Metabolic syndrome is successfully treated by faecal transplantation and fibre

Jul, 2021 - by CMI


The researcher also believes this fibre therapy could be clinically available in five years, therefore, prebiotic supplementation may be an important addition to any treatment aimed at changing one's gut flora.

In a clinical experiment involving very obese patients with metabolic syndrome, faecal transplants were found to be effective only when combined with non-fermentable fibre supplements. Insulin sensitivity improved six weeks following a single faecal transplant in the phase 2 trial.

The gut microbiota has firmly established its significance in current clinical practise, thanks to a recent scientific explosion. Fecal infusions, on the other hand, have a considerably longer history in medicine. The researcher now know that faecal microbiota transplantation (FMT), commonly known as "bacteriotherapy," can transfer host phenotype.

They are also aware that instant bacteria have an impact on overall health, but researchers are currently grappling with how to translate this information into illness therapeutics. Taking faecal samples from a healthy individual and providing them to an unwell one is maybe the simplest way.

This approach, known as faecal microbial transplantation (FMT), is exactly what it sounds like. Stool from a donor is tested for harmful microorganisms before being made into capsules to be given verbally or from time to time assorted with saline and administered through the other end. Therefore the goal is to replace bad bacteria from a healthy subject in a sick subject's microbiome.

The gut microbiome affects all of these processes like metabolism, inflammation, immune function and the potential for enhancing human health through the microbiome is enormous, according to the researchers.

Unfortunately, therapeutic trials including FMT have yielded inconsistent outcomes so far. FMT has been used to treat obesity, inflammatory bowel disease, alcoholism, and even autism. While there are promising signs of efficacy, nothing has yet shown to be consistent enough to cross the finish line. The goal of this new study was to see if giving specific fibre supplements along with the FMT could improve therapeutic effects. These supplements, according to Madsen, could be crucial to FMT's success or failure.

Only the FMT group consuming non-fermentable fibre supplements improved insulin sensitivity at the end of the study, which was the primary outcome.