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  • Published On : Mar 2021
  • Code : CMI4257
  • Industry : Biotechnology
  • Pages : 198
  • Formats :

Oligonucleotides are short DNA or RNA molecules and have specific sequence of nucleotide residue, which makes an entire molecule. Oligonucleotides readily bind in specific sequencing manner to their respective DNA-RNA oligonucleotide to form duplex chain. Oligonucleotides are chemically synthesized molecular chains with phosphoramidite components of natural or chemically modified nucleosides and have wide range of applications in generic testing, research, and forensic.

The global oligonucleotide synthesis market is estimated to be valued at US$ 2,874.1 Million in 2020 and is expected to exhibit a CAGR of 11.3% during the forecast period (2020-2027).

Figure 1. Global Oligonucleotide Synthesis Market Share (%) in Terms of Value, By Region, 2020

Oligonucleotide Synthesis  | Coherent Market Insights

Increasing research and development activities in the field of genomics and genetics is expected to propel the market growth during the forecast period

Research institutes and diagnostic centers have shifted their focus on genomics and genetics due, which has increased demand for high quality synthesized oligonucleotides in the market over the past few years. For instance, in July 2020, researchers of Rosalind Franklin University of Medicine and Science initiated a new therapeutic approach for treating Batten disease, a fatal neurodegenerative disease in children with the help of antisense oligonucleotides. These factors are expected to drive the global oligonucleotide synthesis market growth over the forecast period.

Expansion of manufacturing facilities by market players is expected to drive the market growth during the forecast period

Biotechnological companies are focusing on expanding their manufacturing facilities due to increasing demand for oligonucleotides from pharmaceutical companies. For instance, in March 2020, STA pharmaceuticals, a subsidiary of WuXi AppTech, announced inauguration of its large scale oligonucleotide active pharmaceutical ingredient manufacturing facility in China.

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Oligonucleotide Synthesis Market Report Coverage

Report Coverage Details
Base Year: 2019 Market Size in 2020: US$ 2,874.1 Mn
Historical Data for: 2016 to 2019 Forecast Period: 2020 to 2027
Forecast Period 2020 to 2027 CAGR: 11.3% 2027 Value Projection: US$ 6,080.8 Mn
Geographies covered:
  • North America: U.S. and Canada
  • Latin America: Brazil, Argentina, Mexico, and Rest of Latin America
  • Europe: Germany, U.K., Spain, France, Italy, Russia, and Rest of Europe]
  • Asia Pacific: China, India, Japan, Australia, South Korea, ASEAN, and Rest of Asia Pacific
  • Middle East: GCC, Israel, and Rest of Middle East
  • Africa: South Africa, North Africa, and Central Africa
Segments covered:
  • By Equipment & Services: 
    • Equipment/Synthesizer
    • Reagents
    • Services: Oligo Synthesis, Modification, Purification.
  • By Technology: Column-based, Microarray-based.
  • By Nucleic Acid Type: DNA, RNA.
  • By Application: Drug Discovery, Therapeutics.
  • By End User: Academic Research Institutes, Diagnostic Laboratories, Pharmaceutical-Biotechnology Companies.
Companies covered:

Thermo Fisher Scientific, Sigma-Aldrich Corporation, GE Healthcare, Integrated DNA Technologies, Inc., TriLink Biotechnologies’, Inc, BioAutomation Corporation,  Twist Bioscience, Shanghai SynTheAll Pharmaceutical Co., CUSABIO Technology LLC, Synbio Technologies, GENEWIZ, Eurofins Scientific, Agilent Technologies, Kaneka Eurogentec S.A., and LGC, Biosearch Technologies

Growth Drivers:
  • Increasing research and development activities in the field of genomics and genetics
  • Expansion of manufacturing facilities by market players
Restraints & Challenges:
  • Oligo-degradation in generic testing
  • Low quality of microarray generated oligonucleotide sequence

Global Oligonucleotide Synthesis Market – Impact of Coronavirus (COVID-19) Pandemic

The coronavirus disease (COVID-19) outbreak was first reported on December 31, 2019, in Wuhan, China. The World Health Organization declared COVID-19 as pandemic on March 11, 2020.

According to the Coronavirus Disease (COVID-19) Weekly Epidemiological Update by the World Health Organization, over 61.8 million cases and 1.4 million deaths due to coronavirus disease (COVID-19) were reported up till November 29, 2020 across the globe.

In order to deal with the COVID-19 pandemic, market players and government authorities are collaborating, in order to explore the oligonucleotide platform for the development of COVID-19 treatment. For instance, on April 28, 2020, Sarepta Therapeutics, Inc., and the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID), a department of defense’s lead laboratory for medical biological defense research entered into a cooperative research and development agreement (CRADA) to identify antisense oligonucleotides against SARS-CoV-2 for the potential treatment of COVID-19.

Figure 2. Global Oligonucleotide Synthesis Market Share (%) in Terms of Value, By Equipment & Services, 2020

Oligonucleotide Synthesis  | Coherent Market Insights

Global Oligonucleotide Synthesis Market: Restraints

Natural oligonucleotides are composed of ribose or deoxyribose sugar phosphate as a base, which are quickly degraded in the body by nucleus. Moreover in generic testing, oligo-degradation can affect cell growth and cell proliferation. Furthermore, low quality of microarray generated oligonucleotide sequence is a major challenge in adopting microarray technology for oligonucleotide synthesis. These factors are expected to restrain the global oligonucleotide synthesis market growth.

Key Players

Major players operating in the global oligonucleotide synthesis market include Thermo Fisher Scientific, Sigma-Aldrich Corporation, GE Healthcare, Integrated DNA Technologies, Inc., TriLink BioTechnologies, Inc, BioAutomation Corporation, Twist Bioscience, Shanghai SynTheAll Pharmaceutical Co., CUSABIO Technology LLC, Synbio Technologies, GENEWIZ, Eurofins Scientific, Agilent Technologies, Kaneka Eurogentec S.A., and LGC, Biosearch Technologies

Oligonucleotides are commonly used as primers for polymerase chain reaction (PCR), PCR assays, and panels for biologically related genes. Antisense oligonucleotides are used to reduce levels of protein synthesis by inhibiting mRNA processing or translation. Other uses of oligonucleotides include DNA sequencing, DNA microarrays, fluorescence in situ hybridization (FISH), and nucleic acid aptamers. Moreover, many pharmaceutical companies are focusing on developing nucleic acid-based therapeutics due to which the demand of oligonucleotide is increasing. Hence, market players are focusing on expanding their manufacturing facilities, which is expected to boost the market growth over the forecast period. For instance, in August 2020, Agilent Technologies Inc., announced the expansion of its state-of-the-art production facility in Frederick, Colorado, which develops manufactures oligos that hold potential to be used as treatments for diseases such as COVID-19, cardiovascular disease, cancer, rare and infectious diseases, and other conditions.

Market Dynamics:

Key players are focusing on various inorganic growth strategies such as collaborations, partnerships and agreements, which is expected to propel the growth of the global oligonucleotide synthesis market during the forecast period. For instance, on August 05, 2020, Evotec SE, a drug discovery and development company entered into a strategic partnership with Secarna Pharmaceuticals GmbH & Co. KG, a drug discovery company, for the development of antisense oligonucleotide therapies.

Moreover, in November 2019, CSBio, a peptide and instrumentation manufacturing company entered into a collaboration with Sunresin, a supplier of ion exchange resin and absorption & separation resin for the development of an optimized polystyrene resin for commercial scale oligonucleotide synthesis.

Key features of the study:

  • This report provides in-depth analysis of the global oligonucleotide synthesis market, and provides market size (US$ Bn) and compound annual growth rate (CAGR%) for the forecast period (2020–2027), considering 2019 as the base year
  • It elucidates potential revenue opportunities across different segments and explains attractive investment proposition matrices for this market
  • This study also provides key insights about market drivers, restraints, opportunities, new product launches or approval, market trends,  regional outlook, and competitive strategies adopted by key players
  • It profiles key players in the global oligonucleotide synthesis market based on the following parameters – company overview, financial performance, product portfolio, market presence, distribution strategies, key developments, strategies, and future plans.
  • Key companies covered as a part of this study include Thermo Fisher Scientific, Sigma-Aldrich Corporation, GE Healthcare, Integrated DNA Technologies, Inc., TriLink BioTechnologies, Inc, BioAutomation Corporation, Twist Bioscience, Shanghai SynTheAll Pharmaceutical Co., CUSABIO Technology LLC, Synbio Technologies, GENEWIZ, Eurofins Scientific, Agilent Technologies, Kaneka Eurogentec S.A., and LGC, Biosearch Technologies
  • Insights from this report would allow marketers and management authorities of companies to make informed decisions regarding future product launches, market expansion, and marketing tactics
  • The global oligonucleotide synthesis market report caters to various stakeholders in this industry including investors, suppliers, product manufacturers, distributors, new entrants, and financial analysts
  • Stakeholders would have ease in decision-making through various strategy matrices used in analyzing the global oligonucleotide synthesis market.

Detailed Segmentation:

  • Global Oligonucleotide Synthesis Market, By Equipment & Services:
    • Equipment/Synthesizer
    • Reagents
    • Services
      • Oligo Synthesis
      • Modification
      • Purification
  • Global Oligonucleotide Synthesis Market, By Technology:
    • Column-based
    • Microarray-based
  • Global Oligonucleotide Synthesis Market, By Nucleic Acid Type:
    • DNA
    • RNA
  • Global Oligonucleotide Synthesis Market, By Application:
    • Drug Discovery
    • Therapeutics
  • Global Oligonucleotide Synthesis Market, By End User:
    • Academic Research Institutes
    • Diagnostic Laboratories
    • Pharmaceutical-Biotechnology Companies
  • Global Oligonucleotide Synthesis Market, By Region:
    • North America
      • By Equipment & Services
        • Equipment/Synthesizer
        • Reagents
        • Services
          • Oligo Synthesis
          • Modification
          • Purification
      • By Technology
        • Column-based
        • Microarray-based
      • By Nucleic Acid Type
        • DNA
        • RNA
      • By Application
        • Drug Discovery
        • Therapeutics
      • By End User
        • Academic Research Institutes
        • Diagnostic Laboratories
        • Pharmaceutical-Biotechnology Companies
      • By Country:
        • U.S.
        • Canada
    • Latin America
      • By Equipment & Services
        • Equipment/Synthesizer
        • Reagents
        • Services
          • Oligo Synthesis
          • Modification
          • Purification
      • By Technology
        • Column-based
        • Microarray-based
      • By Nucleic Acid Type
        • DNA
        • RNA
      • By Application
        • Drug Discovery
        • Therapeutics
      • By End User
        • Academic Research Institutes
        • Diagnostic Laboratories
        • Pharmaceutical-Biotechnology Companies  
      • By Country:
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
    • Europe
      • By Equipment & Services
        • Equipment/Synthesizer
        • Reagents
        • Services
          • Oligo Synthesis
          • Modification
          • Purification
      • By Technology
        • Column-based
        • Microarray-based
      • By Nucleic Acid Type
        • DNA
        • RNA
      • By Application
        • Drug Discovery
        • Therapeutics
      • By End User
        • Academic Research Institutes
        • Diagnostic Laboratories
        • Pharmaceutical-Biotechnology Companies  
      • By Country:
        • Germany
        • U.K.
        • France
        • Italy
        • Spain
        • Russia
        • Rest of Europe
    • Asia Pacific
      • By Equipment & Services
        • Equipment/Synthesizer
        • Reagents
        • Services
          • Oligo Synthesis
          • Modification
          • Purification
      • By Technology
        • Column-based
        • Microarray-based
      • By Nucleic Acid Type
        • DNA
        • RNA
      • By Application
        • Drug Discovery
        • Therapeutics
      • By End User
        • Academic Research Institutes
        • Diagnostic Laboratories
        • Pharmaceutical-Biotechnology Companies  
      • By Country:
        • China
        • India
        • Japan
        • Australia
        • South Korea
        • ASEAN
        • Rest of Asia Pacific
    • Middle East
      • By Equipment & Services
        • Equipment/Synthesizer
        • Reagents
        • Services
          • Oligo Synthesis
          • Modification
          • Purification
      • By Technology
        • Column-based
        • Microarray-based
      • By Nucleic Acid Type
        • DNA
        • RNA
      • By Application
        • Drug Discovery
        • Therapeutics
      • By End User
        • Academic Research Institutes
        • Diagnostic Laboratories
        • Pharmaceutical-Biotechnology Companies  
      • By Country:
        • GCC
        • Israel
        • Rest of Middle East
    • Africa
      • By Equipment & Services
        • Equipment/Synthesizer
        • Reagents
        • Services
          • Oligo Synthesis
          • Modification
          • Purification
      • By Technology
        • Column-based
        • Microarray-based
      • By Nucleic Acid Type
        • DNA
        • RNA
      • By Application
        • Drug Discovery
        • Therapeutics
      • By End User
        • Academic Research Institutes
        • Diagnostic Laboratories
        • Pharmaceutical-Biotechnology Companies  
      • By Country/Region:
        • South Africa
        • Central Africa
        • North Africa
  • Company Profiles
    • Thermo Fisher Scientific
      • Company Overview
      • Product Portfolio
      • Financial Overview
      • Key Highlights
      • Market Strategies
    • Sigma-Aldrich Corporation
    • GE Healthcare
    • Integrated DNA Technologies, Inc.
    • TriLink BioTechnologies, Inc
    • BioAutomation Corporation
    • Twist Bioscience
    • Shanghai SynTheAll Pharmaceutical Co.
    • CUSABIO Technology LLC
    • Synbio Technologies
    • GENEWIZ
    • Eurofins Scientific
    • Agilent Technologies
    • Kaneka Eurogentec S.A.
    • LGC, Biosearch Technologies

“*” marked represents similar segmentation in other categories in the respective section.

Frequently Asked Questions

The global oligonucleotide synthesis market size is estimated to surpass US$ 6,080.8 Million by 2027.
The market is expected to register a CAGR of 11.3% during the forecast period (2020-2027).
Increasing research and development activities in the field of genomics and genetics and expansion of manufacturing facilities by market players are driving the market growth.
The equipment/synthesizer segment is estimated to hold major market share in 2020 owing to product launches by market players.
Major factors hampering growth of the market are oligo-degradation in generic testing and low quality of microarray generated oligonucleotide sequence.
Major players operating in the market include Thermo Fisher Scientific, Sigma-Aldrich Corporation, GE Healthcare, Integrated DNA Technologies, Inc., TriLink BioTechnologies, Inc, BioAutomation Corporation, Twist Bioscience, Shanghai SynTheAll Pharmaceutical Co., CUSABIO Technology LLC, Synbio Technologies, GENEWIZ, Eurofins Scientific, Agilent Technologies, Kaneka Eurogentec S.A., and LGC, Biosearch Technologies.

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