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  • Published On : Mar 2022
  • Code : CMI4960
  • Industry : Pharmaceutical
  • Pages : 167
  • Formats :

Central Precocious Puberty (CPP) is referred to as gonadotropin-dependent precocious puberty. It is an endocrine-related developmental disease characterized by the onset of pubertal changes with the development of secondary sexual characteristics, accelerated growth, and bone maturation before the normal age of puberty (8 years in girls and 9 years in boys).

This condition is idiopathic. However, the most common known genetic cause of central precocious puberty is mutation in the MKRN3 gene. In addition to genetics, other influential factors which may affect the condition, include nutrition, socioeconomic status, and exposure to certain chemicals in the environment.

Global Central Precocious Puberty Market - Impact of the Coronavirus (COVID-19) Pandemic

The coronavirus (COVID-19) outbreak was first reported on December 31, 2019, in Wuhan, China. The World Health Organization declared COVID-19 a pandemic on March 11, 2020. According to the Coronavirus (COVID-19) Weekly Epidemiological Update by the World Health Organization, over 346.7 million cases and 5.5 million deaths due to Coronavirus (COVID-19) were reported till January 23, 2022, across the globe.

Impact of COVID-19 on Demand and Supply of Central Precocious Puberty Treatment Drugs

The COVID-19 pandemic and its consequent lockdown in various countries have impacted the financial status of businesses across all sectors including the private healthcare sector. The COVID-19 pandemic has impacted the entire supply chain of the healthcare industry mainly due to strict lockdown in several regions. The COVID-19 pandemic has also affected the economy of various regions across the globe in three main ways: 1) by directly affecting the production and demand; 2) by creating disruptions in distribution channels; 3) through its financial impact on companies and financial markets. Several countries such as Thailand, Indonesia, and Singapore are facing problems with regard to transportation and distribution of healthcare products.

The impact of the COVID-19 pandemic is expected to limit the growth of the global central precocious puberty market during the forecast period, owing to a decrease in the supply of raw materials and pharmaceutical drugs of manufacturing companies associated with central precocious puberty.

The global central precocious puberty market is estimated to be valued at US$ 1,595.2 Mn in 2022 and expected to exhibit a CAGR of 7.9% over the forecast period (2022-2030).

Figure 1: Global Central Precocious Puberty Market Share (%) Analysis, By Drug, 2022

 Central Precocious Puberty  | Coherent Market Insights

Increasing product launches and approvals for the treatment of central precocious puberty are expected to drive the market growth

Market players are focusing on obtaining product approval from regulatory authorities such as U.S. Food and Drug Administration (FDA), which is expected to augment the market growth over the forecast period. For instance, in May 2020, Tolmar Pharmaceuticals, Inc., a pharmaceutical company, received approval for its New Drug Application (NDA) from the U.S. FDA for FENSOLVI (leuprolide acetate) for injectable suspension for the treatment of pediatric patients aged two years and older with central precocious puberty.

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Central Precocious Puberty Market Report Coverage

Report Coverage Details
Base Year: 2019 Market Size in 2022: US$ 1,595.2 Mn
Historical Data for: 2016 to 2019 Forecast Period: 2022 to 2028
Forecast Period 2022 to 2030 CAGR: 7.9% 2030 Value Projection: US$ 2,926.2 Mn
Geographies covered:
  • North America: U.S. and Canada
  • Latin America: Brazil, Argentina, Mexico, and Rest of Latin America
  • Europe: Germany, U.K., Spain, France, Italy, Russia, and Rest of Europe
  • Asia Pacific: China, India, Japan, Australia, South Korea, ASEAN, and Rest of Asia Pacific
  • Middle East: GCC, Israel, and Rest of Middle East
  • Africa: South Africa, North Africa, and Central Africa
Segments covered:
  • By Drug: Leuprolide Acetate, Triptorelin, Histrelin Acetate, Nafarelin
  • By Distribution Channel: Hospital Pharmacies, Retail Pharmacies, Online Pharmacies 
Companies covered:

Teva Pharmaceutical Industries Ltd., AbbVie Inc., Arbor Pharmaceuticals, LLC, Pfizer Inc., Tolmar Pharmaceuticals, Inc., Endo International plc, Ipsen Pharma, Debiopharm Group, and Sun Pharmaceutical Industries Limited

Growth Drivers:
  • Increasing product launch/approvals
  • Increasing partnerships and agreements among market players
Restraints & Challenges:
  • Side effects associated with central precocious puberty treatment drugs

Increasing partnerships and agreements among market players are expected to augment the market growth

Market players are focusing on various inorganic strategies such as partnerships and agreements, which is anticipated to propel the global central precocious puberty market growth over the forecast period. For instance, in January 2016, Debiopharm International SA (Debiopharm), part of Debiopharm Group, entered into an exclusive distribution agreement with Arbor Pharmaceuticals, a pharmaceutical company, for the commercialization and promotion of triptorelin 22.5 mg for CPP in the U.S.

Global Central Precocious Puberty Market – Restraints

Side effects associated with drugs such as Triptodur are anticipated to hinder the marker growth over the forecast period. Side effects associated with Central Precocious Puberty treatment drugs are painful or difficult urination, burning while urination, blood in the urine, bone pain, (in children) new or worsening signs of puberty, seizure, chest pain or pressure, pain spreading to jaw or shoulder, sudden numbness or weakness, and slurred speech.

Global Central Precocious Puberty Market – Regional Analysis

On the basis of region, the global central precocious puberty market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa.

North America is expected to hold a dominant position in the global central precocious puberty market over the forecast period, owing to the increasing availability of drugs for the treatment of central precocious puberty in the U.S. For instance, in October 2017, Arbor Pharmaceuticals, LLC and Debiopharm International SA announced the commercial availability of Triptodur in the U.S. for the treatment of pediatric patients aged two years and older diagnosed with central precocious puberty (CPP).

Figure 2: Global Central Precocious Puberty Market Value (US$ Mn), by Region, 2022

Central Precocious Puberty  | Coherent Market Insights

Global Central Precocious Puberty Market – Competitive Landscape

Major players operating in the global central precocious puberty market include Teva Pharmaceutical Industries Ltd., AbbVie Inc., Arbor Pharmaceuticals, LLC, Pfizer Inc., Tolmar Pharmaceuticals, Inc., Endo International plc, Ipsen Pharma, Debiopharm Group, and Sun Pharmaceutical Industries Limited.

Gonadotropin-releasing hormone (GnRH) agonist are potential treatment options for the CPP as they inhibit stimulation effects of endogenous GnRH and accelerate bone maturation, thereby suppressing early puberty. GnRH therapy delays the onset of puberty leading to delay in menarche Triptodor (triptorelin), Lupron Depot-Ped (leuprolide acetate), and Supprelin LA (histrelin acetate) are approved treatment medications available in the market for central precocious puberty (CPP). Moreover, Triptodur, Lupron Depot-Ped, and Supprelin LA are Gonadotropin-releasing hormone (GnRH) agonists used to prolong the suppression of gonadotropin secretion when required. Triptorelin, a GnRH agonist, effectively suppresses the pituitary-gonadal axis and pubertal development in children with CPP.

Market Dynamics

Reimbursement for the treatment of central precocious puberty is provided through Medicaid, which is expected to offer lucrative growth opportunities for the global central precocious puberty market during the forecast period. According to N.C. Medicaid Bulletin December 2017, Triptodur: an extended-release injectable suspension for intramuscular use, operates under Medicaid Healthcare Common Procedure Coding System (HCPCS) code J3490. According to the same source, from September 2017, N.C. Medicaid and N.C. Health Choice (NCHC) programs cover triptorelin extended-release injectable suspension for intramuscular use (Triptodur) for use in the Physician's Drug Program (PDP). For Medicaid and NCHC billing, the maximum reimbursement rate per unit of Triptodur is: US$ 17,280.00 per kit.

Key features of the study:

  • This report provides an in-depth analysis of the global central precocious puberty market, market size (US$ Million), and compound annual growth rate (CAGR %) for the forecast period (2021-2028), considering 2020 as the base year
  • It elucidates potential revenue opportunities across different segments and explains an attractive investment proposition matrix for this market
  • This study also provides key insights about market drivers, restraints, opportunities, new product launches or approval, regional outlook, and competitive strategies adopted by the leading players
  • It profiles leading players in the global central precocious puberty market based on the following parameters – company overview, financial performance, product portfolio, geographical presence, distribution strategies, key developments and strategies, and future plans
  • Key companies covered as a part of this study include Teva Pharmaceutical Industries Ltd., AbbVie Inc., Arbor Pharmaceuticals, LLC, Pfizer Inc., Tolmar Pharmaceuticals, Inc., Endo International plc, Ipsen Pharma, Debiopharm Group, and Sun Pharmaceutical Industries Limited
  • Insights from this report would allow marketers and the management authorities of the companies to make informed decisions regarding their future product launch, technology up-gradation, market expansion, and marketing tactics
  • The global central precocious puberty market report caters to various stakeholders in this industry including investors, suppliers, manufacturers, distributors, new entrants, and financial analysts
  • Stakeholders would have ease in decision making through various strategy matrices used in analyzing the global central precocious puberty market

Detailed Segmentation:

  • Global Central Precocious Puberty Market, By Drug:
    • Leuprolide Acetate
    • Triptorelin
    • Histrelin Acetate
    • Nafarelin
  • Global Central Precocious Puberty Market, By Distribution Channel:
    • Hospital Pharmacies
    • Retail Pharmacies
    • Online Pharmacies
  • Global Central Precocious Puberty Market, By Region:
    • North America
      • By Country:
        • U.S.
        • Canada
    • Latin America
      • By Country:
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
    • Europe
      • By Country:
        • U.K.
        • Germany
        • Italy
        • Spain
        • France
        • Russia
        • Rest of Europe
    • Asia Pacific
      • By Country
        • China
        • India
        • Japan
        • Australia
        • South Korea
        • ASEAN
        • Rest of Asia Pacific
    • Middle East
      • By Country:
        • GCC
        • Israel
        • Rest of Middle East
    • Africa
      • By Country/Region:
        • South Africa
        • Central Africa
        • North Africa
  • Company Profiles
    • Teva Pharmaceutical Industries Ltd.*
      • Company Overview
      • Product Portfolio
      • Financial Performance
      • Recent Developments/Updates
      • Strategies
    • AbbVie Inc.
    • Arbor Pharmaceuticals, LLC
    • Pfizer Inc.
    • Tolmar Pharmaceuticals, Inc.
    • Endo International plc
    • Ipsen Pharma
    • Debiopharm Group
    • Sun Pharmaceutical Industries Limited

 “*” marked represents similar segmentation in other categories in the respective section.

Frequently Asked Questions

The global central precocious puberty market is expected to exhibit a CAGR of 7.9% during the forecast period (2022-2030).
The market is estimated to be valued at US$ 1,595.2 Mn in 2022.
Teva Pharmaceutical Industries Ltd., AbbVie Inc., Arbor Pharmaceuticals, LLC, Pfizer Inc., Tolmar Pharmaceuticals, Inc., Endo International plc, Ipsen Pharma, Debiopharm Group, and Sun Pharmaceutical Industries Limited are some of the prominent players operating in the market.
The market is expected to be valued at US$ 2,926.2 Mn in 2030.
North America is the prominent region in the market.
Increasing product launch/approvals, partnerships, and agreements among market players are expected to drive the market growth.

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