Cell Free Protein Expression Market, by Product Type (Expression Systems (Prokaryotic Expression Systems, Mammalian Cell Expression Systems, Insect Cell Expression Systems, Yeast Cell Expression Systems, Other Systems) and Consumables and Other Products), BY Application (Therapeutic Application and Research Application) By End User (Pharmaceutical and Biotechnology Companies, Academic and Research Institutes and Contract Research Organizations)- Global Forecast to 2025

  • Published On : Jun 2018 |
  • Pages : 210 Pages |
  • Format : CMI Insight PPT Format CMI Insight PDF Format

Cell Free Protein Expression Market – Insights

Cell free protein expression is also called as cell-free protein synthesis, in vitro translation, cell-free translation or in vitro protein expression. It is a well-developed, rapid, and efficient technique for synthesizing proteins in cell lysates rather than cultured cells. Cell free protein expression uses translation machineries to extract the desired cells. It can be done by using various types of mammalian cells, bacteria, plants, and insect cells over conventional in vivo method. For instance, cell free protein expression system works independently and is free of any cellular context, owing to these benefits it is ideal for high-throughput screening of mutagenesis. Moreover, the whole machinery of cell free expression system sets better environment to manufacture membrane proteins, toxic proteins, and proteins that can undergo degradation. Pharmaceutical and biotechnological industries actively utilize these tools for research and developmental activities as well as for genomics and proteomics. Thus, it is a key factor propelling the cell free protein expression market growth over the forecast period.

The global cell free protein expression market sizewas valued at US$ 177.1 million in 2017, and is expected to witness a CAGR of 6.2% over the forecast period (2018 – 2026).

Global Cell Free Protein Expression Market, By End User (Share Analysis (%)), 2017

Source: Coherent Market Insights Analysis (2018)

Robust research and development is expected to drive growth of the cell free protein expression market

Increasing research and development in the field of proteomics and genomics and high prevalence of infectious disease and cancer are the major factors driving growth of the cell free protein expression market. For instance, According to 2012, EU Industrial R&D Investment Scoreboard, the pharmaceutical and biotechnology sectors represented 17.7% of business R&D expenditure in the world. Moreover, high prevalence of infectious disease and cancer cases across the world are resulting into high adoption of cell samples for research and development of drugs thus, expected to have a meteoric growth for the cell free protein expression market. For instance, According to the estimates by GLOBOCAN 2012, an estimated 850,000 new cancer cases were diagnosed in Africa, while almost 600,000 deaths were attributed to malignant disease. The number of cancer cases is expected to rise to 1,056,000 by 2020. Furthermore, According to the World Health Organization (WHO), in 2012, around 3,319 deaths occurred due to the infectious and parasitic disease infection, in Sub Saharan Africa region and according to the same source, in 2014, Ebola accounted for around 8,000 deaths in this region.

However, high cost, low yield of protein from certain species, lack of eukaryotic co- and post-translational modifications may hamper the growth of the market. For instance, cell free system based on E.coli and wheat germ extracts have some limitation to produce human proteins with post translation modifications (PTMs), which is restraining growth of the cell free protein expression market growth.

Cell Free Protein Expression Market- Regional Analysis

Cell free protein expression market is segmented into six major regions- North America, Latin America, Europe, Asia Pacific, Middle East, and Africa. Increasing cell-based research in North America due to high demand for precision medicine is a major factor driving growth of the cell free protein expression market in this region. In 2015, the Precision Medicine Initiative was launched in the U.S. to revolutionize the treatment of diseases, which include cancer and other chronic diseases, as precision medicine offers tailored treatment for an individual according to genetic makeup of the person. Furthermore, increasing emphasis on proteomics and genomics research activities in UK, Germany, France, and Switzerland are fueling growth of the European cell free protein expression market. For instance, in 2018, UK Biobank is taking initiative to sequence the full genomes of 50,000 UK Biobank volunteer participants. This initiative is funded £30M (US$ 39.8 Mn) grant from the Medical Research Council (MRC). This investment has accelerates research activities for wide range of diseases associated with disability and premature death in mid to later life. The Asia Pacific is estimated to witness significant growth in cell free protein expression market, owing to increasing number of research laboratories, contract research organizations and pharmaceutical companies with increased expenditure on research and development. For instance, China’s expenditure on research and development increased by 11.6% year-on-year to US$ 280 Bn in 2017.

Cell Free Protein Expression Market- Competitive Landscape

Increasing investments and initiatives by various manufacturers supports growth of the cell free protein expression market over the forecast period. For instance, in September 2017, iBio, Inc. with its subsidiary iBio CDMO LLC, a contract development and manufacturing organization (CDMO) collaborated with TheoremDx, Inc. to develop proteins for rapid diagnostic testing products. The collaboration aims to offer plant proteins through robust development and manufacturing in the U.S. and other economies. IBio is expected to provide an expression system to TheoremDx, which allows establishment of new diagnostics through cGMP scale-up production. Both iBio and TheoremDx are specifically focusing on development of rapid diagnostic tests, which can help in identifying and distinguishing neglected tropical diseases such as Zika, West Nile, Dengue, and Chikungunya. This collaboration is a major strategic step for advancement of rapid detection test internationally.

Key players operating in cell free protein expression market include iBio CDMO LLC, Thermo Fisher Scientific Inc., Takara Bio, Inc., New England Biolabs, Promega Corporation, CellFree Sciences Co., Ltd., Biotechrabbit GmbH, Bioneer Corporation, Cube Biotech GmbH, Jena Bioscience GmbH, and GeneCopoeia, Inc.

Cells contain biomolecules such as proteins or nucleic acids, which are present in the cytoplasm enclosed within a membrane. Cell free protein expression is a process, which require biomolecular translation machinery extracted from cells to produce recombinant proteins. Cell-free protein expression can be accomplished with different cell extracts such as rabbit reticulocytes, E. coli (prokaryotic), wheat germs (eukaryotes), and insect cells. It offers various features and advantages as compared to conventional in vivo methods. The first types of lysates developed for cell-free protein expression were derived from prokaryotic organisms. In recent past, systems based on extracts from insect cells, mammalian cells, and human cells have been developed and made available commercially, which is expected to drive growth of the market during the forecast period.

Market Dynamics

The global cell free protein expression market is projected to witness significant growth over the forecast period, owing to increasing prevalence of chronic diseases and increasing development in protein synthesis by key market players. For instance, new developments such as Protein Synthesis Using Recombinant Elements (PURE) offer specialized applications such as in vitro protein evolution, protein micro-arrays, and protein labelling. Furthermore, according to the Centers for Disease Control and Prevention (CDC) data findings, 2015, around 5,251 deaths were reported due to influenza infection in 2015, in the U.S., which in turn is propelling demand for advanced biologics such as therapeutic protein for the treatment of chronic diseases. Moreover, increasing research and development investment by biopharmaceutical industries and biotechnology industries is fostering growth of the cell free protein expression market. For instance, Merck & Co., Inc., a leading healthcare company, invested around US$ 10,124 million in R&D in 2016.

Key features of the study:

  • This report provides in-depth analysis of the cell free protein expression market, market size (US$ Million) and Cumulative Annual Growth Rate (CAGR (%)) for the forecast period: 2018 – 2026, considering 2017 as the base year
  • It elucidates potential revenue opportunity across different segments and explains attractive investment proposition matrix for this market
  • This study also provides key insights about market drivers, restraints, opportunities, new product launches or approval, market trends, regional outlook, and competitive strategy adopted by the leading players
  • It profiles leading players in the global cell free protein expression market based on the following parameters – company overview, financial performance, product portfolio, geographical presence, distribution strategies, key developments and strategies
  • Key companies covered as a part of this study include iBio CDMO LLC, Thermo Fisher Scientific Inc., Takara Bio, Inc., New England Biolabs, Promega Corporation, CellFree Sciences Co., Ltd., Biotechrabbit GmbH, Bioneer Corporation, Cube Biotech GmbH, Jena Bioscience GmbH, and GeneCopoeia, Inc.
  • Insights from this report would allow marketers and management authorities of companies to make informed decision with respect to their future product launch, governmental initiatives, technological up-gradation, market expansion and marketing tactics.
  • The global cell free protein expression market report caters to various stakeholders in this industry, including investors, product manufacturers, distributors and suppliers for cell free protein expression market, research and consulting firms, new entrants and financial analysts.

Detailed Segmentation:

  • Global Cell Free Protein Expression Market, By Product Type:
    • Expression Systems
      • Prokaryotic Expression Systems
      • Mammalian Cell Expression Systems
      • Insect Cell Expression Systems
      • Yeast Cell Expression Systems
      • Other Systems
    • Consumables and Other Products
  • Global Cell Free Protein Expression Market, By Application:
    • Therapeutic Application
    • Research Application
  • Global Cell Free Protein Expression Market, By End User:
    • Pharmaceutical and Biotechnology Companies
    • Academic and Research Institutes
    • Contract Research Organizations
  • Global Cell Free Protein Expression Market, By Region:
    • North America Cell Free Protein Expression Market
      • By Country:
        • U.S.
        • Canada
      • By Product Type:
        • Expression Systems
          • Prokaryotic Expression Systems
          • Mammalian Cell Expression Systems
          • Insect Cell Expression Systems
          • Yeast Cell Expression Systems
          • Other Systems
        • Consumables and Other Products
      • By Application:
        • Therapeutic Application
        • Research Application
      • By End User:
        • Pharmaceutical and Biotechnology Companies
        • Academic and Research Institutes
        • Contract Research Organizations
    • Europe Cell Free Protein Expression Market
      • By Country:
        • U.K.
        • Germany
        • Italy
        • Spain
        • France
        • Russia
        • Rest of Europe
      • By Product Type:
        • Expression Systems
          • Prokaryotic Expression Systems
          • Mammalian Cell Expression Systems
          • Insect Cell Expression Systems
          • Yeast Cell Expression Systems
          • Other Systems
        • Consumables and Other Products
      • By Application:
        • Therapeutic Application
        • Research Application
      • By End User:
        • Pharmaceutical and Biotechnology Companies
        • Academic and Research Institutes
        • Contract Research Organizations
    • Asia Pacific Cell Free Protein Expression Market
      • By Country:
        • Australia
        • India
        • China
        • Japan
        • ASEAN
        • South Korea
        • Rest of Asia Pacific
      • By Product Type:
        • Expression Systems
          • Prokaryotic Expression Systems
          • Mammalian Cell Expression Systems
          • Insect Cell Expression Systems
          • Yeast Cell Expression Systems
          • Other Systems
        • Consumables and Other Products
      • By Application:
        • Therapeutic Application
        • Research Application
      • By End User:
        • Pharmaceutical and Biotechnology Companies
        • Academic and Research Institutes
        • Contract Research Organizations
    • Latin America Cell Free Protein Expression Market
      • By Country:
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
      • By Product Type:
        • Expression Systems
          • Prokaryotic Expression Systems
          • Mammalian Cell Expression Systems
          • Insect Cell Expression Systems
          • Yeast Cell Expression Systems
          • Other Systems
        • Consumables and Other Products
      • By Application:
        • Therapeutic Application
        • Research Application
      • By End User:
        • Pharmaceutical and Biotechnology Companies
        • Academic and Research Institutes
        • Contract Research Organizations
    • Middle East Cell Free Protein Expression Market
      • By Country:
        • GCC
        • Israel
        • Rest of Middle East
      • By Product Type:
        • Expression Systems
          • Prokaryotic Expression Systems
          • Mammalian Cell Expression Systems
          • Insect Cell Expression Systems
          • Yeast Cell Expression Systems
          • Other Systems
        • Consumables and Other Products
      • By Application:
        • Therapeutic Application
        • Research Application
      • By End User:
        • Pharmaceutical and Biotechnology Companies
        • Academic and Research Institutes
        • Contract Research Organizations
    • Africa Cell Free Protein Expression Market
      • By Country:
        • South Africa
        • North Africa
        • Central Africa
      • By Product Type:
        • Expression Systems
          • Prokaryotic Expression Systems
          • Mammalian Cell Expression Systems
          • Insect Cell Expression Systems
          • Yeast Cell Expression Systems
          • Other Systems
        • Consumables and Other Products
      • By Application:
        • Therapeutic Application
        • Research Application
      • By End User:
        • Pharmaceutical and Biotechnology Companies
        • Academic and Research Institutes
        • Contract Research Organizations
  • Company Profiles
    • iBio CDMO LLC*
      • Company Overview
      • Product Portfolio
      • Financial Performance
        Recent Highlights
      • Strategies
    • Thermo Fisher Scientific Inc.
    • Takara Bio, Inc.
    • New England Biolabs
    • Promega Corporation
    • CellFree Sciences Co., Ltd
    • Biotechrabbit GmbH
    • Bioneer Corporation
    • Cube Biotech GmbH
    • Jena Bioscience GmbH
    • GeneCopoeia, Inc.

*” marked represents similar segmentation in other categories in the respective section.

Table of Contents

  1. Research Objective and Assumption
    • Research Objectives
    • Assumptions
    • Abbreviations
  2. Market Purview
    • Report Description
      • Market Definition and Scope
    • Executive Summary
      • Market Snippet, By Technology
      • Market Snippet, By Disease Indication
      • Market Snippet, By End User
      • Market Snippet, By Region
    • Coherent Opportunity Map (COM)
  3. Market Dynamics, Regulations, and Trends Analysis
    • Market Dynamics
      • Drivers
      • Restraints
      • Market Opportunities
    • Impact Analysis
      • Market Trends
      • Epidemiology
      • Key Developments
      • Methods of Cell Free Protein Expression
      • PEST Analysis
      • PORTER’S Five Forces
  4. Global Cell Free Protein Expression Market, By Product Type, 2016 – 2026, (US$ Million)
    • Introduction
      • Market Share Analysis, 2018 and 2026 (%)
      • Y-o-Y Growth Analysis, 2017–2026
      • Segment Trends
    • Expression Systems
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Million)
    • Prokaryotic Expression Systems
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Million)
    • Mammalian Cell Expression Systems
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Million)
    • Insect Cell Expression Systems
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Million)
    • Yeast Cell Expression Systems
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Million)
    • Other Systems
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Million)
    • Consumables and Other Products
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Million)
  5. Global Cell Free Protein Expression Market, By Application, 2016 – 2026, (US$ Million)
    • Introduction
      • Market Share Analysis, 2018 and 2026 (%)
      • Y-o-Y Growth Analysis, 2017–2026
      • Segment Trends
    • Therapeutic Application
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Million)
    • Research Application
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Million)
  6. Global Cell Free Protein Expression Market, By End User, 2016 – 2026, (US$ Million)
    • Introduction
      • Market Share Analysis, 2018 and 2026 (%)
      • Y-o-Y Growth Analysis, 2017–2026
      • Segment Trends
    • Pharmaceutical and Biotechnology Companies
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Million)
    • Academic and Research Institutes
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Million)
    • Contract Research Organizations
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Million)
  7. Global Cell Free Protein Expression Market, By Regions, 2016 – 2026, (US$ Million)
    • Introduction
      • Market Share Analysis, By Region, 2018 and 2026 (%)
      • Y-o-Y Growth Analysis, By Region, 2016 – 2026
      • Regional Trends
    • North America
      • Market Size and Forecast, By Product Type, 2018–2026, (US$ Million)
      • Market Size and Forecast, By Application, 2018–2026, (US$ Million)
      • Market Size and Forecast, By End User, 2018–2026, (US$ Million)
      • Market Size and Forecast, By Country, 2018–2026, (US$ Million)
        • U.S.
        • Canada
    • Europe
      • Market Size and Forecast, By Product Type, 2018–2026 (US$ Million)
      • Market Size and Forecast, By Vehicle Type, 2018–2026 (US$ Million)
      • Market Size and Forecast, By Sales Channel, 2018–2026 (US$ Million)
      • Market Size and Forecast, By Country, 2018–2026, (US$ Million)
        • UK
        • Germany
        • Italy
        • France
        • Russia
        • Rest of Europe
    • Asia Pacific
      • Market Size and Forecast, By Product Type, 2018–2026, (US$ Million)
      • Market Size and Forecast, By Application, 2018–2026, (US$ Million)
      • Market Size and Forecast, By End User, 2018–2026, (US$ Million)
      • Market Size and Forecast, By Country, 2018–2026, (US$ Million)
        • China
        • Japan
        • India
        • ASEAN
        • Australia
        • South Korea
        • Rest of Asia Pacific
    • Latin America
      • Market Size and Forecast, By Product Type, 2018–2026, (US$ Million)
      • Market Size and Forecast, By Application, 2018–2026, (US$ Million)
      • Market Size and Forecast, By End User, 2018–2026, (US$ Million)
      • Market Size and Forecast, By Country, 2018–2026, (US$ Million)
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
    • Africa
      • Market Size and Forecast, By Product Type, 2018–2026, (US$ Million)
      • Market Size and Forecast, By Application, 2018–2026, (US$ Million)
      • Market Size and Forecast, By End User, 2018–2026, (US$ Million)
      • Market Size and Forecast, By Country, 2018–2026, (US$ Million)
        • Northern Africa
        • Central Africa
        • South Africa
    • Middle East
      • Market Size and Forecast, By Product Type, 2018–2026, (US$ Million)
      • Market Size and Forecast, By Application, 2018–2026, (US$ Million)
      • Market Size and Forecast, By End User, 2018–2026, (US$ Million)
      • Market Size and Forecast, By Country, 2018–2026, (US$ Million)
        • GCC Countries
        • Israel
        • Rest of Middle East
  8. Competitive Landscape
    • Heat Map Analysis
    • Company Profiles
      • iBio CDMO LLC
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Thermo Fisher Scientific Inc.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Takara Bio, Inc.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • New England Biolabs
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Promega Corporation
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • CellFree Sciences Co., Ltd
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Biotechrabbit GmbH
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Bioneer Corporation
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Cube Biotech GmbH
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Jena Bioscience GmbH
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • GeneCopoeia, Inc.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
    • Analyst Views
  9. Section
    • References
    • Research Methodology
    • About Us and Sales Contact

*Browse 38 market data tables and 23 figures on "Cell Free Protein Expression Market” - Global forecast to 2025”.

Research Methodology

Coherent Market Insights followsa comprehensive research methodology focused on providing the most precise market analysis. The company leverages a data triangulation model which helps company to gauge the market dynamics and provide accurate estimates. Key components of the research methodologies followed for all our market reports include:

  • Primary Research (Trade Surveys and Experts Interviews)
  • Desk Research
  • Proprietor Data Analytics Model

In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.


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Coherent Market Insights desk research is based on a principle set of research techniques:

  • National level desk research: It Includes research analysis of regional players, regional regulatory bodies, regional trade associations, and regional organization.
  • Multinational level desk research: The research team keeps a track of multinational players, global regulatory bodies, global trade associations, and global organization.

Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:

  • Governmental bodies, National and international social welfare institutions, and organizations creating economic policies among others.
  • Trade association, National and international media and trade press.
  • Company Annual reports, SEC filings, Corporate Presentations, press release, news, and specification sheet of manufacturers, system integrators, brick and mortar - distributors and retailers, and third party online commerce players.
  • Scientific journals, and other technical magazines and whitepapers.

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Preliminary Data Mining

The raw data is obtained through the secondary findings, in house repositories, and trade surveys. It is then filtered to ensure that the relevant information including industry dynamics, trends, and outlook is retained for further research process.

Data Standardization:

Holistic approach is used to ensure that the granular and uncommon parameters are taken into consideration to ensure accurate results. The information from the paid databases are further combined to the raw data in order to standardize it.

Coherent Statistical model

We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:

  • Micro-economic indicators
  • Macro-economic indicators
  • Environmental indicators
  • Socio-political indicators
  • Technology indicators

Data Processing

Once the findings are derived from the statistical model, large volume of data is process to confirm accurate research results. Data analytics and processing tools are adopted to process large chunk of collected informative data. In case, a client customizes the study during the process, the research finding till then are benchmarked, and the process for new research requirement is initiated again.

Data Validation

This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:

  • It provides first-hand information on the market dynamics, outlook, and growth parameters.
  • Industry experts validates the estimates which helps the company to cement the on-going research study.
  • Primary research includes online surveys, face-to face interviews, and telephonic interviews.

The primary research is conducted with the ecosystem players including, but not limited to:

  • Raw Material Suppliers
  • Manufacturers
  • System Integrators
  • Distributors
  • End-users

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