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Being Tired is Only One Aspect Of Extended COVID Exhaustion

Sep, 2022

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Many debilitating symptoms of chronic COVID may be reduced, according to the authors, by focusing on immunological abnormalities using individualised therapy that include anti-inflammatory drugs and interferon inducers. 

The findings demonstrated that long-term COVID patients with severe tiredness had higher amounts of soluble cell surface indicators, inflammatory cytokines, CD8+ T cells, and inflammation-related gene expression in monocytes. In addition, the authors cited a few other studies that showed links between elevated cytotoxic T cell levels and severe clinical variations of SARS-CoV-2 infections.

Patients with long COVID who did not experience extreme exhaustion showed improvement in fitness over the follow-up period, but their percentage of CD45RO- naive CD4+ T-lymphocytes, also known as naive CD4+ lymphocytopenia, significantly decreased. In addition, their CD4+ T regulatory lymphocyte count was lower. The moderately severe type of COVID in non-fatigued long-term patients had restricted expression of interleukin-6 and galectin-9 in their blood levels. Surprisingly, individuals with the clinically mild type of extended COVID who did not suffer tiredness exhibited greater levels of interleukin-6 and galectin-9 in the blood, as well as enhanced activation of monocyte inflammatory genes. Their cytotoxic T-lymphocyte counts weren't overly high, though. The mild form did not have naïve CD4+ lymphocytopenia, in contrast to the moderately severe COVID individuals who did not have tiredness.

Studies comparing the immunological profiles of people with CFS or ME with people who have had long-term COVID fatigue revealed commonalities, including increased CD8+ T cells, higher expression of inflammatory genes in monocytes, and raised blood levels of pro-inflammatory cytokines. Long COVID was linked to serious depressive disorder symptoms, according to the study. Major depressive illness has also been linked to chronic tiredness and its crippling consequences on fitness and quality of life.  Overall, the study found that long COVID patients with severe tiredness had higher expression of inflammatory genes, higher levels of cytotoxic T cells, and higher levels of serum pro-inflammatory cytokines.

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