Monobodies are synthetic binding proteins in which fibronectin type III domain (FN3) is used as a molecular scaffold. Monobodies are robust alternative to antibodies to create target-binding proteins. The term monobody was devised by Koide group in 1998. Monobody belong to a class called antibody mimics aiming to overcome the shortcomings of natural antibody. A major advantage of monobody is that it can be used as genetically encoded intracellular inhibitors. Adnexus (now a part of Bristol-Myers Squibb), uses monobody technology to inhibit tumour angiogenesis since 2007.
Monobody – a technology with great potential in Cancer Treatment
Monobody is a technology which has great potential in the treatment of cancer. Monobody is independent of their environment and can be used as genetically encoded inhibitors. When a monobody binds to a protein then it work as an inhibitor of that protein.
Pegdinetanib, also known as Adnectin, is an antagonist of vascular endothelial growth factor receptor 2 has entered in clinical trial II for the treatment of gliblastoma. Adnectins is based on 10th fibronectin type III domain designed to bind with high affinity and specificity to relevant targets. There are three solvent accessible loops (BC, DE and FG) which are responsible for binding. Various monobody proteins have been developed for clinical efficacy against cancer and infections. The market of monobody will be high in developed region like America because of availability of advance medical technology, good medical facilities and medical infrastructure.
Success of therapeutic antibodies has sparked a growing interest to create molecules that bind to the target molecule specifically and efficiently. A common alternative process is that the libraries of monobody being constructed which can be obtained by capturing natural diversity of an antibody.
Research in the field of Monobody
Researchers at the University of Illinois, Chicago identified a monobody, NS1, which can block oncogene activity. 30% of all cancers are due to RAS mutation. RAS mutation is also found in 90% of pancreatic cancers and frequently occurs in colon cancer, lung cancer and melanoma. The NS1 monobody bind to RAS protein molecule and inhibits its oncogenic activity.
Monobody – a better alternative
Antibodies are successful tools used in diagnostics, purification and therapeutics. Antibodies have their limitations also like high product cost and low stability. Alternative tools based on nucleic acid (aptamers), polypeptides (engineered binding proteins) and inorganic matrices have received attention recently. With increasing research activities for drug development in cancer, more information would be gathered with respect to monobodies too. Because of high specificity and affinity monobodies have potential and can be used in organ transplant in near future and can affect the antibodies market. Successful outcomes will boost investors to develop this technology and address the unmet need of cancer patients undergoing antibody therapy. Use of monobodies as therapeutic drug improves patient situation and hence companies are striving to develop monobodies to be used as therapeutic drugs in the treatment of cancer.
Introduction of monobody will have a major impact in developed regions
The rate of organ transplantation in the U.S. is high. According to National Kidney Foundation there are currently 121,678 people waiting for organ transplant in the U.S of which 100,791 await kidney transplant. Monoclonal antibodies are used in successful transplant and are administered before transplant. It will become one of the major drivers for monobody based therapeutic drugs market. Monobody technology requires high investment to commercialize. The advancement of monobody technology to treat cancer will have an impact on the existing antibody treatment technologies.
Coherent Market Insights followsa comprehensive research methodology focused on providing the most precise market analysis. The company leverages a data triangulation model which helps company to gauge the market dynamics and provide accurate estimates. Key components of the research methodologies followed for all our market reports include:
In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.
Coherent Market Insights desk research is based on a principle set of research techniques:
Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:
Preliminary Data Mining
The raw data is obtained through the secondary findings, in house repositories, and trade surveys. It is then filtered to ensure that the relevant information including industry dynamics, trends, and outlook is retained for further research process.
Holistic approach is used to ensure that the granular and uncommon parameters are taken into consideration to ensure accurate results. The information from the paid databases are further combined to the raw data in order to standardize it.
Coherent Statistical model
We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:
Once the findings are derived from the statistical model, large volume of data is process to confirm accurate research results. Data analytics and processing tools are adopted to process large chunk of collected informative data. In case, a client customizes the study during the process, the research finding till then are benchmarked, and the process for new research requirement is initiated again.
This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:
The primary research is conducted with the ecosystem players including, but not limited to:
Finding it difficult to find the research that would cater to your business demands? Give us a chance to help you. One of our Research Consultants will connect to provide a customized firstname.lastname@example.org
Talk to our research consultant to design an exclusive report as per your research needs.
We aim to fulfil client's research demands with tailored research solutions.
We aim to provide research studies in quickest turnaround time and in a much cost effective manner.
We cover each industry from supply and demand side with an aim to provide a most holistic research study.
We strive to provide most accurate and reliable research findings in our research reports.