Clinics
    • Research Laboratories
    • Others
  • Regional Insights (Revenue, USD Mn, 2019 - 2031)
    • North America
      • U.S.
      • Canada
    • Latin America
      • Brazil
      • Argentina
      • Mexico
      • Rest of Latin America
    • Europe
      • Germany
      • U.K.
      • Spain
      • France
      • Italy
      • Russia
      • Rest of Europe
    • Asia Pacific
      • China
      • India
      • Japan
      • Australia
      • South Korea
      • ASEAN
      • Rest of Asia Pacific
    • Middle East
      • GCC Countries
      • Israel
      • Rest of Middle East
    • Africa
      • South Africa
      • North Africa
      • Central Africa
  • Key Players Insights
    • Gilead Sciences, Inc.
    • Luye Pharma Group
    • Ipsen Biopharmaceuticals, Inc. 
    • Pacira Pharmaceuticals, Inc.
    • Acuitas Therapeutics
    • Takeda Pharmaceutical Company Limited
    • Taiwan Liposome Company, Ltd.
    • Endo International
    • Jazz Pharmaceuticals plc

Frequently Asked Questions

The CAGR of the liposome drug delivery market is projected to be 8.9% from 2024 to 2031.

Emerging therapies and rising incidences of chronic diseases are the major factors driving the growth of the liposome drug delivery market.

Lack of alternative targeting approaches and high costs of development are the major factors hampering the growth of the liposome drug delivery market.

In terms of product, liposomal doxorubicin is estimated to dominate the market revenue share in 2024.

Gilead Sciences, Inc., Luye Pharma Group, Ipsen Biopharmaceuticals, Inc., Pacira Pharmaceuticals, Inc., Acuitas Therapeutics, LIPOSOMA B.V., Takeda Pharmaceutical Company Limited, Taiwan Liposome Company, Ltd., Endo International, and Jazz Pharmaceuticals plc are the major players.

North America is expected to lead the liposome drug delivery market.

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