Sterile Powder Filling Machine Market Analysis

A sterile powdered filling machine is a machine that is used to fill powdered drugs in a vials used in pharmaceutical industries. The powdered drugs provide some of the advantages over other forms of drugs, which support an increase in the production of sterile powdered drugs by the market players. According to an article published in the National Center for Biotechnology Information: 2018, the following are some of the major advantages of using solid or powdered drug forms over liquid dosage forms

• There is a wide choice of ingredients for the manufacturing of powdered drugs, and the dose can easily be achieved for patient administration
• Powders have better physicochemical stability and longer shelf life compared to liquid dosage forms
• Children and adults who have trouble swallowing tablets or capsules may find powders more acceptable
• A large dose that cannot be administered in other forms can be administered as powder. For instance, if the dose of a drug is 1 to 5g, it is sometimes not feasible to manufacture tablets to supply the drug to the patient.
• A rapid dispersion of drugs occurs in the stomach when given in powder forms rather than in compressed form

Global Sterile Powder Filling Machine Market - Impact of the Coronavirus (COVID-19) Pandemic

The COVID-19 pandemic is anticipated to show significant growth of the global sterile powder filling machine market, owing to increasing in partnership among key market players for the development of new vaccines for COVID-19 in powdered form. For instance, in March 2021, Green Light Biosciences Inc., public benefit corporation focused on RNA research, design and manufacturing for human, animal and plant health, partnered with TFF Pharmaceuticals Inc., a clinical stage biopharma company which focuses on developing and marketing drug products based on its patented Thin Film Freezing (TFF) technology, to conduct feasibility studies for a shelf stable powder formulation of a messenger (m) RNA COVID-19 vaccine.

Market players are involved in entering into agreements, in order to develop new medicines for the treatment of diseases such as, COVID-19 this is expected to increase growth of global sterile powder filling machine market, over the forecast period. For instance, in March 2021, Iconovo AB, a company which focuses on developing inhalation products, signed an agreement with Immune System Regulation AB, an immune therapy company, to develop an inhaled covid-19 vaccine in ICOone, patented dry powder inhaler for single use, manufactured by Iconovo AB.

The global sterile powder filling machine market is estimated to be valued at US$ 304.634 Mn in 2022 and is expected to exhibit a CAGR of 4.7% over the forecast period (2022-2030)  

Figure 1: Global Sterile Powder Filling Machine Market Share, (%), Analysis, By Product Type, 2022

Market players are involved in launching sterile powder filling machine is expected to propel the growth of global sterile powder filling machine market, over the forecast period.

Market players are involved in launching sterile powder filling machine is expected to propel the growth of global sterile powder filling machine market. For instance, in 2019, IMA, a designer and manufacturer of automatic machines, is offering its Aseptic Micro-Doser Powder Filling Line, Model MF 400. The machine operates at the speed of 400 vials/minute depending on the number of fill stations. The machine is set up with 2 filling stations, 20 - 32 mm vial diameter range, 40 - 75 mm vial height range, and 20 mm stopper diameter with stopper bowl feeder.

Market players are involved in expansion of their manufacturing units which is expected to drive the global sterile powder filling machine market, over the forecast period.

Expansion of the manufacturing unit by market players is expected to drive the growth of global sterile powder filling machine market. For instance, in 2017, Sri Lanka-based pharmaceutical company Navesta Pharmaceuticals opened a new sterile manufacturing facility in the town of Horana, Sri Lanka. The facility is intended to produce sterile dry powder injectable of beta-lactam antibiotics, which could previously only be imported to the country from other countries. Navesta’s Horana sterile pharmaceutical manufacturing facility will initially produce 50 million vials in a year for filling sterile dry powder beta-lactam injectable.

Sterile Powder Filling Machine Market Report Coverage

Report Coverage	Details
Base Year:	2021	Market Size in 2022:	US$ 304.634 Mn
Historical Data for:	2018 to 2020	Forecast Period:	2022 to 2030
Forecast Period 2022 to 2030 CAGR:	4.7 %	2030 Value Projection:	US$ 438.838 Mn
Geographies covered:	North America: U.S. and Canada Latin America: Brazil, Argentina, Mexico, and Rest of Latin America Europe: Germany, U.K., Spain, France, Italy, Russia, and Rest of Europe Asia Pacific: China, India, Japan, Australia, South Korea, ASEAN, and Rest of Asia Pacific Middle East: GCC, Israel, and Rest of Middle East Africa: South Africa, North Africa, and Central Africa
Segments covered:	By Production Rate: Production Rate: 20 to 60 Fills/Minute, Production Rate: 50 to 100 Fills/Minute, Production Rate: 100 to 300 Fills/Minute, Production Rate: 300 to 500 Fills/Minute By Product Type: Anti-cancer Drugs, Nuclear Medicine, Others (Antifungals, Antibiotics, and other Pharmaceutical Products) By Packaging Type: Vials, Cartridges, Syringes, Others
Companies covered:	Duke Technologies, Adinath International, Multi Pack Machinery, Harsiddh Engineering, SB Machines, OPTIMA Packaging, Ambica Pharma Machines Pvt. Ltd, N.K. INDUSTRIES, COZZOLI MACHINE COMPANY, METACRAFTS Packaging Machinery, Romaco S.r.l., Lodha International LLP, SHIBUYA CORPORATION, MAR USA Inc., PPS A/S, Parth Engineers & Consultant, Bausch + Ströbel Maschinenfabrik Ilshofen GmbH + Co. KG, Syntegon, DEC Group, Dosa Srl, Harro Höfliger Verpackungsmaschinen GmbH, Tofflon Science, M&O Perry Industries, Inc.
Growth Drivers:	Increasing product launch by the market players Expansion of manufacturing unit by the key players
Restraints & Challenges:	Some disadvantages associated with filling of powdered drugs aseptically as well as use of sterile powdered drugs

Global Sterile Powder Filling Machine Market – Restraints

Some disadvantages associated with filling of powdered drugs aseptically as well as use of sterile powdered drugs is expected to hamper the growth of global sterile powder filling machine market. For instance, according to National Center for Biotechnology Information (NCBI): 2018, every year, patients are exposed to contaminated pharmaceutical products, with a mortality rate as high as 15%. Most of the contaminations occur in hospitals and pharmacies as a result of user error, but around 20% of contaminations in sterile products occur as a result of the manufacturing process, including mistakes in aseptic filling. Because of the very real and present danger associated with contaminated products, sterile filling requires a complex and time-consuming quality control process to ensure product efficacy and patient safety. Furthermore, according to the International Society for Pharmacoepidemiology, there is more risk in aseptic filling processes. Filling must be accomplished in a sterile environment (cleanroom, isolator, RABS), and greater levels of testing are required. All components used in the aseptic fill-finish process must be sterilized/sanitized before use. Sterilization with pressurized steam, irradiation or hydrogen peroxide must also be performed in a manner that does not impact the quality and stability of the drug product.

Global Sterile Powder Filling Machine Market – Regional Analysis

On the basis of region, the global sterile powder filling machine market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa

Among regions, North America sterile filling machine market is expected to hold a dominant position during the forecast period, owing to increasing expansion of manufacturing facility by the market players. For instance, on April 12, 2022, Optima Group's Pharma business unit, a company which offers a range of products such as filling and packaging machines for syringes, vials, bottles, and capsules, announced that the company is expanding its manufacturing facility in the U.S. This is expected to increase the company’s customer base in North America.

Furthermore, Europe is also estimated to witness significant growth in the global sterile powder filling machine market, owing to the focus on product launches by the key players. For instance, in 2019, Romaco, Machinery Industry Company, launched the new Macofar Micro MaxX 24 aseptic powder filling machine at the CIP Min Chongqing, China. The machine can fill upto 24,000 vials an hour, representing the high performance class in aseptic powder filling and is mainly used to fill injectable powders. Moreover, the Micro MaxX 24 is equipped with adual powder dosing disc, which allows multiple dosing into the same vial.

Figure 2: Global Sterile Powder Filling Machine Market (US$ Mn), by Region, 2022

Global Sterile Powder Filling Machine Market – Competitive Landscape

Major players operating in the global sterile powder filling machine market include Duke Technologies, Adinath International, Multi Pack Machinery, Harsiddh Engineering, SB Machines, OPTIMA Packaging, Ambica Pharma Machines Pvt. Ltd, N.K. INDUSTRIES, COZZOLI MACHINE COMPANY, METACRAFTS Packaging Machinery, Romaco S.r.l., Lodha International LLP, SHIBUYA CORPORATION, MAR USA Inc., PPS A/S, Parth Engineers & Consultant, Bausch + Ströbel Maschinenfabrik Ilshofen GmbH + Co. KG, Syntegon, DEC Group, Dosa Srl, Harro Höfliger Verpackungsmaschinen GmbH, Tofflon Science, M&O Perry Industries, Inc.