Impact Analysis of Covid-19

The complete version of the Report will include the impact of the COVID-19, and anticipated change on the future outlook of the industry, by taking into the account the political, economic, social, and technological parameters.

Cell-free Protein Expression Market – Insights

Cell-free protein expression, also known as in vitro translation, in vitro protein expression, cell-free translation, or cell-free protein synthesis), is the production of recombinant proteins in cell lysates rather than within cultured cells. Cell-free protein expression uses the biomolecular machinery with all the components extracted from the desired cell type.

Statistics:

The global cell-free protein expression market is estimated to account for US$ 318.9 Mn in terms of value by the end of 2027.

Global Cell-free Protein Expression Market: Drivers

Growing demand for continuous-exchange cell-free protein synthesis is expected to propel growth of the global cell-free protein expression market over the forecast period. The demand for continuous-exchange cell-free (CECF) protein synthesis system is high in production of complex prokaryotic and eukaryotic proteins. This approach significantly prolongs the reaction life times and increases protein yields compared to conventional batch reactions.

Moreover, contamination- and toxic elements-free approach is also expected to aid in growth of the market. Cell-free protein expression system involves lesser chances of contamination, owing to low number of living bacteria/cells in the process. Moreover, absence of any nuclease activities also ensures stability of linear DNA templates during protein synthesis and offers all purified components required to yield a recombinant protein in-vitro. Proteins that can be toxic when expressed in living cells, can easily be expressed in cell-free systems. These features are expected to boost application of cell-free protein expression in applied biologic studies and genomics.

North America region held dominant position in the global cell-free protein expression market in 2019, accounting for 35.5% share in terms of value, followed by Europe.

Figure 1. Global Cell-free Protein Expression Market Share (%), by Region, 2019

Cell Free Protein Expression  | Coherent Market Insights

Global Cell-free Protein Expression Market: Restraints

Cell-free protein expression offers low protein production, which is unsuitable for large industrial applications. This in turn is expected to hinder growth of the global cell-free protein expression market.

Moreover, high cost and short reaction scale of cell-free protein expression is also expected to limit growth of the market. The cost of reagents such as phosphate chemicals in nucleotide form and secondary energy sources is high. Moreover, short reaction scale also leads to limited ability of resultant protein folding.

Global Cell-free Protein Expression Market: Opportunities 

High prevalence of infectious diseases and cancer is expected to offer lucrative growth opportunities for players in the global cell-free protein expression market. For instance, according to the World Health Organization, around 18.1 million new cases and 9.6 million deaths were registered due to cancer worldwide in 2018.

Moreover, R&D in cell-free protein expression is also expected to aid in growth of the market. For instance, in August 2018, researchers from Cornell University, U.S., reported dynamic sequence specific constraint-based modeling of E. coli cell-free protein expression with an objective to enhance the performance limits of cell-free platforms.

Cell Free Protein Expression  | Coherent Market Insights

E.coli Cell-free Protein Expression System segment in the global cell-free protein expression market was valued at US$ 88.6 Mn in 2019 and is expected to reach US$ 140.1 Mn by 2027 at a CAGR of 5.9% during the forecast period.

Market Trends/Key Takeaways

Various organizations are focused on funding research in genomics. For instance, in April 2018, UK Biobank, through a US$ 32 million grant from the Medical Research Council, announced a major initiative to sequence the full genomes of 50,000 UK Biobank volunteer participants during 2018 and 2019.

Cell-free protein expression system is being used for replication of large synthetic genomes. For instance, in February 2020, researchers from Max Planck Institute of Biochemistry, Germany, reported development of an in vitro translation system, which enables self-encoded replication and expression of large DNA genomes under well-defined, cell-free conditions.

Segmentation

Cell Free Protein Expression  | Coherent Market Insights

Value Chain Analysis -

Cell Free Protein Expression  | Coherent Market Insights

Global Cell-free Protein Expression Market: Competitive Landscape  

Major players operating in the global include, Thermo Fisher Scientific, Inc., Takara Bio, Inc., Promega Corporation, New England Biolabs, Jena Bioscience GmbH, GeneCopoeia, Inc., Cube Biotech GmbH, CellFree Sciences Co., Ltd., Moderna Therapeutics, Biotechrabbit GmbH, and Bioneer Corporation.

Global Cell-free Protein Expression Market: Key Developments

Major players in the market are focused on adopting collaboration strategies to expand their product portfolio. For instance, in December 2019, CellFree Sciences Co., Ltd. collaborated with Proteo-Science Center, Ehime University (Japan), to develop a new technology that identifies proteins for binding to target antibodies. The new technology utilizes a protein bead array technology developed by CellFree Sciences Co., Ltd. named ‘CF-PA2Vtech’.

Major players in the market are also focused on expanding their geographical presence. For instance, in July 2019, New England Biolabs started a new subsidiary — New England Biolabs Australia Pty Ltd. — in Australia.

Cell Free Protein Expression is used for expression and manufacturing small amounts of functional proteins. Cell-free protein expression uses the bio molecular machinery with all the components extracted from the desired cell type. Growing demand for continuous-exchange cell-free protein synthesis is expected to propel growth of the global cell-free protein expression market over the forecast period. Moreover, contamination- and toxic elements-free approach is also expected to aid in growth of the market. Cell-free protein expression system involves lesser chances of contamination, owing to low number of living bacteria/cells in the process.

Key features of the study:

  • This report provides in-depth analysis of the Cell Free Protein Expression market  and provides market size (US$ million) and compound annual growth rate (CAGR %) for the forecast period (2019–2027), considering 2018 as the base year
  • It elucidates potential revenue opportunities across different segments and explains attractive investment proposition matrices for this market
  • This study also provides key insights about market drivers, restraints, opportunities, new product launches or approval, market trends,  regional outlook, and competitive strategy adopted by key players
  • It profiles key players in the global Cell Free Protein Expression market  based on the following parameters – company overview, financial performance, product portfolio, market presence, distribution strategies, key developments, strategies, and future plans
  • Key companies covered as a part of this study include, Thermo Fisher Scientific, Inc., Takara Bio, Inc., Promega Corporation, New England Biolabs, Jena Bioscience GmbH, GeneCopoeia, Inc., Cube Biotech GmbH, CellFree Sciences Co., Ltd., Moderna Therapeutics, Biotechrabbit GmbH, and Bioneer Corporation.
  • Insights from this report would allow marketers and the management authorities of the companies to make informed decisions regarding their future product launches, technology up-gradation, market expansion, and marketing tactics
  • The global Cell Free Protein Expression market report caters to various stakeholders in this industry including investors, suppliers, product manufacturers, distributors, new entrants, and financial analysts
  • Stakeholders would have ease in decision-making through various strategy matrices used in analyzing the global Cell Free Protein Expression market

Detailed Segmentation:

  • Cell Free Protein Expression Market, By Product Type:
    • E.coli Cell-free Protein Expression System
    • Rabbit Reticulocytes Cell-free Protein Expression System
    • Wheat Germ Cell-free Protein Expression System
    • Insect Cells Cell-free Protein Expression System
    • Mammalian Cell-free Protein Expression System
    • Labelling Tags
    • Vectors
  • Cell Free Protein Expression Market, By Application:
    • Enzyme Engineering
    • Protein Labeling
    • Protein-Protein interaction
    • Protein Purification
  • Cell Free Protein Expression Market, By Expression Mode:
    • Continuous flow Expression
    • Batch Expression
  • Cell Free Protein Expression Market, By End User:
    • Biotechnological Companies
    • Pharmaceutical Companies
    • Contract Research Organizations
    • Academic/ Research Institutes 
  • Cell Free Protein Expression Market, By Region:
    • North America
      • By Product Type:
        • E.coli Cell-free Protein Expression System
        • Rabbit Reticulocytes Cell-free Protein Expression System
        • Wheat Germ Cell-free Protein Expression System
        • Insect Cells Cell-free Protein Expression System
        • Mammalian Cell-free Protein Expression System
        • Labelling Tags
        • Vectors
      • By Application
        • Enzyme Engineering
        • Protein Labeling
        • Protein-Protein interaction
        • Protein Purification
      • By Expression Mode
        • Continuous flow Expression
        • Batch Expression
      • By End User
        • Biotechnological Companies
        • Pharmaceutical Companies
        • Contract Research Organizations
        • Academic/ Research Institutes
      • By Country:
        • U.S.
        • Canada
    • Latin America
      • By Product Type:
        • E.coli Cell-free Protein Expression System
        • Rabbit Reticulocytes Cell-free Protein Expression System
        • Wheat Germ Cell-free Protein Expression System
        • Insect Cells Cell-free Protein Expression System
        • Mammalian Cell-free Protein Expression System
        • Labelling Tags
        • Vectors
      • By Application
        • Enzyme Engineering
        • Protein Labeling
        • Protein-Protein interaction
        • Protein Purification
      • By Expression Mode
        • Continuous flow Expression
        • Batch Expression
      • By End User
        • Biotechnological Companies
        • Pharmaceutical Companies
        • Contract Research Organizations
        • Academic/ Research Institutes
      • By Country:
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
    • Europe
      • By Product Type:
        • E.coli Cell-free Protein Expression System
        • Rabbit Reticulocytes Cell-free Protein Expression System
        • Wheat Germ Cell-free Protein Expression System
        • Insect Cells Cell-free Protein Expression System
        • Mammalian Cell-free Protein Expression System
        • Labelling Tags
        • Vectors
      • By Application
        • Enzyme Engineering
        • Protein Labeling
        • Protein-Protein interaction
        • Protein Purification
      • By Expression Mode
        • Continuous flow Expression
        • Batch Expression
      • By End User
        • Biotechnological Companies
        • Pharmaceutical Companies
        • Contract Research Organizations
        • Academic/ Research Institutes
      • By Country:
        • Germany
        • U.K.
        • France
        • Italy
        • Spain
        • Russia
        • Rest of Europe
    • Asia Pacific
      • By Product Type:
        • E.coli Cell-free Protein Expression System
        • Rabbit Reticulocytes Cell-free Protein Expression System
        • Wheat Germ Cell-free Protein Expression System
        • Insect Cells Cell-free Protein Expression System
        • Mammalian Cell-free Protein Expression System
        • Labelling Tags
        • Vectors
      • By Application
        • Enzyme Engineering
        • Protein Labeling
        • Protein-Protein interaction
        • Protein Purification
      • By Expression Mode
        • Continuous flow Expression
        • Batch Expression
      • By End User
        • Biotechnological Companies
        • Pharmaceutical Companies
        • Contract Research Organizations
        • Academic/ Research Institutes
      • By Country:
        • China
        • India
        • Japan
        • Australia
        • South Korea
        • ASEAN
        • Rest of Asia Pacific
    • Middle East
      • By Product Type:
        • E.coli Cell-free Protein Expression System
        • Rabbit Reticulocytes Cell-free Protein Expression System
        • Wheat Germ Cell-free Protein Expression System
        • Insect Cells Cell-free Protein Expression System
        • Mammalian Cell-free Protein Expression System
        • Labelling Tags
        • Vectors
      • By Application
        • Enzyme Engineering
        • Protein Labeling
        • Protein-Protein interaction
        • Protein Purification
      • By Expression Mode
        • Continuous flow Expression
        • Batch Expression
      • By End User
        • Biotechnological Companies
        • Pharmaceutical Companies
        • Contract Research Organizations
        • Academic/ Research Institutes
      • By Country:
        • GCC
        • Israel
        • Rest of Middle East
    • Africa
      • By Product Type:
        • E.coli Cell-free Protein Expression System
        • Rabbit Reticulocytes Cell-free Protein Expression System
        • Wheat Germ Cell-free Protein Expression System
        • Insect Cells Cell-free Protein Expression System
        • Mammalian Cell-free Protein Expression System
        • Labelling Tags
        • Vectors
      • By Application
        • Enzyme Engineering
        • Protein Labeling
        • Protein-Protein interaction
        • Protein Purification
      • By Expression Mode
        • Continuous flow Expression
        • Batch Expression
      • By End User
        • Biotechnological Companies
        • Pharmaceutical Companies
        • Contract Research Organizations
        • Academic/ Research Institutes
      • By Country:
        • South Africa
        • Central Africa
        • North Africa
  • Company Profiles
    • Thermo Fisher Scientific, Inc. *
      • Company Overview
      • Product Portfolio
      • Key Highlights
      • Financial Overview
      • Strategies
    • Takara Bio, Inc.
    • Promega Corporation
    • New England Biolabs
    • Jena Bioscience GmbH
    • GeneCopoeia, Inc.
    • Cube Biotech GmbH
    • CellFree Sciences Co., Ltd.
    • Moderna Therapeutics
    • Biotechrabbit GmbH
    • Bioneer Corporation
  • “*” marked represents similar segmentation in other categories in the respective section.

Table of Contents

  1. Research Objectives and Assumptions
    • Research Objectives
    • Assumptions
    • Abbreviations
  2. Market Purview
    • Report Description
      • Market Definition and Scope
    • Executive Summary
      • Market Snippet, By Product Type
      • Market Snippet, By Application
      • Market Snippet, By Expression Mode
      • Market Snippet, By End User
      • Market Snippet, By Region
      • Coherent Opportunity Map (COM)
  3. Market Dynamics, Regulations, and Trends Analysis
    • Market Dynamics
      • Drivers
      • Restraints
      • Market Opportunities
    • Impact Analysis
    • Key Highlights
    • Product launch
    • PEST Analysis
    • Regulatory Scenario
    • Mergers and Acquisitions
  4. Global Cardiovascular Information System Market, By Product Type, 2019 – 2027, (US$ Mn)
    • Introduction
      • Market Share Analysis, 2019 and 2027 (%)
      • Y-o-Y Growth Analysis, 2017 – 2027
      • Segment Trends
    • E.coli Cell-free Protein Expression System
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Rabbit Reticulocytes Cell-free Protein Expression System
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Wheat Germ Cell-free Protein Expression System
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Insect Cells Cell-free Protein Expression System
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Mammalian Cell-free Protein Expression System
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Labelling Tags
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Vectors
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
  5. Global Cardiovascular Information System Market, By Application, 2019 – 2027, (US$ Mn)
    • Introduction
      • Market Share Analysis, 2019 and 2027 (%)
      • Y-o-Y Growth Analysis, 2017 – 2027
      • Segment Trends
    • Enzyme Engineering
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Protein Labeling
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Protein-Protein interaction
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Protein Purification
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
  6. Global Cardiovascular Information System Market, By Expression Mode, 2019 – 2027, (US$ Mn)
    • Introduction
      • Market Share Analysis, 2019 and 2027 (%)
      • Y-o-Y Growth Analysis, 2017 – 2027
      • Segment Trends
    • Continuous flow Expression
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Batch Expression
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
  7. Global Cardiovascular Information System Market, By End User, 2019 – 2027, (US$ Mn)
    • Introduction
      • Market Share Analysis, 2019 and 2027 (%)
      • Y-o-Y Growth Analysis, 2017 – 2027
      • Segment Trends
    • Biotechnological Companies
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Pharmaceutical Companies
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Contract Research Organizations
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Academic/ Research Institutes
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
  8. Global Cardiovascular Information System Market, By Region, 2019 – 2027, (US$ Mn)
    • Introduction
      • Market Share Analysis, By Region, 2019 and 2027 (%)
      • Y-o-Y Growth Analysis, For Regions, 2017–2026
    • North America
      • Market Size and Forecast, By Product Type, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Application, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Expression Mode, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By End User, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Country, 2016 – 2027, (US$ Mn)
        • U.S.
        • Canada
    • Latin America
      • Market Size and Forecast, By Product Type, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Application, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Expression Mode, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By End User, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Country, 2016 – 2027, (US$ Mn)
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
    • Europe
      • Market Size and Forecast, By Product Type, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Application, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Expression Mode, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By End User, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Country, 2016 – 2027, (US$ Mn)
        • Germany
        • U.K.
        • France
        • Italy
        • Spain
        • Russia
        • Rest of Europe
    • Asia Pacific
      • Market Size and Forecast, By Product Type, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Application, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Expression Mode, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By End User, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Country, 2016 – 2027, (US$ Mn)
        • China
        • India
        • Japan
        • Australia
        • South Korea
        • ASEAN
        • Rest of APAC
    • Middle East
      • Market Size and Forecast, By Product Type, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Application, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Expression Mode, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By End User, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Country, 2016 – 2027, (US$ Mn)
        • GCC
        • Israel
        • Rest of Middle East
    • Africa
      • Market Size and Forecast, By Product Type, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Application, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Expression Mode, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By End User, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Country, 2016 – 2027, (US$ Mn)
        • South Africa
        • Central Africa
        • North Africa
  9. Competitive Landscape
    • Company Profiles
      • Thermo Fisher Scientific, Inc.
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Takara Bio, Inc.
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Promega Corporation
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • New England Biolabs
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Jena Bioscience GmbH
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • GeneCopoeia, Inc.
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Cube Biotech GmbH
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • CellFree Sciences Co., Ltd.
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Moderna Therapeutics
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Biotechrabbit GmbH
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Bioneer Corporation
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
  10. Section
    • References
    • Research Methodology
    • About us and Sales Contact

*Browse 28 market data tables and 18 figures on “Cell Free Protein Expression Market - Global forecast to 2027”.

Existing Clientele

Joining thousands of companies around the world committed to making the Excellent Business Solutions.

View All Our Clients

Our Trusted Patner