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  • Published On : Nov 2023
  • Code : CMI6478
  • Pages : 140
  • Formats :
      Excel and PDF
  • Industry : Biotechnology

The flow imaging microscopy analysis market size is expected to reach US$ 67.1 Mn by 2030, from US$ 39.6 Mn in 2023, at a compound annual growth rate (CAGR) of 7.8% during the forecast period. Flow imaging microscopy is an optical method used for characterizing cells, particles, and molecules in a fluid medium. It enables the visualization and analysis of particles/cells ranging from sub-micron to millimeter levels. Flow imaging microscopes are equipped with high-speed digital cameras and software that can capture, process and analyze thousands of images per second. This allows obtaining high throughput, statistically robust data regarding sample characteristics like size, shape, counting and morphology. The key advantages of flow imaging microscopy include real-time imaging and analysis, high resolution, and multi-parametric measurements.

The growth of the flow imaging microscopy analysis market is driven by factors such as increasing Research and development (R&D) investments in life sciences and biotechnology sectors, growing focus on analytical testing in drug discovery, and the development of innovative flow imaging microscopy products integrated with technologies like Artificial Intelligence and automation.

The flow imaging microscopy analysis market is segmented into  product type, sample type, end user and region. By product type, the market is segmented into flow microscopes, cell analyzers, cell sorters, software, and accessories. The flow microscopes segment accounted for the largest share in 2022 due to its wide applications in particle analysis and increasing use of flow imaging microscopy for cell morphology, viability assessments, and protein aggregation studies.

Flow Imaging Microscopy Analysis Market Regional Insights:

  • North America is expected to be the largest market for flow imaging microscopy analysis market during the forecast period, which accounted for over 45.5% of the market share in 2022. The growth of the market in North America is due to the high investments in biotechnology and pharmaceutical research and development (R&D), presence of leading players, and growing focus on single cell analysis.
  • The Europe market is expected to be the second-largest market for flow imaging microscopy analysis market, which accounted for over 34.5% of the market share in 2022. The growth of the market in Europe is due to the well-established healthcare infrastructure, rising prevalence of chronic diseases, and increasing demand for analytical testing services.
  • The Asia Pacific market is expected to be the fastest-growing market for flow imaging microscopy analysis market, with a CAGR of over 15.5% during the forecast period. The growth of the market in Asia Pacific is attributed to the expanding biopharma sector, increasing healthcare expenditure and favorable government funding policies for research.

 Analyst View’s of the Flow Imaging Microscopy Analysis Market:

Flow imaging microscopy is an emerging market due to the increase in research activity, and thus many investors are investing to integrate Artificial Intelligence technology with flow imaging microscopy. This integration is expected to enhance the capabilities of flow imaging microscopy and revolutionize the field. By incorporating AI technology, flow imaging microscopy can automate image analysis and provide real-time data interpretation, thereby saving researchers valuable time and effort. This advancement is anticipated to accelerate scientific discoveries and drive further advancements in various fields such as medicine, biology, and materials science. With AI technology, flow imaging microscopy can analyze large datasets and identify patterns or anomalies that may not be easily detectable by human observers. The integration of AI can enable the development of more accurate and precise measurement techniques, thus leading to more reliable and reproducible results in research experiments. Overall, this collaboration between AI technology and flow imaging microscopy holds immense potential for advancing scientific knowledge and thus pushing the boundaries of the understanding in multiple disciplines.

Figure 1. Global Flow Imaging Microscopy Analysis Market Share (%), By Region, 2023


Flow Imaging Microscopy Analysis Market Drivers:

  • Increasing investments in biopharmaceutical R&D: The biopharmaceutical industry has been steadily increasing investments in R&D activities over the past decade to develop new drug molecules and biologics. For instance, in 2021, according to data, the total R&D expenditure of top biopharma companies amounted to over USD 82 billion. Flow imaging microscopy plays a vital role in biopharmaceutical R&D, thus enabling drug discovery scientists to obtain visual, morphological, and functional information of cells and biological compounds. The technique is widely used in cell-based assays, protein engineering studies, DNA analysis and quality control of biopharmaceutical products. The increased focus on precision medicine and biologics is predicted to generate a surge in biopharma R&D investments, which will also result in a considerable increase in the need for advanced analytical technologies like flow imaging microscopy for research applications.
  • Technological advancements in flow cytometry instruments: Flow cytometry technology has undergone continuous advances over the past years with the launch of new sophisticated analyzers that are equipped with advanced fluidics, optics, and built-in software. The key market players have commercialized high-throughput flow cytometers that are integrated with imaging capabilities for applications requiring morphological and spatial analysis of cells, bead-based assays, and particle characterization.
  • Growing adoption of flow imaging microscopy in drug discovery: Pharmaceutical and biotechnology companies are increasingly adopting flow imaging microscopy for a wide range of drug discovery applications including target identification and validation, lead compound screening, selectivity profiling, and compound optimization stages. Flow imaging allows researchers to visualize and authenticate the binding of potential drug molecules to specific cell surface receptors or proteins. It is also utilized for toxicity testing of drug candidates on living cells. Moreover, flow imaging microscopy facilitates analysis of protein aggregation to identify formulations that improve stability. The growing use of this technology for streamlining and improving the drug discovery process is fueling the growth of the flow imaging microscopy market.
  • Rising industry-academia collaborations: In recent years, there has been an increase in collaborative agreements between academic and research institutes and leading biopharma and microscopy companies to accelerate flow imaging microscopy research. For instance, in 2021, Agilent Technologies, a global instruments, software, services, and consumables for laboratories company, partnered with Baylor College of Medicine for flow cytometry innovation. Prominent institutes like National Institute of Health, MIT are undertaking industry sponsored research which is focused on developing novel flow imaging and single-cell analysis platforms. These partnerships provide access to advanced R&D infrastructure to end users while enabling companies to expand product capabilities. The growing academic-industry linkages are thus supporting market growth. For instance, in December 2022, Leica Microsystems, a leader in microscopy and scientific instrumentation, entered into a partnership with Applied Scientific Instrumentation (ASI), a medical instrumentation company, to commercialize single-objective light-sheet microscopy. The advanced system was unveiled for the first time at Cell Bio 2022 and uniquely combines gentle imaging, conventional sample preparation and high-speed volumetric imaging to capture fast dynamics in three dimensions.

Flow Imaging Microscopy Analysis Market Opportunities:

  • Emergence of microfluidics technology: The advent of microfluidics which is a technology involving manipulation of tiny amounts of fluids on chips, has opened new capabilities for flow imaging microscopy. Integration of microfluidic channels and valves into flow imaging analyzers allows control over single cells and particles with high precision. Researchers have leveraged microfluidics-based flow imaging to isolate rare circulating tumor cells in blood for cancer diagnostics and to study fluid flow behavior within 3D cell cultures. As microfluidics and biochip technologies continue to mature, the synergistic integration with flow imaging microscopy can expand its applications in single cell research, organ-on-chip testing, and point-of-care (POC) devices.
  • Growing significance of rare cell analysis: Detection and analysis of rare cells like circulating tumor cells (CTCs) is gaining traction in cancer research for disease monitoring, diagnosis, and treatment evaluation. Flow imaging microscopy represents a suitable platform for sensitive, label-free isolation and characterization of such rare cells from heterogeneous samples like blood, bone marrow, and tissue dissociates. Key companies are focused on developing dedicated rare cell analysis platforms that are capable of high resolution imaging and classification of CTCs which are based on morphology. As research efforts to establish clinical validity and utility of liquid biopsy tests accelerate, flow imaging microscopy could emerge as an invaluable technology for non-invasive cancer diagnostics and personalized therapies.
  • Rising potential in single cell analysis: Single cell analysis has become an active area of life science research to understand cell functionality, unravel heterogeneity, and identify novel cell subsets. Flow imaging microscopy allows high content analysis of individual cells thereby providing data on morphologies, protein expression and surface marker profiles. Moreover, when coupled with cell sorting systems, it enables isolation of phenotypically distinct single cells for downstream -omic studies. Flow imaging microscopy thus offers capabilities for next generation single cell multi-omics. The increasing research demonstrating its utility for deconstructing cellular systems on the single cell scale highlights the potential opportunities.
  • Expanding application areas: Flow imaging microscopy has proven capability for particle and biological analysis across diverse industries from food, agriculture, environmental to chemical, cosmetics, and forensics. Ongoing advances are  expanding its applications into new domains like tissue analysis, microbiome research, exosome characterization, and drug nanoparticle development. For instance, imaging flow cytometry can enable rapid, structural profiling of tissue samples. Novel imaging cytometry approaches are being applied to study composition of gut microbiota. Such expanded applications across multiple verticals are expected to provide renewed growth avenues.

Flow Imaging Microscopy Analysis Market Report Coverage

Report Coverage Details
Base Year: 2022 Market Size in 2023: US$ 39.6 Mn
Historical Data for: 2018 to 2022 Forecast Period: 2023 - 2030
Forecast Period 2023 to 2030 CAGR: 7.8% 2030 Value Projection: US$ 67.1 Mn
Geographies covered:
  • North America: U.S. and Canada
  • Latin America: Brazil, Argentina, Mexico, and Rest of Latin America
  • Europe: Germany, U.K., Spain, France, Italy, Russia, and Rest of Europe
  • Asia Pacific: China, India, Japan, Australia, South Korea, ASEAN, and Rest of Asia Pacific
  • Middle East:  GCC Countries, Israel, Rest of Middle East
  • Africa:  South Africa, North Africa, and Central Africa
Segments covered:
  • By Product Type: Flow microscopes, Cell analyzers, Cell sorters, Software, and Accessories
  • By Sample Type: Large Molecule, Small Molecule, Liquid & Viscous Samples, and Others (Microfibers & Nanofibers)
  • By End User: Pharmaceutical and Biotechnology companies, Academic and Research institutes, Diagnostic laboratories, and Others (Contract Research Organizations)
Companies covered:

Danaher Corporation, Agilent Technologies, Thermo Fisher Scientific, CELLINK, Sony Corporation, Merck KGaA, Stratedigm Inc., Sysmex Partec GmbH, Bio-Rad Laboratories, Miltenyi Biotec, Predictive Health Diagnostics Company, Inc., ZEISS Group International, Lambert Instruments, Nikon Instruments Inc., Leica Microsystems, and Nikon Corporation

Growth Drivers:
  • Increasing investments in biopharmaceutical R&D
  • Technological advancements in flow cytometry instruments
  • Growing adoption of flow imaging microscopy in drug discovery
  • Rising industry-academia collaborations
Restraints & Challenges:
  • High costs of advanced systems
  • Complexities in data analysis
  • Shortage of trained professionals

Flow Imaging Microscopy Analysis Market Trends:

  • Integration of AI-based analysis solutions: Artificial intelligence (AI) and machine learning are being increasingly integrated with flow cytometry and imaging systems to enable automated sample analysis. Advanced AI algorithms can classify and cluster cell phenotypes in heterogeneous samples with efficacies that match the  skilled operators. Companies are offering dedicated imaging cytometry platforms with built-in AI-powered software that simplify workflow and accelerate result generation. Moreover, researchers have demonstrated utility of coupling advanced AI tools like convolutional neural networks with imaging flow cytometry for applications from cancer diagnostics to food quality monitoring. The adoption of AI is transforming flow imaging microscopy technology to deliver greater ease-of-use, productivity and information.
  • Adoption of spectral flow imaging systems: Conventional flow cytometry analyzes cells/particles that are labeled with fluorescent tags. Spectral flow cytometry is an emerging technology that enables label-free multiparametric phenotyping by capturing the intrinsic light scattering signature of samples across wavelengths. Introduced spectral flow imaging cytometry systems allow simultaneous characterization of cell morphology and internal composition without the need for reagents. Moreover, multispectral imaging provides a complete optical fingerprint of every cell thereby revealing phenotypic complexity. The unique capabilities offered by spectral flow imaging cytometry are leading to rising utilization for translational research.
  • Shift towards user-friendly, automated instruments: To expand adoption beyond highly specialized labs, flow imaging microscopy manufacturers are focused on streamlining instruments and assays for mainstream use. Key trends include development of hassle-free, ready-to-use reagents, pre-configured protocols and simplified data analysis software that requires minimal operator expertise. Companies are launching integrated systems with sample/liquid handling robotics, computer-controlled modules and monitoring sensors to minimize hands-on time. These innovations are helping transition flow imaging microscopy into a plug-and-play, automated workflow amenable for widespread implementation.
  • Miniaturization and portability: Conventionally bulky with complex optical designs, flow imaging microscopy systems are witnessing a gradual shift towards miniaturized, portable instruments. With advances in microfluidics, micromachining, and electronics miniaturization, researchers have developed palm-sized imaging cytometers and on-chip microscopes with performance comparable to standard analyzers. Portable battery-operated systems are also being commercialized. Introduction of such compact, easy-to-use devices can potentially take flow imaging cytometry to point-of-care clinical settings and field applications. Miniaturization coupled with smartphone integration can further propel wider adoption.

Flow Imaging Microscopy Analysis Market Restraints:

  • High costs of advanced systems: The modern  flow imaging microscopy analyzers equipped with high-resolution cameras, multiple lasers, and imaging capabilities are substantially costlier, often priced over US$ 300,000. Operational costs are high considering the requirement of specialized reagents and skilled personnel. The high capital expenditure involved in acquisition and maintenance limits purchases to well-funded research institutions and pharmaceutical companies. Cost constraints thus lead to slower penetration within academic labs and hospitals, especially in developing regions. Availability of budget systems can improve access and boost adoption across applied market segments.
  • Complexities in data analysis: The high content, multi-parametric data generated by imaging flow cytometry requires expertise in using specialized analytical software tools to extract meaningful insights. Researchers need advanced computational and multi-dimensional statistical analysis skills to correctly interpret data identify cell populations and understand inter-relationships. Lack of such expertise and extensive training requirements hinder the wider adoption of flow imaging microscopy. Simplification of the overall image cytometry workflow through end-to-end solutions encompassing automated tools for robust data analysis can help address this challenge.
  • Shortage of trained professionals: The significant technical complexity involved in operating flow imaging microscopy platforms and analyzing the data they generate, necessitates availability of highly trained personnel. However, there is a major shortage of skilled cytometrists and technicians experienced in image-based assays, which can constrain the utilization of these systems in academic and industry labs. Moreover, the limited availability of dedicated training programs, hands-on workshops and online courses focused on flow imaging cytometry further exacerbates this supply-demand gap. Development of comprehensive educational programs to build specialized workforce capacity is critical for broader uptake.

Counterbalance: The key market players are investing in the AI technology to bring the best solution for the current challenges, like the research complexity, and also keeping eye in  bring the new trained professionals.

Recent Developments:

New product launches:

  • On October 12, 2023, Lambert Instruments, a specialized in developing and producing advanced imaging solutions, launched its LIFA vTAU, a camera-based Fluorescence Lifetime Imaging Microscopy (FLIM) turnkey vision system. LIFA vTAU features a single photon avalanche diode (SPAD) detector that can capture up to 100 lifetime images per second, and is capable of multiple image modes, including regular frequency domain FLIM and time-lapse recordings.
  • On September 7, 2023, Nikon Instruments Inc., microscope-based optical and imaging technologies for the life sciences company,  announced the release of the smart imaging system "ECLIPSE Ji", which utilizes AI to automate the acquisition and analysis of cellular images, thereby streamlining research workflows involving cancer and nerve disease. The smart imaging system "ECLIPSE Ji", a digital inverted microscope.
  • On April 12, 2023, Nikon Corporation, a Japanese multinational,  announced the development and launch of the digital imaging microscope “ECLIPSE Ui” as the first-ever microscope for medical use in Japan. It is distributed via Nikon’s subsidiary Nikon Solutions Co., Ltd. The ECLIPSE Ui has a unique design without an eyepiece lens (even though is a microscope), a design which improves the pathologist’s observation posture and enables the sharing of observation images on the display. It contributes to reducing the physical burden on pathologists and improves the workflow of pathological observation.

Acquisition and partnerships:

  • On July 6, 2023, the European Molecular Biology Laboratory (EMBL), an intergovernmental organization dedicated to molecular biology research, and ZEISS Group International, an internationally leading technology, entered a long-term strategic partnership. The collaboration aims to close the gap between early-stage imaging technology development and its application in life science research. Through this collaborative approach, users of the EMBL Imaging Centre and related EMBL imaging services will have access to the latest microscopy technologies and expertise from ZEISS Group International. At the same time, the research carried out at EMBL and projects by Imaging Centre users provided ZEISS Group International with invaluable insights into new applications and opportunities for market-testing their most recent technology developments.
  • In November 2021, Predictive Health Diagnostics Company (PHDC), Inc., a diagnostics platform company that develops, manufactures, and distributes specialty diagnostic tests combining science, technology, and proprietary analytics that detect diseases with significant unmet medical needs and support better therapeutic outcomes, announced its acquisition of MUSE Microscopy, a high-value intellectual property portfolio developed jointly at Lawrence Livermore National Laboratory and University of California, Davis. MUSE (Microscopy with Ultraviolet Surface Excitation) Microscopy is the leading histology-free digital microscope providing the most significant advances in the industry in over 100 years. With this strategic acquisition, PHDC's MUSE platform will be the foundation that supports the company's future development of imaging-based diagnostics.
  • In July 2021, CELLINK, a bioconvergence startup that designs and supplies technologies and services to enhance biology research, entered an agreement to acquire Discover Echo Inc., a U.S. based microscopy and imaging company. The acquisition is CELLINK’s third since mid-May, when it announced its acquisition of Nanoscribe, a high-performance laser lithography system, and Visikol, a contract research services company, in moves that totaled nearly US$ 80 Mn and fortified its presence in the biophotonics space.

Figure 2. Global Flow Imaging Microscopy Analysis Market Share (%), By Product Type, 2023


Top Companies in Flow Imaging Microscopy Analysis Market:

  • Danaher Corporation
  • Agilent Technologies
  • Thermo Fisher Scientific
  • Sony Corporation
  • Merck KGaA
  • Stratedigm Inc.
  • Sysmex Partec GmbH
  • Bio-Rad Laboratories
  • Miltenyi Biotec
  • Predictive Health Diagnostics Company, Inc.
  • ZEISS Group International
  • Lambert Instruments
  • Nikon Instruments Inc.
  • Leica Microsystems
  • Nikon Corporation

Definition: Flow imaging microscopy analysis refers to an advanced optical technique that uses high-speed imaging to capture and analyze images of cells, particles, and molecules that are suspended in a fluid stream. It combines the capabilities of both microscopy and flow cytometry. Flow imaging microscopy systems use digital cameras, advanced optics, and software to obtain quantitative data on sample counts, sizes, shapes, fluorescence intensity and other parameters at the single cell or particle level. This technique offers significant advantages over traditional microscopy and flow cytometry in terms of higher throughput, sensitivity, and multi-parametric analysis capabilities for applications in biomedical research, drug discovery, clinical diagnostics, food and water quality testing, and other areas. With ongoing advances in imaging technologies and analysis software, flow imaging microscopy is emerging as an essential analytical tool across the life sciences, biopharma, and clinical laboratory sectors.

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Frequently Asked Questions

The  CAGR of the flow imaging microscopy Analysis market is 7.8%.

North America leads the flow imaging microscopy analysis market.

The major players operating in the flow imaging microscopy analysis market include Danaher Corporation, Agilent Technologies, Thermo Fisher Scientific, CELLINK, Sony Corporation, Merck KGaA, Stratedigm Inc., Sysmex Partec GmbH, Bio-Rad Laboratories, Miltenyi Biotec, Predictive Health Diagnostics Company, Inc., ZEISS Group International, Lambert Instruments, Nikon Instruments Inc., Leica Microsystems, and Nikon Corporation.

The flow microscopes segment leads the  the flow imaging microscopy analysis market. 

The major factors driving the flow imaging microscopy analysis market       growth are increasing investments in biopharmaceutical r&d, technological advancements in flow cytometry instruments, growing adoption of flow imaging microscopy in drug discovery, and rising industry-academia collaborations.

High costs of advanced systems, complexities in data analysis, and shortage of trained professionals are some key factors hampering the flow imaging microscopy analysis market growth.

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