An Edible Cholera Vaccine Consisting of powdered Rice proved to be Safe

Jun, 2021 - by CMI


The researchers intend to collaborate with pharmaceutical industry partners to advance MucoRice-CTB to the next stage of clinical studies in Japan and beyond.


Ground-up genetically modified rice grains have been used to create a novel vaccine to fight against fatal cholera. The first human experiment revealed no adverse effects and positive immunological response. The peer-reviewed results of the MucoRice-CTB vaccine's Phase 1 clinical trial were published in The Lancet Microbe by researchers from the University of Tokyo and Chiba University.


As a result of COVID-19, vaccine production has achieved huge advancements in 2020. The value of inoculations that can be manufactured, transported and stored cheaply and without refrigeration has been underlined by the complexity of mRNA-based SARS-CoV-2 vaccines.

From start to end, the MucoRice-CTB is stable at room temperature, which is a type of vaccine.


Because of the dose-escalation findings, the researchers are quite hopeful about the future of their MucoRice-CTB vaccine. The members responded to the vaccine from low to high doses, with the highest dose eliciting the strongest immunological response. There was no evidence of major negative effects, according to an independent review board.


Growing a new sort of vaccine The Vibrio cholera bacteria is disseminated primarily through sewage-contaminated drinking water. Cholera can kill within hours if not treated, causing severe dehydration and diarrhoea. There are four current needle-free cholera vaccines available, all of which are administered as drops under the tongue and require cold storage because they are manufactured from the entire dead or live-attenuated cholera virus. 


The novel cholera injection is made genetically adapted from short-grain rice plants of Japanese which produce a harmless form of cholera toxin B that the immune system can identify. The microflora, also known as the microbiome, is a community of microorganisms that dwell in our bodies and either help the individual or damage the people. Although it is widely acknowledged that the microflora of the digestive system has an impact on health and immunity, scientists are just now beginning to unravel the processes behind this link.