LGC Standards unveiled the expansion of its Dr. Ehrenstorfer™ PFAS portfolio with new 13C-labelled reference materials specifically developed for EPA Method 1633, including two ready-to-use isotope labelled internal standard (EIS/NIS) mixtures (24 and 7 analytes) and a comprehensive range of single compound solutions.
These materials are built to streamline calibration, improve data quality, as well as deliver robust, defensible results across aqueous, solid, and biological matrices, enabling laboratories around the world to produce reliable, traceable PFAS measurements. As essential chemical sensors, these reference materials play a critical role in ensuring the accuracy and reliability of PFAS detection across various sample types.
EPA Method 1633A - the multi-matrix LCMS/MS method jointly developed by the U.S. Environmental Protection Agency (EPA) and Department of Defence (DoD) was issued in December 2024 and it is currently the only PFAS method validated in multiple laboratories for wastewater, surface water, groundwater, landfill leachate, soil, sediment, biosolids, and fish/shellfish tissue.
The new labelled mixtures characteristics include:
- EPA Method 1633 EIS Labelled PFAS Mixture (24 analytes; 0.25–5 µg/mL, 1 mL; Part No. DRE-A50000792MW) - Added before extraction to track sample preparation recovery.
- EPA Method 1633 NIS Labelled PFAS Mixture (7 analytes; 0.25–1 µg/mL, 1 mL; Part No. DRE-A50000794MW) - Non-extracted Internal Standard Added before injection to correct for instrument response.
Executive Statement
According to Dr Kelly Cheshire, Global Segment Manager, LGC Standards, with EPA Method 1633 now the recommended multi-matrix standard for PFAS analysis, laboratories need stable, traceable isotope labelled materials they can trust. Their new 13C-labelled mixtures and singles, which serve as reliable biological and chemical indicators, simplify workflows, enhance quantitation, and help labs save time.