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  • Published On : Aug 2022
  • Code : CMI2552
  • Industry : Biotechnology
  • Pages : 177
  • Formats :

Typhoid fever, also simply called as typhoid is a bacterial infection caused by Salmonella typhi, also known as Salmonella enterica serotype Typhi. The typhoid fever is usually caused due to ingestion of contaminated food or water. Typhoid vaccine prevents typhoid fever and provides protection against it. The World Health Organization (WHO) has recommended three typhoid vaccines for use, which include live attenuated vaccine, capsular polysaccharide vaccine, and conjugate vaccine.  

Global typhoid fever vaccines market is estimated to be valued at US$ 351.4 million in 2022 and is expected to exhibit a CAGR of 12.2% during the forecast period (2022-2030).

Figure 1. Global Typhoid Fever Vaccines Market Share (%), by Vaccine Type, 2022

Typhoid Fever Vaccines  | Coherent Market Insights

Increasing government initiatives for rising awareness regarding typhoid vaccines is expected to drive the global typhoid fever vaccines market growth.

Increasing government initiatives for rising awareness regarding typhoid vaccines is expected to drive the global typhoid fever vaccines market growth over the forecast period. Organizations such as World Health Organization (WHO), Gavi, Bill & Melinda Gates Foundation, and others are highly active in creating awareness regarding typhoid and driving immunization efforts against such diseases. For instance, in October 2017, WHO recommended introduction of typhoid vaccine for children over six months in endemic countries. It also recommended catch-up vaccination whenever possible, prioritizing children and adolescents up to 15 years of age. Moreover, World Health Organization (WHO), pre-qualified a typhoid conjugate vaccine (TCV) Typbar TCV, manufactured by Bharat Biotech, Biotechnology company in December 2017. WHO pre-qualification enables the procurement and supply of this vaccine to United Nations International Children's Emergency Fund, the Pan-American Health Organization (PAHO), and GAVI (a vaccine alliance) supported countries. Such frequent initiatives taken by various organizations is expected to drive the market growth over the forecast period.

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Typhoid Fever Vaccines Market Report Coverage

Report Coverage Details
Base Year: 2021 Market Size in 2022: US$ 351.4 Mn
Historical Data for: 2017 to 2020 Forecast Period: 2022 to 2030
Forecast Period 2022 to 2030 CAGR: 12.2% 2030 Value Projection: US$ 884.8 Mn
Geographies covered:
  • North America: U.S. and Canada
  • Latin America: Brazil, Argentina, Mexico, and Rest of Latin America
  • Europe: Germany, U.K., Spain, France, Italy, Russia, and Rest of Europe
  • Asia Pacific: China, India, Japan, Australia, South Korea, ASEAN, and Rest of Asia Pacific
  • Middle East: GCC Countries, Israel, and Rest of Middle East
  • Africa: South Africa, North Africa, and Central Africa
Segments covered:
  • By Vaccine Type: Live Attenuated Vaccine, Capsular Polysaccharide Vaccines, Conjugate Vaccine, Others
  • By Route of Administration: Oral, Parenteral 
Companies covered:

GlaxoSmithKline Plc., Sanofi SA, Bharat Biotech, Bio-Med Pvt. Ltd., PT Bio Farma, PaxVax, Inc. Shanghai Institute of Biological Products Co., Ltd., and Prokarium 

Growth Drivers:
  • Increasing government initiatives for rising awareness regarding typhoid vaccines
  • High prevalence of typhoid in various emerging economies
Restraints & Challenges:
  • Lack of healthcare infrastructure and the skilled professionals 
  • Side effects of vaccine

Figure 2. Global Typhoid Fever Vaccines Market Share (%), by Region, 2022

Typhoid Fever Vaccines  | Coherent Market Insights

High prevalence of typhoid in various emerging economies is expected to drive the global typhoid fever vaccines market growth during the forecast period.

High prevalence of typhoid in various emerging economies is expected to drive the global typhoid fever vaccines market growth during the forecast period. For instance, in November 2021, according to the data published by the World Health Organization, Typhoid fever has an estimated global incidence of 11–21 million cases annually, resulting in 12,0 000–16,0 000 deaths. Every year, an estimated 11–20 million people get sick from typhoid and between 128 000 and 161 000 people die from it worldwide. In 2017, over 10 million typhoid fever cases occurred globally, causing over 116,000 deaths.

Global Typhoid Fever Vaccines Market– Impact of Coronavirus (COVID-19) Pandemic

Since the COVID-19 virus outbreak in December 2019, the disease has spread to over 100 countries across the globe and the World Health Organization had declared it a public health emergency on January 30, 2020.

COVID-19 can affect the economy in three main ways: by directly affecting production and demand of drugs, by creating disruptions in distribution channels, and through its financial impact on firms and financial markets. Due to nationwide lockdowns, several countries, such as China, India, Saudi Arabia, U.A.E., Egypt, and others, are facing problems with regards to the transportation of drugs from one place to another.

However, the COVID-19 pandemic had a negative impact on the global typhoid fever vaccines market, owing to the disruption in delivery and healthcare services during COVID 19 pandemic. For instance, in July 2020, according to the data published by the National Center for Biotechnology Information, due to disruptions in the delivery and uptake of immunization services caused by the COVID-19 pandemic. In 2019, UNICEF procured an estimated 2.43 billion doses of vaccines to around 100 countries to reach around 45% of the world’s children below the 5-year-old age group. COVID-19-induced disruption of routine vaccination affected lives of infants.

Global Typhoid Fever Vaccines Market: Key Developments                                

In April 2022, the Ministry of Health and Population, Gavi, the Vaccine Alliance, UNICEF, WHO and other partners were collaborating on the worldwide typhoid vaccine introduction including a catch-up campaign, which seeks to vaccinate all children from the age of 15 months to 15 years to protect them from typhoid fever. With support from Gavi, the Vaccine Alliance, WHO, UNICEF and other partners, the Government of Nepal launched a new vaccine campaign in April 2022 introducing Typhoid Conjugate Vaccine (TCV) into the routine immunization programme across the country. The three-week campaign, which ran from April 7 2022 to May 1 2022, aimed to reach all children between 15 months and 15 years to quickly achieve wider protection from typhoid, increase the impact of the vaccine introduction and combat the rise of antimicrobial resistance.

Global Typhoid Fever Vaccines Market: Restraint

The major factors that hinder growth of the global typhoid fever vaccines market include lack of healthcare infrastructure and the skilled professionals. Additionally, side effects of typhoid fever vaccine such as pain and mild fever will act as a restrain for the global typhoid fever vaccines market.

Key Players

Major players operating in the global typhoid fever vaccines market include GlaxoSmithKline Plc., Sanofi SA, Bharat Biotech, Bio-Med Pvt. Ltd., PT Bio Farma, PaxVax, Inc. Shanghai Institute of Biological Products Co., Ltd., and Prokarium.

Typhoid fever is a bacterial infection caused by Salmonella typhi, which causes symptoms such as prolonged fever, headache, nausea, loss of appetite, and constipation or sometimes diarrhea. The bacterium usually enters the body through the mouth by the ingestion of contaminated food or water, penetrates the intestinal wall, and multiplies in lymphoid tissue. It then enters the bloodstream and causes bacteremia. People who drink contaminated water or eat food washed in contaminated water can develop typhoid fever. Typhoid fever is majorly caused in area with poor sanitation and lack of clean drinking water. Typhoid fever vaccines are the biological formulations, which provide immunity and protect an individual against typhoid fever.

Currently there are three typhoid vaccines recommended by the World Health organization (WHO) for use which include:

  • Injectable typhoid conjugate vaccine (TCV), consisting of Vi polysaccharide antigen linked to tetanus toxoid protein licensed for children from 6 months of age and adults up to 45 years of age
  • Injectable unconjugated polysaccharide vaccine based on the purified Vi antigen (known as Vi-PS vaccine) for persons aged two years and above, and
  • Oral live attenuated Ty21a vaccine in capsule formulation for those over six years of age

Market Dynamics

Increasing initiatives by governments and various other organizations to increase awareness about typhoid vaccine and rising access of new vaccines is expected to drive the typhoid fever vaccines market growth during forecast period. For instance, in February 2019, Gavi, the Vaccine Alliance in partnership with WHO, Center for Disease Control and Prevention and Zimbabwe’s Ministry of Health launched a campaign to tackle typhoid outbreak in Zimbabwe. Gavi, the Vaccine Alliance is a public-private partnership that helps vaccinate half the world’s children against some of the world’s deadliest diseases.  The campaign aims to vaccinate 325,000 people in nine suburbs of Zimbabwe’s capital with new typhoid conjugate vaccine (TCV). At least 12.4 million children worldwide are categorized as ‘zero-dose’, living in missed communities that cannot access many essential services, including health care.

Key features of the study:

  • This report provides an in-depth analysis of the global typhoid fever vaccines market, and provides market size (US$ Million) and compound annual growth rate (CAGR%) for the forecast period (2022–2030), considering 2021 as the base year
  • It elucidates potential revenue opportunities across different segments and explains attractive investment proposition matrices for this market
  • This study also provides key insights about market drivers, restraints, opportunities, new product launches or approval, market trends, regional outlook, and competitive strategies adopted by key players
  • It profiles key players in the global typhoid fever vaccines market  based on the following parameters – company highlights, products portfolio, key highlights, financial performance, and strategies
  • Key companies covered as a part of this study include GlaxoSmithKline Plc., Sanofi SA, Bharat Biotech, Bio-Med Pvt. Ltd., PT Bio Farma, PaxVax, Inc. Shanghai Institute of Biological Products Co., Ltd., and Prokarium.
  • Insights from this report would allow marketers and the management authorities of the companies to make informed decisions regarding their future product launches, type up-gradation, market expansion, and marketing tactics
  • The global typhoid fever vaccines market report caters to various stakeholders in this industry including investors, suppliers, product manufacturers, distributors, new entrants, and financial analysts
  • Stakeholders would have ease in decision-making through various strategy matrices used in analyzing the global typhoid fever vaccines market

Detailed Segmentation:

  • Global Typhoid Fever Vaccines Market, By Vaccine Type:
    • Live Attenuated Vaccine
    • Capsular Polysaccharide Vaccines
    • Conjugate Vaccine
    • Others
  • Global Typhoid Fever Vaccines Market, By Route of Administration:
    • Oral
    • Parenteral
  • Global Typhoid Fever Vaccines Market, By Region:
    • North America
      • By Country
        • U.S.
        • Canada
    • Latin America
      • By Country
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
    • Europe
      • By Country
        • Germany
        • U.K.
        • France
        • Italy
        • Spain
        • Russia
        • Rest of Europe
    • Asia Pacific
      • By Country
        • China
        • India
        • Japan
        • Australia
        • South Korea
        • ASEAN
        • Rest of Asia Pacific
    • Middle East
      • By Country
        • GCC
        • Israel
        • Rest of Middle East
    • Africa
      • By Region
        • South Africa
        • Central Africa
        • North Africa
  • Company Profiles
    • GlaxoSmithKline Plc.*
      • Company Highlights
      • Products Portfolio
      • Key Highlights
      • Financial Performance
      • Strategies
    • Sanofi SA
    • Bharat Biotech
    • Bio-Med Pvt. Ltd.
    • PT Bio Farma
    • PaxVax, Inc.
    • Shanghai Institute of Biological Products Co., Ltd.
    • Prokarium

“*” marked represents similar segmentation in other categories in the respective section.

Frequently Asked Questions

The global typhoid fever vaccines market size is estimated to be valued at US$ 351.4  million in 2022 and is expected to exhibit a CAGR of 12.2% between 2022 and 2030.
Factors such as increasing government initiatives promoting for rising awareness regarding typhoid vaccines and high prevalence of typhoid in various emerging economies are expected to drive the market growth.
Capsular Polysaccharide Vaccines is the leading vaccine type segment in the market.
The major factors hampering growth of the market include lack of healthcare infrastructure and the skilled professionals, and side effects of vaccine.
Major players operating in the market include GlaxoSmithKline Plc., Sanofi SA, Bharat Biotech, Bio-Med Pvt. Ltd., PT Bio Farma, PaxVax, Inc. Shanghai Institute of Biological Products Co., Ltd., and Prokarium.

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