Small Molecule API Market - Global Forecast to 2026, by API Type (Artificial, and Natural), by Category (Analgesic, Anesthetics, Anticonvulsants, Antimetabolites, Antibacterial, Alkylating Agents, and Others), and by Region (North America, Latin America, Europe, Asia Pacific, Middle East, and Africa) - Size, Share, Outlook, and Opportunity Analysis, 2018- 2026

  • Published On : Apr 2019 |
  • Pages : 261 Pages |
  • Format : CMI Insight PPT Format CMI Insight PDF Format

A Small molecule Active Pharmaceutical Ingredient (API) is a low molecular weight organic compound, which may help to control biological process, with a size on the order of 1 nm. Most of the small molecule can be administered orally and are most likely to be absorbed by the body. Owing to its small size it has properties of rapid diffusibility to reach at intracellular site of action.

Small Molecule API Market – Dynamics

The small molecule API market is witnessing rapid growth due to increasing number of corporate agreements. For instance, BASF Pharma will sell its OMEGA 3 manufacturing facility in Norway to Marine Ingredients. The Highly Potent Active Pharmaceutical Ingredients (HPAPI) is projected to witness high growth rate, owing to easy access to the people for medication in emerging economies. The rising prevalence of diseases such as cancer, cardiovascular, and infectious diseases is expected to propel demand for manufacturing of small molecule APIs. According to the National Center for Biotechnology Information (NCBI) report, in 2014, out of 570,341 deaths 29.4% were due to cancer and 27.1% were due to cardiovascular disease. Increasing consumer awareness, benefits of small molecule API, expiry of patents covering the top-selling pharmaceuticals, and technological advancement in manufacturing sector are expected to drive the market growth over the forecast period. Increasing adoption of generic drugs has resulted into affordable healthcare expenditure, which is expected to increase production of small molecule API’s, in turn driving the global small molecule API market growth. According to the Indian Brand Equity Foundation (IBEF), in 2018, India is largest producer of generic medicines, which supplies 50% of vaccines and 40% of drugs to the U.S. and 25% of drugs to the U.K.

Small Molecule API Market – Regional insights

North America held the largest market share for small molecule API registering for 38.84% in 2017, due to high adoption rate of accelerated regulatory review of innovative medicines. Asia Pacific excluding Japan (APEJ) market is estimated to witness rapid growth in market, owing to high adoption of over the counter (OTC) drugs by large patient population coupled with growing healthcare and pharmaceutical industry and strong research and development in API. According to IBEF, investment in research and development by Indian pharmaceutical companies increased (in term of sales) from 5.3% to 8.5% from 2012 to 2018.

Small Molecule API Market – Competitive landscape

The major player operating in global small molecule API market include ALLERGAN, Aurobindo Pharma, Cambrex Corporation, Albemarle Corporation, D.r. Reddy’s Laboratories Ltd. The other key  players in market are Johnson Matthey, Siegfried Holding AG, Pfizer, Sanofi S.A., Novartis AG, Johnson & Johnson, Bristol-Myers Squibb, Bachem Holding AG, Boehringer Ingelheim GmbH, F. Hoffmann-La Roche Ltd, GlaxoSmithKline PLC, GILEAD Science Inc., Albany Molecular Research Inc., Sun Pharmaceuticals, AstraZeneca,  Merck & Co, Inc., BASF SE, and Teva Pharmaceuticals. In March 2012, the FDA approved Ilumya (Tildrakizumab-asmn) developed by Sun Pharmaceuticals used for Plaque Psoriasis.

Global Small Molecule API - Market Taxonomy

  • On the basis of API type, the global small molecule API market is segmented into:
    • Synthetic
    • Biological
  • On the basis of application, the global small molecule API market is segmented into:
    • Oncology
    • Neurology
    • Metabolic
    • Infectious
    • Cardiovascular
  • On the basis of geography, the global small molecule API market is segmented into
    • North America
    • Europe
    • Asia Pacific
    • Latin America
    • Middle East
    • Africa

A small molecule Active Pharmaceutical Ingredient (API) is a low molecular weight organic compound, which may help to control biological process. Most of the small molecules can be administered orally and are most likely to be absorbed by the body. Owing to its small size it has properties of rapid diffusibility to reach the intracellular site of action.

Market Dynamics

Growing expansion of small molecule API manufacturers in the Asia Pacific region is a major factor driving the small molecule API market growth. For instance, BASF is planning to build a new specialty amines plant at its existing site in Nanjing Chemical Industry Park, China. This new multi-product plant will be able to manufacture 21,000 metric tons of amines year, and it extends BASF’s amines portfolio at the specialty amines complex in Nanjing. The plant is scheduled to stream by 2019. Moreover the small molecule API manufacturers have planned to add global sales and business development staff, followed by quality, regulatory, and project management teams, which have positively influenced growth of the market.

However, stringent regulatory policies for API manufacturing may hinder the market growth. Stringent global regulatory policies on quality assessments of small molecule API manufacturing, facility certification, and increased supply chain security issues across emerging countries have a large impact on the cost of final small molecule API products. The new entrants willing to enter into small molecule API manufacturing are facing financial challenges, owing to aforementioned factors.

Key features of the study:

  • This report provides in-depth analysis of the small molecule API market and provides market size (US$ million) and Compound Annual Growth Rate (CAGR %) for the forecast period (2018 – 2026), considering 2018 as the base year
  • It elucidates potential revenue opportunities across different segments and explains attractive investment proposition matrices for this market
  • This study also provides key insights about market drivers, restraints, opportunities, impact analysis, PEST analysis, collaborations, mergers and acquisitions, regulatory scenarios, technological advancements, steps to manufacture small molecule API, major suppliers of small molecule APIs, market trends
  • It profiles key players in the global small molecule API market based on the following parameters – company overview, financial performance, product portfolio, market presence, distribution strategies, key developments, strategies, and future plans
  • Key companies covered as a part of this study include, Lonza, Sanofi S.A., Sun Pharmaceutical Industries Ltd., Teva Pharmaceutical Industries Ltd., Pfizer, Inc., Aesica Pharmaceuticals Ltd., Albemarle Corporation, Cambrex Corporation, BASF SE, Gland Pharma Limited, Gilead Sciences, Inc., AstraZeneca Plc, Baxter International Inc., Boehringer Ingelheim International GmbH, Celgene Corporation, Piramal Pharma Solutions, Recipharm AB, Evonik Industries AG, Glenmark Pharmaceuticals Limited, Siegfried AG, AbbVie Contract Manufacturing, Aurinia Pharmaceuticals Inc., Bayer AG, Patheon, CordenPharma International
  • Insights from this report would allow marketers and the management authorities of the companies to make informed decisions regarding their future product launches, technology up-gradation, market expansion, and marketing tactics.
  • The global small molecule API market report caters to various stakeholders in this industry including investors, suppliers, product manufacturers, distributors, new entrants, and financial analysts
  • Stakeholders would have ease in decision-making through various strategy matrices used in analyzing the small molecule API market

Detailed Segmentation:

  • Global Small Molecule API Market, By API Type:
    • Artificial
    • Natural
  • Global Small Molecule API Market, By Category:
    • Analgesic
    • Anesthetics
    • Anticonvulsants
    • Antimetabolites
    • Antibacterial
    • Alkylating Agents
    • Others
  • Global Small Molecule API Market, By Geography:
    • North America
      • By API Type:
        • Artificial
        • Natural
      • By Category:
        • Analgesic
        • Anesthetics
        • Anticonvulsants
        • Antimetabolites
        • Antibacterial
        • Alkylating Agents
        • Others
      • By Country:
        • U.S.
        • Canada
    • Latin America
      • By API Type:
        • Artificial
        • Natural
      • By Category:
        • Analgesic
        • Anesthetics
        • Anticonvulsants
        • Antimetabolites
        • Antibacterial
        • Alkylating Agents
        • Others
      • By Country:
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
    • Europe
      • By API Type:
        • Artificial
        • Natural
      • By Category:
        • Analgesic
        • Anesthetics
        • Anticonvulsants
        • Antimetabolites
        • Antibacterial
        • Alkylating Agents
        • Others
      • By Country:
        • Germany
        • U.K.
        • France
        • Italy
        • Spain
        • Russia
        • Rest of Europe
    • Asia Pacific
      • By API Type:
        • Artificial
        • Natural
      • By Category:
        • Analgesic
        • Anesthetics
        • Anticonvulsants
        • Antimetabolites
        • Antibacterial
        • Alkylating Agents
        • Others
      • By Country:
        • China
        • India
        • Japan
        • Australia
        • South Korea
        • ASEAN
        • Rest of Asia Pacific
    • Middle East
      • By API Type:
        • Artificial
        • Natural
      • By Category:
        • Analgesic
        • Anesthetics
        • Anticonvulsants
        • Antimetabolites
        • Antibacterial
        • Alkylating Agents
        • Others
      • By Country:
        • GCC
        • Israel
        • Rest of Middle East
    • Africa
      • By API Type:
        • Artificial
        • Natural
      • By Category:
        • Analgesic
        • Anesthetics
        • Anticonvulsants
        • Antimetabolites
        • Antibacterial
        • Alkylating Agents
        • Others
      • By Country:
        • South Africa
        • Central Africa
        • North Africa
  • Company Profiles
    • Lonza *
      • Company Overview
      • Product Portfolio
      • Financial Performance
      • Key Highlights
      • Market Strategies
    • Sun Pharmaceutical Industries Ltd.
    • Teva Pharmaceutical Industries Ltd.
    • Pfizer, Inc.
    • Aesica Pharmaceuticals Ltd.
    • Albemarle Corporation
    • Cambrex Corporation
    • BASF SE
    • Gland Pharma Limited
    • Gilead Sciences, Inc.
    • AstraZeneca Plc
    • Baxter International Inc.
    • Boehringer Ingelheim International GmbH
    • Celgene Corporation
    • Piramal Pharma Solutions
    • Recipharm AB
    • Evonik Industries AG
    • Glenmark Pharmaceuticals Limited
    • Siegfried AG
    • AbbVie Contract Manufacturing
    • Aurinia Pharmaceuticals Inc.
    • Bayer AG
    • Patheon
    • CordenPharma International

 “*” marked represents similar segmentation in other categories in the respective section.

Table of Contents

  1. Research Objectives and Assumptions
    • Research Objectives
    • Assumptions
    • Abbreviations
  2. Market Purview
    • Report Description
      • Market Definition and Scope
    • Executive Summary
      • Market Snippet, By API Type
      • Market Snippet, By Category
      • Market Snippet, By Region
    • Coherent Opportunity Map (COM)
  3. Market Dynamics, Regulations, and Trends Analysis
    • Market Dynamics
      • Drivers
      • Restraints
      • Market Opportunities
    • Impact Analysis
    • PEST Analysis
    • Collaborations, Mergers and Acquisitions
    • Regulatory Scenario
    • Technological Advancements
    • Steps to Manufacture Small Molecule API
    • Major Suppliers of Small Molecule APIs
    • Market Trends
  4. Global Small Molecule API Market, By API Type, 2018 – 2026, (US$ Mn)
    • Introduction
      • Market Share Analysis, 2018 and 2026 (%)
      • Y-o-Y Growth Analysis, 2017 – 2026
      • Segment Trends
    • Artificial
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Mn)
    • Natural
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Mn)
  5. Global Small Molecule API Market, By Category, 2018 – 2026, (US$ Mn)
    • Introduction
      • Market Share Analysis, 2018 and 2026 (%)
      • Y-o-Y Growth Analysis, 2017 – 2026
      • Segment Trends
    • Analgesic
      •  Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Mn)
    • Anesthetics
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Mn)
    • Anticonvulsants
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Mn)
    • Antimetabolites
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Mn)
    • Antibacterial
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Mn)
    • Alkylating Agents 
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Mn)
    • Others
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Mn)
  6. Global Small Molecule API Market, By Region, 2018 – 2026, (US$ Mn)
    • Introduction
      • Market Share Analysis, By Region, 2018 and 2026 (%)
      • Y-o-Y Growth Analysis, For Regions, 2017–2026
    • North America
      • Market Size and Forecast, By API Type, 2016 – 2026, (US$ Mn)
      • Market Size and Forecast, By Category, 2016 – 2026, (US$ Mn)
      • Market Size and Forecast, By Distribution Channel, 2016 – 2026, (US$ Mn)
      • Market Size and Forecast, By Country, 2016 – 2026, (US$ Mn)
        • U.S.
        • Canada
    • Latin America
      • Market Size and Forecast, By API Type, 2016 – 2026, (US$ Mn)
      • Market Size and Forecast, By Category, 2016 – 2026, (US$ Mn)
      • Market Size and Forecast, By Distribution Channel, 2016 – 2026, (US$ Mn)
      • Market Size and Forecast, By Country, 2016 – 2026, (US$ Mn)
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
    • Europe
      • Market Size and Forecast, By API Type, 2016 – 2026, (US$ Mn)
      • Market Size and Forecast, By Category, 2016 – 2026, (US$ Mn)
      • Market Size and Forecast, By Distribution Channel, 2016 – 2026, (US$ Mn)
      • Market Size and Forecast, By Country, 2016 – 2026, (US$ Mn)
        • Germany
        • U.K.
        • France        
        • Italy
        • Spain
        • Russia
        • Rest of Europe
    • Asia Pacific
      • Market Size and Forecast, By API Type, 2016 – 2026, (US$ Mn)
      • Market Size and Forecast, By Category, 2016 – 2026, (US$ Mn)
      • Market Size and Forecast, By Distribution Channel, 2016 – 2026, (US$ Mn)
      • Market Size and Forecast, By Country, 2016 – 2026, (US$ Mn)
        • China
        • India
        • Japan
        • Australia
        • South Korea
        • ASEAN
        • Rest of APAC
    • Middle East
      • Market Size and Forecast, By API Type, 2016 – 2026, (US$ Mn)
      • Market Size and Forecast, By Category, 2016 – 2026, (US$ Mn)
      • Market Size and Forecast, By Distribution Channel, 2016 – 2026, (US$ Mn)
      • Market Size and Forecast, By Country, 2016 – 2026, (US$ Mn)
        • GCC
        • Israel
        • Rest of Middle East
    • Africa
      • Market Size and Forecast, By API Type, 2016 – 2026, (US$ Mn)
      • Market Size and Forecast, By Category, 2016 – 2026, (US$ Mn)
      • Market Size and Forecast, By Distribution Channel, 2016 – 2026, (US$ Mn)
      • Market Size and Forecast, By Country, 2016 – 2026, (US$ Mn)
        • South Africa
        • Central Africa
        • North Africa
  7. Competitive Landscape
    • Heat Map Analysis
    • Company Profiles
      •  Lonza
        • Company Overview
        • API Type Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Sanofi S.A.
        • Company Overview
        • API Type Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Sun Pharmaceutical Industries Ltd.
        • Company Overview
        • API Type Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Teva Pharmaceutical Industries Ltd.
        • Company Overview
        • API Type Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      •  Pfizer, Inc.
        • Company Overview
        • API Type Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Aesica Pharmaceuticals Ltd.
        • Company Overview
        • API Type Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Albemarle Corporation
        • Company Overview
        • API Type Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Cambrex Corporation
        • Company Overview
        • API Type Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • BASF SE
        • Company Overview
        • API Type Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Gland Pharma Limited
        • Company Overview
        • API Type Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Gilead Sciences, Inc.
        • Company Overview
        • API Type Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • AstraZeneca Plc
        • Company Overview
        • API Type Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • BASF SE
        • Company Overview
        • API Type Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Baxter International Inc.
        • Company Overview
        • API Type Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Boehringer Ingelheim International GmbH
        • Company Overview
        • API Type Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Celgene Corporation
        • Company Overview
        • API Type Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Piramal Pharma Solutions
        • Company Overview
        • API Type Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Recipharm AB
        • Company Overview
        • API Type Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Evonik Industries AG
        • Company Overview
        • API Type Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Glenmark Pharmaceuticals Limited
        • Company Overview
        • API Type Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Siegfried AG
        • Company Overview
        • API Type Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • AbbVie Contract Manufacturing
        • Company Overview
        • API Type Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Aurinia Pharmaceuticals Inc.
        • Company Overview
        • API Type Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Bayer AG
        • Company Overview
        • API Type Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Patheon
        • Company Overview
        • API Type Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • CordenPharma International
        • Company Overview
        • API Type Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
    • Analyst Views
  8. Section
    • References
    • Research Methodology
    • About us and Sales Contact

*Browse 34 market data tables and 23 figures on “Small Molecule API Market - Global forecast to 2026”.

Research Methodology

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  • Primary Research (Trade Surveys and Experts Interviews)
  • Desk Research
  • Proprietor Data Analytics Model

In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.


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Coherent Market Insights desk research is based on a principle set of research techniques:

  • National level desk research: It Includes research analysis of regional players, regional regulatory bodies, regional trade associations, and regional organization.
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Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:

  • Governmental bodies, National and international social welfare institutions, and organizations creating economic policies among others.
  • Trade association, National and international media and trade press.
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Preliminary Data Mining

The raw data is obtained through the secondary findings, in house repositories, and trade surveys. It is then filtered to ensure that the relevant information including industry dynamics, trends, and outlook is retained for further research process.

Data Standardization:

Holistic approach is used to ensure that the granular and uncommon parameters are taken into consideration to ensure accurate results. The information from the paid databases are further combined to the raw data in order to standardize it.

Coherent Statistical model

We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:

  • Micro-economic indicators
  • Macro-economic indicators
  • Environmental indicators
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Data Validation

This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:

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  • Primary research includes online surveys, face-to face interviews, and telephonic interviews.

The primary research is conducted with the ecosystem players including, but not limited to:

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