CpG oligodeoxynucleotide (CpG ODN) is a synthetic oligodeoxynucleotide, which contains unmethylated CpG motifs derived from bacterial DNA with immunostimulatory activities. CpG ODN is a short single-stranded synthetic DNA molecule, which contains one of each of cytosine triphosphate deoxynucleotide and guanine triphosphate deoxynucleotide that makes up the C component in the molecule.
The CpG motifs are considered pathogen-associated molecular patterns (PAMPs), as they are present in microbial genomes in abundance, but are rarely present in vertebrate genomes. These CpG PAMPs are recognized by the pattern recognition receptor (PRR) toll-like receptor 9 (TLR9), which is constitutively expressed only in B cells and plasmacytoid dendritic cells (pDCs) in humans and other higher primates. CpG ODNs show great potential for attachment in prophylactic vaccines designed to prevent infection. Various research companies are targeting synthetic CpG ODN due to the type I pro-inflammatory response it produces and its successful use as vaccine adjuvants.
CpG Oligodeoxynucleotide Market – Dynamics
Increasing demand for vaccination across the globe is expected to contribute to significant growth of the CpG oligodeoxynucleotide market over the forecast period. For instance, according to the UNICEF-Vaccination & Immunization Statistics, in 2017, around 123 million children got immunized with lifesaving vaccines across the world. Moreover, according to the Centers for Disease Control and Prevention (CDC), at least 3,153,876,236 doses of vaccines were distributed in the U.S. from 2006 to 2016.
Rising prevalence of new chronic diseases and the demand for reducing the occurrence of childhood diseases such as polio and others are expected to propel growth of the CpG oligodeoxynucleotide market. According to the Centers for Disease Control and Prevention (CDC), around 25.3 per 100,000 children die at the age of 1-4 years due to congenital malformations, deformations, and chromosomal abnormalities, and others.
CpG Oligodeoxynucleotide Market – Regional Insights
On the basis of geography, the global CpG oligodeoxynucleotide market is segmented into North America, Europe, Latin America, Asia Pacific, Middle East, and Africa. North America held dominant position in the global CpG oligodeoxynucleotide market in 2017. This is owing to high mortality due to various diseases such as pneumonia, diphtheria, pertussis, and others is expected to propel growth of the market in this region. For instance, according to the Centers for Disease Control & Prevention (CDC), in 2016, around 48,632 children died from pneumonia, which was around 15.1 per 100,000 population in the U.S.
Moreover, Asia pacific is expected to witness significant growth in the CpG oligodeoxynucleotide market, owing to rising focus on R&D along with mass manufacturing of cheap and affordable vaccines in the region. For instance, according to the International Vaccine Institute (IVI), India became the new hub for vaccine research with over 60% of the world’s vaccines manufactured in India in 2016.
CpG Oligodeoxynucleotide Market – Competitive Landscape
Major players operating in the global CpG oligodeoxynucleotide market include Novus Biologicals, InvivoGen, Merck KGaA, Hycult Biotech, Miltenyi Biotec, Sapphire Bioscience, Biomol GmbH, and Cosmobio. Key players are focused on adopting market strategies such as mergers and acquisitions, and new product development, in order to retain dominant position in the market. For instance, in July 2014, Techne Corporation acquired Novus Biologicals, a Colorado-based supplier of outsourced and in-house developed antibodies for life science research, for around US$ 60 million in cash.
CpG Oligodeoxynucleotide Market – Taxonomy
On the basis of source, the global CpG oligodeoxynucleotide market is segmented into:
On the basis of end user, the global CpG oligodeoxynucleotide market is segmented into:
On the basis of geography, the global CpG oligodeoxynucleotide market is segmented into:
Coherent Market Insights followsa comprehensive research methodology focused on providing the most precise market analysis. The company leverages a data triangulation model which helps company to gauge the market dynamics and provide accurate estimates. Key components of the research methodologies followed for all our market reports include:
In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.
Coherent Market Insights desk research is based on a principle set of research techniques:
Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:
Preliminary Data Mining
The raw data is obtained through the secondary findings, in house repositories, and trade surveys. It is then filtered to ensure that the relevant information including industry dynamics, trends, and outlook is retained for further research process.
Holistic approach is used to ensure that the granular and uncommon parameters are taken into consideration to ensure accurate results. The information from the paid databases are further combined to the raw data in order to standardize it.
Coherent Statistical model
We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:
Once the findings are derived from the statistical model, large volume of data is process to confirm accurate research results. Data analytics and processing tools are adopted to process large chunk of collected informative data. In case, a client customizes the study during the process, the research finding till then are benchmarked, and the process for new research requirement is initiated again.
This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:
The primary research is conducted with the ecosystem players including, but not limited to:
Finding it difficult to find the research that would cater to your business demands? Give us a chance to help you. One of our Research Consultants will connect to provide a customized solution.[email protected]
Talk to our research consultant to design an exclusive report as per your research needs.
We aim to fulfil client's research demands with tailored research solutions.
We aim to provide research studies in quickest turnaround time and in a much cost effective manner.
We cover each industry from supply and demand side with an aim to provide a most holistic research study.
We strive to provide most accurate and reliable research findings in our research reports.