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  • Published On : Feb 2022
  • Code : CMI4941
  • Industry : Pharmaceutical
  • Pages : 164
  • Formats :

The Gonadotropin-releasing hormone (GnRH) agonists are considered to have greater safety and efficacy profile than anti-androgens and estrogens and are among various therapies of achieving medical castration. Furthermore, the drug is mostly implanted in the body in the form of slow-release formulations which make the patient comfortable, improve the quality of life, and also reduce cost of the treatment. Most of the time, prostate cancer progresses with increasing testosterone hormone. Moreover, the production of testosterone can be stopped by surgically removing the testicles or through medication therapy. Triptorelin is GnRH agonist which is designed to stop the tentacles from making testosterone. This eventually reduces testosterone levels and minimizes the progression of prostate cancer.

The U.S. triptorelin market was valued at US$ 171.7 Mn in 2022 and is expected to exhibit a CAGR of 5.5% over the forecast period (2022-2030).

U.S. Triptorelin Market - Impact of the Coronavirus (COVID-19) Pandemic

The COVID-19 pandemic is expected to drive the growth of the U.S. triptorelin market over the forecast period, as market players are engaged in making the triptorelin available for the patients during the COVID-19 pandemic. For instance, in the year 2020, Arbor Pharmaceuticals, LLC, a U.S.-based specialty pharmaceutical company announced the full availability of Triptodur (triptorelin) in the U.S., two times a year during the COVID-19 pandemic. Triptodur (triptorelin) is an injectable gonadotropin releasing hormone agonist (GnRHa), which is indicated for the treatment of pediatric patients two years of age and older and are suffering from central precocious puberty (CPP).

Moreover, in the year 2020, Arbor Pharmaceuticals, LLC, confirmed that it has ordered supply of Triptodur (triptorelin) for its partner Debiopharm, in order to avoid the shortage during the COVID-19 pandemic.

Figure 1: U.S. Triptorelin Market Share (%) Analysis, By Product Type, 2022

U.S. Triptorelin  | Coherent Market Insights

Manufacturers are providing reimbursement for the drug triptorelin and other resources, this is expected to attract the patients for choosing triptorelin for their treatment. This will drive the growth of the U.S. triptorelin market over the forecast period.

For instance, in the year 2022, Arbor Pharmaceuticals, LLC, subsidiary of Azurity Pharmaceuticals, Inc. is currently offering reimbursement for the patients undergoing treatment for central precocious puberty (CPP) with Triptodur (triptorelin). The company is providing the drug at a low cost so that all the patients can afford the drug. Under this reimbursement policy, the patient can save almost US$ 10,000 per year. The offer is valid in the U.S. and Puerto Rico as allowed by law. Under the policy, only those patients are eligible for the reimbursement policy, who are insured in whole or in part, by Medicaid, Medicare, or other federal or state healthcare programs. 

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U.S. Triptorelin Market Report Coverage

Report Coverage Details
Base Year: 2021 Market Size in 2022: US$ 171.7 Mn
Historical Data for: 2017 to 2021 Forecast Period: 2022 to 2030
Forecast Period 2022 to 2030 CAGR: 5.5% 2030 Value Projection: US$ 274.8 Mn
Geographies covered:
  • U.S.
Segments covered:
  • By Product Type: Triptorelin Pamoate, Triptorelin Acetate, Triptorelin Embonate
  • By Application: Prostate Cancer, Radical Prostatectomy, Endometriosis, Salivary Gland Cancer, Central Precocious Puberty
  • By Distribution Channel: Hospital Pharmacy, Retail Pharmacy, Online Pharmacy
Companies covered:

Ipsen USA, Bachem Americas, Inc., Ferring Pharmaceuticals USA, Dr. Reddy’s Laboratories Ltd, Teva Pharmaceutical Industries Ltd., Arbor Pharmaceuticals, LLC, Watson Laboratories, Inc.

Growth Drivers:
  • Availability of reimbursement for triptorelin by the market players
  • Research for the extended application for triptorelin
Restraints & Challenges:
  • Side-effects of triptorelin

Many government organizations are conducting research and development activities, in order to study triptorelin for extended application of in various treatment modalities and this is expected to drive the growth of the U.S. triptorelin market during the forecast period.

The drug triptorelin is being tested for various applications, this may increase the growth of the market over the forecast period. For instance, Triptorelin is being studied to analyze effects of adjuvant hormonal therapy treatments of Letrozole + Zoledronate, Letrozole and Tamoxifen, and on bone loss in breast cancer patients. According to the clinical trials website, in July 2017, the study was sponsored by National Cancer Institute (NCI), Naples; and are present in phase III clinical stage. Moreover, according the same source, triptorelin market shows lucrative revenue growth in the near future, with the successful completion of this study and potential launch of new products during the forecast period.

U.S. Triptorelin Market – Restraints

U.S. triptorelin market growth is expected to be hampered in the near future, owing to side effects that have been recorded by the U.S. Food and Drug Administration (FDA). For instance, the U.S. FDA, in the year 2019, updated the side-effects for triptorelin that have been observed in the patients who are taking these medicines. They worsen the symptoms during tumor flare, hot flushes, decreased libido and impotence, bone and joint pain (may be increased initially), injection site reactions (pain, mild bruising, and erythema), sweating and weight gain.

Figure 2: U.S. Triptorelin Market Value (US$ Mn) & Y-o-Y Growth (%), 2022 – 2030

U.S. Triptorelin  | Coherent Market Insights

U.S. Triptorelin Market – Competitive Landscape

Major players operating in the U.S. triptorelin market include Aero Medical Ambulance Service, Aero-Dienst GmbH, Airlec Air Espace, U.S.an Air Ambulance, Flightserve International, IAS Medical, Medical Air Service, Quick Air Jet Charter GmbH, Babcock Scandinavian Air Ambulance, and Capital Air Ambulance

Triptorelin is a gonadotropin releasing hormone (GnRH) agonist, it is an inhibitor of synthesis of testosterone (in men) and estrogen (in women), which is used for the treatment of central precocious puberty (CPP) and advanced prostate cancer. According to the National Center for Biotechnology Information (NCBI): 2018, triptorelin is found to be associated with a very low rate of elevations of transient serum enzyme during its therapy for various conditions like central precocious puberty (CPP) and prostate cancer.

Market Dynamics

According to Optum, a provider of integrated health services, has put forth some of the guidelines for the administration of Triptodur (triptorelin). As per the National Health Service, the recommended dosage of Triptodur is 22.5 mg, and it is administered as a single intramuscular injection once every 24 weeks. The following are the guidelines which has to be followed while administering the drug:

  • Triptodur must be administered only under the supervision of a physician
  • Triptodur treatment should be discontinued at the appropriate age i.e. the treatment is stopped at the onset of puberty and it is recommended by the physician
  • Once Triptodur has been administered, the response to Triptodur should always be monitored by monitoring the following factors: luteinizing hormone (LH)levels after a Gonadotropin-releasing hormone (GnRH) or GnRH agonist stimulation test, basal LH, or serum concentration of sex steroid levels beginning 1 to 2 months following initiation of therapy, during therapy as necessary to confirm maintenance of efficacy and with each subsequent dose.
  • After the administration of the drug Triptodur, the patient’s height should be measured every 3 to 6 months and bone age should be monitored periodically

Market players are indulged in inorganic activities such as acquisition, in order to distribute the drug triptorelin in the U.S., this is expected to drive the growth of the U.S. triptorelin market over the forecast period. For instance, in January 2016, Debiopharm International SA (Debiopharm), part of Debiopharm Group, a Swiss-based global biopharmaceutical company, and Arbor Pharmaceuticals, LCC (Arbor), a U.S.-based specialty pharmaceutical company, entered into a distribution agreement for the commercialization and promotion of triptorelin 22.5 mg in the U.S. for central precocious puberty (CPP). Under the terms of the agreement, Arbor Pharmaceuticals, LCC, acquired exclusive commercial rights for triptorelin 22.5 mg in the U.S., for the CPP indication. The product was exported from Debiopharm Research and Manufacturing SA to Arbor and was made available primarily to pediatricians and pediatric endocrinologists.

 Key features of the study:

  • This report provides an in-depth analysis of the S. triptorelin market, provides market size (US$ Million), and compound annual growth rate (CAGR %) for the forecast period (2022-2030), considering 2020 as the base year
  • It elucidates potential revenue opportunities across different segments and explains attractive investment proposition matrix for this market
  • This study also provides key insights about market drivers, restraints, opportunities, new product launches or approval, regional outlook, and competitive strategies adopted by the leading players
  • It profiles leading players in the S. triptorelin market based on the following parameters – company overview, financial performance, product portfolio, geographical presence, distribution strategies, key developments and strategies, and future plans
  • Key companies covered as a part of this study include Aero Medical Ambulance Service, Aero-Dienst GmbH, Airlec Air Espace, U.S.an Air Ambulance, Flightserve International, IAS Medical, Medical Air Service, Quick Air Jet Charter GmbH, Babcock Scandinavian Air Ambulance, Capital Air Ambulance
  • Insights from this report would allow marketers and the management authorities of the companies to make informed decision regarding their future product launch, technology up-gradation, market expansion, and marketing tactics
  • The S. triptorelin market report caters to various stakeholders in this industry including investors, suppliers, manufacturers, distributors, new entrants, and financial analysts
  • Stakeholders would have an ease in decision-making through various strategy matrices used in analyzing the S. triptorelin market

Detailed Segmentation:

  • U.S. Triptorelin Market, By Product Type:
    • Triptorelin Pamoate
    • Triptorelin Acetate
    • Triptorelin Embonate
  • U.S. Triptorelin Market, By Application:
    • Prostate Cancer
    • Radical Prostatectomy
    • Endometriosis
    • Salivary Gland Cancer
    • Central Precocious Puberty
  • U.S. Triptorelin Market, By Distribution Channel:
    • Hospital Pharmacy
    • Retail Pharmacy
    • International
  • Company Profiles
    • Ipsen USA*
      • Company Overview
      • Product Portfolio
      • Financial Performance
      • Recent Highlights
      • Strategies
    • Bachem Americas, Inc.
    • Ferring Pharmaceuticals USA
    • Reddy’s Laboratories Ltd
    • Teva Pharmaceutical Industries Ltd.
    • Arbor Pharmaceuticals, LLC
    • Watson Laboratories, Inc.

“*” marked represents similar segmentation in other categories in the respective section.

Frequently Asked Questions

The U.S. triptorelin market is expected to exhibit a CAGR of 5.5% during the forecast period (2022-2030).
The market was valued at US$ 171.7 Mn in 2022.
Ipsen USA, Bachem Americas, Inc., Ferring Pharmaceuticals USA, Dr. Reddy’s Laboratories Ltd, Teva Pharmaceutical Industries Ltd., Arbor Pharmaceuticals, LLC, Watson Laboratories, Inc. are some of the prominent players operating in the market over the forecast period.
The market is expected to be valued at US$ 274.8 Mn in 2030.
Triptorelin acetate is the major product type in the market.
Availability of reimbursement for triptorelin, research for the extended application for triptorelin are some of the driving factors for the market growth.

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