Ursodeoxycholic Acid Market – Insights
Ursodeoxycholic acid (UDCA) is a bile acid taken as either a tablet or liquid to treat gallstones and to treat and prevent the progression of cystic fibrosis-related liver disorder. UDCA modifies the bile acid pool by decreasing levels of hydrophobic bile acids while increasing proportion of nontoxic hydrophilic bile acids. UDCA can delay development of gastroesophageal varices and progression to cirrhosis. Moreover it can improve long-term survival in patients with primary biliary cirrhosis.
Significant improvement in liver health can be achieved during UDCA therapy in patients with intrahepatic cholestasis of pregnancy, primary sclerosing cholangitis, nonalcoholic fatty liver disease, cystic fibrosis-associated liver disease, total parenteral nutrition-induced cholestasis, graft related liver disease, and in some pediatric cholestatic liver diseases.
The global ursodeoxycholic acid market size was valued at US$ 346.2 million in 2017, and is expected to witness a CAGR of 7.0% over the forecast period (2018 – 2026).
Global Ursodeoxycholic Acid Market Share (%) Analysis, By Application 2017
Source: Coherent Market Insights Analysis (2018)
Increasing prevalence of gall stones and cystic fibrosis is expected to drive growth of the ursodeoxycholic acid market
Ursodeoxycholic acid is increasingly being used for the treatment of chronic cholestatic liver diseases. Increasing prevalence of cystic fibrosis and gall stones is a major factor driving growth of the global ursodeoxycholic acid market during the forecast period. According to the Cystic Fibrosis Foundation 2015 data, around 30,000 people suffered from cystic fibrosis in the U.S. Moreover, around 1,000 new cases of cystic fibrosis are diagnosed in the country, annually. According to the American Gastroenterological Association 2017 report, gallstones is affecting 10-15% of the U.S. population annually, which accounts for around 25 million people.
Women are more likely to develop gallstones in comparison to men. High estrogen levels during pregnancy, birth control pills or hormone replacement therapy are the major factors that produce gallstones in women. Moreover, occurrence of gallstones is also high in older adults and individuals with a family history of gallstones. Surgery is the usual treatment for symptomatic gallstones, however treatment with ursodeoxycholic acid can dissolve smaller stones, which are made mainly of cholesterol.
Ursodeoxycholic Acid Market Restraints
However, some side effects of UDCA are expected to hinder growth of the ursodeoxycholic acid market. Diarrhea is the single most frequent adverse event during UDCA treatment in patients with gallstone disease. According to a study published in the National Center for Biotechnology Information (NCBI) in 2017, diarrhea incidence in gallstone disease patients prescribed with UDCA, was found to be in the range of 2%–9%. Other possible side effects of UDCA include, nausea, vomiting, itching or dry skin, headache, and sleep disturbances. Moreover, side effects of UDCA are evident in pregnant women and its use should be avoided during the first three months of pregnancy.
Ursodeoxycholic Acid Market - Regional Insights
On the basis of region, the global ursodeoxycholic acid market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa. Europe is expected to generate a significant revenue share in the global ursodeoxycholic acid market by 2026, owing to increasing government support for liver diseases treatment. For instance, the American Liver Foundation is a national, non-profit organization that is dedicated to the prevention, treatment, and cure of various liver diseases through research, education, and advocacy.
Global Ursodeoxycholic Acid Market Value (US$ Mn) & Y-o-Y Growth (%)
Source: Coherent Market Insights Analysis (2018)
Ursodeoxycholic Acid Market - Competitive Landscape
Key players operating in the global ursodeoxycholic acid market include, Abil Chempharma, Arcelor Chemicals, Biotavia Labs, Daewoong Chemical, Dipharma Francis, Erregierre, Grindeks, ICE, Mitsubishi Tanabe, Pharma Zell, Suzhou Tianlu, and Zhangshanbelling.
Ursodeoxycholic acid (UDCA) is a naturally occurring bile acid and is used to dissolve gallstones that are rich in cholesterol. It is also used to improve the flow of bile in primary biliary cirrhosis. UDCA solubilizes cholesterol gallstones and improves the liver function in case of cholestatic diseases. UDCA can be obtained from cholic acid, which is the most abundant and least expensive bile acid available.
Increasing incidence of gallstones and cystic fibrosis is expected to propel demand for UDCA, thereby driving the ursodeoxycholic acid market growth. According to a study published in the journal Gastroenterology, 2009, cholelithiasis, the presence of gallstones in the gallbladder, is estimated to occur in 10 – 15% of the adult population in the U.S. Although, gallstones can occur at any age, it is rare before the age of 30. A progressive increase in risk of cholelithiasis is observed with age and in patients over 50, the prevalence ranges is between 25-30%.
Moreover, prevalence of gallstones is two to three times higher in women than in men. According to the American College of Gastroenterology 2018 report, gallstones occur in around 20% of women by the age of 60. Moreover, women between the age of 20 and 60 years are three times more likely to develop gallstones than men.
Furthermore, increasing research studies conducted over the applications of UCDA in other disease indications is expected to fuel growth of the global ursodeoxycholic acid market. According to the University of Sheffield August 2018 study, UDCA improves mitochondrial dysfunction, which is known to be a causative factor for both sporadic and familial Alzheimer’s disease. However, side effects associated with the use of UDCA including diarrhoea, indigestion, headache, nausea, vomiting, unusual bleeding or bruising are expected to confine growth of the market during the forecast period.
Key features of the study:
“*” marked represents similar segmentation in other categories in the respective section.
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