Cytotoxic Drugs Contract Manufacturing Market Analysis & Forecast: 2026-2033

Cytotoxic Drugs Contract Manufacturing Market Size and Trends: 2026-2033

Cytotoxic drugs contract manufacturing market is estimated to be valued at USD 12,606.5 Mn in 2026 and is expected to reach USD 23,157.5 Mn by 2033, exhibiting a compound annual growth rate (CAGR) of 9.1% from 2026 to 2033.

Key Takeaways

• Based on Production Scale, the Industrial Scale segment is expected to lead the market with 60% share in 2026, due to large-scale manufacturing capacity and high commercial output.
• Based on Form, the Liquid segment is projected to hold 58% share of the market in 2026, driven by the prevalence of injectable oncology therapies.
• Based on Product Type, the Intravenous segment is anticipated to account for 55% share of the market in 2026, owing to the demand for intravenous chemotherapy drugs.
• Based on Region, North America is set to lead the cytotoxic drugs contract manufacturing market with 40% share in 2026. While, Asia Pacific is anticipated to be the fastest growing region.

Market Overview

The increasing number of cancer cases across the globe is fueling the demand for cytotoxic drugs, thus propelling the market for cytotoxic drugs contract manufacturing. The complexity involved in the manufacturing of cytotoxic drugs, as well as the regulatory requirements, is encouraging pharmaceutical companies to outsource the manufacturing of these drugs to CDMOs (Contract Development and Manufacturing Organizations). The need for injectable and oral chemotherapy drugs, as well as the growing pipeline of oncology drugs, is also fueling the market.

Current Events and Its Impacts on the Cytotoxic Drugs Contract Manufacturing Market

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How is product and service innovation driving growth in cytotoxic drugs contract manufacturing?

• Advanced Containment Technologies: The application of high-containment facilities (like isolators and closed systems) for handling highly potent cytotoxic compounds.
• End-to-End CDMO Services: The expansion of services from API production to formulation, packaging, and regulatory services, allowing pharmaceutical companies to enter the market quicker.
• Handling Highly Potent APIs (HPAPI): Expertise in handling highly potent APIs, allowing pharmaceutical companies to handle difficult oncology compounds that require strict safety protocols.

Segmental Insights

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Cytotoxic Drugs Contract Manufacturing Market Insights, By Production Scale – Industrial Scale leads due to large-scale manufacturing capacity

Based on production scale, the industrial scale segment is expected to account for the highest market share of 60% in 2026, due to its capability of dealing with large-scale commercial production of cytotoxic drugs. Industrial-scale facilities are better for productivity, quality control, and cost savings than pilot or lab scales. This is why pharmaceutical companies prefer to outsource their production to these types of facilities.

For instance, in May 2025, Shilpa Biologicals announced the opening of a bioconjugation suite at its facility in Dharwad, India, to facilitate the advanced manufacturing of antibody drug conjugates.

Cytotoxic Drugs Contract Manufacturing Market Insights, By Form – Liquid segment dominates with injectable therapies

By form, the liquid segment is expected to have the largest market share of 58% in 2026, driven by the popularity of injectable oncology therapies. Liquid formulations, such as sterile injections and IV solutions, are highly important in cancer therapy and require specialized contract manufacturing facilities that can maintain sterility and contain them well.

For instance, in March 2025, LGM Pharma announced a strategic USD6 million investment to expand its CDMO manufacturing capabilities, specifically increasing capacity for liquid, suspension, semi‑solid, and suppository drug products at its Rosenberg, Texas facility.

Cytotoxic Drugs Contract Manufacturing Market Insights, By Product Type – Intravenous segment grows with demand for chemotherapy drugs

Based on the type of product, the intravenous segment is expected to hold a 55% market share in 2026, driven by the demand for intravenous chemotherapy. Intravenous products are highly demanding in terms of handling and regulatory requirements, making CDMOs a crucial partner for pharmaceutical companies. The demand for intravenous products is driven by the rising prevalence of cancer, ongoing clinical trials, and the need for hospital-administered products.

For instance, in April 2025, PCI Pharma Services, a global CDMO, announced that it would acquire Ajinomoto Althea, Inc., a US-based sterile fill finish CDMO with expertise in injectable drug products, including prefilled syringes and cartridges, with high potency and oncology-relevant formats.

Regional Insights

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North America Cytotoxic Drugs Contract Manufacturing Market Analysis & Trends

North America is anticipated to lead the cytotoxic drugs contract manufacturing market in 2026, with a market share of 40%. The dominance of the North American region can be attributed to factors such as the presence of advanced pharmaceutical infrastructure, a large number of leading CDMOs, a robust pipeline of cancer therapies, and well-established regulatory frameworks.

For instance, in January 2025,Lonza Group announced the extension of its industrial-scale cytotoxic drug manufacturing capacity at its Vacaville, California facility. This extension includes new high-containment suites and aseptic fill-finish lines for injectable and intravenous cancer therapies, further solidifying North America’s position in the global CDMO industry.

Asia Pacific Cytotoxic Drugs Contract Manufacturing Market Analysis & Trends

The Asia Pacific region is expected to be the fastest-growing market for cytotoxic drug contract manufacturing organizations. This is because manufacturing costs are low, investments in pharmaceutical infrastructure are rising, demand for cancer therapies is rising, and government policies in countries like China, India, and Japan are good for business. New companies in the area are learning how to make cytotoxic drugs and highly potent APIs on a large scale.

For instance, in December 2025, Shilpa Biologicals inaugurated a new bioconjugation and sterile manufacturing facility in Dharwad, India, focused on antibody-drug conjugates and other intravenous cytotoxic formulations.

Cytotoxic Drugs Contract Manufacturing Market Outlook for Key Countries

Is the U.S. cytotoxic drugs contract manufacturing market growing due to advanced infrastructure and leading CDMOs?

The U.S. market is currently undergoing substantial growth due to the high number of top-tier CDMOs, advanced industrial-scale facilities, and a robust oncology drug pipeline. The presence of stringent regulatory environments and a well-developed pharmaceutical infrastructure in the US makes it attractive for outsourcing the production of cytotoxic drugs to experienced contract manufacturers.

For instance, in January 2025, Lonza Group expanded its Vacaville, California facility with new high-containment suites and aseptic fill-finish lines for injectable and intravenous oncology drugs.

Is China’s growing pharmaceutical investment boosting cytotoxic contract manufacturing?

The growing investments of China in the manufacturing of pharmaceuticals and the favorable government policies are fueling the growth of the cytotoxic drugs CDMO market. The increasing demand for cancer treatments in the domestic market and the competitive manufacturing costs are encouraging pharmaceutical companies to outsource their production.

For instance, in December 2025, WuXi AppTec inaugurated a new sterile manufacturing facility in Suzhou, China, focused on injectable cytotoxic drugs and highly potent APIs. The facility includes advanced aseptic fill-finish lines and containment systems to meet both domestic and global demand.

Market Report Scope

Cytotoxic Drugs Contract Manufacturing Market Driver

Rising global demand for oncology therapies

The rising incidence of cancer cases globally is fueling the demand for cytotoxic drugs, thereby propelling the growth of the contract manufacturing market. The complexity and containment involved in the manufacturing of cytotoxic drugs are forcing pharmaceutical companies to outsource their manufacturing to CDMOs. The rising use of intravenous and oral chemotherapy and the development of targeted therapies for cancer are further increasing the demand for contract manufacturing.

Cytotoxic Drugs Contract Manufacturing Market Opportunity

Expansion of industrial-scale and specialized CDMO facilities

The market offers substantial growth opportunities with the development and scaling of highly potent and advanced drug manufacturing facilities. Investment in sterile fill-finish lines, high-containment isolators, and end-to-end development services enables CDMOs to secure pharmaceutical clients from across the globe. Development of capabilities in antibody-drug conjugates (ADCs), intravenous formulations, and other complex cytotoxic products creates a platform to capitalize on the growing demand in the North America, Europe, and Asia-Pacific regions.

Analyst Opinion (Expert Opinion)

• The market for cytotoxic drugs contract manufacturing is evolving rapidly, driven by the increasing complexity and specialization of oncology therapies. Pharmaceutical companies are increasingly relying on outsourced CDMO production due to the high risks associated with handling highly potent APIs and the stringent regulatory requirements for sterile and high-containment manufacturing. The trend of in-house manufacturing is slowly diminishing due to the fact that most organizations are now eager to harness the expertise of specialized CDMOs.
• Regionally, North America remains an important hub based on its well-established CDMO infrastructure and regulatory framework, while the Asia-Pacific region is beginning to emerge as a viable option for large-scale manufacturing and cost-effective solutions. The capacity to rapidly scale up the production of sterile liquid and intravenous products is becoming an ever-important criterion in choosing manufacturing partners.
• Overall, the cytotoxic drug CDMO market is moving towards highly specialized, technically complex, and industrial-scale processes. Those companies that invest in advanced containment solutions, knowledge of regulations, and scalable sterile manufacturing capabilities will be well-positioned for success, while those that do not will be rendered irrelevant in this tough oncology outsourcing market.

Top Strategies Followed by Cytotoxic Drugs Contract Manufacturing Market Players

• Established CDMOs focus on advanced capabilities and regulatory compliance. Leading players in this market are heavily investing in high-containment manufacturing, aseptic fill and finish lines, and process automation. They focus on aseptic processing, quality assurance, and compliance with global regulatory requirements to establish long-term relationships with the large pharmaceutical companies. Continuous innovation in the handling of highly potent and complex cytotoxic drugs helps them lead the market.
• Mid-level CDMOs focus on operational efficiency and, at the same time, ensure safety. These mid-level CDMOs aim to optimize their manufacturing processes, focus on cost-effective sourcing of raw materials, and emphasize scalable manufacturing processes. By doing so, they are able to strike a balance between cost efficiency and safety, thus retaining pharmaceutical customers.
• Small-scale and specialized CDMOs focus on niche capabilities. Some target high potency cytotoxic APIs, antibody-drug conjugates (ADCs), or small-scale clinical manufacturing. They set themselves apart by utilizing advanced containment solutions, flexible manufacturing facilities, and affiliations with research organizations. Collaborations and specialized offerings enable them to get noticed and build customer loyalty even with limited manufacturing capacity.

Emerging Startups in the Cytotoxic Drugs Contract Manufacturing Market

• Innovation in handling complex cytotoxic therapies. Certain new CDMOs are working on the development of unique high-containment equipment and automation for aseptic processing of IV and oral cancer drugs. Such technologies have the potential to set new manufacturing norms and may also attract new customers who may require new or difficult-to-manufacture forms of drugs.
• Emphasis on integrated services and speed-to-market. New entrants focus on end-to-end development and manufacturing services, such as formulation, analytical testing, and sterile fill-finish, to accelerate time-to-market for pharmaceutical companies. Integrated services enable small biotech companies to gain access to quality manufacturing services without having to invest in their own facilities.
• Niche skills and partnerships. Some startups focus on niche areas, like cytotoxic APIs for rare cancers or new delivery systems such as liposomal or nanoparticle formulations. They also partner with universities, biotech innovators, or AI-driven process optimization companies to enhance efficiency and product quality.

Cytotoxic Drugs Contract Manufacturing Industry News

• In October 2025, Lonza confirmed a strong third‑quarter performance and reaffirmed its CDMO business outlook, reporting continued strategic contract signings across technologies and sites.
• In November 2025, Catalent announced the debut of its new corporate brand aimed at reinforcing customer service and expanding its global footprint, following its transition to private ownership under Novo Holdings.
• In June 2025, Merck KGaA’s MilliporeSigma business launched a multi‑year collaboration with Simtra BioPharma Solutions to provide integrated services for antibody‑drug conjugate (ADC) drug substance, formulation, and fill‑finish manufacturing, streamlining complex supply chains for oncology therapies.

Market Segmentation

• Production Scale Insights (Revenue, USD Mn, 2026 - 2033)
  • Industrial scale
  • Pilot Scale
  •  Laboratory Scale
• Form Insights (Revenue, USD Mn, 2026 - 2033)
  • Liquid
  • Solid
• Product Type Insights (Revenue, USD Mn, 2026 - 2033)
  • Oral
  •  Intravenous
• Regional Insights (Revenue, USD Mn, 2026 - 2033)
  • North America
    • U.S.
    • Canada
  • Latin America
    • Brazil
    • Argentina
    • Mexico
    • Rest of Latin America
  • Europe
    • Germany
    • U.K.
    • Spain
    • France
    • Italy
    • Russia
    • Rest of Europe
  • Asia Pacific
    • China
    • India
    • Japan
    • Australia
    • South Korea
    • ASEAN
    • Rest of Asia Pacific
  • Middle East
    • GCC Countries
    • Israel
    • Rest of Middle East
  • Africa
    • South Africa
    • North Africa
    • Central Africa
• Key Players Insights
  • Lonza Group
  • Piramal Group
  • Evonik Industries AG
  • Novasep Holding SAS
  • Merck KGaA (SAFC Pharma)
  • Baxter Biopharma Solutions
  • AbbVie Contract Manufacturing
  • Cambrex Corporation
  • BSP Pharmaceuticals S.p.A.
  • CordenPharma Internatisonal
  • Catalent, Inc.
  • Albany Molecular Research Inc.
  • Evotec
  • WuXi AppTec Co., Ltd.
  • Pierre Fabre Laboratories
  • Dishman Group

Sources

Primary Research Interviews

• Pharmaceutical & Biopharmaceutical CDMO Executives
• Cytotoxic Drug Manufacturing Facility Managers
• R&D and Process Development Heads
• Quality Assurance & Regulatory Compliance Officers
• Biotech & Pharma Product Development Teams
• Supply Chain & Operations Managers in Contract Manufacturing
• Industry Consultants & Technical Advisors
• Others

Databases

• Bloomberg Terminal
• Thomson Reuters Eikon
• PharmaCompass
• DrugBank
• Others

Magazines

• Pharmaceutical Technology
• BioPharm International
• Contract Pharma
• Life Science Leader
• Genetic Engineering & Biotechnology News (GEN)
• Others

Journals

• Journal of Pharmaceutical Sciences
• International Journal of Pharmaceutics
• Journal of Controlled Release
• Drug Development and Industrial Pharmacy
• European Journal of Pharmaceutical Sciences
• Others

Newspapers

• The Wall Street Journal (Healthcare Section)
• Financial Times (Pharma & Biotech Section)
• Reuters Health & Pharma News
• Bloomberg News (Pharmaceuticals Section)
• Others

Associations

• International Society for Pharmaceutical Engineering (ISPE)
• European Fine Chemicals Group (EFCG)
• BIO (Biotechnology Innovation Organization)
• Parenteral Drug Association (PDA)
• Others

Public Domain Sources

• FDA & EMA Regulatory Guidelines & Reports
• Company Annual Reports & Investor Presentations
• SEC Filings (10-K, 20-F) of Pharmaceutical Companies
• U.S. National Institutes of Health (NIH) Publications
• ClinicalTrials.gov Database
• Others

Proprietary Elements

• CMI Data Analytics Tool
• Proprietary CMI Existing Repository of Information for the Last 8 Years