Biosimulation Market, by Product & Services (Software and Services), by Application (Drug Discovery and Drug Development), By End User (Pharmaceutical & Biotechnology Organizations, Contract Research Organizations (CROs) and Academic Research Institutions) - Size, Share, trends, and Forecast to 2026

  • Published On : Jul 2018 |
  • Pages : 159 Pages |
  • Format : CMI Insight PPT Format CMI Insight PDF Format

Global Biosimulation Market – Global Industry Insights

Modeling and simulation (M&S) in the drug development process is a scientific approach used in crucial drug development decisions. In order to avoid issues in discovery and development of new drug, biosimulation offers a promising tool, along with saving both time, money, and improving the predictability in early stage of drug development. Biosimulation refers to simulation of biological systems.

FDA also utilizes M&S in the drug development process. FDA’s Center for Drug Evaluation and Research (CDER) is currently using modeling and simulation to predict clinical outcomes, inform clinical trial designs, support evidence of effectiveness, optimize dosing, predict product safety, and evaluate potential adverse event mechanisms. Biosimulation is important for drug development, as it provides information regarding dose precision, drug-drug interaction on a molecular level, as well as physiologically-based pharmacokinetic (PBPK) modelling using sophisticated pharmacodynamics models of the heart, liver, and other systems. In addition to this, according to the US FDA’s Office of Clinical Pharmacology (OCP), 2014 data, PBPK modelling: a mathematical predictions of drug interactions with other drugs is increasingly used by FDA in drug discovery and early development process. Moreover, growing adoption of biosimulation tools in various stages of drug development help to increase growth of the biosimulation market

The global biosimulation market size was valued at US$ 1,323.1 Mn in 2017 and is expected to witness a CAGR of 15.4% over the forecast period (2018 – 2026).                                                

Global Biosimulation Market, By Region: 2018

 Source: Coherent Market Insights Analysis (2018)  

Increasing focus of various key players to accelerate drug discovery and development process is expected to aid in the market growth

Pharmaceutical companies, non-profit organizations, and healthcare regularity organizations are increasingly utilizing funds and their capabilities in drug discovery and development process. Growing engagement by these players in exploiting biosimulation techniques in increasing the effectiveness in drug discovery and development process will help to augment growth of the biosimulation market.          

Various government funding initiatives such as Innovate UK and Horizon 2020 provide businesses and research organizations with grants to help drive their scientific research. Innovate UK is the UK’s innovation agency and part of UK Research and Innovation. It has supported two companies, Adorial Pharma Limited and C4X Discovery, enabling the development of a novel mathematical-based system of drug discovery. Moreover, in March 2016, C4X Discovery Holdings plc, an innovative drug discovery and development organization announced acquisition of Adorial Limited. Combining these two business, along with support by Innovative UK will accelerate commercial and clinical success of biosimulation.

Furthermore, various non-profit organizations, such as the Wellcome Trust and the National Institute of Health are also funding for various drug discovery programs. The Wellcome Trust fund supports over 14,000 people in over 70 countries, and aims to invest upto US$ 7.04 billion (£5 billion) in population health, medical innovation, vaccine development such as the development of a new Ebola vaccine, public health interventions, among others.

Additionally, increasing burden of genetic diseases and growing need to detect early sign of disease, will lead to increase in research and development funding in gene therapy and diagnosis of genetic disease, thereby increasing adoption of biosimulation products and services, over the forecast period. For instance, according to the Research, Condition, and Disease Categories (RCDC) July 2017 data findings, National Institute of Health (NIH) has incurred funding in various disease categories through grants, contracts, and other funding mechanisms. According to the RCDC -2017 annual funding data, NIH spend US$ 422 million, US$ 462 million, and US$ 486 million on gene therapy, genetic clinical trials, and genetic testing, in 2015, 2016, and 2017, respectively.

Strategic collaborations among market players offers lucrative growth opportunities during the forecast period

Major players in biosimulation market are expanding their product offering with strategic acquisition. For instance, in December 2015, Certara, a biosimulation technology-enabled drug development company, acquired XenologiQ, a UK-based quantitative systems pharmacology (QSP) consultancy. This acquisition strengthened Certara’s modeling and simulation capabilities, and supports company’s precision medicine vision. Furthermore, in February 2018, Certara acquired BaseCase Management GmbH, a data visualization software as a service (SaaS) company. This acquisition strengthened Certara’s data visualization and communication capabilities. 

Advancement in Biosimulation Technology

In July 2018, team of scientist from Indian Institute of Science (IISc) developed EndoMimyk: an endoscopy simulator. EndoMimyk excels by using the technology of haptics. EndoMimyk combines haptics technology with advanced simulation and instrumented tools to offer high-fidelity, realistic, and immersive training in gastrointestinal and bronchoscopy procedures. Furthermore, in March 2017, Certara developed a new licensing approach, which provides smaller organizations to access their physiologically-based pharmacokinetic (PBPK) modeling and simulation platform, Simcyp. Simcyp Access is a cloud-based licensing approach, which helps to predict pharmacokinetic outcomes in virtual patient populations.

Key players operating in biosimulation market include Certara, L.P., Simulations Plus, Inc., Dassault Systèmes (Accelrys), Genedata AG, LeadScope, Inc., Compugen Inc., Schrödinger, LLC, In Silico Biosciences, Inc., Advanced Chemistry Development, Inc., Chemical Computing Group ULC, Physiomics PLC, and Pharmaceutical Product Development, LLC (Evidera).

Biosimulation plays important role in research and development process. Biosimulation is widely used in consumer personalized medicine, owing to increasing demand for personalized medicine in offering tailored solutions for various treatment areas such as drug discovery, oncology, cardiology, infectious disease, and psychiatry. Predictive biosimulation offers effective platform to use biological data and mathematical modeling to create a virtual version of patient to test simulated treatments.

Moreover, continuous research is being conducted to create a low-priced or open source version of predictive biosimulation platforms for self-tracking and modeling using patient’s data and to speed up the adoption by software development communities to generate future health scenarios using patient’s medication data.

Market Dynamics

Market players are engaged in developing novel biosimulation platform, in order to offer tailored solution in each therapeutic area. This is expected to aid in growth of the market. For instance, in October 2013, Rhenovia Pharma: a biotechnology firm specialized in biosimulation has developed the first simulator for biological mechanism of epilepsy. Moreover, development of new simulator opens new possibilities for research in epilepsy treatment. Rhenovia’ new simulator replicates the basic biological mechanisms of signal transmission between brain cells and simulates its defects leading to epileptic patterns, thereby leading to prevent epileptic seizures.

Furthermore, growing support from heathcare regulatory organizations in the adoption of biosimulation based software and services will, augment future growth of biosimulation market. Current FDA and EMA guidelines recommends the use of biosimulation in pediatric drug development studies, thereby minimizing the impact on children that must enroll in clinical trials. For instance, in Novembr 2017, Certara stated that U.S. Food and Drug Administration (FDA), expanded its use of Certara’s PBPK Simcyp Population-based Simulator and its Pediatric and Cardiac Safety Simulators. In addition, under the new agreement, FDA has tripled its number of licenses, equipping its Modeling and Simulation (M&S) review team with almost 60 PBPK licenses.

Key features of the study:

  • This report provides in-depth analysis of biosimulation market and provides market size (US$ Million) and Compound Annual Growth Rate (CAGR %) for the forecast period (2018 – 2026), considering 2017 as the base year
  • It elucidates potential revenue opportunity across different segments and explains attractive investment proposition matrix for this market
  • This study also provides key insights about market drivers, restraints, opportunities, new product launches or approval, regional outlook, and competitive strategy adopted by the leading players
  • It profiles leading players in the global biosimulation market based on the following parameters – company overview, financial performance, product portfolio, geographical presence, distribution strategies, key developments, and strategies and future plans
  • Key companies covered as a part of this study include Certara, L.P., Simulations Plus, Inc., Dassault Systèmes (Accelrys), Genedata AG, LeadScope, Inc., Compugen Inc., Schrödinger, LLC, In Silico Biosciences, Inc., Advanced Chemistry Development, Inc., Chemical Computing Group ULC, Physiomics PLC, and Pharmaceutical Product Development, LLC (Evidera)
  • Insights from this report would allow marketers and the management authorities of the companies to make informed decision regarding their future product launch, technology up-gradation, market expansion, and marketing tactics
  • The global biosimulation market report caters to various stakeholders in this industry including investors, suppliers, biosimulation software and services provider, distributors, new entrants, and financial analysts
  • Stakeholders would have ease in decision-making through various strategy matrices used in analyzing the biosimulation market.

Detailed Segmentation:

  • Global Biosimulation Market, By Product & Services:
    • Software
    • Services
  • Global Biosimulation Market, By Application:
    • Drug Discovery
    • Drug Development
  • Global Biosimulation Market, By End User:
    • Pharmaceutical & Biotechnology Organizations
    • Contract Research Organizations (CROs)
    • Academic Research Institutions
  • Global Biosimulation Market, By Geography:
    • North America
      • By Country:
        • U.S.
        • Canada
      • By Product & Services:
        • Software
        • Services
      • By Application
        • Drug Discovery
        • Drug Development
      • By End User:
        • Pharmaceutical & Biotechnology Organizations
        • Contract Research Organizations (CROs)
        • Academic Research Institutions
    • Europe
      • By Country:
        • Germany
        • France
        • Italy
        • UK
        • Spain
        • Russia
        • Rest of Europe
      • By Product & Services:
        • Software
        • Services
      • By Application
        • Drug Discovery
        • Drug Development
      • By End User:
        • Pharmaceutical & Biotechnology Organizations
        • Contract Research Organizations (CROs)
        • Academic Research Institutions
    • Asia Pacific
      • By Country:
        • China
        • India
        • Japan
        • South Korea
        • Australia
        • Rest of Asia Pacific
      • By Product & Services:
        • Software
        • Services
      • By Application
        • Drug Discovery
        • Drug Development
      • By End User:
        • Pharmaceutical & Biotechnology Organizations
        • Contract Research Organizations (CROs)
        • Academic Research Institutions
    • Middle East
      • By Country:
        • GCC
        • Israel
        • Rest of Middle East
      • By Product & Services:
        • Software
        • Services
      • By Application
        • Drug Discovery
        • Drug Development
      • By End User:
        • Pharmaceutical & Biotechnology Organizations
        • Contract Research Organizations (CROs)
        • Academic Research Institutions
    • Latin America
      • By Country:
        • Brazil
        • Argentina
        • Mexico
        • Rest of Latin America
      • By Product & Services:
        • Software
        • Services
      • By Application
        • Drug Discovery
        • Drug Development
      • By End User:
        • Pharmaceutical & Biotechnology Organizations
        • Contract Research Organizations (CROs)
        • Academic Research Institutions
    • Africa
      • By Country:
        • South Africa
        • Central Africa
        • North Africa
      • By Product & Services:
        • Software
        • Services
      • By Application
        • Drug Discovery
        • Drug Development
      • By End User:
        • Pharmaceutical & Biotechnology Organizations
        • Contract Research Organizations (CROs)
        • Academic Research Institutions
  • Company Profiles
    • Certara, L.P.*
      • Company Overview
      • Product Portfolio
      • Financial Performance
      • Recent Developments
      • Strategies
    • Simulations Plus, Inc.
    • Dassault Systèmes (Accelrys)
    • Genedata AG
    • LeadScope, Inc.
    • Compugen Inc.
    • Schrödinger, LLC
    • In Silico Biosciences, Inc.
    • Advanced Chemistry Development, Inc.
    • Chemical Computing Group ULC
    • Physiomics PLC
    • Pharmaceutical Product Development, LLC (Evidera)

“*” marked represents similar segmentation in other categories in the respective section.

Table of Contents

  1. Research Objective and Assumption
    • Research Objectives
    • Assumptions
    • Abbreviations
  2. Market Overview
    • Report Description
      • Market Definition and Scope
    • Executive Summary
      • Market Snippet, By Product & Services
      • Market Snippet, By Application
      • Market Snippet, By End User
      • Market Snippet, By Region
    • Coherent Opportunity Map (COM)
  3. Market Dynamics, Regulations, and Trends Analysis
    • Market Dynamics
      • Drivers
      • Restraints
      • Market Opportunities
      • Market Trends
      • Merger and Acquisitions
      • New Product Approvals/Launch
      • PEST Analysis
      • Porter’s Analysis
  4. Global Biosimulation Market, By Product & Services, 2016 - 2026 (US$ Million)
    • Introduction
      • Market Share Analysis, 2018 and 2026 (%)
      • Y-o-Y  Growth Analysis, 2017 - 2026
      • Segment Trends
    • Software
      • Introduction
      • Market Size and Forecast, and Y-o-Y  Growth, 2016 – 2026, (US$ Million)
    • Services
      • Introduction
      • Market Size and Forecast, and Y-o-Y  Growth, 2016 – 2026, (US$ Million)
  5. Global Biosimulation Market, By Application, 2016 - 2026 (US$ Million)
    • Introduction
      • Market Share Analysis, 2018 and 2026 (%)
      • Y-o-Y  Growth Analysis, 2017 - 2026
      • Segment Trends
    • Drug Discovery
      • Introduction
      • Market Size and Forecast, and Y-o-Y  Growth, 2016 – 2026, (US$ Million)
    • Drug Development
      • Introduction
      • Market Size and Forecast, and Y-o-Y  Growth, 2016 – 2026, (US$ Million)
  6. Global Biosimulation Market, By End User, 2016 - 2026 (US$ Million)
    • Introduction
      • Market Share Analysis, 2018 and 2026 (%)
      • Y-o-Y  Growth Analysis, 2017 - 2026
      • Segment Trends
    • Pharmaceutical & Biotechnology Organizations
      • Introduction
      • Market Size and Forecast, and Y-o-Y  Growth, 2016 – 2026, (US$ Million)
    • Contract Research Organizations (CROs)
      • Introduction
      • Market Size and Forecast, and Y-o-Y  Growth, 2016 – 2026, (US$ Million)
    • Academic Research Institutions
      • Introduction
      • Market Size and Forecast, and Y-o-Y  Growth, 2016 – 2026, (US$ Million)
  7. Global Biosimulation Market, By Regions, 2016 - 2026 (US$ Million)
    • Introduction
      • Market Share Analysis, By Region, 2018 and 2026 (%)
      • Y-o-Y  Growth Analysis, For Regions, 2017 - 2026
    • North America
      • Market Size and Forecast, By Product & Services, 2016 - 2026 (US$ Million)
      • Market Size and Forecast, By Application, 2016 - 2026 (US$ Million)
      • Market Size and Forecast, By End User, 2016 - 2026 (US$ Million)
      • Market Size and Forecast, By Country, 2016 - 2026, (US$ Million)
        • U.S.
        • Canada
    • Europe
      • Market Size and Forecast, By Product & Services, 2016 - 2026 (US$ Million)
      • Market Size and Forecast, By Application, 2016 - 2026 (US$ Million)
      • Market Size and Forecast, By End User, 2016 - 2026 (US$ Million)
      • Market Size and Forecast, By Country, 2016 - 2026, (US$ Million)
        • U.K.
        • Germany
        • Italy
        • France
        • Spain
        • Russia
        • Rest of Europe
    • Asia Pacific
      • Market Size and Forecast, By Product & Services, 2016 - 2026 (US$ Million)
      • Market Size and Forecast, By Application, 2016 - 2026 (US$ Million)
      • Market Size and Forecast, By End User, 2016 - 2026 (US$ Million)
      • Market Size and Forecast, By Country, 2016 - 2026, (US$ Million)
        • China
        • Japan
        • India
        • ASEAN
        • Australia
        • South Korea
        • Rest of Asia Pacific
    • Latin America
      • Market Size and Forecast, By Product & Services, 2016 - 2026 (US$ Million)
      • Market Size and Forecast, By Application, 2016 - 2026 (US$ Million)
      • Market Size and Forecast, By End User, 2016 - 2026 (US$ Million)
      • Market Size and Forecast, By Country, 2016 - 2026, (US$ Million)
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
    • Africa
      • Market Size and Forecast, By Product & Services, 2016 - 2026 (US$ Million)
      • Market Size and Forecast, By Application, 2016 - 2026 (US$ Million)
      • Market Size and Forecast, By End User, 2016 - 2026 (US$ Million)
      • Market Size and Forecast, By Country, 2016 - 2026, (US$ Million)
        • Northern Africa
        • Central Africa
        • South Africa
    • Middle East
      • Market Size and Forecast, By Product & Services, 2016 - 2026 (US$ Million)
      • Market Size and Forecast, By Application, 2016 - 2026 (US$ Million)
      • Market Size and Forecast, By End User, 2016 - 2026 (US$ Million)
      • Market Size and Forecast, By Country, 2016 - 2026, (US$ Million)
        • GCC Countries
        • Israel
        • Rest of Middle East
  8. Competitive Landscape
    • Heat Map Analysis
    • Company Profiles
      • Certara, L.P.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Developments/Updates
        • Strategies
      • Simulations Plus, Inc.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Developments/Updates
        • Strategies
      • Dassault Systèmes (Accelrys) 
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Developments/Updates
        • Strategies
      • Genedata AG
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Developments/Updates
        • Strategies
      • LeadScope, Inc.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Developments/Updates
        • Strategies
      • Compugen Inc.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Developments/Updates
        • Strategies
      • Schrödinger, LLC
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Developments/Updates
        • Strategies
      • In Silico Biosciences, Inc.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Developments/Updates
        • Strategies
      • Advanced Chemistry Development, Inc.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Developments/Updates
        • Strategies
      • Chemical Computing Group ULC
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Developments/Updates
        • Strategies
      • Physiomics PLC
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Developments/Updates
        • Strategies
      • Pharmaceutical Product Development, LLC (Evidera)
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Developments/Updates
        • Strategies
    • Analyst Views
  9. Section
    • References
    • Research Methodology
    • About Us and Sales Contact

*Browse 21 market data tables and 24 figures on "Biosimulation Market - Global forecast to 2026”.

Research Methodology

Coherent Market Insights followsa comprehensive research methodology focused on providing the most precise market analysis. The company leverages a data triangulation model which helps company to gauge the market dynamics and provide accurate estimates. Key components of the research methodologies followed for all our market reports include:

  • Primary Research (Trade Surveys and Experts Interviews)
  • Desk Research
  • Proprietor Data Analytics Model

In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.


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Coherent Market Insights desk research is based on a principle set of research techniques:

  • National level desk research: It Includes research analysis of regional players, regional regulatory bodies, regional trade associations, and regional organization.
  • Multinational level desk research: The research team keeps a track of multinational players, global regulatory bodies, global trade associations, and global organization.

Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:

  • Governmental bodies, National and international social welfare institutions, and organizations creating economic policies among others.
  • Trade association, National and international media and trade press.
  • Company Annual reports, SEC filings, Corporate Presentations, press release, news, and specification sheet of manufacturers, system integrators, brick and mortar - distributors and retailers, and third party online commerce players.
  • Scientific journals, and other technical magazines and whitepapers.

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Preliminary Data Mining

The raw data is obtained through the secondary findings, in house repositories, and trade surveys. It is then filtered to ensure that the relevant information including industry dynamics, trends, and outlook is retained for further research process.

Data Standardization:

Holistic approach is used to ensure that the granular and uncommon parameters are taken into consideration to ensure accurate results. The information from the paid databases are further combined to the raw data in order to standardize it.

Coherent Statistical model

We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:

  • Micro-economic indicators
  • Macro-economic indicators
  • Environmental indicators
  • Socio-political indicators
  • Technology indicators

Data Processing

Once the findings are derived from the statistical model, large volume of data is process to confirm accurate research results. Data analytics and processing tools are adopted to process large chunk of collected informative data. In case, a client customizes the study during the process, the research finding till then are benchmarked, and the process for new research requirement is initiated again.

Data Validation

This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:

  • It provides first-hand information on the market dynamics, outlook, and growth parameters.
  • Industry experts validates the estimates which helps the company to cement the on-going research study.
  • Primary research includes online surveys, face-to face interviews, and telephonic interviews.

The primary research is conducted with the ecosystem players including, but not limited to:

  • Raw Material Suppliers
  • Manufacturers
  • System Integrators
  • Distributors
  • End-users

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