P2X7 Receptor Antagonists Market, by Drugs (AKP-23494954/RQ-00466479, EVT 401, GSK1482160, JNJ-55308942, JNJ-54175446, and Others (e.g.- AZ11657312)), by Application (Central Nervous System Disorders, Immunological Disorders, and Others), and by Region (North America, Latin America, Europe, Asia Pacific, Middle East, and Africa) - Size, Share, Outlook, and Opportunity Analysis, 2018- 2026

  • Published On : May 2019 |
  • Pages : 94 Pages |
  • Format : CMI Insight PPT Format CMI Insight PDF Format

P2X7 Receptor Antagonist Market Insights

The P2X7 receptor is an ATP-gated, non-selective cation channel that has been linked to a number of inflammatory diseases. Activation of the P2X7 receptor by elevated levels of adenosine triphosphate (ATP) results in the release of pro-inflammatory cytokines and elevated levels of these cytokines has been associated with a variety of disease states. So, P2X7 receptor antagonists can be viable therapeutic agents, which is why leading manufacturers such as GlaxoSmithKline Plc., Johnson & Johnson, AstraZeneca Plc., and other manufacturers such as RaQualia Pharma, Evotec AG, and Asahi Kasei Corporation are working towards development of P2X7 receptor antagonist. Currently, there is no P2X7 receptor antagonist available in the market, and not a single P2X7 receptor antagonist in late stages of clinical trials. Therefore, manufacturers are competing on the same level with respect to the P2X7 receptor antagonist development. The category has a lucrative opportunity if a drug is introduced into the market, provided a drug successfully completes clinical trials. First mover to complete clinical trials, (and first to launch) will be able to gain significant share in the market, as healthcare systems always demand new medicines. Currently, opioid medications are heavily used for pain management and are highly addictive. Therefore, approval and launch of a non-addictive pain management option is expected to be a breakthrough in this product space.  

Potential of P2X7 receptor antagonists in treatment of various diseases is expected to drive the global P2X7 receptor antagonist market growth over the forecast period

Various research studies reported activation of P2X7 channels due to release of pro-inflammatory cytokines IL-1b and IL-18. As adenosine triphosphate (ATP) has lowest affinity for P2X7 among all other purinergic ion channels (P2X4, P2X3, and others), extracellular ATP rarely activates P2X7 channel. P2X7 receptor antagonists have significant therapeutic potential, as P2X7 receptors have been found to be associated with regulation of inflammation, and all immune cell types (lymphocytes, macrophages, monocytes, and others) express P2X7R. Moreover, P2X7 ion channel has been directly linked to major depression and animal studies have shown that antagonism of P2X7 with centrally penetrant antagonists resulted in antidepressant-like behavior in animal models. Therefore, inflammation, pain indications, mood disorders, and depression are the potential areas among others where, P2X7 is involved, and its antagonism can modify disease outcomes, or can be a disease-modifying therapy. As such, P2X7 is an ideal drug target as antagonism of P2X7 channel would not cause any serious side effects, as antagonism will only start when the channel is activated by high ATP concentrations, believed to happen during pathology of neuroinflammatory disorders of the Central Nervous System (CNS) such as stroke, epilepsy, multiple sclerosis, chronic neurodegenerative, and neuropsychiatric diseases. These factors are expected to support global P2X7 receptor antagonist market growth over the forecast period.

The global P2X7 receptor antagonist market size was US$ 96.6 million in 2024, and is expected to witness a robust CAGR of 18.3% over the forecast period (2024–2026).

                                                   Figure No.1: Global P2X7 Receptor Antagonist Market Scenario                                                                                                                                                                                           

Source: Coherent Market Insights Analysis (2019)

Robust early stage pipeline is expected to support the global P2X7 receptor antagonist market growth over the forecast period

Manufacturers such as GlaxoSmithKline Plc, Johnson and Johnson, AstraZeneca plc, Asahi Kasei Corporation, and others have potential molecules in the pipeline.

Asahi Kasei Corporation, AstraZeneca Plc, and RaQualia Pharma Inc. have their products in preclinical stages for various indications such as analgesics, inflammation, and other indications.

GlaxoSmithKline Plc, Johnson & Johnson, and Evotec AG have these molecule for indications such as pain conditions, inflammatory conditions, major depressive disorder, and mood disorders.

Although, these molecules are in early stages of development, and faster clinical trials and active interest by companies such as Evotec AG, and Asahi Kasei Pharma to advance the pipeline is expected to support growth of the global P2X7 receptor antagonists market over the forecast period.

Figure No.2: Global P2X7 Receptor Antagonist Market Pipeline Scenario

However, leading international manufacturers such as GlaxoSmithKline Plc. and AstraZeneca Plc. have not been actively pursuing the advancement of P2X7 receptor antagonist category. For instance, GlaxoSmithKline Plc’s P2X7 candidate GSK1482160 is still in Phase 1 clinical trials and the study ended in April 2009. Moreover, the category has less number of candidates in the pipeline as compared to other conditions such as cancer and others. This factor has affected global P2X7 receptor antagonist market growth.

Some of the major players operating in the global P2X7 receptor antagonist market include, GlaxoSmithKline Plc, Johnson & Johnson, AstraZeneca Plc, RaQualia Pharma, Evotec AG, and Asahi Kasei Corporation.

P2X7 receptor antagonists are still in the developmental stage and will require regulatory approval for introduction into the market. Manufacturers need to file an Investigational New Drug Application (IND) with the U.S. Food & Drug Application (FDA). Every drug is required to go through the approval process set by the FDA. P2X7 antagonists will be going through all the clinical trials after filing an Investigational New Drug (IND) application as any other new drug. However, the pharmaceutical organizations face several challenges for introducing these medications in the market due to a stringent regulatory approval process. These factors are considered in global P2X7 receptor antagonist market and factors affecting global P2X7 receptor antagonist market growth.

Market Dynamics

P2X7 Receptor Antagonists drug category is highly lucrative, as no drug therapies are available in this category. Leading organizations are investing in research and development of drugs in this category, which is expected to help market players in generating high revenue using patent protection. Disease and conditions such as major depressive disorders, mood disorders, chronic pain, and inflammation are highly prevalent and their incidence is also increasing. According to National Health Service Digital (NHS Digital), U.K., antidepressants medications prescriptions observed the largest increase in 2016, indicating the prevalence of depressive disorders. If launched, P2X7 receptor antagonists will be capable of acquiring a significant amount of market share for the disease or indication for which they have been approved. Drug manufacturers are also advancing the P2X7 antagonist drug category by developing innovative drugs such as AKP-23494954/RQ-00466479 (Asahi Kasei/RaQualia Pharma). These factors are expected to support global P2X7 receptor antagonist market growth over the forecast period.

Key features of the study:

  • This report provides in-depth analysis of the P2X7 receptor antagonists market and provides market size (US$ Mn) and compound annual growth rate (CAGR %) for the forecast period (2018–2026), considering 2018 as the base year
  • It elucidates potential revenue opportunity across different segments and explains attractive investment proposition matrix for this market
  • This study also provides key insights about market drivers, restraints, opportunities, new product launches or approvals, regional outlook, and competitive strategies adopted by key players
  • It profiles key players in the global P2X7 receptor antagonists market based on the following parameters – company overview, financial performance, product portfolio, geographical presence, distribution strategies, key developments and strategies
  • Key companies covered as a part of this study include, Asahi Kasei Corporation, GlaxoSmithKline Plc, Johnson & Johnson, AstraZeneca Plc, Evotec AG, and RaQualia Pharma
  • Insights from this report would allow marketers and the management authorities of companies to make informed decisions regarding their future product launches, by technology up-gradation, market expansion, and marketing tactics
  • The global P2X7 receptor antagonists market report caters to various stakeholders in this industry including investors, suppliers, product manufacturers, distributors, new entrants, and financial analysts
  • Stakeholders would have ease in decision-making through various strategy matrices used in analyzing the P2X7 receptor antagonists market

Detailed Segmentation:

  • Global P2X7 Receptor Antagonists Market, By Drugs:
    • AKP-23494954/RQ-00466479
    • EVT 401
    • GSK1482160
    • JNJ-55308942
    • JNJ-54175446
    • Others (e.g.- AZ11657312)
  • Global P2X7 Receptor Antagonists Market, By Application:
    • Central Nervous System Disorders
    • Immunological Disorders
    • Others
  • Global P2X7 Receptor Antagonists Market, By Region:
    • North America
      • By Drugs:
        • AKP-23494954/RQ-00466479
        • EVT 401
        • GSK1482160
        • JNJ-55308942
        • JNJ-54175446
        • Others (e.g.- AZ11657312)
      • By Application
        • Central Nervous System Disorders
        • Immunological Disorders
        • Others
      • By Country:
        • U.S.
        • Canada
    • Europe
      • By Drugs:
        • AKP-23494954/RQ-00466479
        • EVT 401
        • GSK1482160
        • JNJ-55308942
        • JNJ-54175446
        • Others (e.g.- AZ11657312)
      • By Application
        • Central Nervous System Disorders
        • Immunological Disorders
        • Others
      • By Country:
        • U.K.
        • Germany
        • Italy
        • France
        • Spain
        • Russia
        • Rest of Europe
    • Asia Pacific
      • By Drugs:
        • AKP-23494954/RQ-00466479
        • EVT 401
        • GSK1482160
        • JNJ-55308942
        • JNJ-54175446
        • Others (e.g.- AZ11657312)
      • By Application
        • Central Nervous System Disorders
        • Immunological Disorders
        • Others
      • By Country:
        • China
        • India
        • Japan
        • ASEAN
        • Australia
        • South Korea
        • Rest of Asia Pacific
    • Latin America
      • By Drugs:
        • AKP-23494954/RQ-00466479
        • EVT 401
        • GSK1482160
        • JNJ-55308942
        • JNJ-54175446
        • Others (e.g.- AZ11657312)
      • By Application
        • Central Nervous System Disorders
        • Immunological Disorders
        • Others
      • By Country:
        • Brazil
        • Mexico
        • Rest of Latin America
    • Middle East
      • By Drugs:
        • AKP-23494954/RQ-00466479
        • EVT 401
        • GSK1482160
        • JNJ-55308942
        • JNJ-54175446
        • Others (e.g.- AZ11657312)
      • By Application
        • Central Nervous System Disorders
        • Immunological Disorders
        • Others
      • By Country:
        • GCC
        • Israel
        • Rest of Middle East
    • Africa
      • By Drugs:
        • AKP-23494954/RQ-00466479
        • EVT 401
        • GSK1482160
        • JNJ-55308942
        • JNJ-54175446
        • Others (e.g.- AZ11657312)
      • By Application
        • Central Nervous System Disorders
        • Immunological Disorders
        • Others
      • By Country:
        • Central Africa
        • South Africa
        • North Africa
  • Company Profiles
    • Asahi Kasei Corporation*
      • Company Overview
      • Product Portfolio
      • Financial Performance
      • Key Strategies
      • Recent Developments
    • GlaxoSmithKline Plc
    • Evotec AG
    • RaQualia Pharma
    • AstraZeneca Plc
    • Johnson & Johnson

 “*” marked represents similar segmentation in other categories in the respective section.

Table of Contents

  1. Research Objectives and Assumptions
    • Research Objectives
    • Assumptions
    • Abbreviations
  2. Market Purview
    • Report Description
      • Market Definition and Scope
    • Executive Summary
      • Market Snippet, By Drugs
      • Market Snippet, By Application
      • Market Snippet, By Region
    • Coherent Opportunity Map (COM)
  3. Market Dynamics, Regulations, and Trends Analysis
    • Pipeline Analysis
    • Market Dynamics
      • Drivers
      • Restraints
      • Market Opportunities
      • Impact Analysis
    • Key Developments
    • PEST Analysis
    • Epidemiology
  4. Global P2X7 Receptor Antagonists Market, By Drugs, 2024–2026 (US$ Mn)
    • Introduction
      • Market Share Analysis, 2024 and 2026 (%)
      • Y-o-Y Growth Analysis, 2025-2026
      • Segment Trends
    • AKP-23494954/RQ-00466479
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2024–2026, (US$ Mn)
    • EVT 401
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2024–2026, (US$ Mn)
    • GSK1482160
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2024–2026, (US$ Mn)
    • JNJ-55308942
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2024–2026, (US$ Mn)
    • JNJ-54175446
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2024–2026, (US$ Mn)
    • Others (e.g.- AZ11657312)
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2024–2026, (US$ Mn)
  5. Global P2X7 Receptor Antagonists Market, By Application, 2024–2026 (US$ Mn)
    • Introduction
      • Market Share Analysis, 2024 and 2026 (%)
      • Y-o-Y Growth Analysis, 2025-2026
      • Segment Trends
    • Central Nervous System Disorders
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2024–2026, (US$ Mn)
    • Immunological Disorders
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2024–2026, (US$ Mn)
    • Others
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2024–2026, (US$ Mn)
  6. Global P2X7 Receptor Antagonists Market, By Region, 2024–2026 (US$ Mn)
    • Introduction
      • Market Share Analysis, By Region, 2024 and 2026 (%)
      • Y-o-Y Growth Analysis, For Regions, 2025-2026
    • North America
      • Market Size and Forecast, By Drugs, 2024–2026 (US$ Mn)
      • Market Size and Forecast, By Application, 2024–2026 (US$ Mn)
      • Market Size and Forecast, By Country, 2024–2026 (US$ Mn)
        • U.S.
        • Canada
    • Europe
      • Market Size and Forecast, By Drugs, 2024–2026 (US$ Mn)
      • Market Size and Forecast, By Application, 2024–2026 (US$ Mn)
      • Market Size and Forecast, By Country, 2024–2026 (US$ Mn)
        • U.K.
        • Germany
        • Italy
        • France
        • Spain
        • Russia
        • Rest of Europe
    • Asia Pacific
      • Market Size and Forecast, By Drugs, 2024–2026 (US$ Mn)
      • Market Size and Forecast, By Application, 2024–2026 (US$ Mn)
      • Market Size and Forecast, By Country, 2024–2026 (US$ Mn)
        • China
        • India
        • Japan
        • ASEAN
        • Australia
        • South Korea
        • Rest of APAC
    • Latin America
      • Market Size and Forecast, By Drugs, 2024–2026 (US$ Mn)
      • Market Size and Forecast, By Application, 2024–2026 (US$ Mn)
      • Market Size and Forecast, By Country, 2024–2026 (US$ Mn)
        • Brazil
        • Mexico
        • Rest of Latin America
    • Africa
      • Market Size and Forecast, By Drugs, 2024–2026 (US$ Mn)
      • Market Size and Forecast, By Application, 2024–2026 (US$ Mn)
      • Market Size and Forecast, By Country, 2024–2026 (US$ Mn)
        • Central Africa
        • South Africa
        • North Africa
    • Middle East
      • Market Size and Forecast, By Drugs, 2024–2026 (US$ Mn)
      • Market Size and Forecast, By Application, 2024–2026 (US$ Mn)
      • Market Size and Forecast, By Country, 2024–2026 (US$ Mn)
        • GCC
        • Israel
        • Rest of Middle East
  7. Competitive Landscape
    • Company Profiles
      • Asahi Kasei Corporation
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • GlaxoSmithKline Plc
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • Johnson & Johnson
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • AstraZeneca Plc
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • Evotec AG
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • RaQualia Pharma
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
  8. Section
    • References
    • Research Methodology
    • About us and Sales Contact

*Browse 16 market data tables and 14 figures on "P2X7 Receptor Antagonists Market - Global forecast to 2026”.

Research Methodology

Coherent Market Insights followsa comprehensive research methodology focused on providing the most precise market analysis. The company leverages a data triangulation model which helps company to gauge the market dynamics and provide accurate estimates. Key components of the research methodologies followed for all our market reports include:

  • Primary Research (Trade Surveys and Experts Interviews)
  • Desk Research
  • Proprietor Data Analytics Model

In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.


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Coherent Market Insights desk research is based on a principle set of research techniques:

  • National level desk research: It Includes research analysis of regional players, regional regulatory bodies, regional trade associations, and regional organization.
  • Multinational level desk research: The research team keeps a track of multinational players, global regulatory bodies, global trade associations, and global organization.

Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:

  • Governmental bodies, National and international social welfare institutions, and organizations creating economic policies among others.
  • Trade association, National and international media and trade press.
  • Company Annual reports, SEC filings, Corporate Presentations, press release, news, and specification sheet of manufacturers, system integrators, brick and mortar - distributors and retailers, and third party online commerce players.
  • Scientific journals, and other technical magazines and whitepapers.

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Preliminary Data Mining

The raw data is obtained through the secondary findings, in house repositories, and trade surveys. It is then filtered to ensure that the relevant information including industry dynamics, trends, and outlook is retained for further research process.

Data Standardization:

Holistic approach is used to ensure that the granular and uncommon parameters are taken into consideration to ensure accurate results. The information from the paid databases are further combined to the raw data in order to standardize it.

Coherent Statistical model

We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:

  • Micro-economic indicators
  • Macro-economic indicators
  • Environmental indicators
  • Socio-political indicators
  • Technology indicators

Data Processing

Once the findings are derived from the statistical model, large volume of data is process to confirm accurate research results. Data analytics and processing tools are adopted to process large chunk of collected informative data. In case, a client customizes the study during the process, the research finding till then are benchmarked, and the process for new research requirement is initiated again.

Data Validation

This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:

  • It provides first-hand information on the market dynamics, outlook, and growth parameters.
  • Industry experts validates the estimates which helps the company to cement the on-going research study.
  • Primary research includes online surveys, face-to face interviews, and telephonic interviews.

The primary research is conducted with the ecosystem players including, but not limited to:

  • Raw Material Suppliers
  • Manufacturers
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