PROTEIN SEQUENCING MARKET SIZE AND SHARE ANALYSIS - GROWTH TRENDS AND FORECASTS (2025-2032)

Protein Sequencing Market Size and Share Analysis  

Protein Sequencing Market is estimated to be valued at USD 2.39 Bn in 2025 and is expected to reach USD 5.32 Bn in 2032, exhibiting a compound annual growth rate (CAGR) of 12.1% from 2025 to 2032.

Key Takeaways

• Based on the Technology, the Edman Degradation segment dominate the market with 46.4% market share.
• North America is expected to be the largest market for protein sequencing during the forecast period, accounting for over 33.5% of the market share in 2025.
• Europe is expected to be the second-largest market for protein sequencing, accounting for over 22% of the market share in 2025.
• Asia Pacific is expected to be the fastest-growing market for protein sequencing, exhibiting a CAGR of over 17% during the forecast period.

Market Overview

The protein sequencing market has been witnessing dramatic growth on the back of technological advancements, the growing need for personalized medicine, and the widening scope of applications in drug discovery, biomarker identification, and disease research. The increasing interest in unravelling the complexities of proteins, their structures, and functions has driven the use of protein sequencing methods.

Current Events and Its Impact on Market

Uncover macros and micros vetted on 75+ parameters: Get instant access to report

Pricing Analysis

The protein sequencing industry has undergone a tremendous transformation in pricing dynamics due to advances in technology, competition, and growing demand for precision medicine. Conventional techniques of protein sequencing like Edman degradation are more costly and time-consuming, and hence less viable for large-scale applications. Mass spectrometry (MS) and next-generation sequencing (NGS) are now more cost-effective methods, bringing the cost of protein sequencing down in the last few years.

The cost of NGS-based protein sequencing has also gone down significantly as sequencing platforms and automation have improved, making them available to hospitals, research organizations, and academic institutions. The cost of an average proteomics analysis in 2024 can be anywhere between $1,000 and $5,000 depending on the sample size and the level of complexity in the analysis. Sequencing the entire structure and function of a single protein, for instance, can run in excess of $2,000 to $3,000.

The availability of AI-based data analysis tools further reduces costs of operation by facilitating mass data processing. This also minimizes the time required for interpretation and increases cost-effectiveness. Although top-end platforms, such as those provided by Thermo Fisher Scientific and Illumina, are at a premium price, the general market trend indicates protein sequencing is gaining access as it becomes more affordable, finding uses in broader applications in research and clinical environments.

Role of AI in the Protein Sequencing Market

The incorporation of Artificial Intelligence (AI) is transforming the protein sequencing industry, greatly improving the efficiency, accuracy, and scalability of proteomics research. AI technologies, most notably machine learning (ML) and deep learning, are being used to examine large amounts of intricate proteomic data, accelerating protein identification, structure prediction, and functional annotation. Protein folding is one of the primary domains where AI is making a mark. For example, AI systems such as DeepMind's AlphaFold have shown remarkable advances in protein structure prediction with great accuracy, a problem that has historically required years of labour-intensive research.

AI is also speeding up the data analysis process, which is important in large-scale proteomic investigations. Through the automation of data interpretation, AI eliminates human mistakes, enhances reproducibility, and enables the handling of larger datasets within shorter periods. This enables the creation of personalized medicine since AI can assist in the identification of patient-specific protein biomarkers that inform directed therapy, particularly in oncology.

In addition, AI platforms are making it possible to use the information of next-generation sequencing (NGS) more efficiently, decreasing the cost and time involved in sequencing. Consequently, the integration of AI and protein sequencing is not only making technologies available but also expanding the limits of what can be achieved with drug discovery, diagnostics, and personalized therapeutics, thus driving market expansion.

End user feedback on the Protein Sequencing Industry

IVF Clinics

IVF clinics are increasingly incorporating protein sequencing to enhance knowledge of fertility and embryonic development. Most clinics report a rising interest in employing proteomics to detect biomarkers associated with embryo quality, genetic predisposition, and implantation success. The clinics' feedback presents the fact that protein sequencing is a costly process and requires more streamlined and user-friendly platforms.

Biotechnology and Pharmaceutical Companies

Pharmaceutical and biotech firms are excited about the promise of protein sequencing to discover drugs, identify biomarkers, and enable personalized medicine. Biotechnology and pharmaceutical chemical firms are using proteomics to create targeted therapies, especially in cancer and rare genetic diseases.

Research and Academic Institutions

Academic research is a large consumer of protein sequencing for basic research in applications such as molecular biology, structural biology, and systems biology. Results from researcher feedback suggest that sequencing platforms have become more affordable in terms of cost and technology, but worries persist about the data analysis complexity and the requirement for large amounts of computational resources.

Biobanks

Biobanks are making greater use of protein sequencing to document protein biomarkers and facilitate large-scale epidemiological research. Biobank end-user input emphasizes the need for high-throughput sequencing approaches capable of supporting heterogeneous biological samples. But biobanks are confronted with sample preservation, the complexity of proteomic information, and long-term storage requirements. They look for more effective ways to handle and analyze massive datasets with a preference for platforms with strong integration possibilities with other omics technologies (e.g., genomics and transcriptomics).

Protein Sequencing Market Drivers:

• Growing investments in proteomics research: Growing investments in proteomics research are fueling the protein sequencing market growth. Proteomics, or the science of proteins and their structure and functions, has gained growing interest and investments across the world. Public and private investments in proteomics have crossed the level of US$ 2.7 billion in 2020. Thermo Fisher Scientific raised a USD 50 million investment in a public-private collaboration to drive nano proteomics research and development.

• Technological innovations in protein sequencing technologies: Technological innovations in protein sequencing technologies are propelling their enhanced uptake. Mass spectrometry platforms such as the timsTOF fleX introduced by Market Players allow 4D proteomics with greater resolution, mass accuracy, and sequencing rate.

• The advent of personalized medicine: The advent of personalized medicine and the growing emphasis on targeted therapies are accelerating the application of protein sequencing. Protein sequencing facilitates the discovery of individualized protein biomarkers that enable the creation of personalized diagnostics and medications customized to individuals.

Protein Sequencing Market Trends:

• The growing adoption of mass spectrometry for protein sequencing: The growing adoption of mass spectrometry techniques for protein sequencing is having a significant influence on the global protein sequencing market. Mass spectrometry has emerged as a powerful analytical tool that enables rapid, precise and sensitive characterization and identification of proteins from complex biological samples.
  • For instance, in 2024, the Journal of Proteome Research released a number of publications on the progress and application of MS in proteomics. For example, the quantification of a number of human proteins using species-specific tryptic peptides proved the power of MS in clinical diagnostics, pointing out its usefulness in accurate protein identification and quantification.

• Companies are increasingly focusing on developing integrated, automated sequencing systems. For instance, in March 2022, Thermo Fisher Scientific, a biotechnology company, launched the CE-IVD marked Ion Torrent Genexus Dx Integrated Sequencer, an automated, next-generation sequencing (NGS) platform that delivers results in as little as a single day.

• Use of bioinformatics tools and AI: Use of bioinformatics tools and AI for sequence analysis is rising given the vast data generated from high-throughput techniques. Software platforms like Protein Metrics' Byos allow automated, real-time protein identification from mass spec data. Sophisticated algorithms for de novo sequencing and PTM characterization also continue advancing.

• There is growing adoption of microfluidics and nanoPOTS: There is growing adoption of microfluidics and nanoPOTS for protein sequencing. Microfluidic chips allow sequencing from tiny samples, integrating sample prep and analysis. Nano- Plotter systems automate sample deposition for high-throughput Edman sequencing. These provide greater efficiency and flexibility.

Protein Sequencing Market Opportunities:

• Significant growth opportunities exist in emerging economies: Significant growth opportunities exist in emerging economies due to expanding R&D and biopharma investments. Emerging markets like China, India, and Brazil are ramping up investments in life science research and drug development. This creates substantial opportunities for protein sequencing equipment and services to support proteomics projects and biologics advancement in these high-growth markets.

• The rising adoption of next-generation sequencing: The rising adoption of next-generation sequencing is opening immense opportunities in the global protein sequencing market. Next-generation sequencing (NGS) allows high-throughput sequencing of biomolecules like DNA and RNA, and enables sequencing of entire genomes and proteomes at an unprecedented scale and speed.

• Advances in sequencing technologies: Advances in sequencing technologies offer a great opportunity for growth in the global protein sequencing market. Next generation sequencing platforms now allow for fast, inexpensive and accurate sequencing of entire genomes as well as protein-coding regions. Technologies such as nanopore sequencing and sequencing by synthesis have greatly increased sequencing throughput and speed.

• Growth of large-scale proteomics projects: Growth of large-scale proteomics projects provides opportunities for protein sequencing. Initiatives like the Human Proteome Project and the 100K Pathogen Genome Project increase interest in high-throughput, comprehensive protein sequencing to characterize proteomes. This provides growth avenues for analytics companies.

Segmental Analysis

To learn more about this report, Download Free Sample

Protein Sequencing Market Insights, By Technology

Based on the Technology, the Edman Degradation dominate the market with 46.4% market share in 2025. This growth is attributed by its established reliability and precision in sequencing amino acids in peptides. This makes it an ideal and preferred method in the proteomics research and protein analysis. The widespread adoption across various sectors such as academic, pharmaceutical, and biotechnology.

Protein Sequencing Market Regional Insights:

To learn more about this report, Download Free Sample

• North America is expected to be the largest market for protein sequencing during the forecast period. The growth of the market in North America is attributed to the high investments in proteomics and genomics research, presence of leading players, and increasing biopharma sector. Increasing product launches in the region is expected to drive the growth of the protein sequencing market in the region over the forecast period.
• Europe is expected to be the second-largest market for protein sequencing in 2025. The growth of the market in the region is attributed to increasing research on proteomics and molecular biology, funds for biotechnology research, and increasing inorganic growth strategies by market players in the region.
• Asia Pacific is expected to be the fastest-growing market for protein sequencing during the forecast period. The growth of the market in Asia Pacific is attributed to the improving R&D infrastructure, growing biopharma sector, and opportunities in emerging economies.

Protein Sequencing Market Dominating Countries  

United States Protein Sequencing Market Analysis and Trend

The United States is a prominent contributor to the global protein sequencing industry, fueled by its powerful biotechnology industry, state-of-the-art research centers, and considerable investment in life sciences. The existence of players such as Illumina, Thermo Fisher Scientific, and Agilent Technologies, as well as a large number of academic institutions, has further spurred innovation in protein sequencing technologies.

Germany Protein Sequencing Market Analysis and Trend

Germany is a prominent market player in the protein sequencing market of Europe, due to its established pharma and health industry. Germany's excellence in healthcare innovation, with support from top research centers such as the Max Planck Institute, is fueling the use of sophisticated protein sequencing methods. Germany is also an important commercialization hub for sequencing technology, with industry players like Biozym and Bruker driving market expansion.

Market Report Scope

Recent Developments

• In February 2024, Quantum-Si introduced a new version of its Platinum protein sequencing platform, with improved assays, a novel amino acid recognizer, and enhanced analytical tools. These enhancements provide increased performance, high reproducibility, and the capacity to discover unknown proteins, resulting in a substantial cost per amino acid reduction.
• In June 2024, Agilent launched the HES 2.0 ion source at the American Society for Mass Spectrometry 2024 conference. The innovation delivers atto-gram-level sensitivity and has a built-in intelligence system to automate workflows, boosting the functionality of their GC/MS and LC/Q-TOF technologies.

Analyst View

• The Protein Sequencing Market is a quick-growing and quick-evolving industry fueled by various primary drivers. Increasing demand for personalized drugs and targeted therapies, which largely depend on information about the genetic structure and protein design of a patient, is one of the primary drivers of the market. Moreover, the progressive technologies for sequencing including mass spectrometry and next-generation sequencing have significantly improved the accuracy and efficiency of protein sequencing and have further accelerated the growth of the market.
• The Protein Sequencing Market is full of promise for growth and development. With the increasing focus on drug discovery and development, coupled with the increasing prevalence of chronic diseases, demand for solutions in protein sequencing will most likely be spurred on further.
• In terms of regional dominance, North America currently holds the largest share of the Protein Sequencing Market, attributed to the presence of well-established research institutions, biotechnology companies, and substantial investments in research and development. However, the Asia-Pacific region is expected to exhibit the fastest growth in the coming years, driven by increasing government initiatives, expanding healthcare infrastructure, and rising awareness about personalized medicine.

Protein Sequencing Market Segmentation

• By Technology
• • Edman Degradation
  • Mass Spectrometry
  • Others
• By Product
• • Instruments
  • Reagents, Kits & Consumables
  • Software & Services
• By Application
• • Academic Research
  • Clinical Diagnosis
  • Biopharmaceuticals
  • Others
• By End user
• • Pharmaceutical & Biotechnology Companies
  • Academic & Research Institutes
  • Contract Research Organizations
• By Region
• • North America
  • Europe
  • Asia Pacific
  • Latin America
  • Middle East 
  • Africa
• Top Companies in Protein Sequencing Market:
• • Agilent Technologies
  • Thermo Fisher Scientific
  • SGS S.A.
  • Shimadzu Corp
  • Waters Corp.
  • Bio-Rad Laboratories
  • Bruker Corporation
  • Charles River Laboratories
  • Selvita
  • Rapid Novor Inc.

Sources

Primary Research Interviews:

• Senior Executives from leading proteomics instrument manufacturers
• R&D Directors at biopharmaceutical companies
• Clinical Laboratory Managers specializing in protein analysis
• Academic Researchers in structural biology
• Others

Databases:

• Bloomberg Professional Services (Market Data & Financial Analysis)
• GlobalData’s Pharmaceutical Intelligence Center
• Others

Magazines:

• Biopharma Trends (Coverage of Protein Analysis Technologies)
• Genetic Engineering & Biotechnology News (Proteomics Innovations)
• Analytical Chemistry Monthly
• Others

Journals’:

• Journal of Proteome Research (ACS Publications)
• Molecular & Cellular Proteomics
• Nature Biotechnology
• Others

Newspapers:

• The Wall Street Journal (Biotech Sector Updates)
• Financial Times (Pharmaceutical Industry Trends)
• BioWorld
• Others

Associations:

• American Association for Clinical Chemistry (AACC)
• Human Proteome Organization (HUPO)
• Association of Biomolecular Resource Facilities (ABRF)
• Others

Public Domain Sources:

• ClinicalTrials.gov (Protein Sequencing Clinical Studies)
• National Center for Biotechnology Information (NCBI) Databases
• U.S. FDA Drug Approval Reports
• Others

Proprietary Elements:

• CMI Data Analytics Tool
• Proprietary CMI Existing Repository of Information for Last 8 Years

Definition: Protein sequencing is the analytical process of determining the linear amino acid sequence of a protein. It gives important information regarding the structure of the protein, post-translational modifications, function, and interaction. The most important technologies involved are Edman degradation, mass spectrometry, etc. Protein sequencing is used in academic research to analyze biological pathways, clinical diagnosis for the detection of variations, development and quality control of biopharmaceuticals, forensic applications, and food analysis. With increased proteomics and genomics research, investments in biopharma, and technological developments, the protein sequencing market is expected to grow substantially.