Impact Analysis of Covid-19
The complete version of the Report will include the impact of the COVID-19, and anticipated change on the future outlook of the industry, by taking into the account the political, economic, social, and technological parameters.
Cell-free Protein Expression Market – Insights
Cell-free protein expression, also known as in vitro translation, in vitro protein expression, cell-free translation, or cell-free protein synthesis), is the production of recombinant proteins in cell lysates rather than within cultured cells. Cell-free protein expression uses the biomolecular machinery with all the components extracted from the desired cell type.
The global cell-free protein expression market is estimated to account for US$ 318.9 Mn in terms of value by the end of 2027.
Global Cell-free Protein Expression Market: Drivers
Growing demand for continuous-exchange cell-free protein synthesis is expected to propel growth of the global cell-free protein expression market over the forecast period. The demand for continuous-exchange cell-free (CECF) protein synthesis system is high in production of complex prokaryotic and eukaryotic proteins. This approach significantly prolongs the reaction life times and increases protein yields compared to conventional batch reactions.
Moreover, contamination- and toxic elements-free approach is also expected to aid in growth of the market. Cell-free protein expression system involves lesser chances of contamination, owing to low number of living bacteria/cells in the process. Moreover, absence of any nuclease activities also ensures stability of linear DNA templates during protein synthesis and offers all purified components required to yield a recombinant protein in-vitro. Proteins that can be toxic when expressed in living cells, can easily be expressed in cell-free systems. These features are expected to boost application of cell-free protein expression in applied biologic studies and genomics.
North America region held dominant position in the global cell-free protein expression market in 2019, accounting for 35.5% share in terms of value, followed by Europe.
Figure 1. Global Cell-free Protein Expression Market Share (%), by Region, 2019
Global Cell-free Protein Expression Market: Restraints
Cell-free protein expression offers low protein production, which is unsuitable for large industrial applications. This in turn is expected to hinder growth of the global cell-free protein expression market.
Moreover, high cost and short reaction scale of cell-free protein expression is also expected to limit growth of the market. The cost of reagents such as phosphate chemicals in nucleotide form and secondary energy sources is high. Moreover, short reaction scale also leads to limited ability of resultant protein folding.
Global Cell-free Protein Expression Market: Opportunities
High prevalence of infectious diseases and cancer is expected to offer lucrative growth opportunities for players in the global cell-free protein expression market. For instance, according to the World Health Organization, around 18.1 million new cases and 9.6 million deaths were registered due to cancer worldwide in 2018.
Moreover, R&D in cell-free protein expression is also expected to aid in growth of the market. For instance, in August 2018, researchers from Cornell University, U.S., reported dynamic sequence specific constraint-based modeling of E. coli cell-free protein expression with an objective to enhance the performance limits of cell-free platforms.
E.coli Cell-free Protein Expression System segment in the global cell-free protein expression market was valued at US$ 88.6 Mn in 2019 and is expected to reach US$ 140.1 Mn by 2027 at a CAGR of 5.9% during the forecast period.
Market Trends/Key Takeaways
Various organizations are focused on funding research in genomics. For instance, in April 2018, UK Biobank, through a US$ 32 million grant from the Medical Research Council, announced a major initiative to sequence the full genomes of 50,000 UK Biobank volunteer participants during 2018 and 2019.
Cell-free protein expression system is being used for replication of large synthetic genomes. For instance, in February 2020, researchers from Max Planck Institute of Biochemistry, Germany, reported development of an in vitro translation system, which enables self-encoded replication and expression of large DNA genomes under well-defined, cell-free conditions.
Value Chain Analysis -
Global Cell-free Protein Expression Market: Competitive Landscape
Major players operating in the global include, Thermo Fisher Scientific, Inc., Takara Bio, Inc., Promega Corporation, New England Biolabs, Jena Bioscience GmbH, GeneCopoeia, Inc., Cube Biotech GmbH, CellFree Sciences Co., Ltd., Moderna Therapeutics, Biotechrabbit GmbH, and Bioneer Corporation.
Global Cell-free Protein Expression Market: Key Developments
Major players in the market are focused on adopting collaboration strategies to expand their product portfolio. For instance, in December 2019, CellFree Sciences Co., Ltd. collaborated with Proteo-Science Center, Ehime University (Japan), to develop a new technology that identifies proteins for binding to target antibodies. The new technology utilizes a protein bead array technology developed by CellFree Sciences Co., Ltd. named ‘CF-PA2Vtech’.
Major players in the market are also focused on expanding their geographical presence. For instance, in July 2019, New England Biolabs started a new subsidiary — New England Biolabs Australia Pty Ltd. — in Australia.