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  • Published In : Feb 2024
  • Code : CMI6274
  • Pages :140
  • Formats :
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  • Industry : Food and Beverages

The Nitric Oxide Supplements Market size was valued at US$ 810 Mn in 2023 and is expected to reach US$ 1,600 Mn by 2030, growing at a compound annual growth rate (CAGR) of 10.2% from 2023 to 2030. Nitric oxide supplements are formulations containing amino acids like arginine and citrulline that help boost nitric oxide levels in the body. Nitric oxide is a molecule produced by the body that helps expand blood vessels to improve blood flow and circulation. These supplements provide various benefits like improved exercise performance, heart health, and muscle growth.

The nitric oxide supplements market is segmented based on application, product type, and region. By application, the market is segmented into pharmaceuticals, food & beverages, cosmetics, diagnostics, animal feed, and others. The pharmaceuticals segment accounts for the largest share owing to the rising use of nitric oxide supplements for treating various medical conditions.

Nitric Oxide Supplements Market Regional Insights

  • North America is expected to be the largest market for nitric oxide supplements during the forecast period, accounting for over 40% of the market share in 2023. The growth of the market in North America is attributed to the high health consciousness and sports activity participation.
  • Europe is expected to be the second-largest market for nitric oxide supplements, accounting for over 25% of the market share in 2023. The growth of the market is attributed to the increasing geriatric population and rising prevalence of chronic diseases.
  • Asia Pacific is expected to be the fastest-growing market for nitric oxide supplements, growing at a CAGR of over 12% during the forecast period. The growth of the market in Asia Pacific is attributed to the growing spending on fitness and wellness products.

Figure 1. Global Nitric Oxide Supplement Market share (%), by Region 2023 


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Nitric Oxide Supplements Market - Drivers

  • Increasing health consciousness and adoption of active lifestyles: The growing health consciousness among consumers is a key factor driving the demand for nitric oxide supplements. Consumers are increasingly focused on preventive healthcare and managing diseases through nutrition and supplements. With rising awareness of the various health benefits offered by nitric oxide, such as improved blood circulation, better heart health, and muscle growth, its supplements are witnessing high demand. For instance, as per data of Centers for Disease Control and Prevention, the number of American adults who engage in aerobic and muscle-strengthening activities that meet guidelines increased from 50.8% in 2018 to 53.3% in 2020.
  • Rising acceptance of dietary supplements: The market for dietary and nutritional supplements has expanded remarkably over the past decade driven by rising health consciousness. Consumer confidence in dietary supplements is improving with greater research on their potential health benefits. For instance, as per data of a 2021 study published by the Food and Agricultural Organization, pomegranate peel extract was as effective as beetroot in increasing nitric oxide production after consumption. This discovery has led some supplement brands to incorporate pomegranate peel into their nitric oxide formulas.
  • Increase in lifestyle diseases: Lifestyle diseases like obesity, diabetes, high blood pressure, high cholesterol, etc. are rising rapidly worldwide. Consumers are increasingly relying on products like nitric oxide supplements to manage these chronic conditions and reduce disease progression through improved circulation and vascular function. For instance, the International Diabetes Federation estimates that approximately 537 million adults were living with diabetes in 2021 worldwide, and the numbers are predicted to rise to 643 million by 2030 and 783 million by 2045.
  • Favorable demographic shifts: The growing geriatric population which is more susceptible to nitric oxide deficiency and vascular problems is creating opportunities for nitric oxide supplement manufacturers. Urbanization leading to sedentary occupations and lifestyle changes have also contributed to an increase in lifestyle diseases. For instance, as per data from the United Nations, the number of people aged 65 years and over is projected to double from 727 million in 2020 to over 1.5 Mn by 2050. As people get older, they become more prone to cardiovascular issues like high blood pressure and heart disease. Nitric oxide is known to help relax and dilate blood vessels which can assist in lowering blood pressure and reducing risks associated with poor cardiovascular health.

Nitric Oxide Supplements Market - Opportunities

  • Product innovations and new product launches: Major nitric oxide supplement manufacturers are investing significantly in research and product innovations to develop novel formulations, unique ingredient combinations and better delivery formats. Sustained R&D in this field is leading to the introduction of supplements with improved absorption, bioavailability, and effectiveness. For instance, studies published in the European Journal of Sport Science in 2022 found nitric oxide assisted muscle recovery after high-intensity exercise by improving blood flow.
  • Growing popularity of e-commerce: The emerging e-commerce and m-commerce channels present immense opportunities for nitric oxide supplement brands to improve their distribution reach and strengthen customer engagement. Internet proliferation coupled with rising smartphone penetration has led to booming online sales of supplements. For instance, according to data from the United Nations Conference on Trade and Development (UNCTAD), the global e-commerce sales saw steady annual increases during the COVID-19 pandemic, growing from US$ 26.7 trillion in 2019 to US$ 27.7 trillion in 2020 and further projected to reach US$ 29 trillion in 2021.
  • Surging demand in developing nations: Developing economies like China, India, and Brazil etc. represent high-growth markets for nutritional supplements including nitric oxide boosters due to expanding middle-class and health-conscious population. For instance: According to the World Health Organization report published in 2022, non-communicable diseases caused approximately 74% of deaths in India in 2019. This growing disease burden along with increasing health expenses is reinforcing the need for cost-effective wellness products like nitric oxide supplements.
  • Increasing use in functional foods/beverages: The rising clean-label trend and demand for fortified F&B products is leading to growing usage of nitric oxide boosting ingredients like beetroot and L-arginine in foods and drinks. Expanding application in energy drinks, bars, smoothies, and athletic foods provides huge scope for market growth.
  • For instance, as per the 2021 report by the World Health Organization, cardiovascular diseases are the leading cause of death globally, taking over 18 million lives each year. Innovation and availability of cardiovascular-supporting foods and drinks in the market could hugely benefit public health outcomes.

Nitric Oxide Supplements Market Report Coverage

Report Coverage Details
Base Year: 2022 Market Size in 2023: US$ 810 Mn
Historical Data for: 2017 to 2021 Forecast Period: 2023 - 2030
Forecast Period 2023 to 2030 CAGR: 10.2% 2030 Value Projection: US$ 1,600 Mn
Geographies covered:
  • North America: U.S. and Canada
  • Latin America: Brazil, Argentina, Mexico, and Rest of Latin America
  • Europe: Germany, U.K., Spain, France, Italy, Russia, and Rest of Europe
  • Asia Pacific: China, India, Japan, Australia, South Korea, ASEAN, and Rest of Asia Pacific
  • Middle East & Africa:  GCC Countries, Israel,  South Africa, North Africa, Central Africa, and Rest of Middle East
Segments covered:
  • By Application: Pharmaceuticals, Food & Beverages, Cosmetics, Diagnostics, Animal Feed, and Others
  • By Product Type: Arginine-based, Citrulline-based, Beetroot-based, Creatine-based, and Others
Companies covered:

Thermo Fisher Scientific, Merck KGaA, GENERAL ELECTRIC, Horiba, Teledyne Analytical Instruments, Yokogawa Electric Corporation, Spectris, Emerson Electric Co., ABB, Honeywell International Inc, Siemens AG, AMETEK.Inc, DKK-TOA CORPORATION, Drägerwerk AG & Co. KGaA, Analytical Systems Keco, ECD, Nova Analytical Systems, Shimadzu Corporation, Servomex, and Adev

Growth Drivers:
  • Rising demand for dietary supplements
  • Increasing adoption of fitness culture  
  • Growing health consciousness
  • Surge in number of gym-goers and athletes
Restraints & Challenges:
  • Stringent regulatory frameworks
  • Adverse effects in some cases
  • Low adoption in underdeveloped countries  
  • High cost of some supplements

Nitric Oxide Supplements Market - Trends

  • Increasing focus on organic and plant-based ingredients: Consumers today are increasingly looking for clean-label and plant-based supplements made using natural, organic ingredients. Organic and vegan nitric oxide supplements are gaining significant popularity among health-conscious buyers wary of synthetic additives and harsh chemicals. For instance, government data from the USDA Economic Research Service shows organic food 2021 sales reached a new high of US$ 62.8 Bn in 2022, up by 5.9% from 2021. The demand is driven by health, environmental, and animal welfare preferences of consumers. Sales of herbal supplements also grew 8.8% from 2020 to 2022 according to the data from Natural Products Association.
  • Growing adoption among older demographics: The expansion of the target demographic for nitric oxide supplements beyond just gym-goers and athletes to the aging population is a rising trend. Geriatric consumers are showing substantial interest in nitric oxide supplements to mitigate age-related vascular dysfunction, low energy, muscle loss etc. For instance, an analysis of sales data from iHerb, an online vitamin and supplement seller, found a 27% increase in nitric oxide product sales to customers aged 65-80 between 2020 and 2022.
  • Increasing use by females: Traditionally males including athletes, gym enthusiasts, and bodybuilders were the primary consumers for nitric oxide boosting supplements. However, adoption among female users has risen substantially in recent years driven by growing health consciousness and participation in fitness activities. For instance, Health Canada statistics 2023 show a 23% rise in the number of women purchasing supplements containing nitric oxide compounds like citrulline and beet root extract between 2020 and 2022. This trend reflects women taking a more proactive role in overall wellness and recognizing nitric oxide's diverse benefits.
  • Surging demand for convenience formats: Manufacturer are expanding their nitric oxide supplements range by launching on-the-go powder sachets, easy-to-consume gummies, quick dissolving tablets etc. to meet the rising consumer demand for portable and convenient formats. For instance, data from iHerb, one of the largest global suppliers of supplements, shows that their sales of chewable and gummy nitric oxide supplements grew by 38% from 2020 to 2021, now representing over 15% of total nitric oxide product revenue. Similarly, Amazon reported a 44% increase in sales of ready-to-drink nitric oxide supplements between 2021 and 2022 according to their earnings statement.

Nitric Oxide Supplements Market - Restraints

  • Potential side effects in sensitive groups: While generally safe, nitric oxide supplements may cause headaches, nausea, flushed skin, etc. in some sensitive individuals when taken at very high doses for prolonged periods. This can make consumers wary of incorporating them into their daily routine. For instance, as per the 2020 report by American Heart Association, uncontrolled drops in blood pressure can cause dizziness, fainting, or even strokes in diabetics and cardiovascular patients.
  • Counter balance: Consumers should opt for high-quality supplements from reputable manufacturers that meet all the regulatory standards. This step can help avoid side effects that might arise from contaminants or inaccurately reported dosing.
  • Limited adoption in lower income groups: High costs and premium pricing of some branded nitric oxide supplements make them unaffordable for lower income and price-sensitive consumer groups, restraining adoption. This inhibits market growth in developing countries and regions with lower disposable incomes. For instance, as per data from the World Bank in 2022, around 32 million Americans lived below the poverty line. With limited disposable incomes, even relatively inexpensive supplements may be seen as extra and unnecessary expenses by low-income groups.
  • Counter balance: Explore partnerships with nonprofit organizations, healthcare providers, or government bodies that could subsidize the cost for lower-income individuals. This could involve creating a financial assistance program to make the supplements more affordable for those in need. Facilitate the development of generic versions of nitric oxide supplements that are more affordable than brand-name products. Generic supplements could be made available through government healthcare programs or at discounted pharmacies
  • Lack of awareness in developing regions: Despite strong growth prospects, the penetration of nitric oxide supplements remains low in developing countries like India, China etc. due to the lack of awareness about the role and benefits of nitric oxide. Misconceptions regarding safety and efficacy also prevail among more conservative consumer groups. For instance, as per data by World Bank, nearly 35% of the global population was living on income less than US$ 3.20 per day in 2020, limiting their options to pay for health supplements.
  • Counter balance: Partner with local healthcare providers, community leaders, and educators to develop and disseminate informational campaigns that highlight the potential benefits and uses of nitric oxide supplements. Work with health ministries and local health authorities to incorporate information on nitric oxide supplements into their public health programs. Ensuring that correct information is part of official guidelines can improve credibility and reach.

Analyst’s views

The nitric oxide supplement market is expected to grow at a steady rate over the forecast period. Nitric oxide plays an important role in cardiovascular health and supplements offering its benefits see strong demand. Increased awareness about heart health among consumers is a key driver for the market.

However, lack of clinical research data for the long term effects could act as a restraint. Also, availability of alternative supplements targeting similar functions pose competition. Nonetheless, opportunities lie in educating consumers about nitric oxide's benefits and positioning products for specific target segments like athletes and elderly.

The North American region currently dominates the nitric oxide supplement market owing to a health-conscious consumer base and high spend capability. Growing elderly population suffering from cardiovascular issues further boosts demand. Europe is another major region benefitting from initiatives to promote active aging.

Emerging markets of Asia Pacific present lucrative prospects. Rising living standards and health expenditure open new consumers. Indonesia, India, and China have the largest population bases most conducive for future market expansion.

Overall, the nitric oxide supplement industry seems placed for steady growth if companies strengthen clinical evidence, improve accessibility through e-commerce, and focus on specialized formulations. Region-specific promotions catering to local health priorities also expand the consumer base. While competition exists, first-movers with quality products gain significant market share.

Recent Developments

New product launches

  • In January 2022, Nutrabolt launched C4 Ultimate nitric oxide booster powder. It contains vitamins, amino acids, and other ingredients to boost nitric oxide levels. Nutrabolt is a global active health and wellness company, and the company's portfolio includes performance-oriented products under three consumer-loved brands: C4, XTEND, and CELLUCOR. Nutrabolt's products are distributed in over 125 countries and are sold through company-owned DTC platforms like Amazon, and other third-party e-commerce marketplaces, and are available at leading retailers across the U.S. The company's new headquarters is designed to be a LEED-certified facility with a focus on healthy living and sustainable features. The company's mission is to innovate, inspire, and make products that maximize human potential accessible to all.
  • In September 2021, HUM Nutrition introduced a vegan-friendly nitric oxide support supplement called Here Comes The Sun. It contains vitamin C, beetroot extract, and selenium. HUM Nutrition is a company that offers a range of vitamins and supplements for skin, hair, body, and mood. Their products are formulated by a team of Registered Dietitian Nutritionists (RDNs) and contain clinically tested actives, verified clean ingredients, and are free of artificial colors, sweeteners, flavors, and preservatives. HUM Nutrition products are available at Target and on their website, where customers can take a 3-minute quiz to get personalized product recommendations and access to an RD Nutritionist for free expert advice. Nutrabolt, on the other hand, is a fast-growing company in the nutritional supplement market that recently celebrated its 20th anniversary and made a significant investment in the future with the groundbreaking of a new headquarters in Austin, Texas, which is slated to open in 2024. Nutrabolt's portfolio is distributed in over 125 countries and is available at leading retailers across the U.S.
  • In June 2020, Evogen Nutrition launched GlycerSize, a stimulant-free nitric oxide amplifier containing glycerol monostearate. It helps with muscle hydration and endurance. Evogen Nutrition offers a range of products designed to support the needs of athletes and fitness enthusiasts. The company's commitment to excellence and its association with top athletes and coaches have contributed to its strong presence in the market.
  • The differences between Evogen Nutrition products and other supplement brands lie in Evogen's specific product offerings, formulation, and the unique benefits they provide to fitness enthusiasts and athletes. Evogen's products are designed and formulated by CEO Hany "the Pro Creator" Rambod, a 24-time Olympia winning coach, and are known for their innovation and focus on the fitness community

Acquisition and partnerships

  • In October 2021, iSatori Inc was acquired by Glanbia Performance Nutrition. This allowed Glanbia Performance Nutrition to expand its nitric oxide supplements portfolio.
  • In January 2020, Nutrition 21 partnered with Arizon Nutritional Supplements to distribute its nitric oxide boosting supplement NOX Edge to various retailers

Figure 2. Global Nitric Oxide Supplements Market Share (%), by Application, 2023


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Top Companies in the Nitric Oxide Supplements Market

  • Thermo Fisher Scientific
  • Merck KGaA
  • Horiba
  • Teledyne Analytical Instruments
  • Yokogawa Electric Corporation
  • Spectris
  • Emerson Electric Co.
  • ABB
  • Honeywell International Inc
  • Siemens AG
  • Ametek .Inc
  • Drägerwerk AG & Co. KGaA
  • Analytical Systems Keco
  • ECD
  • Nova Analytical Systems
  • Shimadzu Corporation
  • Servomex
  • Adev

Definition: The nitric oxide supplements market refers to the industry and companies involved in the manufacturing, marketing, and distribution of supplements that help boost nitric oxide levels in the body. Nitric oxide is a molecule that helps expand blood vessels and improve circulation. It offers various benefits such as increased endurance, better workout performance, improved heart health, and muscle growth.

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Frequently Asked Questions

Stringent regulatory norms, product recalls, adverse effects like headaches and nausea in some cases, low adoption in underdeveloped regions, and high cost of certain supplements are hampering the market growth.

Major factors driving the nitric oxide supplements market growth Rising health consciousness, increasing gym-goers and athletes, growing adoption of active lifestyles, demand for dietary supplements.

The arginine-based supplements segment leads the market owing to the extensive research on L-arginine for boosting nitric oxide.

The major players operating in the market are Thermo Fisher Scientific, Merck KGaA, GENERAL ELECTRIC, Horiba, Teledyne Analytical Instruments, Yokogawa Electric Corporation, Spectris, Emerson Electric Co., ABB, Honeywell International Inc, Siemens AG, AMETEK.Inc, DKK-TOA CORPORATION, Drägerwerk AG & Co. KGaA, Analytical Systems Keco, ECD, Nova Analytical Systems, Shimadzu Corporation, Servomex, and Adev.

North America is expected to lead the nitric oxide supplements market.

The CAGR of the nitric oxide supplements market is expected to be 10.2% during 2023-2030.

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