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Unbalanced Cell Division Provides New Therapeutic Treatment for Baldness

May, 2021

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The biological mechanisms that trigger baldness in people are still a mystery, yet researchers are uncovering such mysteries and laying the groundwork for innovations that might one day treat it.

Scientists in Japan have discovered a new process by which splitting cells can rupture in hair follicles reducing their major development as people get older. Scientists from Tokyo Medical and Dental University and the University of Tokyo conducted the study to learn more about how hair follicle stem cells support in the development of new hair and why that vital connection can decompose. A balanced mixture of multiple forms of cell replication is needed for the long-term viability of hair follicle stem cells. Hair follicle stem cells are broken into 2 types of cells with the same way in cyclic symmetric cell division, whereas they are divided into a distinguishing cell and a different, self-renewing stem cell in asymmetric cell division. These two processes collaborate to keep the masses of hair follicle stem cells intact and capable of hair regeneration. On the other hand, if they wouldn't function properly, it can result in rupture of the follicles.

 “Symmetrical and asymmetrical cell divisions must be balanced for optimal tissue function,” says Emi Nishimura, the study's corresponding author. “The body suffers when stem cells selectively experience one of either type of cell division or, worse still, differ from the standard process of either type of cell division. The researchers devised studies involving both young and old rodents, in which they observed the separation of hair follicle stem cells using two different types of tests. While the younger mice displayed regular, healthy symmetrical and asymmetrical divisions, the elder mice started to show an unusual, atypical form of cell division. The researchers discovered that as rodents aged, these proteins became progressively destabilized, causing the hair follicle stem cell division to produce a new, aberrant cell form. As a result, the hair follicle stem cells became depleted as they grew older, causing them to be removed from the body. As a result, hair follicles thinning and degradation occurred over time.

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