Impact Analysis of Covid-19

The complete version of the Report will include the impact of the COVID-19, and anticipated change on the future outlook of the industry, by taking into the account the political, economic, social, and technological parameters.

Bone Graft and Substitutes Market Insights

Bone grafting is a surgical procedures which includes replacement of missing bone. Different types of bone grafts such as autologous bone graft, allograft, and synthetic bone graft are used in bone grafting procedures. Increasing adoption of bone graft substitutes such as ceramics, polymers, bioactive glass, and others are expected to drive the market growth over the forecast period. Technological advancements in implementation of human growth factors into bone grafts that has osteoconductive and osteoinductive properties such as demineralized bone matrix, bone morphogenetic proteins, and platelet rich plasma (PRP), are expected to offer growth opportunities for market players to establish a strong position in the global bone graft and substitutes market over the forecast period.

Researchers are focused on developing innovative bone grafts for treating bone related disorders. For instance, in 2015, scientists at the Texas A&M University, developed a new synthetic material- a biodegradable scaffold to fill the gaps for new bone growth to advance grafting treatments required by the people for treating bone defects and bone cancers.

The global bone graft and substitutes market is estimated to be valued at US$ 3,046.7 million in 2019, and is expected to exhibit a CAGR of 5.5% during the forecast period (2019–2027).

Figure 1. Global Bone Graft and Substitutes Market Share (%), By Product Type, (2019 & 2027)

Bone Graft & Substitutes  | Coherent Market Insights

Source: Coherent Market Insights Analysis (2019)

Increasing prevalence of bone cancer is expected to drive global bone graft and substitutes market growth

Rising prevalence of bone cancer is expected to fuel demand for bone grafts and substitutes thereby supporting the global bone graft and substitutes market growth over the forecast period. For instance, according to 2017 American Society of Clinical Oncology (ASCO) estimates, around 3,450 people of all ages in the U.S. were diagnosed with primary bone cancer. Thus, new cases of bone cancer are expected to propel growth of the bone cancer treatment market in the U.S.

Furthermore, key players are focused on strategies such as acquisitions is expected to drive the global bone graft and substitutes market growth over the forecast period. For instance, Kuros Biosciences acquired Xpand Biotechnology in 2016, as a share swapping deal, wherein Kuros used Xpand’s granular formulation ‘MagnetOs’, in order to prepare novel dental bone grafts. With this acquisition, Kuros has anticipated to make significant sales in Europe, American states, and other regions.

Global Bone Graft and Substitutes Market- Restraints

Bone grafting surgeries have provided life-sustaining options to large number of patients suffering from various bone issues, however, the risks associated with surgery failure and graft failure are expected to hamper the market growth over the forecast period. For instance, according to Dental-Implants-01, the dental bone graft failure rates range from 5-10% on an average, as a result of infections and improper stabilization of the grafts. Thus, the failure of implantation is expected to hinder growth of the global bone graft and substitutes market over the forecast period.

Global Bone Graft and Substitutes Market- Regional Analysis

Regional segmentation of the global bone graft and substitutes market comprises North America, Latin America, Europe, Asia Pacific, Middle East, and Africa.

North America is expected to hold a dominant position in the global bone graft and substitutes market over the forecast period, owing to factors such as advancements in the field of bone grafting technology and bone graft and substitutes by the key players in the region. For instance, the U.S-based Artoss, Inc. incorporated nano-biology and nanotechnology while manufacturing artificial bone grafts. The company launched NanoBone granules in 2015, followed by NanoBone SFX putty in 2016. Moreover, Thermo Fisher Scientific Inc., EverlyWell, Inc., Lactation Lab, and OmegaQuant, LLC are some of the U.S.-based companies that offer various types of bone graft and substitutes market in the region.

Moreover, Europe is expected to witness significant growth in the global bone graft and substitutes market over the forecast period, owing to rising number of implant procedures performed in the European countries that are expected to drive demand for bone graft and substitutes in Europe. For instance, according to Meddevicetracker, over 56,000 shoulder arthroplasty surgeries were performed in Europe in 2015. New generation implants such as bone grafts have demonstrated improved clinical outcomes thereby reducing the complications.

Furthermore, Asia Pacific is expected to witness significant global bone graft and substitutes market growth, owing to increasing initiatives by Asia Pacific countries such as China, Japan and India in the development of innovative products of bone graft and its substitutes. For instance, the National Chemical Laboratory, Pune (India) developed two new bone graft substitutes PoroSyn and SynOst (bioactive synthetic bone graft granules and putty) in May 2017 that aims to augment and regenerate the bones lost during an accident, disease or injury.

Figure 2: Global Bone Graft and Substitutes Market Share (%), By Region, (2019 & 2027)

Bone Graft & Substitutes  | Coherent Market Insights

Source: Coherent Market Insights Analysis (2019)

Global Bone Graft and Substitutes Market- Competitive Landscape

Key players operating in the global bone graft and substitutes market include Ace Surgical Supply Co., Inc., NovaBone Product, LLC., Exactech, Inc., Medtronic Plc., LifeNet Health, Zimmer Biomet Holdings, Inc., Stryker Corporation., BioHorizons Implant Systems, Inc., Globus Medical, Inc., RTI Surgical, Inc., Geistlich Pharma, Megagen, Novadip Biosciences, Mesoblast Ltd., Alphatec Spine, Inc., Institut Straumann AG, NuVasive, Inc., OsteoMed LLC, KYERON Medical Innovations, ORTHOFIX INTERNATIONAL N.V., Johnson & Johnson, Bone Therapeutics SA, K2M Group Holdings, Inc., and OsteoNovus

The incorporation of a bone graft can be defined as a procedure of interdigitation and envelopment of the donor bone tissue with the new bone deposited by the recipient. It is a versatile that replaces the lost bone tissue, enhances bone growth using natural mechanisms. The natural bone graft are the most successful types of bone grafts and are considered to be the gold standard for replacement of missing bones. Bone grafts are in used in various purposes such as to fill the cavities resulting from cysts, tumors, or other causes, to stimulate the healing of fractures that have failed to heal after an initial treatment attempt, and others.

Market Dynamics

According to the Journal of Materials Science and Materials in Medicine, 2014, bone grafting frequency is the second most frequent tissue transplantation technique carried out globally after blood transfusion. The 2014 statistics reported in the Journal of Materials Science and Materials in Medicine, states that over 2 million bone grafting procedures are performed annually with over 500,000 graft implant procedures carried out in the U.S. itself. This is attributed to the ease of use and handling of new devices, improved safety profile, time advantages, intraoperative costs as well as the adaptability to a variety of clinical challenges.

The global bone graft, substitutes and membrane market is expected to witness a significant growth over the forecast period, owing to adoption of new technologies by manufacturers for development of innovative and novel bone graft substitutes. This includes the launches of novel growth factor enhanced grafts that improves the quality of grafts in terms of post-surgical recovery. For instance, in 2015, Cerapedics, a privately owned orthobiologics company received the U.S. FDA approval for i-Factor, which is a peptide enhanced graft that is used in cervical discectomy and fusion. The graft was based on small peptide (P-15) technology that helps in supporting bone growth through cell attachment and activation

Key features of the study:

  • This report provides in-depth analysis of the global bone graft and substitutes market, market size (US$ Mn), and compound annual growth rate (CAGR %) over the forecast period (2019–2027), considering 2018 as the base year
  • It elucidates potential revenue opportunities across different segments and explains attractive investment proposition matrices for this market
  • This study also provides key insights about market drivers, restraints, opportunities, new technology launches or approval, market trends, regional outlook, and competitive strategies adopted by leading players
  • It profiles leading players in the global bone graft and substitutes market based on the following parameters – company overview, financial performance, technology portfolio, geographical presence, distribution strategies, key developments, and strategies
  • Key players covered as a part of this study include Ace Surgical Supply Co., Inc., NovaBone Product, LLC., Exactech, Inc., Medtronic Plc., LifeNet Health, Zimmer Biomet Holdings, Inc., Stryker Corporation., BioHorizons Implant Systems, Inc., Globus Medical, Inc., RTI Surgical, Inc., Geistlich Pharma, Megagen, Novadip Biosciences, Mesoblast Ltd., Alphatec Spine, Inc., Institut Straumann AG, NuVasive, Inc., OsteoMed LLC, KYERON Medical Innovations, ORTHOFIX INTERNATIONAL N.V., Johnson & Johnson, Bone Therapeutics SA, K2M Group Holdings, Inc., and OsteoNovus
  • Insights from this report would allow marketers and management authorities of companies to make informed decision with respect to future technology launches, government initiatives, technological upgradation, market expansion, and marketing tactics
  • The global bone graft and substitutes market report caters to various stakeholders in this market, including investors, technology manufacturers, distributors, and suppliers for global bone graft and substitutes market, research and consulting firms, new entrants, and financial analysts

Detailed Segmentation:

  • Global bone graft and substitutes market, by product type:
    • Bone Grafts
        • Allografts
        • Xenografts
    • Bone Graft Substitutes
        • Ceramics
        • Composites
        • Polymers
        • Demineralized Bone Matrix
        • Bone Morphogenetic Proteins
        • Others
  • Global bone graft and substitutes market, by application:
    • Spinal Fusion
    • Dental Bone Grafts
    • Craniomaxillofacial
    • Joint Reconstruction
    • Trauma & Extremities
    • Oncology
  • Global bone graft and substitutes market, by region:
    • North America
      • By Country:
        • U.S.
        • Canada
      • By Product Type:
        • Bone Grafts
            • Allografts
            • Xenografts
        • Bone Graft Substitutes
            • Ceramics
            • Composites
            • Polymers
            • Demineralized Bone Matrix
            • Bone Morphogenetic Proteins
            • Others
      • By Application:
        • Spinal Fusion
        • Dental Bone Grafts
        • Craniomaxillofacial
        • Joint Reconstruction
        • Trauma & Extremities
        • Oncology
    • Europe
      • By Country:
        • U.K.
        • Germany
        • Italy
        • Spain
        • France
        • Russia
        • Rest of Europe
      • By Product Type:
        • Bone Grafts
            • Allografts
            • Xenografts
        • Bone Graft Substitutes
            • Ceramics
            • Composites
            • Polymers
            • Demineralized Bone Matrix
            • Bone Morphogenetic Proteins
            • Others
      • By Application:
        • Spinal Fusion
        • Dental Bone Grafts
        • Craniomaxillofacial
        • Joint Reconstruction
        • Trauma & Extremities
        • Oncology
    • Asia Pacific
      • By Country:
        • Australia
        • India
        • China
        • Japan
        • ASEAN
        • South Korea
        • Rest of Asia Pacific
      • By Product Type:
        • Bone Grafts
            • Allografts
            • Xenografts
        • Bone Graft Substitutes
            • Ceramics
            • Composites
            • Polymers
            • Demineralized Bone Matrix
            • Bone Morphogenetic Proteins
            • Others
      • By Application:
        • Spinal Fusion
        • Dental Bone Grafts
        • Craniomaxillofacial
        • Joint Reconstruction
        • Trauma & Extremities
        • Oncology
    • Latin America
      • By Country:
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
      • By Product Type:
        • Bone Grafts
            • Allografts
            • Xenografts
        • Bone Graft Substitutes
            • Ceramics
            • Composites
            • Polymers
            • Demineralized Bone Matrix
            • Bone Morphogenetic Proteins
            • Others
      • By Application:
        • Spinal Fusion
        • Dental Bone Grafts
        • Craniomaxillofacial
        • Joint Reconstruction
        • Trauma & Extremities
        • Oncology
    • Middle East
      • By Country:
        • GCC
        • Israel
        • Rest of Middle East
      • By Product Type:
        • Bone Grafts
            • Allografts
            • Xenografts
        • Bone Graft Substitutes
            • Ceramics
            • Composites
            • Polymers
            • Demineralized Bone Matrix
            • Bone Morphogenetic Proteins
            • Others
      • By Application:
        • Spinal Fusion
        • Dental Bone Grafts
        • Craniomaxillofacial
        • Joint Reconstruction
        • Trauma & Extremities
        • Oncology
    • Africa
      • By Country/Region:
        • South Africa
        • Central Africa
        • North Africa
      • By Product Type:
        • Bone Grafts
            • Allografts
            • Xenografts
        • Bone Graft Substitutes
            • Ceramics
            • Composites
            • Polymers
            • Demineralized Bone Matrix
            • Bone Morphogenetic Proteins
            • Others
      • By Application:
        • Spinal Fusion
        • Dental Bone Grafts
        • Craniomaxillofacial
        • Joint Reconstruction
        • Trauma & Extremities
        • Oncology
  • Company Profiles
      • Ace Surgical Supply Co., Inc.*
        • Company Overview
        • Technology Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • NovaBone Product, LLC.
      • Exactech, Inc.
      • Medtronic Plc.
      • LifeNet Health
      • Zimmer Biomet Holdings, Inc.
      • Stryker Corporation.
      • BioHorizons Implant Systems, Inc.
      • Globus Medical, Inc.
      • RTI Surgical, Inc
      • Geistlich Pharma
      • Megagen
      • Novadip Biosciences
      • Mesoblast Ltd.
      • Alphatec Spine, Inc.
      • Institut Straumann AG
      • NuVasive, Inc.
      • OsteoMed LLC
      • KYERON Medical Innovations
      • ORTHOFIX INTERNATIONAL N.V.
      • Johnson & Johnson
      • Bone Therapeutics SA
      • K2M Group Holdings, Inc.
      • OsteoNovus

 “*” marked represents similar segmentation in other categories in the respective section.

Table of Contents

  1. Research Objectives and Assumptions
    • Research Objectives
    • Assumptions
    • Abbreviations
  2. Market Overview
    • Report Description
      • Market Definition and Scope
    • Executive Summary
      • Market Snippet, By Product Type
      • Market Snippet, By Application
      • Market Snippet, By Region
    • Coherent Opportunity Map (COM)
  3. Market Dynamics, Regulations, and Trends Analysis
    • Market Dynamics
      • Drivers
      • Restraints
      • Market Opportunities
    • Impact Analysis
    • Market Trends
    • Key Developments
    • Technology Advancements
    • Historical Overview
    • Merger and Acquisition
    • Regulatory Scenario
    • PORTER’S Five Forces
    • PEST Analysis
  4. Global Bone Graft and Substitutes Market , By Product Type, 2016 – 2027, (US$ Million)
    • Introduction
      • Market Share Analysis, 2018 and 2027 (%)
      • Y-o-Y Growth Analysis, 2017 – 2027
      • Segment Trends
    • Bone Grafts
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
        • Allografts
          • Introduction
          • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
        • Xenografts
          • Introduction
          • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
    • Bone Graft Substitutes
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
        • Ceramics
          • Introduction
          • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
        • Composites
          • Introduction
          • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
        • Polymers
          • Introduction
          • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
        • Demineralized Bone Matrix
          • Introduction
          • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
        • Bone Morphogenetic Proteins
          • Introduction
          • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
        • Others
          • Introduction
          • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
  5. Global Bone Graft and Substitutes Market , By Application, 2016 – 2027, (US$ Million)
    • Introduction
      • Market Share Analysis, 2018 and 2027 (%)
      • Y-o-Y Growth Analysis, 2017 – 2027
      • Segment Trends
    • Spinal Fusion
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
    • Dental Bone Grafts
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
    • Craniomaxillofacial
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
    • Joint Reconstruction
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
    • Trauma & Extremities
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
    • Oncology
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
  6. Global Bone Graft and Substitutes Market , By Region, 2016 – 2027, (US$ Million)
    • Introduction
      • Market Share Analysis, By Region, 2018 and 2027 (%)
      • Y-o-Y Growth Analysis, By Region, 2016 – 2027
      • Regional Trends
    • North America
      • Market Size and Forecast, By Product Type, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Application, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Country, 2016 – 2027, (US$ Million)
        • U.S.
        • Canada
    • Europe
      • Market Size and Forecast, By Product Type, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Application, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Country, 2016 – 2027, (US$ Million)
        • U.K.
        • Germany
        • Italy
        • France
        • Spain
        • Russia
        • Rest of Europe
    • Asia Pacific
      • Market Size and Forecast, By Product Type, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Application, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Country, 2016 – 2027, (US$ Million)
        • China
        • Japan
        • India
        • ASEAN
        • Australia
        • South Korea
        • Rest of Asia Pacific
    • Latin America
      • Market Size and Forecast, By Product Type, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Application, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Country, 2016 – 2027, (US$ Million)
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
    • Middle East
      • Market Size and Forecast, By Product Type, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Application, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Country, 2016 – 2027, (US$ Million)
        • GCC
        • Israel
        • Rest of Middle East
    • Africa
      • Market Size and Forecast, By Product Type, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Application, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Country/Region, 2016 – 2027, (US$ Million)
        • North Africa
        • Central Africa
        • South Africa
  7. Competitive Landscape
    • Heat Map Analysis
    • Company Profiles
      • Ace Surgical Supply Co., Inc.
        • Company Overview
        • Technology Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • NovaBone Product, LLC.
        • Company Overview
        • Technology Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Exactech, Inc.
        • Company Overview
        • Technology Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Medtronic Plc.
        • Company Overview
        • Technology Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • LifeNet Health
        • Company Overview
        • Technology Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Zimmer Biomet Holdings, Inc.
        • Company Overview
        • Technology Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Stryker Corporation.
        • Company Overview
        • Technology Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • BioHorizons Implant Systems, Inc.
        • Company Overview
        • Technology Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Globus Medical, Inc.
        • Company Overview
        • Technology Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • RTI Surgical, Inc
        • Company Overview
        • Technology Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Geistlich Pharma
        • Company Overview
        • Technology Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Megagen
        • Company Overview
        • Technology Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Novadip Biosciences
        • Company Overview
        • Technology Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Mesoblast Ltd.
        • Company Overview
        • Technology Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Alphatec Spine, Inc.
        • Company Overview
        • Technology Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Institut Straumann AG
        • Company Overview
        • Technology Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • NuVasive, Inc.
        • Company Overview
        • Technology Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • OsteoMed LLC
        • Company Overview
        • Technology Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • KYERON Medical Innovations
        • Company Overview
        • Technology Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • ORTHOFIX INTERNATIONAL N.V.
        • Company Overview
        • Technology Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Johnson & Johnson
        • Company Overview
        • Technology Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Bone Therapeutics SA
        • Company Overview
        • Technology Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • K2M Group Holdings, Inc.
        • Company Overview
        • Technology Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • OsteoNovus
        • Company Overview
        • Technology Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
    • Analyst Views
  8. Section
    • References
    • Research Methodology
    • About us and Sales Contact

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