Impact Analysis of Covid-19

The complete version of the Report will include the impact of the COVID-19, and anticipated change on the future outlook of the industry, by taking into the account the political, economic, social, and technological parameters.

Tissue Glue and Bio-adhesive Sealants Market – Insights

Tissue glue is used as an alternative method for wound closure that is painless, fast, and does not require a follow-up visit for removal. Tissue glue is made from cyanoacrylate compounds. Tissue glue finds application in superficial lacerations, low wound tension, and after placement of deep sutures to close skin.

Bio-adhesive sealants are developed from proteins, collagen, thrombin, fibrin, gelatin, and polysaccharides such as chitosan are used for acute thoracic aortic dissection repair, controlling intraoperative bleeding in vascular procedures, and for soft tissue sealing.

The global tissue glue and bio-adhesive sealants market is estimated to account for US$ 1,509.6 Mn in terms of value in 2019 is expected to reach US$ 2,876.9 Mn by the end of 2027.

Global Tissue Glue and Bio-adhesive Sealants Market: Drivers

Increasing prevalence of bone-related disorders is expected to propel growth of the global tissue glue and bio-adhesive sealants market over the forecast period. For instance, according to the paper ‘New Osteoporotic/Vertebral Compression Fractures’, published in 2018 by National Center for Biotechnology Information (NCBI), the U.S. records 700,000 cases of vertebral compression fractures, annually.

Increasing number of arthroplasty procedures is also expected to aid in growth of the market. For instance, in 2018, the American Academy of Orthopaedic Surgeons (AAOS) and the American Joint Replacement Registry (AJRR) recorded over 1 million patients and over 1.4 million hip and knee arthroplasty procedures.

North America region held dominant position in the global tissue glue and bio-adhesive sealants market in 2018, accounting for 51.5% share in terms of value, followed by Europe.

Tissue Glue and Bio-adhesive Sealants  | Coherent Market Insights

Global Tissue Glue and Bio-adhesive Sealants Market: Restraints

There are several complications in cemented arthroplasty such as inflammation of surrounding soft tissue and breakdown of cement, which may prompt the need for second arthroplasty surgery. Such risks decrease the demand for cemented arthroplasty, which in turn restrains growth of the global tissue glue and bio-adhesive sealants market to a certain extent.

Moreover, lack of adoption of tissue glue and bio-adhesive sealants in emerging economies is also expected to hamper growth of the market. This can be attributed to lack of awareness regarding the benefits, clinical efficacy, safety, and cost-effectiveness of tissue glue and bio-adhesive sealants compared to substitute products or procedures and tissue repair therapies.

Global Tissue Glue and Bio-adhesive Sealants Market: Opportunities

Increasing number of surgeries and amputations is expected to offer lucrative growth opportunities for players in the global tissue glue and bio-adhesive sealants market. For instance, according to the study, ‘Estimating the Prevalence of Limb Loss in the United States: 2005 to 2050", published in the Archives of Physical Medicine and Rehabilitation, there will be an estimated 3.6 million people in the U.S. living with limb loss by 2050.

Moreover, increasing R&D in tissue glue and bio-adhesive sealants is also expected to aid in growth of the market. For instance, in December 2018, researchers from Uppsala University and Stockholm University reported development of new class of bioinspired calcium phosphate cements that can glue tissues together and bond tissues to metallic and polymeric biomaterials.

Tissue Glue and Bio-adhesive Sealants  | Coherent Market Insights

Market Trends/Key Takeaways

The market is witnessing increasing adoption of inorganic activities by market players. For instance, in December 2019, CryoLife, Inc. partnered with Misonix for commercialization of CryoLife's NeoPatch product for the treatment of various indications outside of cardiac and vascular surgery. 

Key players in the market are focused on adopting tissue glue and bio-adhesive sealants in reconstruction of peripheral nerves. For instance, in January 2018, Gecko Biomedical received a funding of US$6 million under the Investments for the Future Program for R&D in reconstruction of peripheral nerves using 3D-printed micro-conducts secured by one of the company’s exclusive adhesives.

Regulations

U.S.

U.S. FDA Regulations for Human Cells, Tissues, and Cellular and Tissue-based Products (HCT/Ps)

  • Human cells, tissues, and cellular and tissue-based products (HCT/P's) are regulated by the Center for Devices and Radiological Health (CDRH) 
  • Products are included under Section 361 of PHS Act
  • Premarket review and approval not required; Product regulated solely under Tissue Regulations to control spread of communicable disease (21 CRF 1271)
  • Establishment registration and product listing required (21 CRF 1271 -Subpart B)

These HCT/P's are regulated solely as "361 products" when they meet all of the criteria in 21 CFR 1271.10(a):

  • Bone (including demineralized bone)
  • Ligaments
  • Tendons
  • Fascia
  • Cartilage
  • Ocular tissues (corneas & sclera)
  • Skin
  • Vascular grafts (veins & arteries), except preserved umbilical cord veins
  • Pericardium
  • Amniotic membrane (when used alone (-without added cells-) for ocular repair)
  • Dura mater
  • Heart valve allografts
  • Hematopoietic stem cells derived from peripheral or umbilical cord blood
  • Semen
  • Oocytes
  • Embryos

Value Chain Analysis

Tissue Glue and Bio-adhesive Sealants  | Coherent Market Insights

Global Tissue Glue and Bio-adhesive Sealants Market: Competitive Landscape

Major players operating in the global tissue glue and bio-adhesive sealants market include, Cryolife, Baxter International Inc., Luna Innovations Incorporated, B. Braun Melsungen AG, Johnson and Johnson, Dentsply Sirona Inc., Cohera Medical, Inc., Chemence Medical, Inc., Tissuemed Ltd., C.R. Bard Inc., and Integra LifeSciences Corporation.

Global Tissue Glue and Bio-adhesive Sealants Market: Key Developments

Key players in the market are focused on product development and approval to expand their product portfolio. For instance, in January 2020, Polyganics received CE marking for LIQOSEAL, its easy-to-use and innovative dural sealant patch.

Key players in the market are focused on adopting MA&A strategies to expand their product portfolio. For instance, in December 2019, Advanced Medical Solutions Group plc., a provider of tissue adhesives,  acquired Biomatlante SA, a developer and manufacturer of surgical biomaterial technologies.

Bio adhesives are naturally present polymeric material and possess adhesive properties. Synthetic bio adhesives are also available in the market and have different applications such as protections of tissues, to promote wound healing, replacement for surgical sutures, and as a replacement for conventional drug delivery systems. Bio adhesives are biocompatible products, and hence are often used in biological applications and mainly in surgeries as sealants. Manufacturers such as Cryolife, Baxter International Inc., Luna Innovations Incorporated, B. Braun Melsungen AG, Johnson and Johnson and others offer products in this market. For instance, in December 2019, CryoLife, Inc. partnered with Misonix for commercialization of CryoLife's NeoPatch product for the treatment of various indications outside of cardiac and vascular surgery.

Restraints of the Global Tissue Glue and Bio-Adhesive Sealants Market

Presence of variety of traditional sealants, and sutures is expected to restrain growth of the market over the forecast period. Moreover, low awareness of such products in emerging economies is also expected to negatively impact growth of the market over the forecast period.

Key features of the study:

  • This report provides in-depth analysis of the global tissue glue and bio-adhesive sealants market and provides market size (US$ Million) and compound annual growth rate (CAGR %) for the forecast period (2019–2027), considering 2018, as the base year
  • It elucidates potential revenue opportunity across different segments and explains attractive investment proposition matrix for this market
  • This study also provides key insights about market drivers, restraints, opportunities, new product launches or approval, regional outlook, and competitive strategy adopted by leading players
  • It profiles leading players in the global tissue glue and bio-adhesive sealants market based on the following parameters – company overview, financial performance, product portfolio, geographical presence, distribution strategies, key developments, strategies, and future plans
  • Key companies covered as a part of this study include Cryolife, Baxter International Inc., Luna Innovations Incorporated, B. Braun Melsungen AG, Johnson and Johnson, Dentsply Sirona Inc., Cohera Medical, Inc., Chemence Medical, Inc., Tissuemed Ltd., C.R. Bard Inc., and Integra LifeSciences Corporation.
  • Insights from this report would allow marketers and the management authorities of companies to make informed decision regarding future product launches, technology up-gradation, market expansion, and marketing tactics
  • The global tissue glue and bio-adhesive sealants market report caters to various stakeholders in this industry including investors, suppliers, product manufacturers, distributors, new entrants, and financial analysts.
  • Stakeholders would have ease in decision-making through various strategy matrices used in analyzing the market.

Detailed Segmentation

  •  Global Tissue Glue and Bio-Adhesive Sealants Market, By Product Type:
    • Protein Based Sealants
    • Collagen Based Sealants
    • Thrombin-based Sealants
    • Fibrin Sealant
    • Gelatin-based Sealant
    • Others
  • Global Tissue Glue and Bio-Adhesive Sealants Market, By Application:
    • Cardiovascular Surgery
    • Laparoscopic Surgeries
    • Burns and Skin Grafting
    • Digestive
    • Cosmetic, Reconstructive and Hand Surgery
    • General Surgeries
    • Others
  • Global Tissue Glue and Bio-Adhesive Sealants Market, By End User:
    • Hospitals
    • Specialty Clinics
    • Ambulatory Surgical Centers (ASCs)
  • Global Tissue Glue and Bio-Adhesive Sealants Market, By Geography:
    • North America
      • By Product Type
        • Protein Based Sealants
        • Collagen Based Sealants
        • Thrombin-based Sealants
        • Fibrin Sealant
        • Gelatin-based Sealant
        • Others
      • Application
        • Cardiovascular Surgery
        • Laparoscopic Surgeries
        • Burns and Skin Grafting
        • Digestive
        • Cosmetic, Reconstructive and Hand Surgery
        • General Surgeries
        • Others
      • By End User
        • Hospitals
        • Specialty Clinics
        • Ambulatory Surgical Centers (ASCs)
      • By Country:
        • U.S.
        • Canada
    • Europe
      • By Product Type
        • Protein Based Sealants
        • Collagen Based Sealants
        • Thrombin-based Sealants
        • Fibrin Sealant
        • Gelatin-based Sealant
        • Others
      • Application
        • Cardiovascular Surgery
        • Laparoscopic Surgeries
        • Burns and Skin Grafting
        • Digestive
        • Cosmetic, Reconstructive and Hand Surgery
        • General Surgeries
        • Others
      • By End User
        • Hospitals
        • Specialty Clinics
        • Ambulatory Surgical Centers (ASCs)
      • By Country:
        • U.K.
        • Germany
        • Italy
        • France
        • Spain
        • Russia
        • Rest of Europe
    • Asia Pacific
      • By Product Type
        • Protein Based Sealants
        • Collagen Based Sealants
        • Thrombin-based Sealants
        • Fibrin Sealant
        • Gelatin-based Sealant
        • Others
      • Application
        • Cardiovascular Surgery
        • Laparoscopic Surgeries
        • Burns and Skin Grafting
        • Digestive
        • Cosmetic, Reconstructive and Hand Surgery
        • General Surgeries
        • Others
      • By End User
        • Hospitals
        • Specialty Clinics
        • Ambulatory Surgical Centers (ASCs)
      • By Country:
        • China
        • India
        • Japan
        • ASEAN
        • Australia
        • South Korea
        • Rest of Asia Pacific
    • Latin America
      • By Product Type
        • Protein Based Sealants
        • Collagen Based Sealants
        • Thrombin-based Sealants
        • Fibrin Sealant
        • Gelatin-based Sealant
        • Others
      • Application
        • Cardiovascular Surgery
        • Laparoscopic Surgeries
        • Burns and Skin Grafting
        • Digestive
        • Cosmetic, Reconstructive and Hand Surgery
        • General Surgeries
        • Others
      • By End User
        • Hospitals
        • Specialty Clinics
        • Ambulatory Surgical Centers (ASCs)
      • By Country:
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
    • Middle East:
      • By Product Type
        • Protein Based Sealants
        • Collagen Based Sealants
        • Thrombin-based Sealants
        • Fibrin Sealant
        • Gelatin-based Sealant
        • Others
      • Application
        • Cardiovascular Surgery
        • Laparoscopic Surgeries
        • Burns and Skin Grafting
        • Digestive
        • Cosmetic, Reconstructive and Hand Surgery
        • General Surgeries
        • Others
      • By End User
        • Hospitals
        • Specialty Clinics
        • Ambulatory Surgical Centers (ASCs)
      • By Country:
        • GCC
        • Israel
        • Rest of Middle East
    • Africa
      • By Product Type
        • Protein Based Sealants
        • Collagen Based Sealants
        • Thrombin-based Sealants
        • Fibrin Sealant
        • Gelatin-based Sealant
        • Others
      • Application
        • Cardiovascular Surgery
        • Laparoscopic Surgeries
        • Burns and Skin Grafting
        • Digestive
        • Cosmetic, Reconstructive and Hand Surgery
        • General Surgeries
        • Others
      • By End User
        • Hospitals
        • Specialty Clinics
        • Ambulatory Surgical Centers (ASCs)
      • By Country/Region:
        • Central Africa
        • South Africa
        • North Africa
  • Company Profiles
    • Cryolife, Inc.*
      • Company Overview
      • Product Portfolio
      • Financial Performance
      • Key Strategies
      • Recent Developments
    • Baxter International Inc.
    • Luna Innovations Incorporated
    • B. Braun Melsungen AG
    • Johnson and Johnson
    • Dentsply Sirona Inc.
    • Cohera Medical, Inc.
    • Chemence Medical, Inc.
    • Tissuemed Ltd.
    • C.R. Bard Inc.
    • Integra LifeSciences Corporation

“*” marked represents similar segmentation in other categories in the respective section.

Table of Contents

  1. Research Objective and Assumption
    • Research Objectives
    • Assumptions
    • Abbreviations
  2. Market Purview
    • Report Description
      • Market Definition and Scope
    • Executive Summary
      • Market Snippet, By Product Type
      • Market Snippet, By Application
      • Market Snippet, By End User
    • Coherent Opportunity Map (COM)
  3. Market Dynamics, Regulations, and Trends Analysis
    • Market Dynamics
      • Drivers
      • Restraints
      • Market Opportunities
    • Impact Analysis
    • Key Developments
    • Technological Advancement
    • Regulatory Scenario
  4. Global Tissue Glue and Bio-adhesive Sealants Market, By Product Type, 2017 – 2027 (US$ Mn)
    • Introduction
      • Market Share Analysis, 2019 and 2027 (%)
      • Y-o-Y Growth Analysis, 2019–2027
      • Segment Trends
    • Protein Based sealants
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019 – 2027, (US$ Mn)
      • Segment Trends
    • Collagen Based sealants
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019 – 2027, (US$ Mn)
      • Segment Trends
    • Thrombin-based Sealants
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019 – 2027, (US$ Mn)
      • Segment Trends
    • Fibrin Sealant
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019 – 2027, (US$ Mn)
      • Segment Trends
    • Gelatin-based Sealants
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019 – 2027, (US$ Mn)
      • Segment Trends
    • Others
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019 – 2027, (US$ Mn)
      • Segment Trends
  5. Global Tissue Glue and Bio-adhesive Sealants Market, By Application, 2017 – 2027 (US$ Mn)
    • Introduction
      • Market Share Analysis, 2019 and 2027 (%)
      • Y-o-Y Growth Analysis, 2019–2027
      • Segment Trends
    • Cardiovascular Surgery
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019 – 2027, (US$ Mn)
    • Laparoscopic Surgeries
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019 – 2027, (US$ Mn)
    • Burns and Skin Grafting
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019 – 2027, (US$ Mn)
    • Digestive
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019 – 2027, (US$ Mn)
    • Cosmetic, Reconstructive and Hand Surgery
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019 – 2027, (US$ Mn)
    • General Surgeries
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019 – 2027, (US$ Mn)
    • Others
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019 – 2027, (US$ Mn)
  6. Global Tissue Glue and Bio-adhesive Sealants Market, By End User, 2017 – 2027 (US$ Mn)
    • Introduction
      • Market Share Analysis, 2019 and 2027 (%)
      • Y-o-Y Growth Analysis, 2019–2027
      • Segment Trends
    • Hospitals
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019 – 2027, (US$ Mn)
    • Specialty Clinics
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019 – 2027, (US$ Mn)
    • Ambulatory Surgical Centers (ASCs)
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019 – 2027, (US$ Mn)
  7. Global Tissue Glue and Bio-adhesive Sealants Market, By Regions, 2017 – 2027 (US$ Mn)
    • Introduction
      • Market Share Analysis, 2019 and 2027 (%)
      • Y-o-Y Growth Analysis, 2019–2027
      • Segment Trends
    • North America
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019 – 2027, (US$ Mn)
        • U.S.
        • Canada
    • Europe
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019 – 2027, (US$ Mn)
        • U.K.
        • Germany
        • Italy
        • France
        • Spain
        • Russia
        • Rest of Europe
    • Asia Pacific
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019 – 2027, (US$ Mn)
        • China
        • India
        • Japan
        • ASEAN
        • Australia
        • South Korea
        • Rest of Asia Pacific
    • Latin America
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019 – 2027, (US$ Mn)
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
    • Middle East
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019 – 2027, (US$ Mn)
        • GCC
        • Israel
        • Rest of Middle East
    • Africa
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019 – 2027, (US$ Mn)
        • North Africa
        • Central Africa
        • South Africa
  8. Competitive Landscape
    • Company Profiles
      • Cryolife, Inc.
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • Baxter International Inc.
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • Luna Innovations Incorporated
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • Braun Melsungen AG
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • Johnson and Johnson
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • Dentsply Sirona Inc.
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • Cohera Medical, Inc.
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • Chemence Medical, Inc.
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • Tissuemed Ltd.
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • R. Bard Inc.
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • Integra LifeSciences Corporation
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
  9. Section
    • References
    • Research Methodology
    • About us and Sales Contact

*Browse 26 market data tables and 22 figures on “Tissue Glue and Bio-adhesive Sealants Market – Global forecast to 2027.

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