A biological preparation that is used to provide active acquired immunity to a particular disease are called as vaccines. Vaccines are commonly of four types: live-attenuated vaccines, toxoid vaccines, subunit vaccines, and inactivated vaccines. Inactivated vaccines are created by inactivating a virus, bacteria or pathogens with the treatment of chemical (formaldehyde) or heat. These pathogens are grown in controlled culture condition and are killed to reduce their infectivity. Inactivated vaccines are not as effective as live-attenuated vaccines. Multiple booster shots and immunologic adjuvants are required to provide an effective immune response against the diseases. Inactivated vaccines are on the U.S. Recommended Childhood Immunization Schedule, which includes the seasonal influenza vaccine and inactivated polio vaccine. Less immunogenicity of older vaccines are propelling demand for newly developed innovative vaccines with better efficacy. Researchers and market players are investing in R&D for the development of safe and effective vaccines, thereby boosting growth of the inactivated vaccines market.

Inactivated Vaccine Market – Dynamics

Introduction of new inactivated vaccines after completion of clinical studies are expected to boost growth of the inactivated vaccines market over the forecast period. For instance, in 2017, Merck’s investigational inactivated varicella zoster virus vaccine (V212) showed a decrease in the incidence of herpes zoster case by an estimated 64% in immunocompromised subjects in the first phase 3 trial. Clinical studies also revealed that V212 lessens the incidence of herpes zoster pain by around 69.5%. Moreover, V212 demonstrated 83.7% reduction in the incidence of post herpetic neuralgia. Rising prevalence of various viral and bacterial diseases around the globe have increased the demand for inactivated vaccines, which in turn will fuel the market growth. For instance, according to the World Health Organization (WHO) report in 2018, annual epidemics due to influenza were estimated to result in around 3 to 5 million cases of severe illness and around 290,000 to 650,000 deaths. Moreover, WHO 2018 report also showed that around 21 million cases and 222,000 typhoid-related deaths occur annually worldwide.

Inactivated Vaccine Market – Regional Insights

On the basis of region, the global inactivated vaccine market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa. North America holds the dominant position in the global inactivated vaccines market, owing to the presence of key market players in this region, especially in the U.S. Moreover, favorable government support towards the growth of healthcare sector is also likely to accelerate the growth of inactivated vaccine market revenue in this region. For instance, in 2016, the U.S. Department of Health and Human Services shifted fund of around US$ 81 million from other projects, to continue the work on developing vaccines to fight Zika virus. Asia Pacific is expected to witness growth in the market, followed by Europe, owing to growing activities in the healthcare research and development of new innovative products. For instance, in 2013, Bharat Biotech launched JENVAC vaccine to provide long-term protection and immunogenicity against Japanese encephalitis. The important benefit of this novel fully indigenous inactivated vaccine is that it can be administered during disease epidemics, as it is an inactivated vaccine and is highly purified.

Inactivated Vaccine Market – Competitive Landscape

Major players operating in the global inactivated vaccine market include GlaxoSmithKline Plc, Seqirus, Valneva SE, Pfizer Inc., Merck & Co., Inc., Emergent BioSolutions, Bharat Biotech, and Sanofi. Major market players are involved in adopting market strategies such as mergers, acquisitions, partnership, collaborations, and development of new products with leading companies and research institutes, in order to retain dominant position in the market. For instance, in 2017, the U.S. Food and Drug Administration (FDA) approved GlaxoSmithKline Plc’s Shingrix, a zoster vaccine recombinant for the prevention of shingles in adults above the age of 50 years. Shingrix is a non-live, recombinant subunit vaccine given intramuscularly in two doses.

Inactivated Vaccine Market – Taxonomy

On the basis of vaccine type, the global inactivated vaccine market is segmented into: