Impact Analysis of Covid-19

The complete version of the Report will include the impact of the COVID-19, and anticipated change on the future outlook of the industry, by taking into the account the political, economic, social, and technological parameters.

Protein A—a 42-kDa chemical component found in the cell wall of staphylococcus aureus—finds wide application in biotechnological industry. This is mainly attributed to features such as its ability to bind all human IgG class immunoglobulins except IgG3.

Statistics:

The global protein A resin market is estimated to account for US$ 511.7 Mn in terms of value in 2020 and is expected to reach US$ 907.3 Mn by the end of 2027.

Global Protein A Resin Market: Drivers

Approval of monoclonal antibodies for the treatment of various diseases is expected to propel growth of the global protein A resin market over the forecast period. For instance, in December 2019, The World Health Organization (WHO) prequalified its first biosimilar medicine – trastuzumab –– a monoclonal antibody for the treatment of early stage breast cancer. On an average trastuzumab costs US$ 20,000. However, the biosimilar version of trastuzumab is generally 65% cheaper than the originator.

Moreover, emergence of chronic diseases is also expected to aid in growth of the global protein A resin market. For instance, according to the American Cancer Society, in 2019, there will be an estimated 1,762,450 new cancer cases diagnosed and 606,880 cancer deaths in the U.S.

Statistics:

Natural Protein A held dominant position in the global protein A resin market in 2019, accounting for 63.1% share in terms of value, followed by Recombinant Protein A, respectively.

Figure 1. Global Protein A Resin Market Share (%), by Value, by Product, 2019

Protein A Resin  | Coherent Market Insights

Global Protein A Resin Market: Restraints

Rise in alternate methods for purification of monoclonal antibodies is expected to hinder growth of the global protein A resin market. Affinity chromatography, which utilizes protein A resin, is a conventional method for purification of monoclonal antibodies. However, cost and availability of protein A resin is very high to perform purification process. To reduce production costs, various companies prefer alternative methods such as membrane chromatography, mixed chromatography, and aqueous two-phase extractions (ATPS) for purification of monoclonal antibodies in large scales.

Moreover, high costs associated with protein A resin is also expected to hinder growth of the market.  The cost of protein A resin is US$ 15,000 – US$ 16,000 per one litre. Large-scale manufacturers require protein A in large amounts for purification, which increases production costs of monoclonal antibodies.

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Protein A Resin Market Report Coverage

Report Coverage Details
Base Year: 2019 Market Size in 2019: US$ 474.0 Mn
Historical Data for: 2016 to 2019 Forecast Period: 2020 to 2027
Forecast Period 2020 to 2027 CAGR: 8.5% 2027 Value Projection: US$ 907.3 Mn
Geographies covered:
  • North America: U.S., Canada
  • Latin America: Brazil, Argentina, Mexico, Rest of Latin America
  • Europe: Germany, U.K., Spain, France, Italy, Russia, Rest of Europe
  • Asia Pacific: China, India, Japan, Australia, South Korea, ASEAN, Rest of Asia Pacific
  • Middle East: GCC Countries, Israel, Rest of Middle East
  • Africa: South Africa, North Africa, Central Africa
Segments covered:
  • By Product: Natural Protein A, Recombinant Protein A.
  • By Matrix Type: Agarose-based, Glass or Silica Based, Organic Polymer Based.
  • By Application: Immunoprecipitation (IP), Antibody Purification.
  • By End User: Biopharmaceutical Manufacturers, Clinical Research Laboratories, Academic Institutes.
Companies covered:

GE Healthcare, Thermo Fisher Scientific, Repligen, Tosoh Bioscience, EMD Millipore, Novasep, GenScript Biotech Corporation, Purolite Life Sciences, and Expedeon Ltd.

Growth Drivers:
  • Technological advancement
  • Increasing approvals of monoclonal antibodies
Restraints & Challenges:
  • Rise in alternate methods for purification of monoclonal antibodies

Global Protein A Resin Market: Opportunities 

Launch of new monoclonal antibodies is expected to offer lucrative growth opportunities for players in the global protein A resin market. For instance, in September 2019, Biocare Medical, LLC launched a new mouse monoclonal antibody, p16 INK4a, for in vitro diagnostic use in the qualitative identification of the p16 INK4a protein by immunohistochemistry in formalin-fixed paraffin-embedded human tissues.

Moreover, increasing investment for R&D in monoclonal antibodies and biologics manufacturing is also expected to aid in growth of the global protein A resin market. For instance, in February 2018, Ferring Pharmaceuticals announced to invest around US$ 30 million in the new Ferring Biotech Center in Saint-Prex, Switzerland, for R&D in monoclonal antibodies and biologics manufacturing.

The global protein A resin market was valued at US$ 474.0 Mn in 2019 and is forecast to reach a value of US$ 907.3 Mn by 2027 at a CAGR of 8.5% between 2020 and 2027.

Figure 2. Global Protein A Resin Market Value (US$ Mn), and Y-o-Y Growth (%), 2019-2027

Protein A Resin  | Coherent Market Insights

Market Trends/Key Takeaways

R&D in synthesis of proteins is expected to propel growth of the global protein A resin market over the forecast period. For instance, in May 2020, researchers from Massachusetts Institute of Technology reported developed a protocol to rapidly produce protein chains up to 164 amino acids long.

Major players in the global protein A resin market are focused on launch of new products to expand their product portfolio. For instance, in June 2018, Purolite Life Sciences, a provider of pharmaceutical applications, launched new-generation protein A agarose resin ‘Praesto Jetted A50’. This new resin is a combination of jetting technology and high performance protein A ligand.

Global Protein A Resin Market: Competitive Landscape

Major players operating in the global protein A resin market include, GE Healthcare, Thermo Fisher Scientific, Repligen, Tosoh Bioscience, EMD Millipore, Novasep, GenScript Biotech Corporation, Purolite Life Sciences, and Expedeon Ltd.

Global Protein A Resin Market: Key Developments

Major players in the global protein A resin market are focused on investment in expansion of manufacturing capabilities to enhance their market share. For instance, in September 2018, Purolite Life Sciences started a manufacturing facility in Llantrisant Business Park, Wales, capable of producing 100,000L of its Praesto range of agarose Protein A affinity resins.

Protein A is a bacterial protein, which has capacity to bind mammalian antibodies of class immunoglobulin G with great affinity. Protein G binds to all subclasses of human immunoglobulin G (IgG) makes it useful for purifying polyclonal or monoclonal IgG antibodies whose subclasses have not been determined. Monoclonal antibodies are defined as ‘an antibody produced by a single clone of cells'. It can be used to carry drugs, toxins, or radioactive substances traditional to cancer cells. Monoclonal antibodies have been showing promising results in the management of chronic diseases such as cancers and rheumatoid arthritis. These are essential and are broadly used as purification and separation materials due to high resolution, across the biopharmaceutical industry. Natural protein A can be produced from Staphylococcus aureus, though protein A is now commonly produced recombinant in Escherichia coli. Chromatography with these has several advantages as a separation method, over conventional techniques such as solvent extraction, crystallization, and distillation.

Restraints of the Global Protein A Resin Market

Major factors hampering the growth of the protein A resin market during the forecast period constitutes of rise in alternate methods for purification of monoclonal antibodies.

Key features of the study:

  • This report provides in-depth analysis of the global protein A resin market and provides market size (US$ Million) and compound annual growth rate (CAGR %) for the forecast period (2020–2027), considering 2019, as the base year
  • It elucidates potential revenue opportunity across different segments and explains attractive investment proposition matrix for this market
  • This study also provides key insights about market drivers, restraints, opportunities, new product launches or approval, regional outlook, and competitive strategy adopted by leading players
  • It profiles leading players in the global protein A resin market based on the following parameters – company overview, financial performance, product portfolio, geographical presence, distribution strategies, key developments, strategies, and future plans
  • Key companies covered as a part of this study include GE Healthcare, Thermo Fisher Scientific, Repligen, Tosoh Bioscience, EMD Millipore, Novasep, GenScript Biotech Corporation, Purolite Life Sciences, and Expedeon Ltd.
  • Insights from this report would allow marketers and the management authorities of companies to make informed decision regarding future product launches, technology up-gradation, market expansion, and marketing tactics
  • The global protein A resin market report caters to various stakeholders in this industry including investors, suppliers, product manufacturers, distributors, new entrants, and financial analysts.
  • Stakeholders would have ease in decision-making through various strategy matrices used in analyzing the market.

Detailed Segmentation

  • Global Protein A Resin Market, By Product:
    • Natural Protein A
    • Recombinant Protein A
  • Global Protein A Resin Market, By Matrix Type:
    • Agarose-based
    • Glass or Silica Based
    • Organic Polymer Based
  • Global Protein A Resin Market, By Application:
    • Immunoprecipitation (IP)
    • Antibody Purification
  • Global Protein A Resin Market, By End User:
    • Biopharmaceutical Manufacturers
    • Clinical Research Laboratories
    • Academic Institutes
  • Global Protein A Resin Market, By Geography:
    • North America
      • By Product
        • Natural Protein A
        • Recombinant Protein A
      • By Matrix Type
        • Agarose-based
        • Glass or Silica Based
        • Organic Polymer Based
      • By Application
        • Immunoprecipitation (IP)
        • Antibody Purification
      • By End User
        • Biopharmaceutical Manufacturers
        • Clinical Research Laboratories
        • Academic Institutes
      • By Country:
        • U.S.
        • Canada
    • Europe
      • By Product
        • Natural Protein A
        • Recombinant Protein A
      • By Matrix Type
        • Agarose-based
        • Glass or Silica Based
        • Organic Polymer Based
      • By Application
        • Immunoprecipitation (IP)
        • Antibody Purification
      • By End User
        • Biopharmaceutical Manufacturers
        • Clinical Research Laboratories
        • Academic Institutes
      • By Country:
        • U.K.
        • Germany
        • Italy
        • France
        • Spain
        • Russia
        • Rest of Europe
    • Asia Pacific
      • By Product
        • Natural Protein A
        • Recombinant Protein A
      • By Matrix Type
        • Agarose-based
        • Glass or Silica Based
        • Organic Polymer Based
      • By Application
        • Immunoprecipitation (IP)
        • Antibody Purification
      • By End User
        • Biopharmaceutical Manufacturers
        • Clinical Research Laboratories
        • Academic Institutes
      • By Country:
        • China
        • India
        • Japan
        • ASEAN
        • Australia
        • South Korea
        • Rest of Asia Pacific
    • Latin America
      • By Product
        • Natural Protein A
        • Recombinant Protein A
      • By Matrix Type
        • Agarose-based
        • Glass or Silica Based
        • Organic Polymer Based
      • By Application
        • Immunoprecipitation (IP)
        • Antibody Purification
      • By End User
        • Biopharmaceutical Manufacturers
        • Clinical Research Laboratories
        • Academic Institutes
      • By Country:
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
    • Middle East:
      • By Product
        • Natural Protein A
        • Recombinant Protein A
      • By Matrix Type
        • Agarose-based
        • Glass or Silica Based
        • Organic Polymer Based
      • By Application
        • Immunoprecipitation (IP)
        • Antibody Purification
      • By End User
        • Biopharmaceutical Manufacturers
        • Clinical Research Laboratories
        • Academic Institutes
      • By Country:
        • GCC
        • Israel
        • Rest of Middle East
    • Africa
      • By Product
        • Natural Protein A
        • Recombinant Protein A
      • By Matrix Type
        • Agarose-based
        • Glass or Silica Based
        • Organic Polymer Based
      • By Application
        • Immunoprecipitation (IP)
        • Antibody Purification
      • By End User
        • Biopharmaceutical Manufacturers
        • Clinical Research Laboratories
        • Academic Institutes
      • By Country/Region:
        • Central Africa
        • South Africa
        • North Africa
  • Company Profiles
    • GE Healthcare*
      • Company Overview
      • Product Portfolio
      • Financial Performance
      • Key Strategies
      • Recent Developments
    • Thermo Fisher Scientific
    • Repligen
    • Tosoh Bioscience
    • EMD Millipore
    • Novasep
    • GenScript Biotech Corporation
    • Purolite Life Sciences
    • Expedeon Ltd.
    • Other Players

 “*” marked represents similar segmentation in other categories in the respective section.

Table of Contents

  1. Research Objective and Assumption
    • Research Objectives
    • Assumptions
    • Abbreviations
  2. Market Purview
    • Report Description
      • Market Definition and Scope
    • Executive Summary
      • Market Snippet, By Product
      • Market Snippet, By Matrix Type
      • Market Snippet, By Application
      • Market Snippet, By End User
    • Coherent Opportunity Map (COM)
  3. Market Dynamics, Regulations, and Trends Analysis
    • Market Dynamics
      • Drivers
      • Restraints
      • Market Opportunities
    • Impact Analysis
    • Key Developments
    • Regulatory Scenario
    • PEST Analysis
    • COVID-19 Impact Analysis
  4. Global Protein A Resin Market, By Product, 2019 – 2027 (US$ Mn)
    • Introduction
      • Market Share Analysis, 2019 and 2027 (%)
      • Y-o-Y Growth Analysis, 2017–2027
      • Segment Trends
    • Natural Protein A
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
      • Segment Trends
    • Recombinant Protein A
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
      • Segment Trends
  5. Global Protein A Resin Market, By Matrix Type, 2019 – 2027 (US$ Mn)
    • Introduction
      • Market Share Analysis, 2019 and 2027 (%)
      • Y-o-Y Growth Analysis, 2017–2027
      • Segment Trends
    • Agarose-based
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Glass or Silica Based
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Organic Polymer Based
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
  6. Global Protein A Resin Market, By Application, 2019 – 2027 (US$ Mn)
    • Introduction
      • Market Share Analysis, 2019 and 2027 (%)
      • Y-o-Y Growth Analysis, 2017–2027
      • Segment Trends
    • Immunoprecipitation (IP)
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Antibody Purification
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
  7. Global Protein A Resin Market, By End User, 2019 – 2027 (US$ Mn)
    • Introduction
      • Market Share Analysis, 2019 and 2027 (%)
      • Y-o-Y Growth Analysis, 2017–2027
      • Segment Trends
    • Biopharmaceutical Manufacturers
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Clinical Research Laboratories
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Academic Institutes
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
  8. Global Protein A Resin Market, By Regions, 2019 – 2027 (US$ Mn)
    • Introduction
      • Market Share Analysis, 2019 and 2027 (%)
      • Y-o-Y Growth Analysis, 2017–2027
      • Segment Trends
    • North America
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
        • U.S.
        • Canada
    • Europe
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
        • U.K.
        • Germany
        • Italy
        • France
        • Spain
        • Russia
        • Rest of Europe
    • Asia Pacific
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
        • China
        • India
        • Japan
        • ASEAN
        • Australia
        • South Korea
        • Rest of Asia Pacific
    • Latin America
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
    • Middle East
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
        • GCC
        • Israel
        • Rest of Middle East
    • Africa
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
        • North Africa
        • Central Africa
        • South Africa
  9. Competitive Landscape
    • Company Profiles
      • GE Healthcare
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • Thermo Fisher Scientific
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • Repligen
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • Tosoh Bioscience
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • EMD Millipore
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • Novasep
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • GenScript Biotech Corporation
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • Purolite Life Sciences
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • Expedeon Ltd.
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • Other Players
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
  10. Section
    • References
    • Research Methodology
    • About us and Sales Contact

*Browse 31 market data tables and 22 figures on “Protein A Resin Market – Global forecast to 2027.

Frequently Asked Questions

The global protein A resin market was valued at US$ 474.0 Mn in 2019 and is forecast to reach a value of US$ 907.3 Mn by 2027 at a CAGR of 8.5% between 2020 and 2027.
Major factor driving the growth of global protein A resin market during the forecast period include technological advancement, and increasing approvals of monoclonal antibodies.
Major factors hampering the growth of the protein A resin market during the forecast period constitutes of rise in alternate methods for purification of monoclonal antibodies.
Natural Protein A held dominant position in the global protein A resin market in 2019.
North America Protein A Resin market is expected to generate the highest revenue during the forecast period.
Some of the key players operating in the market are GE Healthcare, Thermo Fisher Scientific, Repligen, Tosoh Bioscience, EMD Millipore, Novasep, GenScript Biotech Corporation, Purolite Life Sciences, and Expedeon Ltd.
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