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  • To Be Published : Dec 2022
  • Code : CMI4806
  • Industry : Pharmaceutical
  • Pages : N/A
  • Formats :

Struggle during sleep, waking up too early, and not being able to fall back to sleep or waking up during the sleep cycle involves circadian rhythm sleep disorders. Constant or irregular disruption of sleep patterns are caused by circadian rhythm sleep disorders. Breakdown in ‘internal body clock’ or inconsistency within ‘internal body clock’ affects the duration of sleep, which can create issues at work time, social activities and in school.

More than adults the teen may naturally have late bedtime, which increases risk of delayed sleep-wake phase disorder. On the other hand, older people sleep and wake up early, which raises their advanced sleep wake phase disorder risk.

Moreover, medical conditions such as stroke, head injury, dementia, lack of sleep, jet lag, various work shifts, older age, particular drugs, lack of exposure to sunlight for longer time, are the situations, which can trigger circadian rhythm sleep disorder.

The diagnosis for circadian rhythm sleep disorder are often challenging and requires consulting with the sleep specialist. Wrist watch device named Actigraph helps to record sleep and wake activity from days to weeks.

Treatment option for circadian rhythm sleep disorder includes lifestyle and behavior therapy, bright light therapy, medications, and chronotherapy.

Circadian Rhythm Sleep Disorders Market – Dynamics

Circadian Rhythm Sleep Disorders Market – Drivers:

  • Excessive daytime sleepiness:

The excessive daytime sleepiness can affect the drivers, As per public health, due to sleepiness at wheel (while driving) many road accidents happens. Population who suffers from excessive daytime sleepiness is about 5%. 

  • Increase in sleep-wake disorders:

As per stated by AJMC, (The center for biosimilar), the prevalence of narcolepsy had increased about 14%, from 38.9 in 2013 to 44.3 in 2016. The OSA increased 41% of prevalence from the study period of 2429 to 3240. This increased prevalence was also observed in other examined sleep disorders.

Furthermore, increasing U.S. FDA approval, announcement of new information or manufacturing capabilities and agreements by market players are expected to boost the circadian rhythm sleep disorder market growth over the forecast period.

For instance, Vanda Pharmaceutical, in December 2020 announced that U.S. Food and Drug Administration (FDA) approved its HETLIOZ capsule and liquid formulations for the diagnosis of children and adults, associated with Smith-Magenis Syndrome (SMS) a development disorder which causes sleep disturbances.

Moreover, in October 2018, Eisai announced that they presented new information for phase II evaluation of Lemborexant, an experimental sleep-wake regulation agent, for the diagnosis of irregular sleep wake rhythm disorder in sufferer patient with mild to moderate Alzheimer’s disease. Alzheimer ’s disease data was presented in 11th Clinical Trials conference in Barcelona, Spain. Including insomnia disorder, Lemborexant is also developed for diagnosis of multiple sleep-wake disorders.

Circadian Rhythm Sleep Disorders Market – Regional Insights

Among regions, North America and Europe are estimated to account for significant market share in the global circadian rhythm sleep disorders market. This is attributed to rising prevalence of chronic diseases (Obesity, Depression, Cardiovascular disease) and geriatric population. For instance, according to the European Commission, 2013 report, total 17% of European Population was above age 65 years. Therefore, rise in geriatric population is expected to drives growth of the circadian rhythm sleep disorders market in European Region. By National Library of Medicine, most common circadian rhythm sleep disorder is delayed sleep phase disorder with an estimated prevalence of 0.17% in the U.S. population and 7–16% prevalence among adolescents.

Circadian Rhythm Sleep Disorders Market – Taxonomy

By Treatment Type:

  • Healthy Lifestyle Changes
  • Bright Light Therapy
  • Melatonin

By Application Type:

  • Delayed Sleep Phase Disorder
  • Advanced Sleep Phase Disorder
  • Jet Lag
  • Shift Work Disorder
  • Irregular Sleep Wake Rhythm
  • Non-24-hour Sleep-wake Syndrome

By Distribution Channel:

  • Institutional Sales
  • Retail Sales

By Drugs:

  • Melatonin
  • Modafinil
  • Tasimelteon

By End User:

  • Hospitals
  • Home Care Settings
  • Sleep Centers

By Region:

  • North America
  • Europe
  • Asia Pacific
  • Middle East & Africa
  • Latin America

Circadian Rhythm Sleep Disorders Market – Competitive Landscape

Key players operating in the circadian rhythm sleep disorder market include:

  • Vanda Pharmaceuticals
  • Aeroflow, Inc.
  • Cephalon, Inc.
  • Takeda Pharmaceutical Company
  • Teva Pharmaceutical Industries Ltd.
  • Mylan N.V.
  • The Sunbox Company
  • Verilux, Inc.
  • Northern Light Technologies
  • Koninklijke Philips N.V.
  • Amjo Corp.

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