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  • Published On : Jun 2023
  • Code : CMI5800
  • Pages : 160
  • Formats :
      Excel and PDF
  • Industry : Pharmaceutical

The global Smallpox Treatment market size was valued at US$ 67.49 million in 2023 and is expected to reach US$ 78.06 billion by 2030, grow at a compound annual growth rate (CAGR) of 1.8% from 2023 to 2030. The increasing stockpiling of smallpox therapeutics is a key driver fueling the smallpox treatment growth during the forecast period.

The smallpox treatment market is segmented by drug type, route of administration, end user, and region. Based on drug type, the market is segmented into antivirals, vaccines, and others. Antivirals are the most widely used drugs for the treatment of smallpox. The market for antivirals is expected to grow at the highest CAGR during the forecast period. This is due to the increasing availability of new antiviral drugs for the treatment of smallpox.

Smallpox Treatment Market Regional Insights:

  • North America: North America is the largest market for Smallpox Treatments, accounting for a share of over 61% in 2022, North America holds the largest market share for smallpox treatment. This can be attributed to several factors such as the high prevalence of smallpox in the region, substantial government funding for research and development, and a high level of awareness about the disease. The region's advanced healthcare infrastructure and strong pharmaceutical industry contribute to its dominance in the market.
  • Europe: Europe is the second-largest market for Smallpox Treatments, accounting for a share of over 25% in 2022 and Europe follows North America as the second largest market for smallpox treatment. Similar to North America, Europe experiences a significant prevalence of smallpox and benefits from considerable government funding for research and development initiatives. The region's well-established healthcare systems, presence of leading pharmaceutical companies, and emphasis on public health contribute to its substantial market share.
  • Asia Pacific: Asia Pacific is the fastest-growing market for Smallpox Treatments, accounting for a share of over 10% in 2022 and Asia Pacific is a region witnessing rapid growth in the smallpox treatment market. Factors such as a growing prevalence of smallpox, increasing government funding for research and development, and rising awareness about the disease contribute to the market expansion. The region's large population, especially in countries like China and India, plays a significant role in the increased demand for smallpox therapeutics.

Figure 1. Global Smallpox Treatment Market Share (%), by Region, 2023

 | Coherent Market Insights

Smallpox Treatment Market Drivers:

  • Prevalence of Smallpox: The prevalence of smallpox, particularly in regions where the disease is still a concern or poses a potential threat, is a significant driver for the smallpox treatment market. Higher prevalence increases the demand for effective treatments and drives research and development efforts to combat the disease.
  • Government Funding and Initiatives: Government funding plays a crucial role in driving the smallpox treatment market. Governments allocate funds for research and development activities, including the development of new therapeutics and vaccines, stockpiling of treatments, and strengthening healthcare infrastructure to effectively manage smallpox outbreaks.
  • Awareness and Education: Awareness about smallpox among healthcare professionals, policymakers, and the general population is vital for the growth of the treatment market. Increased awareness leads to early detection, prompt treatment, and preventive measures, thereby driving the demand for smallpox treatment options.
  • Emergency Preparedness and Response: The need for emergency preparedness and response to potential smallpox outbreaks or bioterrorism threats is another driver of the treatment market. Governments and international organizations invest in stockpiling smallpox treatments, vaccines, and related products to ensure readiness in case of an emergency, thereby stimulating the market.

Smallpox Treatment Market Opportunities:

  • Vaccine Development and Innovation: While smallpox has been eradicated, there is still a need for ongoing research and development of new and improved vaccines. Opportunities exist for the development of safer, more effective, and easier-to-administer vaccines. Advancements in vaccine technology, such as the use of novel adjuvants or alternative delivery methods, can improve vaccine efficacy and enhance immunization strategies.
  • Antiviral Therapeutics: There is a growing need for the development of antiviral therapeutics to treat smallpox infections. Research and development efforts can focus on identifying and developing new antiviral agents or repurposing existing antiviral drugs to effectively combat the variola virus. The development of targeted therapies that inhibit viral replication or boost the immune response can provide valuable treatment options.
  • Strengthening Healthcare Infrastructure: Opportunities exist to strengthen healthcare infrastructure, particularly in regions with limited resources or vulnerable populations. This includes enhancing laboratory capabilities for rapid diagnosis, improving surveillance and monitoring systems, and establishing effective healthcare delivery systems to ensure timely and appropriate treatment for smallpox cases.
  • Public Health Awareness and Education: Increasing public awareness about smallpox, its prevention, and available treatment options can have a significant impact on disease control and prevention. Opportunities exist to develop comprehensive public health campaigns that educate the public, healthcare professionals, and policymakers about smallpox, its risks, and the importance of vaccination and early treatment.

Smallpox Treatment Market Report Coverage

Report Coverage Details
Base Year: 2022 Market Size in 2022: US$ 67.49 Mn
Historical Data for: 2017 to 2021 Forecast Period: 2023 - 2030
Forecast Period 2023 to 2030 CAGR: 1.8% 2030 Value Projection: US$ 78.06 Mn
Geographies covered:
  • North America: U.S. and Canada
  • Latin America: Brazil, Argentina, Mexico, and Rest of Latin America
  • Europe: Germany, U.K., Spain, France, Italy, Russia, and Rest of Europe
  • Asia Pacific: China, India, Japan, Australia, South Korea, ASEAN, and Rest of Asia Pacific
  • Middle East & Africa
Segments covered:
  • By Treatment Type: Antiviral Drugs, Vaccination, Supportive Care
  • By Product Type: Vaccines, Antiviral Drugs
  • By Distribution Channel: Hospitals, Clinics, Retail Pharmacies, Online Pharmacies
  • By End User: Healthcare Facilities, Research Institutes Others
Companies covered:

SIGA Technologies Inc., Bavarian Nordic A/S, Takeda Pharmaceutical Company Limited, Johnson & Johnson, Emergent BioSolutions Inc., Novartis International AG, GlaxoSmithKline plc, Sanofi Pasteur SA, Merck & Co. Inc., Pfizer Inc., Bharat Biotech International Ltd., BioCryst Pharmaceuticals Inc., Chimerix  Inc., Nanotherapeutics Inc., Bavarian Nordic A/S

Growth Drivers:
  • Prevalence of Smallpox
  • Government Funding and Initiatives
  • Awareness and Education
  • Emergency Preparedness and Response
Restraints & Challenges:
  • Eradication of Smallpox
  • Regulatory Hurdles
  • Potential Side Effects

Smallpox Treatment Market Trends:

  • Vaccine Stockpiling and Preparedness: Governments and international organizations continue to prioritize smallpox vaccine stockpiling and preparedness efforts. This trend involves maintaining an adequate supply of smallpox vaccines and related products to respond swiftly to potential outbreaks or bioterrorism threats.
  • Advanced Diagnostic Techniques: Diagnostic techniques for smallpox are evolving, with a focus on rapid and accurate detection. Advances in molecular diagnostic methods, such as PCR (polymerase chain reaction), can enable early identification of smallpox cases, facilitating prompt treatment and containment measures.
  • Digital Solutions and Data Management: The integration of digital solutions and data management systems in smallpox treatment is gaining prominence. This trend includes the use of electronic medical records, data analytics, and real-time monitoring systems to enhance surveillance, track vaccination coverage, and facilitate prompt response during potential outbreaks.
  • Emerging Technologies: Advancements in biotechnology and emerging technologies, such as gene editing, synthetic biology, and nanotechnology, hold potential for revolutionizing smallpox treatment. These technologies may contribute to the development of innovative vaccine platforms, antiviral therapies, and diagnostic tools for improved management of smallpox.

Smallpox Treatment Market Restraints:

  • Eradication of Smallpox: The eradication of smallpox is a significant restraint in the smallpox treatment market. As smallpox no longer exists in the wild, there is no ongoing transmission or active cases of the disease, resulting in a limited market for smallpox treatments.
  • Regulatory Hurdles: Regulatory hurdles pose challenges in the development and approval of smallpox treatments. The stringent regulatory requirements for safety and efficacy evaluation, even in emergency situations, can delay the availability of new treatments or repurposed drugs for smallpox.
  • Potential Side Effects: Smallpox treatments, including vaccines and antiviral therapeutics, can have potential side effects and adverse reactions. Ensuring safety and minimizing risks associated with these treatments is a critical concern, particularly in the absence of active smallpox cases where the risk-benefit balance needs careful evaluation.

Recent Developments

New product launches

  • Emergent BioSolutions Inc. announced the launch of TPOXX, a smallpox antiviral drug. TPOXX is the first and only FDA-approved smallpox antiviral drug.
  • Pfizer Inc. announced the start of a Phase 3 clinical trial for its smallpox vaccine, VX-101. VX-101 is a live-attenuated smallpox vaccine that is designed to protect against smallpox infection
  • SIGA Technologies Inc. announced the start of a Phase 2 clinical trial for its smallpox antiviral drug, SG-740. SG-740 is a novel antiviral drug that is designed to treat smallpox infection.

Acquisition and partnerships

  • In 2017, Emergent BioSolutions Inc. acquired Bavarian Nordic A/S's smallpox vaccine business for $275 million. This acquisition gave Emergent BioSolutions the exclusive rights to develop and market Bavarian Nordic A/S's smallpox vaccine, JYNNEOS.
  • In 2018, SIGA Technologies acquired Chimerix, a U.S. company that develops and manufactures antiviral drugs. The acquisition gave SIGA Technologies a portfolio of smallpox treatments, including Tecovirimat, which is in development for the treatment of smallpox
  • In 2019, Dynavax Technologies Corp. partnered with Inovio Pharmaceuticals Inc. to develop and commercialize INO-4800, a DNA-based vaccine that is designed to protect against smallpox infection.

Figure 2. Global Smallpox Treatment Market Share (%), by Treatment Type, 2023

 | Coherent Market Insights

Top companies in Smallpox Treatment Market

  1. SIGA Technologies, Inc.
  2. Bavarian Nordic A/S
  3. Takeda Pharmaceutical Company Limited
  4. Johnson & Johnson
  5. Emergent BioSolutions Inc.
  6. Novartis International AG
  7. GlaxoSmithKline plc
  8. Sanofi Pasteur SA
  9. Merck & Co., Inc.
  10. Pfizer Inc.
  11. Bharat Biotech International Ltd.
  12. BioCryst Pharmaceuticals, Inc.
  13. Chimerix, Inc.
  14. Nanotherapeutics, Inc.
  • Bavarian Nordic A/S

Frequently Asked Questions

The key factors hampering the growth of the Smallpox Treatment market include the eradication of smallpox, limited commercial viability, regulatory hurdles, potential side effects of treatments, and limited demand and market size.

The major factors driving the market growth include the prevalence of smallpox, government funding and initiatives, awareness and education about smallpox, and emergency preparedness and response efforts.

The leading component segment in the market includes antiviral drugs, which are widely used for the treatment of smallpox.

Some of the major players operating in the market include SIGA Technologies Inc., Bavarian Nordic A/S, Takeda Pharmaceutical Company Limited, Johnson & Johnson, Emergent BioSolutions Inc., Novartis International AG, GlaxoSmithKline plc, Sanofi Pasteur SA, Merck & Co., Inc., Pfizer Inc., Bharat Biotech International Ltd., BioCryst Pharmaceuticals, Inc., Chimerix, Inc., Nanotherapeutics, Inc., and others.

North America is expected to lead the Smallpox Treatment market, followed by Europe and Asia Pacific.
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