TOPICAL PAIN RELIEF MARKET SIZE AND SHARE ANALYSIS - GROWTH TRENDS AND FORECASTS (2025 - 2032)

Global Topical Pain Relief Market Size and Forecast – 2025 to 2032

The Global Topical Pain Relief Market is estimated to be valued at USD 11.10 Bn in 2025 and is expected to reach USD 15.93 Bn by 2032, exhibiting a compound annual growth rate (CAGR) of 5.3% from 2025 to 2032.

Key Takeaways of the Global Topical Pain Relief Market:

• In terms of product type, gels are expected to hold the largest market share at 25.6% in 2025.
• Based on active ingredient, Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) is expected to lead the market with a 32.1% share in 2025.
• The Over-the-Counter (OTC) Pain Relief segment is projected to dominate the market with a 54.3% share in 2025.
• North America is expected to lead the market, holding a share of 38.3% in 2025. Asia Pacific is anticipated to be the fastest-growing region, with a market share of 26.3% in 2025.

Market Overview:

The global topical pain relief market trend is influenced by factors such as the increasing prevalence of chronic pain conditions, rising geriatric population, and growing preference for topical pain relief products over oral medications due to their localized effect and fewer side effects. Additionally, the introduction of novel formulations, such as patches and gels, and the availability of over-the-counter topical pain relief products are expected to fuel market growth during the forecast period.

Currents Events and their Impact

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Segmental Insights

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Topical Pain Relief Market Insights, By Product Type - Gels Dominate Due to Rapid Absorption and Easy Application

In terms of product type, the gels segment is expected to contribute the highest share of the market with 25.6% in 2025 owing to their unique properties and advantages over other topical formulations. Gels are semi-solid preparations that consist of a liquid phase dispersed within a solid phase, creating a network-like structure. This unique composition allows for rapid absorption of the active ingredients into the skin, providing quick relief from pain and inflammation.

One of the primary factors driving the growth of the gels segment is the ease of application. Gels are non-greasy, lightweight, and easily spreadable, making them more convenient for patients to use compared to other topical formulations such as ointments or creams. The non-greasy nature of gels also ensures that they do not leave any residue on the skin or clothing, further enhancing their appeal among consumers.

Topical Pain Relief Market Insights, By Active Ingredient - Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Dominate the Active Ingredient Segment Due to Proven Efficacy and Wide Availability

In terms of active ingredient, Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) is projected to contribute the highest share of the market with 32.1% in 2025. NSAIDs are a class of medications that reduce pain, inflammation, and fever by inhibiting the production of prostaglandins, which are chemicals responsible for causing these symptoms. The widespread use of topical NSAIDs in pain management can be attributed to their proven efficacy, safety profile, and wide availability.

One of the key factors driving the growth of the nonsteroidal anti-inflammatory drugs (NSAIDs) segment is their well-established efficacy in treating a variety of pain conditions. Topical NSAIDs have been extensively studied and have demonstrated significant pain relief in conditions such as osteoarthritis, rheumatoid arthritis, and acute musculoskeletal injuries. The ability of topical NSAIDs to provide localized pain relief without the systemic side effects associated with oral NSAIDs has further contributed to their popularity.

Global Topical Pain Relief Market Insights, By Type - OTC Pain Relief Dominates Due to Accessibility, Cost-Effectiveness, and Consumer Preference for Self-Care

The global topical pain relief market is segmented into prescription pain relief and over-the-counter (OTC) pain relief. The Over-the-Counter (OTC) Pain Relief segment is expected to dominate the market with a share of 54.3% in 2025 due to its wide accessibility, cost-effectiveness, and growing consumer preference for self-care. OTC products are readily available without a prescription, providing affordable solutions for mild to moderate pain, making them a popular choice for everyday use. Conversely, prescription pain relief products are typically used for more severe pain and require a doctor's prescription, catering to a smaller, more specific patient group.

Macro & Micro Economic Factors Impacting Growth of Global Topical Pain Relief Market

• Microeconomic factors include consumer preferences shifting towards non-opioid pain management solutions, increased demand for innovative formulations, and the competitive landscape where companies are vying for market share through product differentiation and pricing strategies. Additionally, the rise of e-commerce has reshaped distribution channels, making products more accessible to consumers.
• Macroeconomic factors encompass broader economic conditions such as rising disposable incomes, particularly in emerging markets, which enable greater spending on healthcare. Global health initiatives promoting pain management awareness and regulatory changes facilitating faster approvals for new products also play significant roles. Furthermore, economic stability in various regions can impact healthcare expenditure, driving growth in the topical pain relief segment. Overall, these factors collectively shape the market dynamics, influencing both demand and supply.

Regional Insights

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North America Topical Pain Relief Market Analysis And Trends

North America’s dominance in the global topical pain relief market with an estimated share of 38.3% in 2025 can be attributed to several factors. The region boasts a well-established healthcare infrastructure, high consumer awareness, and a strong presence of key market players. The U.S., in particular, has a large population of aging individuals and a high prevalence of chronic pain conditions, driving the demand for topical pain relief products. Moreover, the region's favorable reimbursement policies and insurance coverage for pain management treatments contribute to its market dominance.

For instance, in March 2021, Hisamitsu America, the division of Japan-based Hisamitsu Pharmaceutical Co.—a global leader in transdermal drug delivery and makers of the Salonpas brand—launched Salonpas Arthritis Pain Relief Gel. The product contains prescription-strength diclofenac, a U.S. FDA-approved over-the-counter nonsteroidal anti-inflammatory drug clinically proven to relieve arthritis pain in major joints. Known for introducing the first U.S. FDA-approved OTC topical pain reliever in 2008, Salonpas continues to lead the U.S. topical pain relief market with its science-backed approach.

Asia Pacific Topical Pain Relief Market Analysis And Trends

The Asia Pacific region is expected to exhibit the fastest growth in the global topical pain relief market with a share of 26.3% in 2025. This growth can be ascribed to several factors, including the rising geriatric population, increasing prevalence of chronic diseases, and growing awareness about pain management therapeutics. The region's expanding healthcare infrastructure, coupled with rising disposable incomes, has fueled the demand for topical pain relief products. Countries like China and India, with their large populations and rapidly developing economies, present significant growth opportunities for market players. Additionally, the increasing adoption of western lifestyles and the surge in sports and fitness activities have contributed to the rising incidence of musculoskeletal disorders, further driving the demand for topical pain relief products in the region.

For instance, in February 2025, Wellnex Life, an Australian health and wellness company, secured market authorization from the Therapeutic Goods Administration (TGA) for its new liquid paracetamol plus caffeine soft gel. This approval supports the company’s global expansion, including its entry into the U.K. topical pain relief market, and adds to its existing TGA-approved products like liquid paracetamol and liquid mini-ibuprofen.

Global Topical Pain Relief Market Outlook for Key Countries:

U.S. Topical Pain Relief Market Trends

The U.S. market for topical pain relief products is characterized by a high level of product innovation and a diverse range of offerings. The country's large consumer base, coupled with a growing emphasis on self-care and non-invasive pain management, has driven the demand for over-the-counter topical analgesics. Key players such as Johnson & Johnson, Pfizer Inc., and Sanofi have a strong presence in the U.S. topical pain relief market, offering well-known brands and investing in marketing and distribution strategies to reach a wide consumer base.

For instance, in April 2025, Kingsway Pharmaceuticals launched PBZ OTC Pyribenzamine Antihistamine Cream, the first new topical antihistamine in 50 years, available in Target stores nationwide starting in April 2025. Powered by Tripelennamine HCL, PBZ OTC provides fast relief from itching caused by insect bites, poison ivy, sunburn, and more. Safe for use with oral allergy medications like Benadryl, it is family-friendly and suitable for ages 2 and up.

Canada Topical Pain Relief Market Trends

The Canada topical pain relief market is evolving with several key trends. There is a growing shift toward non-opioid alternatives and multimodal pain management strategies, driven by concerns over opioid use. The rise of online pharmacies and digital therapeutics is enhancing access to pain relief solutions. Additionally, personalized pain management solutions are becoming more popular, tailoring treatments based on individual pain profiles.

For instance, in February 2025, Apotex Inc., Canada’s largest pharmaceutical company, signed a licensing deal with Germany-based Grünenthal, a global leader in pain management, to gain exclusive Canadian rights to Qutenza—a topical, non-opioid patch used for treating neuropathic pain.

Germany Topical Pain Relief Market Trends

Germany's market for topical pain relief products is driven by the country's aging population and increasing prevalence of chronic pain conditions. The market is characterized by a focus on natural and organic ingredients, reflecting consumers' preferences for safe and sustainable products. German consumers are also willing to pay a premium for high-quality and innovative topical pain relief solutions. Major players in the German topical pain relief market include Beiersdorf AG and Boiron SA, which offers a range of natural and homeopathic topical pain relief products.

For instance, in October 2024, LEO Pharma A/S, a global leader in medical dermatology, launched Anzupgo (delgocitinib) cream in Germany as the first country to make the treatment available. This marks the introduction of the first topical treatment specifically indicated for adults with moderate to severe Chronic Hand Eczema (CHE), for whom topical corticosteroids are inadequate or inappropriate.

Japan Topical Pain Relief Market Trends

Japan continues to lead the Asia Pacific region in the topical pain relief market, owing to its large elderly population and high prevalence of musculoskeletal disorders. The country's well-established healthcare system and a strong emphasis on self-care have fueled the demand for over-the-counter topical analgesics. Japanese consumers are known for their brand loyalty and preference for high-quality products, creating opportunities for premium and innovative offerings. Hisamitsu Pharmaceutical Co., Inc. is a notable player in the Japanese topical pain relief market, offering a wide range of topical pain relief patches and sprays.

For instance, in March 2021, Hisamitsu America, the division of Japan-based Hisamitsu Pharmaceutical Co.—a global leader in transdermal drug delivery and makers of the Salonpas brand— launched Salonpas Arthritis Pain Relief Gel. The product contains prescription-strength diclofenac, a U.S. FDA-approved OTC NSAID clinically proven to relieve arthritis pain in major joints.

India Topical Pain Relief Market Trends

India's market for topical pain relief products is driven by the country's large population, increasing disposable incomes, and growing awareness about pain management. The market is highly price-sensitive, with consumers preferring affordable and easily accessible products. The increasing prevalence of lifestyle-related disorders and the rising popularity of ayurvedic and herbal pain relief products have created significant growth opportunities in the Indian topical pain relief market.

For instance, in September 2024, Mankind Pharma, a leading Indian pharmaceutical company known for its wide range of consumer healthcare products, launched Nimulid Strong, a topical analgesic gel and spray formulated with 2X diclofenac concentration. Designed to target neck pain, the launch is supported by the #GardanHilaateRaho campaign, which emphasizes the role of neck mobility in effective communication.

Market Players, Key Developments, and Competitive Intelligence:

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Key Developments:

• On May 6, 2025, Innocan Pharma Corporation Ltd., a biotech company specializing in cannabinoid-based therapies, received its first fully granted patent in Mexico for a proprietary cannabis-based topical pain relief formulation. The patent covers a unique blend of cannabidiol and minerals, clinically shown to provide fast, targeted pain relief within 20 minutes—marking a key milestone in Innocan’s expanding intellectual property portfolio.
• In September 2024, Organon, a global healthcare company focused on improving women’s health, announced its agreement to acquire Dermavant Sciences, a Roivant company specializing in immuno-dermatology. The deal includes VTAMA (tapinarof) cream, 1%, a novel, non-steroidal topical treatment approved for adult plaque psoriasis and currently under U.S. FDA review for atopic dermatitis in patients aged two and older.
• In September 2024, Eli Lilly and Company, a global pharmaceutical leader headquartered in Indiana, U.S announced U.S. FDA approval of EBGLYSS (lebrikizumab-lbkz) on September 13, 2024. This IL-13 inhibitor is approved for adults and children (12+ years, ≥40 kg) with moderate-to-severe atopic dermatitis not adequately managed with topical treatments. EBGLYSS offers rapid skin clearance in four weeks and itch relief in two, with sustained efficacy through a monthly maintenance dose.
• In August 2024, Advil, a flagship pain relief brand under Haleon (formerly part of GSK Consumer Healthcare), debuted its first topical solution with Advil Targeted Relief. This over-the-counter cream combines four potent pain-relieving ingredients to deliver focused relief for up to 8 hours, addressing back pain, muscle soreness, sprains, strains, and arthritis.

Top Strategies Followed by Global Topical Pain Relief Market Players

• Established players in the global topical pain relief market are focusing on extensive research and development to innovate high-performance products. These companies invest heavily in R&D to develop new formulations, delivery methods, and technologies that enhance the effectiveness and user experience of their products. By continuously innovating, they aim to stay ahead of the competition and maintain their market leadership position. Strategic partnerships are another key strategy employed by leading companies in the industry. They form alliances with major industry players or original equipment manufacturers (OEMs) to solidify their market presence and expand their reach.
  • For example, In December 2022, Lupin, a global pharmaceutical company, announced the launch of its generic version of Pennsaid, a treatment for knee pain caused by osteoarthritis, in the U.S. topical pain relief market. The company's product, Diclofenac Sodium Topical Solution 2%, is the generic equivalent of Horizon Pharma Therapeutics' Pennsaid.

• Mid-level players in the global topical pain relief market are focusing on delivering cost-effective solutions to target price-sensitive consumers. They develop quality products that offer value for money, without compromising on effectiveness. By providing affordable alternatives to premium brands, these companies aim to capture a significant share of the market, particularly in emerging economies where price is a key consideration for consumers.
  • For example, Biofreeze, a mid-level player in the global topical pain relief market, focuses on providing affordable and effective pain relief products, such as Biofreeze Pain Reliever Gel particularly for muscle and joint pain. Biofreeze has gained significant market share by offering cost-effective solutions to price-sensitive consumers, particularly in emerging markets.

• Small-scale players in the global topical pain relief market often focus on niche specialization to differentiate themselves from the competition. They develop unique products with innovative features that cater to specific market segments or customer needs. By targeting niche markets, these companies can establish a loyal customer base and generate significant revenue, despite their smaller size.
  • For example, Boiron, a homeopathic company, offers Arnicare Gel, which is made from Arnica Montana, a plant known for its anti-inflammatory and pain-relieving properties. This product targets consumers seeking natural alternatives for pain relief, particularly for bruising, muscle pain, and sprains.

Market Report Scope

Topical Pain Relief Market Dynamics

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Topical Pain Relief Market Driver - Increasing Prevalence of Chronic Pain Conditions

The rising prevalence of chronic pain conditions is a significant driver for the global topical pain relief market. Chronic pain, which persists for an extended period, affects millions of people worldwide. Conditions such as arthritis, lower back pain, neuropathic pain, and fibromyalgia are becoming increasingly common, particularly among the aging population. As people live longer, the likelihood of developing chronic pain conditions increases. Moreover, sedentary lifestyles, obesity, and stress can exacerbate these conditions. The growing burden of chronic pain has led to a higher demand for effective pain management solutions, including topical pain relief products. These products offer localized pain relief without the systemic side effects associated with oral medications. Topical formulations, such as creams, gels, patches, and sprays, provide targeted relief directly to the affected area, making them an attractive option for many patients.

As the prevalence of chronic pain continues to rise, the demand for topical pain relief products is expected to grow, driving the market forward. For instance, on May 12, 2025, UPMC Enterprises and Redesign Health launched a new startup, Glimmer Health, aimed at improving chronic pain management. The company partners with primary care providers to offer a more personalized and holistic approach to treating ongoing pain. This marks the second collaboration between UPMC Enterprises and Redesign Health, following their 2022 launch of Pip Care, a surgical app and healthcare coaching platform.

Topical Pain Relief Market Opportunity - Advancements in Formulation Technology for Market

The global topical pain relief market is poised for significant growth opportunities driven by advancements in formulation technology. Innovative developments in drug delivery systems, such as transdermal patches, nano-emulsions, and liposomal formulations, are revolutionizing the way topical pain relief products are administered and absorbed by the body. These advanced formulations offer improved skin penetration, controlled release of active ingredients, and enhanced bioavailability, leading to more effective and targeted pain relief for patients.

Moreover, the incorporation of novel drug delivery technologies allows for the formulation of combination products that can address multiple pain-related symptoms simultaneously, providing a more comprehensive treatment approach. The advancements in formulation technology also enable the development of user-friendly and convenient product formats, such as sprays, gels, and roll-ons, which cater to the varying preferences and needs of consumers. As a result, these technological advancements present a significant opportunity for manufacturers to differentiate their products, capture market share, and drive innovation in the global topical pain relief market, ultimately benefiting patients seeking effective and convenient pain management solutions.

Analyst Opinion (Expert Opinion)

• The global topical pain relief market is experiencing robust growth driven by technological advancements, increasing consumer awareness, and rising demand for non-invasive treatments. Key drivers include innovations in product formulations, such as the development of faster-acting and long-lasting topical analgesics, as well as increasing regulatory support for over-the-counter pain relief products. Additionally, the growing preference for self-care solutions and an aging population are contributing to the rise in demand for topical pain relief products. However, challenges such as the need for strict regulatory standards and the high competition from alternative pain management methods, like opioids and oral medications, pose significant hurdles for the market.
• Notable industry events, such as the Global Pain Congress and the International Pain Summit, have played a crucial role in knowledge-sharing, policy formulation, and technology showcases. These conferences highlight emerging trends and discuss innovative solutions in pain management. In terms of market-related initiatives, companies like Pfizer and Johnson & Johnson have introduced new, clinically effective topical pain relief products, while governments in regions like North America and Europe have launched initiatives to improve access to non-addictive pain relief solutions, thereby shaping the market's future trajectory.

Market Segmentation

•  Product Type Insights (Revenue, USD Bn, 2020 - 2032)
  • Gels
  • Creams
  • Ointments
  • Patches
  • Sprays
  • Roll-ons
•  Active Ingredient Insights (Revenue, USD Bn, 2020 - 2032)
  • Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
  • Counterirritants
  • Anesthetics
  • Salicylates
  • Capsaicin
  • Menthol
•  Type Insights (Revenue, USD Bn, 2020 - 2032)
  • Prescription Pain Relief
  • Over-the-Counter (OTC) Pain Relief
•  Application Insights (Revenue, USD Bn, 2020 - 2032)
  • Arthritis Pain
  • Muscle and Joint Pain
  • Back Pain
  • Sports Injuries
  • Neuropathic Pain
  • Post-Surgical Pain
•  Patient Demographics Insights (Revenue, USD Bn, 2020 - 2032)
  • Adults
  • Geriatrics
  • Pediatrics
•  Distribution Channel Insights (Revenue, USD Bn, 2020 - 2032)
  • Online Pharmacies
  • Retail Pharmacies
  • Hospitals Pharmacy
  • Supermarkets/Hypermarkets
  • Health and Wellness Stores
• Regional Insights (Revenue, USD Bn, 2020 - 2032)
  • North America
    • U.S.
    • Canada
  • Latin America
    • Brazil
    • Argentina
    • Mexico
    • Rest of Latin America
  • Europe
    • Germany
    • U.K.
    • Spain
    • France
    • Italy
    • Russia
    • Rest of Europe
  • Asia Pacific
    • China
    • India
    • Japan
    • Australia
    • South Korea
    • ASEAN
    • Rest of Asia Pacific
  • Middle East
    • GCC Countries
    • Israel
    • Rest of Middle East
  • Africa
    • South Africa
    • North Africa
    • Central Africa

Sources

Primary Research Interviews

• Interviews with healthcare professionals (e.g., doctors, physiotherapists, chiropractors)
• Surveys of patients using topical pain relief products
• Discussions with pharmacists and drug store managers
• Interviews with industry experts and key opinion leaders (KOLs) in pain management
• Consultations with manufacturers of raw materials for topical pain relief formulations

Databases

• World Health Organization (WHO)
• Centers for Disease Control and Prevention (CDC)
• U.S. Food and Drug Administration (FDA)
• European Medicines Agency (EMA)
• National Institutes of Health (NIH)

Magazines

• Pain Medicine News
• Drug Development & Delivery
• Pharmaceutical Technology
• Pharmacy Times
• OTC Bulletin

Journals

• The Journal of Pain
• Pain Medicine
• European Journal of Pain
• Journal of Clinical Pharmacy and Therapeutics
• The Journal of Rheumatology

Newspapers

• The New York Times
• The Guardian
• The Washington Post
• BBC News
• Financial Times

Associations

• American Pain Society (APS)
• International Association for the Study of Pain (IASP)
• National Fibromyalgia Association (NFA)
• American Academy of Pain Medicine (AAPM)
• The Arthritis Foundation

Public Domain Sources

• ClinicalTrials.gov
• Google Scholar
• World Pain Society
• Open Access Journals (e.g., Frontiers in Pain Research)

Proprietary Elements

• CMI Data Analytics Tool Proprietary analytics tool to analyze real-time market trends, consumer behavior, and technology adoption in market
• Proprietary CMI Existing Repository of Information for Last 8 Years