PROTEIN SEQUENCING MARKET SIZE AND SHARE ANALYSIS - GROWTH TRENDS AND FORECASTS (2023 - 2030)

The Protein Sequencing Market size is expected to reach US$ 4 Billion by 2030, from US$ 1.9 billion in 2023, at a CAGR of 11.2% during the forecast period. Protein sequencing is the process of determining the amino acid sequence of a protein. It provides vital information about protein structure, function, and interactions. The key technologies used are Edman degradation, mass spectrometry, and others. Protein sequencing finds applications in academic research, clinical diagnosis, biopharmaceuticals, forensics, and food analysis. The growth of the market is driven by increasing investments in proteomics research, growth in the biopharmaceutical sector, and technological advancements in sequencing methods.

The Protein Sequencing Market is segmented by technology, product, application, end-user, and region. By technology, the Edman degradation segment accounts for the largest share of the market. This is attributed to its accuracy and reliability for N-terminal sequencing.

Protein Sequencing Market Regional Insights:

• North America is expected to be the largest market for Protein Sequencing Market during the forecast period, accounting for over 42% of the market share in 2022. The growth of the market in North America is attributed to the high investments in proteomics and genomics research, presence of leading players, and increasing biopharma sector.
• The Europe market is expected to be the second-largest market for Protein Sequencing Market, accounting for over 36% of the market share in 2022. The growth of the market in is attributed to the increasing research on proteomics and molecular biology, funds for biotechnology research, and presence of leading players.

• The Asia Pacific market is expected to be the fastest-growing market for Protein Sequencing Market, with a CAGR of over 17% during the forecast period. The growth of the market in Asia Pacific is attributed to the improving R&D infrastructure, growing biopharma sector, and opportunities in emerging economies.

Figure 1. Global Protein Sequencing Market Share (%), By Region, 2023

Protein Sequencing Market Drivers:

• Increasing investments in proteomics research: is driving the protein sequencing market. Proteomics, the study of proteins and their structure and functions, has seen rising interest and investments globally. Public and private funding for proteomics reached over USD 2.7 billion in 2020. Moreover, the number of proteomics studies published annually crossed 14,000 in 2019, up from just 2500 in 2001. These investments are fueling the adoption of protein sequencing as it provides vital insights into protein pathways, interactions and disease biomarkers to advance proteomics research.
• Growth of the biopharmaceutical sector: is propelling the demand for protein sequencing. The biopharma market has witnessed rapid expansion in recent years, reaching over USD 290 billion in 2021. Biologics accounted for over 30% of new drug approvals in 2021. As protein sequencing is critical for biopharmaceutical R&D and manufacturing, its growth is fueled by the rise of biologics. Protein sequencing aids in developing biologics like monoclonal antibodies, identifying drug targets, and ensuring drug safety and quality.
• Technological advances in protein sequencing methods: are driving their increased adoption. Companies have introduced mass spectrometry platforms like the timsTOF fleX that enable 4D proteomics with higher resolution, mass accuracy and sequencing speeds. Similarly, novel Edman sequencers offer automated N-terminal degradation and analysis. These advances allow deeper proteome coverage, detection of PTMs, and real-time, high-throughput sequencing to benefit research.
• The emergence of personalized medicine: and increasing focus on targeted therapies is fueling the use of protein sequencing. Sequencing helps identify unique protein biomarkers that allow development of personalized diagnostics and treatments tailored to individuals. Moreover, knowledge of mutant protein sequences guides the design of targeted therapies against them. Protein sequencing thus underpins precision diagnostics and medicines.

Protein Sequencing Market Opportunities:

• Significant growth opportunities exist in emerging economies: due to expanding R&D and biopharma investments. Emerging markets like China, India and Brazil are ramping up investments into life science research and drug development. This creates substantial opportunities for protein sequencing equipment and services to support proteomics projects and biologics advancement in these high-growth markets.
• The rising adoption of next-generation sequencing: is enabling new sequencing applications. NGS technologies like ChIP-seq allow sequencing of associated proteins, expanding sequencing into areas like protein-protein and protein-DNA interaction studies, improving understanding of biological pathways. Cross-platform bioinformatics tools also allow deeper multi-omics analysis.
• Advances in sequencing technologies: are opening up new applications. Long-read sequencing can characterize full-length proteins and modifications. Highly sensitive, high-resolution mass spec systems allow top-down intact protein analysis. Microfluidic and single-cell analysis platforms enable sequencing from minute samples. Such advances are driving adoption in new areas.
• Growth of large-scale proteomics projects: provides opportunities for protein sequencing. Initiatives like the Human Proteome Project and the 100K Pathogen Genome Project increase interest in high-throughput, comprehensive protein sequencing to characterize proteomes. This provides growth avenues for analytics companies.

Protein Sequencing Market Trends:

• The growing adoption of mass spectrometry for protein sequencing: over Edman degradation. Though Edman sequencing remains the gold standard for N-terminal analysis, mass spec is gaining wider use for its speed, sensitivity and ability to sequence entire proteins. Hybrid platforms that combine mass spec with ion mobility separation further enhance capabilities.
• Companies are increasingly focusing on developing integrated, automated sequencing systems. For instance, the BioLcx 4000 from ProteinSimple combines Edman chemistry with microfluidic arrays for automatic, parallel N-terminal sequencing of proteins. Automated sample preparation workflows reduce errors and scientist workload.
• Use of bioinformatics tools and AI: for sequence analysis is rising given the vast data generated from high-throughput techniques. Software platforms like Protein Metrics' Byos allow automated, real-time protein identification from mass spec data. Sophisticated algorithms for de novo sequencing and PTM characterization also continue advancing.
• There is growing adoption of microfluidics and nanoPOTS: for protein sequencing. Microfluidic chips allow sequencing from tiny samples, integrating sample prep and analysis. Nano- Plotter systems automate sample deposition for high-throughput Edman sequencing. These provide greater efficiency and flexibilit

Protein Sequencing Market Restraints:

• High costs of protein sequencing instruments and services: constrain market growth, especially across price-sensitive emerging markets. Advanced mass spec systems like the timsTOF fleX cost over $500,000. Even outsourced sequencing services can be expensive for academic researchers with limited budgets. This impedes adoption outside well-funded institutes and companies.
• The need for specialized personnel to operate advanced protein sequencing platforms: also limits their adoption. Expertise is required for tasks ranging from sample preparation to data analysis. Lack of qualified personnel increases reliance on service providers. Training programs for sequencers can help address this gap.
• Technical limitations of existing techniques in terms of throughput and depth of coverage: continue to restrain applications. Edman sequencing is low-throughput and provides only N-terminal information. Mass spec analysis of whole proteins remains challenging. Such issues limit comprehensive characterization of complex proteomes.

Recent Developments:

New product launches:

• In March 2022, Bruker Corporation launched the timsTOF fleX platform for high-throughput 4D proteomics. This enables faster and more sensitive protein sequencing.
• In January 2021, Thermo Fisher Scientific launched the Exploris 480 mass spectrometer for protein and small molecule analysis. It provides higher resolution and sensitivity.
• In June 2020, Agilent Technologies introduced the 6560 Ion Mobility Q-TOF LC/MS system for biopharma applications. It enables enhanced protein characterization.

Acquisition and partnerships:

• In September 2022, SGS acquired BioProof AG, a contract service lab specialized in GMP biologics testing. This expanded SGS’s biologics capabilities.
• In June 2021, Charles River Laboratories acquired Vigene Biosciences, a viral vector CDMO. This helped expand Charles River’s cell and gene therapy capabilities.
• In April 2020, Agilent partnered with SGS to provide analytical testing solutions for cell and gene therapies. This combined Agilent's analytical instruments and SGS's testing expertise.

Figure 2. Global Protein Sequencing Market Share (%), By Application, 2023

Top companies in Protein Sequencing Market:

• Agilent Technologies
• Thermo Fisher Scientific
• SGS S.A.
• Shimadzu Corp
• Waters Corp.
• Bio-Rad Laboratories
• Bruker Corporation
• Charles River Laboratories
• Selvita
• Rapid Novor Inc.

Definition: Protein sequencing is the analytical process of determining the linear amino acid sequence of a protein. It provides vital information about the protein's structure, post-translational modifications, function, and interactions. The key technologies used are Edman degradation, mass spectrometry, and others. Protein sequencing has applications in academic research to study biological pathways, clinical diagnosis for detecting variations, biopharmaceutical development and quality control, forensics, and food analysis. With growth in proteomics and genomics research, investments in biopharma, and technological advances, the protein sequencing market is poised for strong growth.

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