Antithrombin is a protein present in blood that inhibits blood clotting by inactivating thrombin. Antithrombin is produced by liver and consists of 432 amino acids. There are two major reasons of antithrombin deficiency, which include acquired antithrombin deficiency caused due to other diseases such as nephrotic syndrome, liver failure, severe trauma, and metastatic tumors and inherited antithrombin deficiency caused due to a genetic mutation or abnormality. According to the NCBI (National Center for Biotechnology Information), inherited antithrombin deficiency is a rarely occurring deficiency and only a maximum of 0.2% of the global population has this deficiency. One of the most popular drugs for the treatment of antithrombin deficiency available in the market is ATryn, which was developed by rEVO Biologics and received the U.S. Food and Drug Administration (FDA) approval in 2009. Antithrombin shows synergistic activity with heparin that enhances the antithrombin binding with Thrombin (factor II a) and Factor Xa. Antithrombin III blood test is required to measure the amount of deficiency of antithrombin that is causing the blood to clot more easily than normal.
Antithrombin Market – Market Dynamics
Increasing incidence of coagulation disorders, open heart surgeries, and extracorporeal circulation during hemodialysis is augmenting growth of antithrombin market. According to the Centers for Disease Control and Prevention (CDC), 2015, around 900,000 people is affected from venous thromboembolism every year in the U.S. Furthermore, 5 to 8% of the U.S. population has increased risk of suffering from thrombosis due to one of the several genetic risk factors known as inherited thrombophilia.
Therapeutic drug pipeline or advancements in drug administering technology is also expected to fuel growth of antithrombin market. For instance, Fitusiran (ALN-AT3), developed by Alnylam Pharmaceuticals, Inc., is a subcutaneously administered, investigational RNAi therapeutic targeting antithrombin (AT). This therapeutic that can be used for the treatment of hemophilia and rare bleeding disorders (RBDs) is in late stage (Phase 2-phase 3) clinical trial. Moreover, GTC Biotherapeutics, Inc.’s product called as ATryn Antithrombin (Recombinant), derived from human blood donors, is used for hereditary antithrombin deficiency and it recently got market approval in the U.S., thereby significantly contributing to the growth of antithrombin market. Therefore, introduction of new types of antithrombin products with different indication over the forecast period is expected to fuel growth of the global antithrombin market. Furthermore, increasing use of antithrombin in combination with heparin is likely to support the growth of antithrombin market. For instance, heparin resistance in cardiac surgery is likely to create opportunities for use of antithrombin products in anticoagulation therapy.
However, increasing regulations on animal testing have impeded a number of healthcare companies from manufacturing new drugs, thereby restraining the market growth.
Antithrombin Market - Regional Analysis
On the basis of region, the global antithrombin market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa. North America is expected to gain significant traction in the global antithrombin market, followed by Europe, owing to adoption of robust developed technologies and antithrombin therapies, and high awareness and increasing regulatory approval of drugs in these regions.
Moreover, improving healthcare infrastructure in emerging economies such as China and India, and increasing research and development activities are contributing towards the growth of antithrombin market in Asia Pacific region. For instance, in 2016, China Biologic Products, Inc.’s subsidiary, Shandong Taibang Biological Products Co. Ltd., recently obtained approval from the China Food and Drug Administration (CFDA) to begin human clinical trials using its Human Antithrombin III (ATIII) product for the treatment of hereditary and acquired ATIII deficiency which are more prone during surgical or obstetrical procedures, and treatment of thromboembolism.
Antithrombin Market – Competitive Landscape
The antithrombin market is characterized by the presence of few established players. There is stiff competition in the market, as these few players occupy major market share. Key players operating in the global antithrombin market include Grifols, Shire Plc., rEVO Biologics Inc., CSL Limited, Kedrion S.p.A, Lee Bisolutions, Scripps Laboratories Inc., GTC Biotherapeutics, Inc.’s, Green Cross Corp., and BDI Pharma.
Antithrombin Market – Taxonomy
On the basis of application, the global antithrombin market is segmented into:
On the basis of source, the global antithrombin market is segmented into:
On the basis of dosage form, the global antithrombin market is segmented into:
On the basis of region, the global antithrombin market is segmented into:
Coherent Market Insights followsa comprehensive research methodology focused on providing the most precise market analysis. The company leverages a data triangulation model which helps company to gauge the market dynamics and provide accurate estimates. Key components of the research methodologies followed for all our market reports include:
In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.
Coherent Market Insights desk research is based on a principle set of research techniques:
Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:
Preliminary Data Mining
The raw data is obtained through the secondary findings, in house repositories, and trade surveys. It is then filtered to ensure that the relevant information including industry dynamics, trends, and outlook is retained for further research process.
Holistic approach is used to ensure that the granular and uncommon parameters are taken into consideration to ensure accurate results. The information from the paid databases are further combined to the raw data in order to standardize it.
Coherent Statistical model
We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:
Once the findings are derived from the statistical model, large volume of data is process to confirm accurate research results. Data analytics and processing tools are adopted to process large chunk of collected informative data. In case, a client customizes the study during the process, the research finding till then are benchmarked, and the process for new research requirement is initiated again.
This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:
The primary research is conducted with the ecosystem players including, but not limited to:
Finding it difficult to find the research that would cater to your business demands? Give us a chance to help you. One of our Research Consultants will connect to provide a customized solution.[email protected]
Talk to our research consultant to design an exclusive report as per your research needs.
We aim to fulfil client's research demands with tailored research solutions.
We aim to provide research studies in quickest turnaround time and in a much cost effective manner.
We cover each industry from supply and demand side with an aim to provide a most holistic research study.
We strive to provide most accurate and reliable research findings in our research reports.