Deep Brain Stimulation Devices
Deep brain stimulation (DBS) device, often described as brain pacemaker, aids in alleviating symptoms of Parkinson’s disease (PD). The device is implanted at one of the three FDA approved brain sites to block the electrical signals from these sites to the brain. The three FDA approved targeted brain sites are ventrointermedialis (VIM) nucleus of the thalamus, subthalamic nucleus (STN), and globus pallidus pars interna (GPi). DBS surgery is performed on patient’s suffering from Parkinson’s disease for at least four years, and are on medications albeit with motor complications. Though there are other surgical options such as thalamotomy and pallidotomy, deep brain stimulation is the most preferred option, as it does not involve tissue destruction and is a reversible surgical treatment.
The global deep brain stimulation devices market was valued at US$ 664.4 million in 2015 and is expected to expand at a CAGR of 8.2% during the forecast period (2016 – 2024).
Figure 1. Global Deep Brain Stimulation Devices Market Size and Forecast, US$ Million and Y-o-Y Growth (%), 2014–2024
Source: Coherent Market Insights Analysis (2017)
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Rising incidence rate of Parkinson’s disease is expected to fuel the deep brain stimulation devices market growth
According to the Parkinson’s disease Foundation, as of 2016, over 10 million people are suffering from Parkinson’s disease globally. The findings published by the organization showed that incidence rate of PD increases with age and only 4% of people were diagnosed with PD before the age of 50 years. According to the Parkinson’s disease Foundation, incidence rate of PD in the U.S is as high as 60,000 each year. According to Parkinson’s Australia Inc., around 11,544 new cases of PD were diagnosed in Australia in 2014 and as per the statistics released by Parkinson Canada, the number of people suffering from Parkinson’s disease in Canada is expected to increase to over 163,700 by 2031 (double than the prevalence in 2011). Therefore, increasing incidence of PD across the globe is projected to drive the deep brain stimulation devices market growth.
Development in technology to increase therapeutic outcome and enhance application of DBS in other disease treatment
According to a study published in the Neuron journal in December 2016, deep brain stimulation, targeting entorhinal cortex and hippocampus regions in the brain, demonstrated negative impact on improving memory. Researchers, however, are optimistic about obtaining successful results through further research in enhancing memory, especially in Alzheimer patients.
Activa PC+S system by Medtronic Inc., is a closed-loop DBS device being utilized for research purpose among few physicians in Europe. This system records the electrical activity in brain and develops an algorithm of the closed-loop system. The device is being tested in patients with advanced Parkinson’s disease. Once commercialized, the closed-loop DBS system would make treatment for Parkinson’s disease more effective and customized according to unique patient needs. This is expected to benefit patients significantly and thus augment the deep brain stimulation devices market development.
Increasing demand for minimally-invasive treatment options in emerging economies to create opportunities in the respective deep brain stimulation devices market
Parkinson’s and Alzheimer disease involves long-term administration of medications, making it unaffordable to major section of the population in emerging economies in Asia, Africa, and Latin America. Advent of minimally-invasive technology has led to increase in demand for such procedures and devices for treatment of chronic disease conditions such as diabetes, stroke, Parkinson’s disease, blood clot, and Alzheimer’s disease. Deep brain stimulation devices being an effective minimally-invasive therapy for Parkinson’s patients, is projected to gain significant growth traction in emerging economies such as India, China, Brazil, Israel, and North African countries. This in-turn is expected to fuel the deep brain stimulation devices market growth.
Deep brain stimulation (DBS) surgery is carried out as part of treatment of various neural debilitating conditions such as Parkinson’s disease, dementia, and Alzheimer’s disease. Patients fitted with a deep brain stimulation device can get long-term relief from debilitating symptoms of Parkinson’s disease. There is significant reduction in side-effects caused due to medications, though medications may be required in some patient post-surgery. The DBS device is mainly placed in one of the three FDA approved target sites in Parkinson’s disease. Most commonly preferred target sites are the Globus Pallidus Interna (GPi) and Subthalamic Nucleus (STN).
Aging increases the risk of Alzheimer’s disease, Parkinson’s disease and dementia. Thus, growing geriatric population is a major factor driving demand for deep brain stimulation devices. Though drug therapies are available for treating these diseases, surgical procedures are recommended in later stages of the condition. Furthermore, deep brain stimulation devices reduce the side effects and improves patient condition by reducing incidence of tremors. Patients are inclined towards adoption of minimally invasive procedures, as these require low healing time and leave behind minimal scars. Surgeons too prefer such procedures as it significantly reduces risk element from accidental damage to surrounding tissue. This is another factor fueling demand for deep brain stimulation devices globally. However, as these devices need to be implanted in the brain, it is extremely challenging and in turn reduces acceptance of DBS devices among patients.
This report segments the global deep brain stimulation devices market on the basis of application and geography. Applications of deep brain stimulation devices are Parkinson's disease, essential tremor, dystonia, and others. For comprehensive understanding of market dynamics, the global market has been divided into key geographical regions, namely North America, Europe, Asia Pacific, Latin America, Africa, and Middle East. Each of these regions is further segmented on the basis of major countries for a macro-level understanding of the market.
Key features of the study:
“*” marked represents similar segmentation in other categories in the respective section.
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