Global Bone Graft and Substitutes Market, by Product Type (Bone Grafts and Bone Graft Substitutes), by Application (Spinal Fusion, Dental Bone Grafts, Craniomaxillofacial, Joint Reconstruction, Trauma and Extremities), and by Region (North America, Latin America, Europe, Asia Pacific, the Middle East, and Africa) and by Geography - Trends and Forecast to 2025

Bone Grafts and Substitutes Market – A Major Step Towards Regenerative Medicines

A bone graft is used to repair and rebuild diseased bone and transplant bone tissues of the hips, knees, spine, and various other bones in the body. Bone grafts are also used in order to repair the bone loss caused by fractures and cancers. The body accepts the newly implanted graft and provides a framework for growth of new living bone. Bone grafts used in a surgical procedures can be obtained either from the patient’s own body, a donor or can be entirely man-made from natural or synthetic materials. The two most common types of bone grafts used include an allograft, which refers to a bone obtained from a deceased donor or a cadaver that is sterilized and stored in the tissue or bone banks, whereas the other most frequently used bone graft includes autografts, which is obtained from the patient’s own body parts such as ribs, pelvis, wrist, and hips. Apart from autografts and allografts, bone graft substitutes made up of materials with osteoconductive and osteogenerative properties such as ceramics and polymers are also gaining popularity in the market due to the easy availability of these grafts and its nature to promote natural bone growth.

Rise in trauma cases are responsible for accelerating growth of the global bone grafts and substitutes market

Bone grafting is majorly performed in cases of sinus lift, ridge augmentation, fracture repair, nerve repositioning, and dental implantation. Bone damage is majorly attributed to rising incidence of trauma and accident cases across the globe. According to the Centers for Disease Control and Prevention (CDC), around 2.5 million people were hospitalized in the U.S. in 2014, due to accident injuries, indicating high risk of bone damage. This in turn, increases the demand for bone grafts and substitutes. The potential ability of bone grafting to repair the damage using natural mechanism can thus, be helpful and incorporated for bone healing procedures. Moreover, the National Trauma Institute in 2014, revealed that economic burden due to trauma cases increased to US$ 671 billion, including healthcare costs and lost productivity costs. Among geographical regions, North America contributes the maximum share in the bone grafts and substitutes market, owing to the increasing research and development activities in the field of bone grafting, which results in development of innovative bone grafts in the region. For instance, Artoss, Inc., a U.S.- based company introduced a complete line of bone grafts in 2017, which incorporates use of nanotechnology in the production of these grafts. Various other factors such as presence of key operating players and collaborative partnerships among the players are responsible for positioning North America as the largest market for bone grafts and substitutes. On the other hand, Asia Pacific is expected to gain significant traction, owing to the rise in medical tourism as well as development of novel bone graft substitutes by regional players, exhibiting equivalent efficiency at affordable prices.

The global bone grafts and substitutes market was valued at US$ 2,640.1 million in 2016 and is expected to witness a robust CAGR of 5.5% over the forecast period (2017 - 2025).

Figure 1. Global Bone Graft and Substitutes Market, by Region 2017 (US$ Mn)

Bone Graft and Substitutes Market

SOURCE: COHERENT MARKET INSIGHTS ANALYSIS, 2017 

Consistent development resulting in innovative bone grafting products expected to propel growth of the market

A large number of players are focused on the development of novel products for bone grafting. For instance, in May 2017, the National Chemical Laboratory in India, developed two novel bone graft substitutes that are aimed towards augmenting and regenerating the bones that are lost during accident or injuries. The products are now in clinical trial phase for performance testing and are expected to be available in prices lesser than the currently available imported varieties of the same, leading to emergence of local players in the Asia Pacific market. Moreover, companies are also entering into mergers and acquisitions to strengthen their position in the market. For instance, Kuros Biosciences acquired Xpand Biotechnology in 2016, wherein Kuros will use Xpand’s granular formulation for the production of novel bone graft substitutes. Major players operating the global bone graft and substitutes market include Ace Surgical Supply Co., Inc., NovaBone Product LLC, Medtronic Plc, Stryker Corporation, Zimmer Biomet Holdings, Inc., BioHorizons Implant Systems, Inc., Novadip Biosciences, Orthofix International N.V., Globus Medical, Inc., and Bone Therapeutics SA.          

Bone grafts and substitutes are the natural and synthetic products used by the surgeons to repair and reform bones in the spine, hips and knees through a medical procedure known as bone grafting. The bone used during grafting could be natural or synthetic. The most common types of bone grafts used are the autograft and allograft. An autograft comes from patients own body such as hips, pelvis and wrist. Allograft uses bone from deceased donor or a cadaver bone that has been cleaned and stored in the tissue banks. Bone graft substitutes are the synthetic or derived from allografts in varied forms. Synthetic bone grafts are made up of ceramics, composites, and polymer. Bone grafts substitutes are allografts based (Demineralized Bone Matrix), factor based such as transforming growth factor beta (TGF-beta), and platelet derived growth factor (PDGF), fibroblast growth factor (FGF), and bone morphogenetic proteins (BMP) and cell based bone grafts substitutes to generate new tissue alone or placed into support matrix (eg, mesenchymal stem cells). Bone graft and substitutes are primarily used because of fractures, fusion of two bones, bone and tissue regeneration and for bone healing with the implanted devices.

The major factors driving the market are rising incidences of musculoskeletal conditions, increasing base of elderly population and development of biocompatible synthetic bone grafts.

Market Dynamics

Bone grafts and substitutes market witnessed new product launches, partnerships and agreements in last few months. In October, 2017, DSM Biomedical signed a partnership agreement with a privately held orthobiologics company, Cerapedics to develop peptide enhanced bone graft. The strategic partnership will complement DSM’s material regeneration abilities with Cerapedics synthetic small peptide (P-15) technology. In April, 2017, BoneSupport AB extended its U.S distribution agreement with Zimmer Biomet for its Cerament bone void filler product. According to the agreement Zimmer will have exclusive rights to distribute portfolio of bone void fillers for trauma, orthopedics and foot and ankle applications. In May, 2017, NovaBone introduced NovaBone IRM and IRM MacroPOR to its product portfolio. According to NovaBone, the products possess osteogenic and osteoblastic characteristics and are highly irrigation resistant. Increase in awareness of non-invasive technologies among the patients and shift towards derived forms of bone graft substitutes are also expected to favor the market in near future.

Key features of the study:

  • This report provides an in-depth analysis of global bone graft and substitutes market provides market size (US$ Million) and Cumulative Annual Growth Rate (CAGR %) for the forecast period (2017 – 2025), considering 2016 as the base year.
  • It elucidates potential revenue opportunity across different segments and explains attractive investment proposition matrix for this market.
  • This study also provides key insights about market drivers, restraints, opportunities, new product launches or approval, regional outlook, and competitive strategy adopted by the leading players.
  • It profiles leading players in the global bone grafts and substitutes market based on the following parameters – company overview, financial performance, product portfolio, geographical presence, distribution strategies, key developments and strategies, and future plans.
  • Key companies covered as a part of this study include Stryker Corporation, Medtronic Inc., DePuySynthes, Zimmer Biomet Holdings, NuVasive Inc., Orthofix International N.V, Bone Therapeutics, RTI Surgical Inc., Institute Straumann AG and BioHorizons IPH
  • Insights from this report would allow marketers and the management authorities of the companies to make informed decision regarding their future product launch, technology up-gradation, market expansion, and marketing tactics.
  • The global bone grafts and substitutes market report caters to various stakeholders in this industry including investors, suppliers, implant devices and consumables manufacturers, distributors, new entrants, and financial analysts.
  • Stakeholders would have ease in decision making through the various strategy matrices used in analyzing the implant devices and consumables market.

Detailed Segmentation:

  • Global Bone Graft and Substitutes Market, By Product type:
    • Bone Grafts
      • Allograft
      • Xenograft
    • Bone Graft Substitutes
      • Ceramic
      • Composite
      • Polymer
      • Bone Morphogenetic Proteins (BMP)
      • Demineralized Bone Matrix (DBM)
      • Others
    • Global Bone Graft and Substitutes Market, By Application:
      • Spinal Fusion
      • Dental
      • Craniomaxillofacial
      • Joint Reconstruction
      • Trauma and Extremities
  • Global Bone Graft and Substitutes Market, By Geography:
    • North America
      • By  Product Type:
        • Bone Grafts
          • Allograft
          • Xenograft
        • Bone Graft Substitutes
          • Ceramic
          • Composite
          • Polymer
          • Bone Morphogenetic Proteins (BMP)
          • Demineralized Bone Matrix (DBM)
          • Others
      • By Application:
        • Spinal Fusion
        • Dental
        • Craniomaxillofacial
        • Joint Reconstruction
        • Trauma and Extremities
      • By Country
        • U.S.
        • Canada
    • Europe
      • By  Product Type:
        • Bone Grafts
          • Allograft
          • Xenograft
        • Bone Graft Substitutes
          • Ceramic
          • Composite
          • Polymer
          • Bone Morphogenetic Proteins (BMP)
          • Demineralized Bone Matrix (DBM)
          • Others
      • By Application:
        • Spinal Fusion
        • Dental
        • Craniomaxillofacial
        • Joint Reconstruction
        • Trauma and Extremities
      • By Country
        • U.K.
        • Germany
        • Italy
        • France
        • Russia
        • Rest of Europe
        •  
    • Asia Pacific
      • By  Product Type:
        • Bone Grafts
          • Allograft
          • Xenograft
        • Bone Graft Substitutes
          • Ceramic
          • Composite
          • Polymer
          • Bone Morphogenetic Proteins (BMP)
          • Demineralized Bone Matrix (DBM)
          • Others
        • By Application:
          • Spinal Fusion
          • Dent
          • Craniomaxillofacial
          • Joint Reconstruction
          • Trauma and Extremities
        • By Country
        • China
        • India
        • Japan
        • ASEAN
        • Australia
        • South Korea
        • Rest of Asia Pacific
    • Latin America
      • By  Product Type:
        • Bone Grafts
          • Allograft
          • Xenograft
  • Bone Graft Substitutes
    • Ceramic
    • Composite
    • Polymer
    • Bone Morphogenetic Proteins (BMP)
    • Demineralized Bone Matrix (DBM)
          • Others
      • By Application:
        • Spinal Fusion
        • Dental
        • Craniomaxillofacial
        • Joint Reconstruction
        • Trauma and Extremities
      • By Country
        • Brazil
        • Mexico
        • Rest of Latin America
    • Middle East
      • By  Product Type:
        • Bone Grafts
          • Allograft
          • Xenograft
  • Bone Graft Substitutes
    • Ceramic
    • Composite
    • Polymer
    • Bone Morphogenetic Proteins (BMP)
    • Demineralized Bone Matrix (DBM)
          • Others
      • By Application:
        • Spinal Fusion
        • Dental
        • Craniomaxillofacial
        • Joint Reconstruction
        • Trauma and Extremities
      • By Country
        • GCC
        • Israel
        • Rest of Middle East
    • Africa
      • By  Product Type:
        • Bone Grafts
          • Allograft
          • Xenograft
  • Bone Graft Substitutes
    • Ceramic
    • Composite
    • Polymer
    • Bone Morphogenetic Proteins (BMP)
    • Demineralized Bone Matrix (DBM)
          • Others
      • By Application:
        • Spinal Fusion
        • Dental
        • Craniomaxillofacial
        • Joint Reconstruction
        • Trauma and Extremities
      • By Country
        • North Africa
        • Central Africa
        • South Africa
  • Company Profiles
  • Stryker Corporation*
      • Company Overview
      • Product Portfolio
      • Financial Performance
      • Key Strategies
      • Recent Developments
    • Zimmer Biomet Holdings
    • Orthofix International N.V
    • Medtronic, Inc.
    • DePuySynthes
    • RTI Surgical Inc.
    • Bone Therapeutics
    • Institute Straumann AG
    • NuVasive Inc.

“*” marked represents similar segmentation in other categories in the respective section.

Table of Contents

  1. Research Objective and assumption
    • Research Objectives
    • Assumptions
    • Abbreviations
  2. Market Purview
    • Market Definition and Scope
    • Market Snippet By Product Type
    • Market Snippet By Application
    • Market Snippet By Region
    • Report Description
    • Executive Summary
    • Coherent Opportunity Map (COM)
  3. Market Dynamics, Regulations, and Trends Analysis
    • Drivers
    • Restraints
    • Market Opportunities
    • Market Dynamics
    • Regulatory Scenario
    • Industry Trend
    • Merger and Acquisitions
    • New Product Approvals/Launch
    • Promotion and Marketing Initiatives
  4. Global Bone Graft and Substitutes Market, By Product type, 2015 - 2025 (US$ Million)
    • Market Share Analysis, 2016 and 2025 (%)
    • Y-O-Y Growth Analysis, 2015 - 2025
    • Segment Trends
    • Introduction
    • Market Size and Forecast, and Y-O-Y Growth, 2015 - 2025, (US$ Million)
      • Allograft
        • Introduction
        • Market Size and Forecast, and Y-O-Y Growth, 2015 - 2025, (US$ Million)
      • Xenograft
        • Introduction
        • Market Size and Forecast, and Y-O-Y Growth, 2015 - 2025, (US$ Million)
    • Introduction
    • Bone Grafts
    • Bone Graft Substitutes
      • Introduction
      • Market Size and Forecast, and Y-O-Y Growth, 2015 - 2025, (US$ Million)
        • Ceramic
          • Introduction
          • Market Size and Forecast, and Y-O-Y Growth, 2015 - 2025, (US$ Million)
        • Composite
          • Introduction
          • Market Size and Forecast, and Y-O-Y Growth, 2015 - 2025, (US$ Million)
        • Polymer
          • Introduction
          • Market Size and Forecast, and Y-O-Y Growth, 2015 - 2025, (US$ Million)
        • Bone Morphogenetic Proteins (BMP)
          • Introduction
          • Market Size and Forecast, and Y-O-Y Growth, 2015 - 2025, (US$ Million)
        • Demineralized Bone Matrix (DBM)
          • Introduction
          • Market Size and Forecast, and Y-O-Y Growth, 2015 - 2025, (US$ Million)
        • Others
          • Introduction
          • Market Size and Forecast, and Y-O-Y Growth, 2015 - 2025, (US$ Million)
  5. Global Bone Graft and Substitutes Market, By Application, 2015 - 2025 (US$ Million)
    • Introduction
      • Market Share Analysis, 2016 and 2025 (%)
      • Y-O-Y Growth Analysis, 2015 - 2025
      • Segment Trends
    • Spinal Fusion
      • Introduction
      • Market Size and Forecast, and Y-O-Y Growth, 2015 - 2025, (US$ Million)
    • Dental
      • Introduction
      • Market Size and Forecast, and Y-O-Y Growth, 2015 - 2025, (US$ Million)
    • Craniomaxillofacial
      • Introduction
      • Market Size and Forecast, and Y-O-Y Growth, 2015 - 2025, (US$ Million)
    • Joint Reconstruction
      • Introduction
      • Market Size and Forecast, and Y-O-Y Growth, 2015 - 2025, (US$ Million)
    • Trauma and Extremities
      • Introduction
      • Market Size and Forecast, and Y-O-Y Growth, 2015 - 2025, (US$ Million)
  6. Global Bone Graft and Substitutes, By Regions, 2015 - 2025 (US$ Million)
    • Market Share Analysis, By Region, 2016 and 2025 (%)
    • Y-o-Y Growth Analysis, For Regions, 2015 – 2025
    • Regional Trends
    • Market Size and Forecast, By Product Type, 2015 - 2025 (US$ Mn)
    • Market Size and Forecast, By Application, 2015 - 2025 (US$ Mn)
    • Market Size and Forecast, By Country, 2015 - 2025 (US$ Mn)
      • U.S.
      • Canada
  • Market Size and Forecast, By Product Type, 2015 - 2025 (US$ Mn)
  • Market Size and Forecast, By Application, 2015 - 2025 (US$ Mn)
  • Market Size and Forecast, By Country, 2015 - 2025 (US$ Mn)
    • Germany
    • U.K.
    • France
    • Italy
    • Spain
    • Russia
    • Rest of Europe
  • Market Size and Forecast, By Product Type, 2015 - 2025 (US$ Mn)
  • Market Size and Forecast, By Application, 2015 - 2025 (US$ Mn)
  • Market Size and Forecast, By Country, 2015 - 2025 (US$ Mn)
    • China
    • India
    • Japan
    • Australia
    • South Korea
    • ASEAN
    • Rest of APAC
  • Market Size and Forecast, By Product Type, 2015 - 2025 (US$ Mn)
  • Market Size and Forecast, By Application, 2015 - 2025 (US$ Mn)
  • Market Size and Forecast, By Country, 2015 - 2025 (US$ Mn)
    • Brazil
    • Mexico
    • Rest of Latin America
  • Market Size and Forecast, By Product Type, 2015 - 2025 (US$ Mn)
  • Market Size and Forecast, By Application, 2015 - 2025 (US$ Mn)
  • Market Size and Forecast, By Country, 2015 - 2025 (US$ Mn)
    • GCC
    • Israel
    • Rest of Middle East
  • Market Size and Forecast, By Product Type, 2015 - 2025 (US$ Mn)
  • Market Size and Forecast, By Application, 2015 - 2025 (US$ Mn)
  • Market Size and Forecast, By Country, 2015 - 2025 (US$ Mn)
    • South Africa
    • North Africa
    • Central Africa
      • Introduction
      • North America
      • Europe
      • Asia Pacific
      • Latin America
      • Middle East
      • Africa
    1. Competitive Landscape
      • Medtronic plc
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Developments/Updates
        • Future Plans
      • Heat Map Analysis
      • Company Profiles
    2. RTI Surgical, Inc.
          • Company Overview
          • Product Portfolio
          • Financial Performance
          • Recent Developments/Updates
          • Future Plans
        • Stryker Corporation
          • Company Overview
          • Product Portfolio
          • Financial Performance
          • Recent Developments/Updates
          • Future Plans
        • Zimmer Biomet Holdings
          • Company Overview
          • Product Portfolio
          • Financial Performance
          • Recent Developments/Updates
          • Future Plans
        • Orthofix International N.V.
          • Company Overview
          • Product Portfolio
          • Financial Performance
          • Recent Developments/Updates
          • Future Plans
        • DePuySynthes
          • Company Overview
          • Product Portfolio
          • Financial Performance
          • Recent Developments/Updates
          • Future Plans
        • Bone Therapeutics
          • Company Overview
          • Product Portfolio
          • Financial Performance
          • Recent Developments/Updates
          • Future Plans
        • NuVasive Inc.
          • Company Overview
          • Product Portfolio
          • Financial Performance
          • Recent Developments/Updates
          • Future Plans
        • Institute Straumann AG
          • Company Overview
          • Product Portfolio
          • Financial Performance
          • Recent Developments/Updates
          • Future Plans
      • Analyst Views
      • References
      • Research Methodology
      • About us and Sales Contact 
      1. Section

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