Disease-modifying antirheumatic drugs (DMARDs) are a group of medications commonly used in people with rheumatoid arthritis. Some of these drugs are also used in treating other conditions such as ankylosing spondylitis, psoriatic arthritis, and systemic lupus erythematosus. Disease-modifying antirheumatic drugs work to decrease pain and inflammation, to reduce or prevent joint damage, and to preserve the structure and function of the joints.
The global disease-modifying antirheumatic drug (DMARD) market is estimated to be valued at US$ 20,671.1 million in 2022 and is expected to exhibit a CAGR of 3.5% during the forecast period (2022-2030).
Figure 1.Global Disease-Modifying Antirheumatic Drug (DMARD) Market Share (%) in Terms of Value, By Drug Type, 2022
Increasing prevalence of rheumatoid arthritis disease is expected to drive the market growth during the forecast period.
Increasing prevalence of rheumatoid arthritis disease which is expected to drive the global disease-modifying antirheumatic drug (DMARD) market growth over the forecast period. For instance, according to data published by National Center for Biotechnology Information in June 2022, stated that the annual incidence of RA (Rheumatoid Arthritis) in the U.S. and other western nations of northern Europe is about 40 per 100,000 persons.
|Base Year:||2021||Market Size in 2022:||US$ 20,671.1 Mn|
|Historical Data for:||2017-2020||Forecast Period:||2022 to 2030|
|Forecast Period 2022 to 2030 CAGR:||3.5%||2030 Value Projection:||US$ 27,167.8 Mn|
Sanofi., Pfizer, F. Hoffman-La Roche AG, Johnson & Johnson, AbbVie Inc., Eli Lilly & Company, Amgen Inc., Swedish Orphan Biovitrum AB, Bristol-Myers Squibb Company, UCB S.A., Gilead Sciences, Inc., and Cumberland Pharmaceuticals Inc
|Restraints & Challenges:||
Figure 2. Global Disease-Modifying Antirheumatic Drug (DMARD) Market Share (%), By Distribution Channel, 2022
Increasing product launches for the treatment of rheumatoid arthritis, psoriasis, etc., are expected to drive the market growth during the forecast period
Increasing product launches for the treatment of rheumatoid arthritis, psoriasis which is expected to drive the global disease-modifying antirheumatic drug (DMARD) market growth during the forecast period. For instance, in November 2020, Cumberland Pharmaceuticals Inc., a U.S. specialty pharmaceutical company, announced the launch of RediTrex injection. RediTrex is a new line of pre-filled syringes specifically designed for ease of handling and dosing accuracy for the subcutaneous administration of methotrexate in patients with rheumatoid arthritis and psoriasis.
Global Disease-Modifying Antirheumatic Drug (DMARD) Market– Impact of Coronavirus (COVID-19) Pandemic
The supply of raw materials required for production of pharmaceuticals has been severely disrupted due to the forced quarantine and lack of labor during the COVID-19 pandemic. As the link between regional warehouses is not smooth, transportation of raw materials between regions cannot be carried out successfully. This shortage of raw materials and components has negatively affected the supply chain of the global intraocular melanoma treatment market. Thus, COVID-19 pandemic is expected to have negative impact on supply chain of disease-modifying antirheumatic drug market. According to an article published by the Exploratory Research in Clinical and Social Pharmacy journal in June 2021, a study was carried out to evaluate the impact of COVID-19 on pharmaceutical systems and supply chain in resource-limited countries in Sub-Saharan countries such as Namibia. This study revealed negative impact on availability and access of essential drugs, sanitation and hygiene products, and antimicrobials. Most pharmaceutical companies and pharmacies in Namibia experienced delayed manufacturing and distribution of drugs, which is attributed to reduced inter-country transportation of pharmaceutical goods and limited in-country capacity to manufacture drugs. For instance, according to a review article published by the European Pharmaceutical Review journal in November 2020, COVID-19 pandemic has caused major challenges with respect to drug shortages and increased manufacturing costs across the globe. Moreover, the same source stated that COVID-19 pandemic has also led to problems such as stockpiling drugs, transportation delay, and others. Some measures that can be taken to ease the supply of pharmaceuticals during the pandemic include next generation technologies such as digital network platforms designed to work across multiple pharmaceutical enterprises and ensure the timely delivery of drugs to patients across the globe.
Global Disease-Modifying Antirheumatic Drug (DMARD) Market: Restraint
The major factors that hinder growth of the global disease-modifying antirheumatic drug (DMARD) market include side effects associated with the disease-modifying antirheumatic drug. Azathioprine (Imuran) is used for many different inflammatory conditions, including RA. The most common side effects are nausea and vomiting, sometimes with stomach pain and diarrhea. Long-term use of azathioprine is associated with an increased risk of cancer.
Key players operating in the market include Sanofi., Pfizer, F. Hoffman-La Roche AG, Johnson & Johnson, AbbVie Inc., Eli Lilly & Company, Amgen Inc., Swedish Orphan Biovitrum AB, Bristol-Myers Squibb Company, UCB S.A., Gilead Sciences, Inc., and Cumberland Pharmaceuticals Inc.
Disease-modifying anti-rheumatic drugs (DMARDs) can treat the underlying cause of condition and reduce inflammation. They are given to people with autoimmune conditions, such as rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, ankylosing spondylitis and others. These are conditions where the immune system, which normally fights infection, attacks the body’s own healthy tissues. DMARDs can improve symptoms such as pain, stiffness and swelling, but they may take a few weeks or even months to fully take effect. There are different types of DMARDs, and they work in slightly different ways. The three main types are: synthetic (sDMARD), targeted synthetic DMARDs, biological DMARDs (bDMARD) and others
Key players operating in the global disease-modifying anti-rheumatic drugs (DMARDs) market are focusing on increasing product launches and product approvals which is expected to drive the market growth during the forecast period. For instance, in January 2018, Hetero, one of the leading generic pharmaceutical companies launched its fourth biosimilar drug ‘Adalimumab’ under the brand name ‘Mabura’ in India. Mabura is an anti-inflammatory biologic medication specific for human tumor necrosis factor (TNF). It is indicated for the treatment of rheumatoid arthritis and other auto-immune disorders such as psoriatic arthritis, ankylosing spondylitis, Crohn’s disease, and ulcerative colitis. Moreover, in September 2020, Pfizer Inc. is an American multinational pharmaceutical and biotechnology corporation announced that the U.S. Food and Drug Administration (FDA) approved XELJANZ (tofacitinib) for the treatment of children and adolescents 2 years and older with active polyarticular course juvenile idiopathic arthritis (pcJIA). Two formulations were approved, a tablet and an oral solution, and are dosed based upon weight. This approval makes XELJANZ the first and only Janus kinase (JAK) inhibitor approved in the U.S. for the treatment of pcJIA.
Key features of the study:
“*” marked represents similar segmentation in other categories in the respective section.
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