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Pollutant Imposed Free-Radicals and its effect in Speeding up Aging

Jun, 2021

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Changes in lifestyle must be the main aspect to resist these premature senescence and aging process, improving the outcomes of several comorbidities, in a holistic approach.

Human body gets greatly affected by different types of pollution and the polluting agents greatly affect the inner metabolic mechanism of the body. UV-rays, Ozone, smoke, industrial chemicals and other cosmic ray are the most common among the polluting agents. The polluting agents cause production of different types of reactive oxygen species (ROS) and free radicals, that damage out DNA function and hence greatly affect the metabolism as a whole.

Scientists of West Virginia University in association with University in association with University of Minnesota, lately found that presence of unrepaid DNA- Damage, can increase the process of senescence and aging process.

The researcher conducted this study on a genetically modified mouse, where a crucial protein is missing that is related with the DNA repair system. Haematopoiesis is the process which includes the involvement of haematopoiesis stem cells, for the production macrophages, WBC, RBC, Lymphocytes etc. The protein related to DNA repair mechanism is found to be missing in this haematopoiesis mechanism, and thereby the model system is unable to repair the damaged DNA in these haematopoietic cellular products.

As the age progresses and the mouse becomes 5 years old, it has a lot impaired functions like hypertension, visual impairment, osteoporosis, renal dysfunction, hearing loss along with several age related functions. This damage is not only limited in case of only immune cells and their progenitors other organs like kidney and liver and their cells are also facing reduced functional ability. All of these problems, are totally linked with, unpaired DNA or the impaired DNA repair mechanism.

The damage is very much imminent in this genetically modified mouse model as compare to the wild-type mouse. The imminent production of free radicals upon exposure to environmental pollutants reacts with the Proteins or the DNA, causing reduced metabolic ability and thereby improper functioning of these bioactive molecules sets in.

Thus, lifestyle change must be the main aspect to resist these premature senescence and aging process, improving the outcomes of several comorbidities, in a holistic approach.

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