all report title image
  • Published On : Dec 2021
  • Code : CMI4828
  • Industry : Biotechnology
  • Pages : 196
  • Formats :

Bioreactors are bioprocessing devices that are used for biochemical processing that involves biological active substances and micro-organisms. This bioprocessing can be aerobic or anaerobic. The various type of bioreactors are designed as cylindrical structures and come in different sizes and capacities with various materials such as glass bioreactors, carbon steel, stainless steel bioreactors, ceramic bioreactors, and Polytetrafluoroethylene (PTFE) plastic. Bioreactors can be used in vaccine production for static culture or roller bottle technology. During the production process, bioreactors provide sterile gas such as oxygen and carbon dioxide into the culture medium. The constant stirring distributes the nutrients and reduces the size of gas bubbles that arise due to the sterile gas supply in the culture vessel, thus releasing oxygen into the nutrient solution. The pharmaceutical industry’s increased efforts to create vaccines or medications is expected to drive the growth of the market. For instance, according to the India Brand Equity Foundation (IBEF), between April 2020 and June 2021, the foreign direct investment (FDI) into the Indian pharmaceutical industry totaled at US$ 18.12 billion.

Global Small Scale Bioreactor Market - Impact of the Coronavirus (COVID-19) Pandemic

The COVID-19 pandemic is expected to drive the growth of the small scale bioreactors market over the forecast period, owing to increasing activities among market players for use of bioreactors for vaccine production. For instance, in November 2020, AstraZeneca, a multinational biopharmaceutical company, signed an agreement with the Australian government and a biotech firm CSL, which is located in Australia, to begin production of the COVID-19 vaccine candidate in Australia developed by the University of Oxford for nation wise distribution in the first half of 2021. According to reports, production began at CSL's bioreactor facility in Victoria, Australia with the creation of vials containing COVID-19 vaccine cells frozen in liquid nitrogen.

Increasing awareness about technological aspects of bioreactors by institutes and organizations is expected to increase the growth of the small scale bioreactors market over the forecast period. For instance, on October 25, 2021, the researchers at the Department of Biotechnology from National Institute of Technology, Andhra Pradesh conducted a training program for Bioremediation by photo and electrochemical bioreactors where they explained about designing and modeling of bioreactors, production of platform chemicals through biochemical and chemical route and Bio-hydrogen production.

The global small scale bioreactors market is estimated to be valued at US$ 1,233.5 Mn in 2021 and is expected to exhibit a CAGR of 10.6 % over the forecast period (2021-2028).  

Figure 1: Global Small Scale Bioreactor Market Share, (%), Analysis, By Product Type, 2021

Small Scale Bioreactors  | Coherent Market Insights

Increasing research and development activities by the market players for developing the bioreactors is expected to drive the growth of the global small scale bioreactors market over the forecast period.

Market players are involved in research and development activities for developing the bioreactors. This is expected to increase the growth of the market over the forecast period. For instance, according to the article published in the journal Plos One by the researchers of Keck Graduate Institute of Applied Life Sciences, U.S., in June 2021, a study was conducted to investigate a scaled model of the Express bioreactor developed by Sepragen Corporation, a supplier of equipment’s and chromatography application to biotechnology industry. This study was done to find out how this bioreactor system would work with shear sensitive human Mesenchymal Stem Cells (hMSCs). The results of the study showed that the cells showed excellent expression of stem cell biomarkers. hMSC also retained the ability to differentiate into bone, cartilage, and adipocytes. Therefore, hMSC demonstrates the effectiveness of bioreactor systems with floating matrices for the production of high-purity hMSCs.

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Small Scale Bioreactor Market Report Coverage

Report Coverage Details
Base Year: 2020 Market Size in 2021:

US$ 1,233.5 Mn

Historical Data for: 2018 to 2020 Forecast Period: 2021 to 2028
Forecast Period 2021 to 2028 CAGR: 10.6% 2028 Value Projection:

US$ 2,494.8 Mn

Geographies covered:
  • North America: U.S. and Canada
  • Latin America: Brazil, Argentina, Mexico, and Rest of Latin America
  • Europe: Germany, U.K., Spain, France, Italy, Russia, and Rest of Europe
  • Asia Pacific: China, India, Japan, Australia, South Korea, ASEAN, and Rest of Asia Pacific
  • Middle East: GCC, Israel, and Rest of Middle East
  • Africa: South Africa, North Africa, and Central Africa
Segments covered:
  • By Product Type: Reusable Bioreactors ( Stainless Steel Bioreactors, Glass Bioreactors), Single-use Bioreactors
  • By Capacity: 5 ML -100 ML, 100 ML -250 ML, 250 ML -500 ML, 500ML-1L, 1L-3L, 3L-5L
  • By End User: Biopharmaceutical Companies, Contract Manufacturing Organizations, Research Organizations
Companies covered:

Merck KGaA  ,Danaher Corporation, Getinge AB, Sartorius AG ,Thermo Fisher Scientific Inc. , Lonza Group , Eppendorf AG , Miltenyi Biotec ,Solaris Biotechnology Srl, Infors AG, Biosan, MicroDigital Co. Ltd., 2mag AG, MDX Biotechnik International GmbH, Esco Lifesciences Group, HiTec Zang GmbH, Hanil Scientific Inc., Adolf Kühner AG, Ori Biotech , Aglaris and AdvaBio

Growth Drivers:
  • Increasing research and development activities
  • Rising adoption of single-use bioreactors
Restraints & Challenges:
  • Limitations of small scale bioreactors

Market players are indulged in inorganic activities such as collaborations, agreements, and partnerships due to increasing use of single use bioreactors. This is expected to increase the growth of the global small scale bioreactors market over the forecast period.

Increasing use of single use bioreactors is expected to increase the growth of the small scale bioreactors market over the forecast period. For instance, in October 2021, 3M Separation and Purification Sciences which provides filtration and purification for water solutions , has  announced a global agreement with Thermo Fisher Scientific Inc. an supplier of scientific instruments , reagents and software supplies that will make it easier for biopharmaceutical customers to pair the 3M Harvest RC Chromatographic Clarifier, a single-stage purification solution, with the Thermo Scientific’s HyPerforma single-use bioreactor. This combination is to bring greater efficiency and scalability to the therapeutic manufacturing process.

 Global Small Scale Bioreactor Market – Restraints

The constraints and challenges for bioreactors during biological processing may hamper the growth of the small scale bioreactors market over the forecast period. For instance, the current tendency in biopharmaceutical manufacturing to create a tailored plant to the specific bioprocessing requirements of a given molecule, there are processing restrictions, such as non-customizable bioreactors. Molecules, on the other hand, do not behave the same way during the development, scale-up, and manufacturing phases. Customizing single use bioreactors to process specific molecules negates bioreactor’s main advantage of automatic configuration and Disposal Single use bioreactors are frequently made from plastic derivatives such as Appliflex ST which is fully customized bioreactor designed for specific bioprocessing needs by Applikon biotechnology In addition to concerns about potential leachable and extractable materials, the large-scale disposal of such plastic reactors on a regular basis is an environmental concern.

Global Small Scale Bioreactor Market – Regional Analysis

On the basis of region, the global small scale bioreactors market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa.

North America is expected to exhibit significant growth in the small scale bioreactors market, owing to the presence of market players in the region. For instance, in July 15, 2021, H.E.L Group (H.E.L), which is an developer and manufacturer of  tools used in laboratory for processing optimization, scale up and safety, has announced that company had expanded their operations such as encompass sales, instrument service and technical and field application support in regions of North America ,by opening a West Coast hub in California and a Central Region hub in Missouri.

Furthermore, the increasing launches of products in the region is expected to drive the Europe small scale bioreactors market growth during the forecast period. For instance, in March 2020, REPROCELL Europe Ltd., engaged in the development of stem cell technologies, announced the launch of ABLE Biot single-use bioreactors series for stem cell culture in Germany, France, Switzerland, Denmark, Sweden, The Netherlands, Scotland, England, Ireland, Wales, and Norway. This device has magnetic stir and disposable system which provides uniform agitation culture environment for cultivation of stem cells.

Figure 2: Global Small Scale Bioreactor Market (US$ Mn), by Region, 2021

Small Scale Bioreactors  | Coherent Market Insights

Global Small Scale Bioreactor Market – Competitive Landscape

Major players operating in the global small scale bioreactor market include Merck KGaA, Danaher Corporation, Getinge AB, Sartorius AG,Thermo Fisher Scientific Inc., Lonza Group, Eppendorf AG, Miltenyi Biotec, Solaris Biotechnology Srl, Infors AG, Biosan, MicroDigital Co., Ltd., 2mag AG, MDX Biotechnik International GmbH, Esco Lifesciences Group, HiTec Zang GmbH, Hanil Scientific Inc., Adolf Kühner AG, Ori Biotech, Aglaris, AdvaBio

Bioreactors are processing vessels used for providing effective environment for enzymes or cells during biochemical processing which involves biological active substances and microorganisms. The bioreactor processes are aerobic or anaerobic. There are various types of bioreactors such as Glass bioreactors, carbon steel bioreactors, stainless steel bioreactors, ceramic bioreactors, and PTFE plastic bioreactors are all cylindrical constructions that come in a variety of sizes and capacities. As the pharmaceutical industries increased efforts to create vaccinations or medications where bioreactors are used in vaccine production, it can be employed for static culture or roller bottle technology. Bioreactors inject sterile gas such as oxygen and carbon dioxide into the culture medium throughout the manufacturing process. Constant stirring disperses the nutrients and lowers the size of gas bubbles formed by the sterile gas supply in the culture vessel, allowing oxygen to enter the nutrient solution.

Market Dynamics

Market players are indulged in research and development activities which is expected to increase the growth of the global small scale bioreactors market over the forecast period. For instance, according to article published in the journal Frontiers in Bioengineering and Biotechnology, August 2020, researchers of University College of London, U.K. conducted the study to review Small-Scale Fluidized Bed Bioreactor (sFBB) for Long-Term Dynamic Culture of 3D Cell Constructs and in vitro Testing. The results of the study demonstrated that sFBB serve as a device for long-term culture and analysis of 3D cell constructs with prospects of engineering in vitro models, which could more closely reproduce the in vivo conditions and in a more cost-effective manner, and ultimately contribute towards reducing the use of animal models in research.

Increasing number of inorganic growth strategies such as collaborations of key players in the regions such as North America, Europe, and Asia pacific is expected to drive the growth of small scale bioreactors market over the forecast period. For instance, in August 2020, Pluristem Therapeutics Inc., a regenerative medicine company, announced that its subsidiary, Pluristem Ltd., had signed a non-binding Memorandum of Understanding (MOU) with the United Arab Emirates-based Abu Dhabi Stem Cells Center (ADSCC), a specialist healthcare center focused on cell therapy and regenerative medicine. Under this collaboration, the company and the healthcare center will work for the development of cell therapies and regenerative medicines for the treatment of severe diseases including COVID-19.

Key features of the study:

  • This report provides an in-depth analysis of global small scale bioreactors market, provides market size (US$ Million), and compound annual growth rate (CAGR %) for the forecast period (2021-2028), considering 2020 as the base year
  • It elucidates potential revenue opportunities across different segments and explains attractive investment proposition matrix for this market
  • This study also provides key insights about market drivers, restraints, opportunities, new product launches or approval, regional outlook, and competitive strategies adopted by the leading players
  • It profiles leading players in the global small scale bioreactors market based on the following parameters – company overview, financial performance, product portfolio, geographical presence, distribution strategies, key developments and strategies, and future plans.
  • Key companies covered as a part of this study include Merck KGaA, Danaher Corporation, Getinge AB, Sartorius AG ,Thermo Fisher Scientific Inc. , Lonza Group , Eppendorf AG , Miltenyi Biotec ,Solaris Biotechnology Srl, Infors AG, Biosan, MicroDigital Co. Ltd., 2mag AG, MDX Biotechnik International GmbH, Esco Lifesciences Group, HiTec Zang GmbH, Hanil Scientific Inc., Adolf Kühner AG, Ori Biotech, Aglaris and AdvaBio.
  • Insights from this report would allow marketers and the management authorities of the companies to make informed decision regarding their future product launch, technology up-gradation, market expansion, and marketing tactics
  • The global small scale bioreactors market report caters to various stakeholders in this industry including investors, suppliers, manufacturers, distributors, new entrants, and financial analysts
  • Stakeholders would have ease in decision-making through various strategy matrices used in analyzing the global small scale bioreactors market

Detailed Segmentation:

  • Global Small Scale Bioreactors Market, By Product Type:
    • Reusable Bioreactors
    • Stainless Steel Bioreactors
    • Glass Bioreactors
    • Single-use Bioreactors
  • Global Small Scale Bioreactors Market, By Capacity:
    • 5 ML -100 ML
    • 100 ML-250 ML
    • 250 ML -500 ML
    • 500 ML-1 L
    • 1L-3L
    • 3L-5L
  • Global Small Scale Bioreactors Market, By End User :
    • Biopharmaceutical Companies
    • Contract Manufacturing Organizations
    • Research Organizations
  • Global Small Scale Bioreactors Market, By Region:
    • North America
      • By Product Type:
        • Reusable Bioreactors
          • Stainless Steel Bioreactors
          • Glass Bioreactors
        • Single-use Bioreactors
      • By Capacity:
        • 5 ML -100 ML
        • 100 ML-250 ML
        • 250 ML -500 ML
        • 500 ML-1 L
        • 1L-3L
        • 3L-5L
      • By End User:
        • Biopharmaceutical Companies
        • Contract Manufacturing Organizations
        • Research Organizations
      • By Country:
        • U.S.
        • Canada
    • Latin America
      • By Product Type:
        • Reusable Bioreactors
          • Stainless Steel Bioreactors
          • Glass Bioreactors
        • Single-use Bioreactors
      • By Capacity:
        • 5 ML -100 ML
        • 100 ML-250 ML
        • 250 ML -500 ML
        • 500 ML-1 L
        • 1L-3L
        • 3L-5L
      • By End User:
        • Biopharmaceutical Companies
        • Contract Manufacturing Organizations
        • Research Organizations
      • By Country:
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
    • Europe
      • By Product Type:
        • Reusable Bioreactors
          • Stainless Steel Bioreactors
          • Glass Bioreactors
        • Single-use Bioreactors
      • By Capacity:
        • 5 ML -100 ML
        • 100 ML-250 ML
        • 250 ML -500 ML
        • 500 ML-1 L
        • 1L-3L
        • 3L-5L
      • By End User:
        • Biopharmaceutical Companies
        • Contract Manufacturing Organizations
        • Research Organizations
      • By Country:
        • U.K.
        • Germany
        • Italy
        • Spain
        • France
        • Russia
        • Rest of Europe
    • Asia Pacific
      • By Product Type:
        • Reusable Bioreactors
          • Stainless Steel Bioreactors
          • Glass Bioreactors
        • Single-use Bioreactors
      • By Capacity:
        • 5 ML -100 ML
        • 100 ML-250 ML
        • 250 ML -500 ML
        • 500 ML-1 L
        • 1L-3L
        • 3L-5L
      • By End User:
        • Biopharmaceutical Companies
        • Contract Manufacturing Organizations
        • Research Organizations
      • By Country:
        • Australia
        • India
        • China
        • Japan
        • ASEAN
        • South Korea
        • Rest of Asia Pacific
    • Middle East
      • By Product Type:
        • Reusable Bioreactors
          • Stainless Steel Bioreactors
          • Glass Bioreactors
        • Single-use Bioreactors
      • By Capacity:
        • 5 ML -100 ML
        • 100 ML-250 ML
        • 250 ML -500 ML
        • 500 ML-1 L
        • 1L-3L
        • 3L-5L
      • By End User:
        • Biopharmaceutical Companies
        • Contract Manufacturing Organizations
        • Research Organizations
      • By Country:
        • GCC
        • Israel
        • Rest of Middle East
    • Africa
      • By Product Type:
        • Reusable Bioreactors
          • Stainless Steel Bioreactors
          • Glass Bioreactors
        • Single-use Bioreactors
      • By Capacity:
        • 5 ML -100 ML
        • 100 ML-250 ML
        • 250 ML -500 ML
        • 500 ML-1 L
        • 1L-3L
        • 3L-5L
      • By End User:
        • Biopharmaceutical Companies
        • Contract Manufacturing Organizations
        • Research Organizations
      • By Country/Region:
        • South Africa
        • Central Africa
        • North Africa
  • Company Profiles
    • Sartorius AG *
      • Company Overview
      • Product Portfolio
      • Financial Performance
      • Recent Highlights
      • Strategies
    • Thermo Fisher Scientific Inc.
    • Merck KGaA
    • Danaher Corporation
    • Lonza Group
    • Eppendorf AG
    • Miltenyi Biotec
    • Getinge AB
    • Solaris Biotechnology Srl
    • Infors AG
    • Biosan
    • MicroDigital Co., Ltd.
    • 2mag AG
    • MDX Biotechnik International GmbH
    • Esco Lifesciences Group
    • HiTec Zang GmbH
    • Hanil Scientific Inc.
    • Adolf Kühner AG
    • Ori Biotech
    • Aglaris
    • AdvaBio

“*” marked represents similar segmentation in other categories in the respective section

Frequently Asked Questions

The global small scale bioreactor market is expected to exhibit a CAGR of 10.6% during the forecast period (2021-2028).
The market is estimated to be valued at US$ 1,233.5 Mn in 2021.
Merck KGaA, Danaher Corporation, Getinge AB,Sartorius AG, Thermo Fisher Scientific Inc., Lonza Group, Eppendorf AG, Miltenyi Biotec, Solaris Biotechnology Srl, Infors AG, Biosan, MicroDigital Co., Ltd., 2mag AG,MDX Biotechnik International GmbH, Esco Lifesciences Group, HiTec Zang GmbH, Hanil Scientific Inc., Adolf Kühner AG, Ori Biotech, Aglaris, AdvaBio are some of the prominent players operating in the market over the forecast period.
The market is expected to be valued at US$ 2,494.8 Mn in 2028.
North America is the prominent region in the market.
Reusable bioreactors, which belongs to product type, is the prominent segment in the market.

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