Cold Pain Therapy Market, By Product (OTC-Based Products and Prescription-Based Products), By Therapy Type (Cryosurgery, Icepack Therapy, and Chamber Therapy), By Device Type (Spray Cryogun, Dipstick Applicator, and Cryoprobe), By Application (Dermatology, Oncology, and Musculoskeletal Disorder), By Distribution Channel (Online Pharmacies, Retail Pharmacies, and Hospital Pharmacies) - Global Industry Insights, Trends, Outlook and Opportunity Analysis, 2017–2025

Cold pain therapy is a therapeutic application of cold, used in the treatment of acute soft tissue injuries and to reduce the pain in post-operative condition in orthopedic surgeries, treatment of benign and malignant lesions, and in pain management. Cryotherapy can be applied topically (on the skin surface), surgically or percutaneously. This can also be used to treat various skin conditions such as oral mucositis and tumors in the liver, kidney, bones, breasts and lungs, skin tumors, skin tags, pre-cancerous skin moles, and injuries.

Cryosurgery procedure involves use of extreme cold, produced with help of liquid nitrogen (or argon gas) to destroy abnormal tissues. According to the National Cancer Institute (NCI), cryosurgery is used for treatment of several types of cancers and some non-cancerous conditions. It is reported to be effective for treatment in early stage skin cancer, retinoblastoma, actinic keratosis, and cervical intraepithelial neoplasia. According to a study published in Journal of the National Cancer Institute, in October 2017, it was observed that cryotherapy was effective in controlling the side effects of chemotherapy induced peripheral neuropathy.

According to the U.S. Food & Drug Administration (FDA), cryotherapy is 'super cooling' of the body tissues for therapeutic purposes. Moreover, cryotherapy involves use of products such as ice packs on a certain portion of the body such as lower back. Whole Body Cryotherapy (WBC) involves exposing the body to liquid nitrogen vapors to reach ultra-low temperature ranging from -200 to -300 degrees Fahrenheit. WBC treatment is provided in relatively confined spaces or chamber for two to four minutes. However, U.S. FDA does not have sufficient evidence to recommend use of WBC to treat disease or conditions such as Alzheimer’s disease, rheumatoid arthritis, stress, multiple sclerosis, anxiety or chronic pain. Use of WBC has various risks such as burns, frostbite, and eye injury from extremely low temperature.

Increasing prevalence of skin, prostate, retinoblastoma, cervical cancer, and others and increasing rate of accidental and sport injuries are the major driving factors affecting growth of the cold pain therapy market. For instance, according to the Centers for Disease Control and Prevention (CDC), 12,578 women in the U.S. were diagnosed with cervical cancer while 4,115 women in the U.S. died from cervical cancer in 2014. In addition, according to the Cancer Research UK, 3,224 new cases of cervical cancer were reported in 2014, in the U.K., alone.

Moreover, increasing workplace related injuries and sport injuries is expected to boost growth of the cold pain therapy market. For instance, according to the Health and Safety Executive (HSE), 0.6 million non-fatal injuries at workplace were accounted in 2016. Moreover, new cases of work-related illness in the U.K. accounted for loses of US$ 12.4 billion in 2016. Furthermore, according to the U.S. Bureau of Labor Statistics 2016, around 2.9 million non-fatal workplace injuries and illness were reported by private industry employees in 2016.

Cold Pain Therapy Market Taxonomy:

On the basis of product, cold pain therapy market segmented into:

  • OTC-based products
    • Pharmaceuticals
      • Gels, ointment and creams
      • Patches
      • Spray and foams
      • Roll-ons
    • Medical devices
      • Cold packs
      • Cooling pads, wraps and pads
    • Prescription-based products
      • Motorized cryotherapy devices
      • Non-motorized cryotherapy devices

On the basis of therapy type, cold pain therapy market segmented into:

  • Cryosurgery
  • Icepack therapy
  • Chamber therapy

On the basis of device type, cold pain therapy market segmented into:

  • Spray cryogun
  • Dipstick applicator
  • Cryoprobe
  • Other devices

On the basis of application, cold pain therapy market segmented into:

  • Dermatology
  • Oncology
  • Musculoskeletal disorder
  • Pain management
  • Sport medicine
  • Physical therapy
  • Ophthalmology
  • Post-operative
  • Post-trauma

On the basis of distribution channel, cold pain therapy market segmented into:

  • Online pharmacies
  • Retail pharmacies
  • Hospital pharmacies

Recent developments in the cold pain therapy market

In July 2017, CSA Medical, Inc. received FDA clearance to expand truFreeze catheter offering to include Rapid AV Spray Kit. truFreeze system is used in cryosurgical procedures for application in gynecology, dermatology, general surgery, and in the removal of malignant lesions. Moreover, the addition of rapid AV Spray kit with truFreeze catheter is expected to reduce the surgical time thereby, reducing overall patient treatment time. 

In January 2017, PENTAX Medical — a company engaged in manufacturing, development and R&D activities in endoscopic product and services — acquired the C2 Therapeutics. C2 Therapeutics manufactures C2 CryoBalloon Ablation System for endoscopic ablation of tissue. Moreover, the acquisition enabled PENTAX Medial to strengthen its therapeutic endoscopy products and service portfolio.

Key players in the cold pain therapy market:

Some of the key players in the cold pain therapy market are CryoConcepts LP, Metrum Cryoflex, Brymill Cryogenic Systems, Mectronic Mediccale S.r.l., Sanarus, Wallach Surgical Devices, Zimmer MedizinSystems, CooperSurgical Inc., CSA Medical, Inc., Cortex Technology, Erbe Elektromedizin, GmbH, Special Medical Technology Co., Ltd, Medtronic plc, Galil Medical, Inc., and PHYSIOMED AG.

Research Methodology

Coherent Market Insights followsa comprehensive research methodology focused on providing the most precise market analysis. The company leverages a data triangulation model which helps company to gauge the market dynamics and provide accurate estimates. Key components of the research methodologies followed for all our market reports include:

  • Primary Research (Trade Surveys and Experts Interviews)
  • Desk Research
  • Proprietor Data Analytics Model

In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.


Smiley face

Coherent Market Insights desk research is based on a principle set of research techniques:

  • National level desk research: It Includes research analysis of regional players, regional regulatory bodies, regional trade associations, and regional organization.
  • Multinational level desk research: The research team keeps a track of multinational players, global regulatory bodies, global trade associations, and global organization.

Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:

  • Governmental bodies, National and international social welfare institutions, and organizations creating economic policies among others.
  • Trade association, National and international media and trade press.
  • Company Annual reports, SEC filings, Corporate Presentations, press release, news, and specification sheet of manufacturers, system integrators, brick and mortar - distributors and retailers, and third party online commerce players.
  • Scientific journals, and other technical magazines and whitepapers.
Smiley face

Preliminary Data Mining

The raw data is obtained through the secondary findings, in house repositories, and trade surveys. It is then filtered to ensure that the relevant information including industry dynamics, trends, and outlook is retained for further research process.

Data Standardization:

Holistic approach is used to ensure that the granular and uncommon parameters are taken into consideration to ensure accurate results. The information from the paid databases are further combined to the raw data in order to standardize it.

Coherent Statistical model

We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:

  • Micro-economic indicators
  • Macro-economic indicators
  • Environmental indicators
  • Socio-political indicators
  • Technology indicators

Data Processing

Once the findings are derived from the statistical model, large volume of data is process to confirm accurate research results. Data analytics and processing tools are adopted to process large chunk of collected informative data. In case, a client customizes the study during the process, the research finding till then are benchmarked, and the process for new research requirement is initiated again.

Data Validation

This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:

  • It provides first-hand information on the market dynamics, outlook, and growth parameters.
  • Industry experts validates the estimates which helps the company to cement the on-going research study.
  • Primary research includes online surveys, face-to face interviews, and telephonic interviews.

The primary research is conducted with the ecosystem players including, but not limited to:

  • Raw Material Suppliers
  • Manufacturers
  • System Integrators
  • Distributors
  • End-users

Choose License Type

"How Can I Help You" ?

Finding it difficult to find the research that would cater to your business demands? Give us a chance to help you. One of our Research Consultants will connect to provide a customized solution.

[email protected]

Key Benefits

  • Custom Research Solution

    Talk to our research consultant to design an exclusive report as per your research needs.

  • Customer Fulfilment

    We aim to fulfil client's research demands with tailored research solutions.

  • Quick Turnaround Time Reports

    We aim to provide research studies in quickest turnaround time and in a much cost effective manner.

  • 360-degree Approach

    We cover each industry from supply and demand side with an aim to provide a most holistic research study.

  • Assured Quality

    We strive to provide most accurate and reliable research findings in our research reports.