Coherent Market Insights

Epigenetics Drugs & Diagnostic Technologies Market to Surpass US$ 37.3 Bn by 2030

Epigenetics Drugs & Diagnostic Technologies Market to Surpass US$ 37.3 Bn by 2030 - Coherent Market Insights

Publish In: Jul 18, 2023

Epigenetics Drugs and Diagnostic Technologies Market, by Type (Epigenetic Drugs, (DNMT Inhibitors (Azacitidine and Decitabine), HDAC Inhibitors (Vorinostat, and Romidepsin) and Others) and Epigenetics Diagnostic Technologies (DNAMethylation and CHIP Technology) and By Region (North America, Latin America, Europe, Asia Pacific, Middle East, and Africa) is estimated to be valued at US$ 11.2 billion in 2023 and is expected to exhibit a CAGR of 18.8 % during the forecast period (2023-2030), as highlighted in a new report published by Coherent Market Insights.

The strategies adopted by key market players including acquisitions is expected to drive the global epigenetics drugs & diagnostic technologies market growth over the forecast period. For instance, on January 6, 2020, Merck KGaA, a U.S.-based science and technology company, announced an exclusive worldwide research collaboration and license agreement with Taiho Pharmaceutical Co, Ltd., a Japan-based pharmaceutical company and Astex Pharmaceuticals, a U.K.-based biotechnology company for the treatment of cancer. The collaboration is mainly focused on KRAS gene. The KRAS gene provides instructions for making a protein called K-Ras that is part of a signaling pathway known as the RAS/MAPK pathway. Somatic mutations in the KRAS gene are involved in the development of several types of cancer, particularly pancreatic and colorectal cancers.  Under the terms of the agreement, Merck KGaA, Taiho Pharmaceutical Co, Ltd and Astex Pharmaceuticals will combine preclinical candidates and their data with knowledge and expertise from their respective research programs. In exchange for providing Merck KGaA an exclusive global license to their small molecule inhibitor candidates, Taiho Pharmaceutical Co, Ltd and Astex Pharmaceuticals will receive an aggregate upfront payment of US$ 50 million and will be eligible to receive approximately US$ 2.5 billion contingent upon the achievement of preclinical, clinical, regulatory, and sales milestones for multiple products arising from the agreement, as well as tiered royalties on sales. Merck KGaA will fund research and development and will be responsible for the commercialization of products globally. Taiho Pharmaceutical Co, Ltd has retained co-commercialization rights in Japan and an option to promote in specific areas of South-East Asia.

Global Epigenetics Drugs & Diagnostic Technologies Market - Impact of Coronavirus (COVID-19) Pandemic

The World Health Organization (WHO) designated the illness caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which first appeared in Wuhan (province of Hubei, China), in the last months of 2019, as "coronavirus disease 2019" or COVID-19. This virus spreads quickly, and had a serious negative impact on the economies, social behaviors, and healthcare of every country in the world.

COVID-19 affected the economy in three main ways: by directly affecting production and demand, by creating disruptions in distribution channels, and through its financial impact on firms and financial markets. Due to the lockdown, several countries, such as India, China, Brazil, and others, faced problems regarding the transportation of drugs from one place to another.

COVID-19 had a positive impact on the global epigenetics drugs & diagnostic technologies market  due to the increasing need for epigenetics in COVID-19 research. For instance, according to an article published by a journal, Clinical Epigenetics on October 21, 2020, epigenetic alternation plays an important role during the onset of COVID-19-related complications. The presence of the so-called cytokine storm induced by the virus leads to ARDS aggravation and widespread tissue damage resulting in multi-organ failure and death. SARS-CoV-2 infection, by interfering with the host epigenetic machinery, might alter the expression of proinflammatory cytokines, such as IL-1, IL-6, IL-18, IFN-γ, and TNF-α. Epigenetic studies hence can open up new opportunities to develop antiviral drugs by evaluating epigenetic modulators as targets and exploring new chromatin-based therapies for different virus families, including coronaviruses, which could reveal fundamental new landscapes of virus-host interaction and their role in disease severity. Hence, from this analysis, it is concluded that understanding the epigenetic regulation underlying the immune response to SARS-CoV-2 will help design and develop novel specific strategies to prevent and treat the infection. These initiatives can drive the market growth.

Global Epigenetics Drugs & Diagnostic Technologies Market: Key Developments

Increasing collaborations between key market players for developing new range of products are expected to drive the global epigenetics drugs & diagnostic technologies market growth.

For instance, on August 15, 2022, EpiAxis Therapeutics, an Australia-based epigenetics company with a focus on developing novel cancer treatments and Peptilogics, a U.S.-based clinical-stage biotechnology company revolutionizing the discovery and development process for novel peptide therapeutics, announced that they have entered a collaboration to leverage Artificial Intelligence (AI) for drug discovery to inhibit epigenetic oncology targets, aiming to reprogram cancer cells and drive immune reinvigoration. The collaboration will combine EpiAxis Therapeutics’ deep epigenetic expertise and Peptilogics’ AI platform (Nautilus) to advance drug discovery for cancers that escape existing therapies through epigenetic change, including metastatic breast cancer. Peptilogics’ Nautilus platform enables in-silico predictive peptide design across different targets to efficiently access new functional chemical space and design therapeutics. Additionally, Peptilogics’ purpose-built supercomputer accelerates model development, prediction, and evaluation of peptide sequences to produce higher quality hits with greater chance of success.

Browse 21 Market Data Tables and 20 Figures spread through 160 Pages and in-depth TOC on Global Epigenetics Drugs & Diagnostic Technologies Market, by Type (Epigenetic Drugs, (DNMT Inhibitors (Azacitidine and Decitabine), HDAC Inhibitors (Vorinostat, and Romidepsin) and Others) and Epigenetics Diagnostic Technologies (DNAMethylation and CHIP Technology), and By Region (North America, Latin America, Europe, Asia Pacific, Middle East, and Africa)

To know the latest trends and insights prevalent in this market, click the link below:

https://www.coherentmarketinsights.com/market-insight/epigenetics-drugs-and-diagnostic-technologies-market-4026

Key Takeaways of the Global Epigenetics Drugs & Diagnostic Technologies Market:

  • The global epigenetics drugs & diagnostic technologies market is expected to exhibit a CAGR of 8 % during the forecast period. Funding raised by key market players is expected to accelerate its research and development activities. For instance, on November 17, 2021, Chroma Medicine, a U.S.-based genomic medicine startup company working on epigenetic editing, received US$ 125 million funding to make gene editing tool for manufacturing drugs that can alter epigenome. It is an approach to yield a new way to treat inherited diseases. The epigenetic editors are meant to change the complex circuitry that causes genes to make proteins, but not the underlying DNA itself. Epigenetic editing could represent a new path for genetic medicines, which have increasingly focused on ways to more precisely and safely control gene expression.
  • Among type, the epigenetic drugs segment is expected to dominate the global epigenetics drugs & diagnostic technologies market over the forecast period, owing to the launch of new drug candidates. For instance, on June 18, 2020, the U.S. Food and Drug Administration granted accelerated approval to Epizyme’s tazemetostat, a first-in-class inhibitor of the epigenetic writer EZH2, for epithelioid sarcoma, a rare soft tissue cancer. Approval was based on two open-label, single-arm cohorts of a multi-center trial in patients with histologically confirmed Follicular Lymphoma (FL) after at least two prior systemic therapies. EZH2 mutations were identified prospectively using formalin-fixed, paraffin-embedded tumor samples, which were centrally tested using the cobas EZH2 Mutation Test. Patients received tazemetostat 800 mg orally twice daily until confirmed disease progression or unacceptable toxicity.
  • Among region, North America is expected to be the dominant region in the global epigenetics drugs & diagnostic technologies market, owing to the increasing research and development activities in the region. For instance, on May 4, 2023, according to an article published by Journal Blood, Cornell University, a U.S.-based private research university conducted clinical trials on 17 patients with blood cancer called peripheral T-cell lymphoma with T-follicular helper phenotype (PTCL-TFH), also known as angioimmunoblastic T-cell lymphoma. It was found that after completion of treatment with standard four-drug chemotherapy regimen known as CHOP with another drug called azaciditine, 88.2% patients showed better results. It was concluded that adding epigenetic drug to standard chemotherapy was effective in pilot study for T-cell lymphoma. Hence combining standard chemotherapy with azacitidine, an epigenetic drug is a promising strategy to treat cancer. This can increase growth of global epigenetics drugs & diagnostic technologies market.
  • The major players operating in the global epigenetics drugs & diagnostic technologies market include Regenacy Pharmaceuticals, Inc., Astex Pharmaceuticals, 4SC AG, CellCentric Ltd., Celleron Therapeutics Ltd., Bristol-Myers Squibb Company, Oryzon Genomics S.A., ChromaMedicine, Inc., Epizyme, Inc., and EpiGentek Group Inc.

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