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Impact Analysis of Covid-19

The complete version of the Report will include the impact of the COVID-19, and anticipated change on the future outlook of the industry, by taking into the account the political, economic, social, and technological parameters.

Clomiphene citrate is an oral medication that is often used to treat certain types of female infertility. Infertility is a global health issue, as its affects both men and women. Infertility in females could be due to increasing age, polycystic ovarian syndrome (PCOS), obesity, and multiple miscarriages.

 Clomiphene citrate works by stimulating an increase in the amount of hormones that support the growth and release of a mature egg (ovulation). This medication is not recommended for women whose ovaries no longer make eggs properly (primary pituitary or ovarian failure). Other names of clomiphene citrate are Clomid, Clomifene, Chloramifene, and Chloramiphene. It is also used for the treatment of polycystic ovary syndrome (PCOS), secondary amenorrhea, psychogenic amenorrhea, amenorrhea galactorrhea syndrome, and others. It is taken as a 50 mg pill that is usually taken for five days in a row in the beginning of a woman’s menstrual cycle.

Clomiphene Citrate Market - Impact of Coronavirus (Covid-19) Pandemic

The COVID-19 pandemic has significantly hampered demand for clomiphene citrate because the women who are under treatment of clomiphene citrate for infertility or PCOS, tests positive for COVID-19 infection, they must suspend the clomiphene citrate treatment and other fertility treatment alongside, as per the American Society for Reproductive Medicine (ASRM). However, according to the American Society for Reproductive Medicine data of March 2020, there are reports of women who have tested positive for COVID-19 delivering babies free of the COVID-19 infection. The coronavirus is not a fatal infection for a pregnant women.

The clomiphene citrate market is estimated to be valued at US$ 10.02 million in 2020 and is expected to exhibit a CAGR of 5.4% during the forecast period (2020-2027).

Figure 1: Clomiphene Citrate Market Share (%) Analysis, By Indication, 2020

Clomiphene Citrate  | Coherent Market Insights

The increasing rate of infertility is expected to drive growth of the clomiphene citrate market

Infertility is a health issue that affects both men and women, worldwide. Increasing infertility rates is expected to propel global demand for clomiphene citrate over the forecast period. For instance, according to the Centers for Disease Control and Prevention (CDC) report of 2018, around 6% of women aged 15 to 44 years in the U.S. were unable to conceive after one year of continuous intercourse. Furthermore, around 12% of women aged 15 to 44 years in the U.S. had difficulty in conceiving or carrying a pregnancy till child birth in 2017. Infertility also affects men. According to the same source, around 9% of men aged 25 to 44 years in the U.S. reported that they required medical help for reproduction in 2017. Clomiphene is used to treat infertility in both men and women. The U.S. FDA approved clomiphene citrate for women infertility in 1960s whereas, its often prescribed off-label for treatment of male infertility.

Clomiphene Citrate Market – Restraints

The clomiphene citrate market is expected to be negatively affected, owing to clomiphene citrate’s inefficiency in terms of being a less effective treatment to achieve pregnancy and live child births when compared to other medicines such as Letrozole. For instance, in 2014, a team of researchers at National Institutes of Health’s (NIH) Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) found that women treated with Letrozole showed high rate of ovulation and live births than women treated with the standard drug, clomiphene citrate. Furthermore, as per the same source, among women who received Letrozole, 27.5% of them eventually had a live birth and among women who received clomiphene, only 19.1% of them experienced a live child birth. The cumulative ovulation rate was higher for Letrozole group, with ovulation occurring 61.7% of the time and the women in the clomiphene group ovulated 48.3% of the time.

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Clomiphene Citrate Market Report Coverage

Report Coverage Details
Base Year: 2019 Market Size in 2019: US$ 10.02 Mn
Historical Data for: 2017 to 2019 Forecast Period: 2020 to 2027
Forecast Period 2020 to 2027 CAGR: 5.4% 2027 Value Projection: US$ 14.51 Mn
Geographies covered:
  • North America: U.S. and Canada
  • Latin America: Brazil, Argentina, Mexico, and Rest of Latin America
  • Europe: Germany, U.K., Spain, France, Italy, Russia, and Rest of Europe
  • Asia Pacific: China, India, Japan, Australia, South Korea, ASEAN, and Rest of Asia Pacific
  • Middle East: GCC, Israel, and Rest of Middle East
  • Africa: South Africa, North Africa, and Central Africa
Segments covered:
  • By Indication: PCOS, Secondary Amenorrhea, Psychogenic Amenorrhea, Amenorrhea Galactorrhea Syndrome, Others.
  • By Distribution Channel: Hospital Pharmacies, Retail Pharmacies, Online Pharmacies.
Companies covered:

Sanofi S.A., Par Pharmaceutical, Merck & Co. Inc., Teva Pharmaceutical Industries Ltd., Cipla Inc., Unichem Laboratories Ltd., Emcure Pharmaceuticals Ltd., Serum Institute of India Pvt. Ltd., Incepta Pharmaceuticals Ltd., and Shanghai Trifecta Pharma Co. Ltd.

Growth Drivers:
  • Increasing Prevalence of Infertility in Men and Women
  • Increasing Use of Generic Clomiphene Citrate
Restraints & Challenges:
  • Inefficiency and Side Effects of Clomiphene Citrate

Clomiphene Citrate Market – Regional Analysis

The North America clomiphene citrate market is expected to hold a dominant position in the global clomiphene citrate market, owing to the high prevalence of polycystic ovary syndrome (PCOS) in the U.S. For instance, according to the Centers for Disease and Disease Control Prevention 2019, PCOS is one of the most common causes of female infertility, affecting 6 to 12% (as many as 5 million) women of reproductive age in the U.S. Moreover, more than half of the women with PCOS develop type 2 diabetes by age 40.

Furthermore, Europe clomiphene citrate market is expected to gain traction in the near future, owing to various strategies implemented by the key players in the region. Key players are focused on providing reimbursements to patients to make the medicines available at affordable prices. For instance, Sanofi S.A. provides reimbursement for CLOMID under the Pharmaceutical Benefits Scheme (PBS) in Europe and Australia, in order to make the medicines available at affordable prices for patients. PBS provides timely, reliable, and affordable access to fertility medications to the people in Europe and Australia. The medicine is prescribed for the treatment of ovulatory failure in selected infertile women who wish to become pregnant.

Figure 2: Clomiphene Citrate Market Value (US$ Mn) & Y-o-Y Growth (%), 2017-2027

Clomiphene Citrate  | Coherent Market Insights

Clomiphene Citrate Market - Competitive Landscape

Key players operating in the clomiphene citrate market include Sanofi S.A., Par Pharmaceutical, Merck & Co. Inc., Teva Pharmaceutical Industries Ltd., Cipla Inc., Unichem Laboratories Ltd., Emcure Pharmaceuticals Ltd., Serum Institute of India Pvt. Ltd., Incepta Pharmaceuticals Ltd., and Shanghai Trifecta Pharma Co. Ltd.

According to the data published in the National Institutes of Health (NIH) in January 2017, the most common overall cause of female infertility is the failure to ovulate, which occurs in 40% of women with infertility issues, globally. To treat such infertility problems in females, clomiphene citrate is the first choice of medicine for the past 40 years, according to the Global Library of Women’s Medicine. Gynecologists prescribe clomiphene for 1 to 6 months or more with a low dose of 50 mg daily (1 tablet) for 5 days. If ovulation does not occur after the first course of therapy, a second course of 100 mg daily (two 50 mg tablets given as a single daily dose) for 5 days is prescribed.

According to a study called ‘Clomiphene citrate usage pattern in India' conducted by Fertility Science and Research in 2014, ovulation rate was reported to increase from 21% to 60% and the pregnancy rate was noticed to be increased by 11% to 30% by majority of participants. The ovulation rate and pregnancy rate was increased using clomiphene citrate because of increased secretion of hypothalamic gonadotropin-releasing hormone (GnRH) to increase the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which will, in turn, stimulate ovarian follicular activity.

Market Dynamics

High incidence of polycystic ovarian syndrome is expected to be a key driver for the clomiphene citrate market growth. For instance, according to an article published in 2014 in Clinical Epidemiology, polycystic ovarian syndrome affects 8% to 20% of the reproductive-age women, globally. According to the World Health Organization, in 2012, polycystic ovarian syndrome affected 116 million women, worldwide.

The clomiphene citrate market growth is hindered by side effects shown by this drug, which includes headache, nausea, upper respiratory tract infection, abdominal tenderness, sinus congestion, mood swings, acne, breast tenderness, weight gain, pelvic discomfort, abnormal bleeding or spotting, vomiting, injection site pain, redness, dizziness, and ovarian hyper-stimulation syndrome (OHSS). For instance, according to a study published in NCBI, in 2016, 10% to 20% of women who consumed clomiphene citrate developed a mild form of OHSS, which will usually resolve on its own. Severe cases of OHSS occurred in less than one percent of patients in the U.S.

Key features of the study:

  • This report provides in-depth analysis of the global clomiphene citrate market, market size (US$ Mn), and compound annual growth rate (CAGR (%)) for the forecast period: 2020-2027, considering 2019 as the base year
  • It elucidates potential revenue opportunity across different segments and explains attractive investment proposition matrix for this market
  • This study also provides key insights about market drivers, restraints, opportunities, new product launches or approval, market trends, regional outlook, and competitive strategies adopted by leading players
  • It profiles key players in the global clomiphene citrate market based on the following parameters – company overview, financial performance, product portfolio, geographical presence, distribution strategies, key developments, and strategies
  • Key players covered as a part of this study include Sanofi S.A., Par Pharmaceutical, Merck & Co. Inc., Teva Pharmaceutical Industries Ltd., Cipla Inc., Unichem Laboratories Ltd., Emcure Pharmaceuticals Ltd., Serum Institute of India Pvt. Ltd., Incepta Pharmaceuticals Ltd., and Shanghai Trifecta Pharma Co. Ltd.
  • Insights from this report would allow marketers and management authorities of companies to make informed decision with respect to their future product launch, governmental initiatives, technological up-gradation, market expansion, and marketing tactics
  • The global clomiphene citrate market report caters to various stakeholders in this industry, including investors, product manufacturers, distributors, and suppliers for clomiphene citrate market, research and consulting firms, new entrants, and financial analysts

Detailed Segmentation:

  • Global Clomiphene Citrate Market, By Indication:
    • PCOS
    • Secondary Amenorrhea
    • Psychogenic Amenorrhea
    • Amenorrhea Galactorrhea Syndrome
    • Others
  • Global Clomiphene Citrate Market, By Distribution Channel::
    • Hospital Pharmacies
    • Retail Pharmacies
    • Online Pharmacies
  • Global Clomiphene Citrate Market, By Region:
    • North America
      • By Country:
        • U.S.
        • Canada
      • By Indication:
        • PCOS
        • Secondary Amenorrhea
        • Psychogenic Amenorrhea
        • Amenorrhea Galactorrhea Syndrome
        • Others
      • By Distribution Channel:
        • Hospital Pharmacies
        • Retail Pharmacies
        • Online Pharmacies
    • Europe
      • By Country:
        • U.K.
        • Germany
        • Italy
        • Spain
        • France
        • Russia
        • Rest of Europe
      • By Indication:
        • PCOS
        • Secondary Amenorrhea
        • Psychogenic Amenorrhea
        • Amenorrhea Galactorrhea Syndrome
        • Others
      • By Distribution Channel:
        • Hospital Pharmacies
        • Retail Pharmacies
        • Online Pharmacies
    • Asia Pacific
      • By Country:
        • Australia
        • India
        • China
        • Japan
        • ASEAN
        • South Korea
        • Rest of Asia Pacific
      • By Indication:
        • PCOS
        • Secondary Amenorrhea
        • Psychogenic Amenorrhea
        • Amenorrhea Galactorrhea Syndrome
        • Others
      • By Distribution Channel:
        • Hospital Pharmacies
        • Retail Pharmacies
        • Online Pharmacies
    • Latin America
      • By Country:
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
      • By Indication:
        • PCOS
        • Secondary Amenorrhea
        • Psychogenic Amenorrhea
        • Amenorrhea Galactorrhea Syndrome
        • Others
      • By Distribution Channel:
        • Hospital Pharmacies
        • Retail Pharmacies
        • Online Pharmacies
    • Middle East
      • By Country:
        • GCC
        • Israel
        • Rest of Middle East
      • By Indication:
        • PCOS
        • Secondary Amenorrhea
        • Psychogenic Amenorrhea
        • Amenorrhea Galactorrhea Syndrome
        • Others
      • By Distribution Channel:
        • Hospital Pharmacies
        • Retail Pharmacies
        • Online Pharmacies
    • Africa
      • By Country/Region:
        • South Africa
        • Central Africa
        • North Africa
      • By Indication:
        • PCOS
        • Secondary Amenorrhea
        • Psychogenic Amenorrhea
        • Amenorrhea Galactorrhea Syndrome
        • Others
      • By Distribution Channel:
        • Hospital Pharmacies
        • Retail Pharmacies
  • Online Pharmacies
    • Company Profiles
      • Sanofi S.A.*
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
    • Par Pharmaceutical
    • Merck & Co. Inc.
    • Teva Pharmaceutical Industries Ltd.
    • Cipla Inc.
    • Unichem Laboratories Ltd.
    • Emcure Pharmaceuticals Ltd.
    • Serum Institute of India Pvt. Ltd.
    • Incepta Pharmaceuticals Ltd.
    • Shanghai Trifecta Pharma Co. Ltd.

“*” marked represents similar segmentation in other categories in the respective section.

Table of Contents

  1. Research Objectives and Assumptions
    • Research Objectives
    • Assumptions
    • Abbreviations
  2. Market Overview
    • Report Description
      • Market Definition and Scope
    • Executive Summary
      • Market Snippet, By Indication
      • Market Snippet, By Distribution Channel
      • Market Snippet, By Region
    • Coherent Opportunity Map (COM)
  3. Market Dynamics, Regulations, and Trends Analysis
    • Market Dynamics
      • Drivers
      • Restraints
      • Market Opportunities
    • Impact Analysis
    • Market Trends
    • Regulatory Scenario
    • Reimbursement Scenario
    • New Product Launches/Approvals
    • PEST Analysis
    • Impact Analysis of COVID-19 On Market
    • Clomiphene Citrate Usage Pattern
    • Prescription Algorithm And Insights
    • Pricing Analysis of Clomiphene Citrate
  4. Global Clomiphene Citrate Market, By Indication, 2016 – 2027, (US$ Million)
    • Introduction
      • Market Share Analysis, 2020 and 2027 (%)
      • Y-o-Y Growth Analysis, 2017 – 2027
      • Segment Trends
    • PCOS
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
    • Secondary Amenorrhea
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
    • Psychogenic Amenorrhea
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
    • Amenorrhea Galactorrhea Syndrome
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
    • Others
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
  5. Global Clomiphene Citrate Market, By Distribution Channel, 2016 – 2027, (US$ Million)
    • Introduction
      • Market Share Analysis, 2020 and 2027 (%)
      • Y-o-Y Growth Analysis, 2017 – 2027
      • Segment Trends
    • Hospital Pharmacies
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
    • Retail Pharmacies
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
    • Online Pharmacies
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
  6. Global Clomiphene Citrate Market, By Region, 2016 – 2027, (US$ Million)
    • Introduction
      • Market Share Analysis, By Region, 2020 and 2027 (%)
      • Y-o-Y Growth Analysis, By Region, 2017 – 2027
      • Regional Trends
    • North America
      • Market Size and Forecast, By Indication, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Distribution Channel, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Country, 2016 – 2027, (US$ Million)
        • U.S.
        • Canada
    • Europe
      • Market Size and Forecast, By Indication, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Distribution Channel, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Country, 2016 – 2027, (US$ Million)
        • U.K.
        • Germany
        • Italy
        • France
        • Spain
        • Russia
        • Rest of Europe
    • Asia Pacific
      • Market Size and Forecast, By Indication, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Distribution Channel, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Country, 2016 – 2027, (US$ Million)
        • China
        • Japan
        • India
        • ASEAN
        • Australia
        • South Korea
        • Rest of Asia Pacific
    • Latin America
      • Market Size and Forecast, By Indication, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Distribution Channel, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Country, 2016 – 2027, (US$ Million)
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
    • Middle East
      • Market Size and Forecast, By Indication, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Distribution Channel, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Country, 2016 – 2027, (US$ Million)
        • GCC Countries
        • Israel
        • Rest of Middle East
    • Africa
      • Market Size and Forecast, By Indication, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Distribution Channel, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Country/Region, 2016 – 2027, (US$ Million)
        • North Africa
        • Central Africa
        • South Africa
  7. Competitive Landscape
    • Company Profiles
      • Sanofi S.A.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Par Pharmaceutical
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Merck & Co. Inc.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Teva Pharmaceutical Industries Ltd.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Cipla Inc.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Unichem Laboratories Ltd.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Emcure Pharmaceuticals Ltd.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Serum Institute of India Pvt. Ltd.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Incepta Pharmaceuticals Ltd.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Shanghai Trifecta Pharma Co. Ltd.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
  8. Section
    • References
    • Research Methodology
    • About us and Sales Contact

*Browse 26 market data tables and 29 figures on "Global Clomiphene Citrate Market” - Forecast to 2027”

Frequently Asked Questions

The CAGR of the clomiphene citrate market is expected to be 5.4% during the forecast period (2020-2027).
The value of clomiphene citrate market is estimated to be US$ 10.02 million in 2020.
The prominent players in the global clomiphene citrate market include Sanofi S.A., Par Pharmaceutical, Merck & Co. Inc., Teva Pharmaceutical Industries Ltd., Cipla Inc., Unichem Laboratories Ltd., Emcure Pharmaceuticals Ltd., Serum Institute of India Pvt. Ltd., Incepta Pharmaceuticals Ltd., and Shanghai Trifecta Pharma Co. Ltd.
The clomiphene citrate market is expected to be valued at US$ 14.51 million in 2027.
North America is the major region in the clomiphene citrate market.
The increasing prevalence of infertility in men and women and increasing use of generic clomiphene citrate are expected to drive growth of the clomiphene citrate market over the forecast period.
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