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  • Published On : Jul 2021
  • Code : CMI4543
  • Industry : Pharmaceutical
  • Pages : 163
  • Formats :

An immunodeficiency disease is caused when the immune system of the body fails to carry out its regular function of providing protection from various pathogens such as virus, bacteria, fungus, parasites, and others. These immunodeficiency diseases can be classified into primary and secondary immunodeficiency diseases. Primary immunodeficiency diseases are present in an individual at birth itself and are a result of gene mutations such as deletion of gene, duplication of gene and others. These genetic defects may lead to primary immunodeficiency diseases such as combined immunodeficiency disease, DiGeorge syndrome, hypogammaglobulinemia, Bruton’s disease, and others. Some of the factors responsible for causing secondary immunodeficiency disease include malnutrition, diabetes, radiation, severe burns, and others. Few examples of secondary immunodeficiency diseases include HIV-AIDS, leukemia, viral hepatitis, multiple myeloma, and others. Immunodeficiency diseases can be treated using antibiotic therapy, immunoglobulin therapy, anti-viral drugs, stem cell, and gene therapy.

Global Immunodeficiency Therapeutics Market - Impact of the Coronavirus (COVID-19) Pandemic

Coronavirus (COVID-19) outbreak was first reported on December 31, 2019, in Wuhan, China. The World Health Organization declared COVID-19, as pandemic on March 11, 2020.

According to the Coronavirus (COVID-19) Weekly Epidemiological Update by the World Health Organization, over 186,240,393 cases and 4,027,861 deaths due to Coronavirus disease (COVID-19) were reported till July 11, 2021, across the globe.

Impact of COVID-19 on Demand and Supply of Immunodeficiency Therapeutics

The COVID-19 pandemic and lockdown in various countries across the globe have impacted the financial status of businesses across all sectors. The pharmaceutical sector is one such sector which has been majorly impacted by the pandemic.

The COVID-19 pandemic has impacted the entire supply chain of the pharmaceutical industry mainly due to strict lockdown in several regions. However, the demand for immunodeficiency therapeutics is expected to increase in COVID-19 pandemic owing to association of immunodeficiency diseases with COVID-19. For instance, according to an article published by the Centers for Disease Control and Prevention (CDC) in May 2021, people suffering from immunodeficiency disorders such as HIV-AIDS and primary immunodeficiency disease are more likely to get infected with severe COVID-19 since their immune functions are suppressed due to the immunodeficiency diseases. Thus, impact of the Coronavirus (COVID-19) pandemic is expected to bolster the growth of the global immunodeficiency therapeutics market during the forecast period.

The global immunodeficiency therapeutics market is estimated to be valued at US$ 6,991.1 Mn in 2021, and is expected to exhibit a CAGR of 6.1% over the forecast period (2021-2028).

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Immunodeficiency Therapeutics Market Report Coverage

Report Coverage Details
Base Year: 2020 Market Size in 2021: US$ 6,991.1 Mn
Historical Data for: 2017 to 2020 Forecast Period: 2021 to 2028
Forecast Period 2021 to 2028 CAGR: 6.1% 2028 Value Projection: US$ 10,581.6 Mn
Geographies covered:
  • North America: U.S. and Canada
  • Latin America: Brazil, Argentina, Mexico, and Rest of Latin America
  • Europe: Germany, U.K., Spain, France, Italy, Russia, and Rest of Europe
  • Asia Pacific: China, India, Japan, Australia, South Korea, ASEAN, and Rest of Asia Pacific
  • Middle East: GCC, Israel, and Rest of Middle East
  • Africa: South Africa, North Africa, and Central Africa
Segments covered:
  • By Therapy Type: Immunoglobulin Therapy, Antibiotics Therapy, Stem Cell and Gene Therapy, Others
  • By Test Type: Blood Test, Prenatal Testing
  • By Disease Type: Antibody Deficiency, Cellular Immunodeficiency, Innate Immune Disorders, Others
  • By Distribution Channel: Hospital Pharmacy, Retail Pharmacy, Online Pharmacy
Companies covered:

Pfizer Inc., CSL Behring, Grifols, S.A., Abbott, ADMA Biologics, Inc., AstraZeneca, Baxter, Bayer AG, Biocon, Bristol-Myers Squibb Company, BDI Pharma, Inc., Bharat Serums and Vaccines Ltd., Eli Lilly and Company, GlaxoSmithKline plc., Lupin Pharmaceuticals Inc., Novartis AG, Octapharma AG, Sanofi, and Takeda Pharmaceutical Company Limited

Growth Drivers:
  • Increasing prevalence of immunodeficiency diseases
  • Advancement in genetics technology
  • Increasing research and development activities by the market players
Restraints & Challenges:
  • High cost of immunodeficiency treatment
  • Side-effects of immunotherapy

Figure 1: Global Immunodeficiency Therapeutics Market Share (%) Analysis, By Therapy Type, 2021

Immunodeficiency Therapeutics  | Coherent Market Insights

The rising cases of immunodeficiency diseases is the major factor that is expected to drive the global immunodeficiency therapeutics market growth over the forecast period.

The rising prevalence of immunodeficiency disease is expected to drive growth of global immunodeficiency therapeutics market over the forecast period. For instance, according to an article published by the National Institutes for Health (NIH), U.S. in May 2021, the prevalence of ADA-SCID (Adenosine deaminase-severe combined immunodeficiency syndrome) is estimated to be one in 200,000 to 1,000,000 newborns across the world. Moreover, according to the data published by the World Health Organization (WHO) in November 2020, around 1.5 million new human immunodeficiency virus (HIV) infections were reported globally in 2020 and 37.6 million are reported to be suffering from HIV worldwide in 2020. HIV causes acquired immunodeficiency disorder syndrome (AIDS).

Moreover, increasing number of research and development activities for improving the effectiveness of immunodeficiency therapeutics is expected to aid in the growth of the market over the forecast period. For instance, according to an article published by National Institute of Health (NIH) in May 2021, an investigational research study conducted in in U.S. and U.K. and supported by NIH showed that., 96% of children receiving new experimental lentiviral gene therapy for immunodeficiency diseases reported restored immune function.

The rising advancements of technology in the field of genetics is expected to drive the growth of the global immunodeficiency therapeutics market over the forecast period. For instance, according to an article published in the Genes & Diseases international scientific journal in March 2020, recent technological advancements such as next generation sequencing (NGS) have enabled researchers to explore newer genetic variations related to common variable immunodeficiency (CVID) in order to improve its diagnosis.

Global Immunodeficiency Therapeutics Market – Restraints

However, growth of the immunodeficiency therapeutics market may be hampered, owing to high cost of immunotherapy and side effects of immunodeficiency disease treatment. For instance, according to an article published by ScienceDirect in April 2020, the total cost of immunodeficiency disease treatment is estimated to be US$ 6,500 to US$ 108,463 per patient.

Global Immunodeficiency Therapeutics Market – Regional Analysis

On the basis of region, the global immunodeficiency therapeutics market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa.

North America is expected to hold dominant position in the global immunodeficiency therapeutics market over the forecast period, owing to rising number of product approvals. For instance, in September 2020, Octapharma USA Inc., a biopharmaceutical company received Medicare Part B approval for its product Cutaquig which is used for treatment of humoral immunodeficiency in adults and children. Medicare is an insurance provider which covers the treatment costs related to the Medicare part B listed diseases. Such approvals from insurance providers is expected to encourage people to opt for immunotherapy and thus drive the growth of global immunodeficiency therapeutics market over the forecast period.

Figure 2: Global Immunodeficiency Therapeutics Market Value (US$ Mn), by Region, 2021

Immunodeficiency Therapeutics  | Coherent Market Insights

Global Immunodeficiency Therapeutics Market – Competitive Landscape

Major players operating in the global immunodeficiency therapeutics market include Pfizer Inc., CSL Behring, Grifols, S.A., Abbott, ADMA Biologics, Inc., AstraZeneca, Baxter, Bayer AG, Biocon, Bristol-Myers Squibb Company, BDI Pharma, Inc., Bharat Serums and Vaccines Ltd., Eli Lilly and Company, GlaxoSmithKline plc., Lupin Pharmaceuticals Inc., Novartis AG, Octapharma AG, Sanofi, and Takeda Pharmaceutical Company Limited

Immunodeficiency disorders or diseases render the ability of the immune system to fight against microbial infection, thus making a person immuno-compromised. Thus, people suffering from immunodeficiency diseases or disorders are more likely to fall sick. An immunodeficiency disorder may be either congenital or acquired. Congenital immunodeficiency disorder refers to the one which occurs by birth while acquired disorder refers to the one which occurs later in life. For instance, primary immunodeficiency disease is a congenital immunodeficiency disease which is a result of defect in genes that regulate the immune system. These genes are involved in functioning of immune organs such as spleen, lymph nodes, bone marrow, tonsils, and others. Some of the common primary immunodeficiency diseases include X-linked agammaglobulinemia (XLA), common variable, immunodeficiency (CVID), and severe combined immunodeficiency (SCID). Human immunodeficiency virus, spleen removal surgery, unsanitary conditions, and malnutrition are the most common causes of immunodeficiency disorders. Immunodeficiency diseases or disorders may exhibit signs such as yeast infection, cold, pink eye, diarrhea, pneumonia, and others. Recent advances in the field of immunology and genetics has created large number of opportunities for development and commercialization of newer, safer, and more efficient immunodeficiency therapeutics.

Market Dynamics

Market players are conducting clinical trials for developing safer and more efficient treatments for immunodeficiency diseases, which could contribute to the growth of the global immunodeficiency therapeutics market over the forecast period. For instance, in March 2017, Octapharma AG, a Switzerland based pharmaceutical company initiated phase III clinical trial study to investigate the efficiency, safety and tolerability of its product Octanorm (cutaquig) which is a ready to use liquid formulation of normal human IgG to be administered subcutaneously for treatment of primary immunodeficiency disease. The results for this clinical study were published by PubMed in April 2020, and show that Octanorm, manufactured by Octapharma AG is safe for indicated use.

Market players are focusing on launch of products, which is expected to strengthen their position in the global immunodeficiency therapeutics market. For instance, in June 2019, Octapharma AG launched its new product called cutaquig which is a 16.5% immune globulin solution to be used for treatment of primary humoral immunodeficiency.

Market players are involved in inorganic business strategies such a partnership to strengthen their position globally, this is expected to drive the growth of the global immunodeficiency therapeutics market. For instance, in January 2020, SAB Biotherapeutics Inc., a U.S. based biotechnology company entered into a collaborative partnership with CSL Behring, a U.S. based biopharmaceutical company to carry out research based on novel therapies which could be used for treatment of immune disorders such as chronic inflammatory demyelinating polyneuropathy (CIDP), multifocal motor neuropathy (MMN), primary immunodeficiency disease, and others.

Key features of the study:

  • This report provides an in-depth analysis of global immunodeficiency therapeutics market, provides market size (US$ Million), and compound annual growth rate (CAGR %) for the forecast period (2021-2028), considering 2020 as the base year
  • It elucidates potential revenue opportunities across different segments and explains attractive investment proposition matrix for this market
  • This study also provides key insights about market drivers, restraints, opportunities, new product launches or approval, regional outlook, and competitive strategies adopted by the leading players
  • It profiles leading players in the global immunodeficiency therapeutics market based on the following parameters – company overview, financial performance, product portfolio, geographical presence, distribution strategies, key developments and strategies, and future plans
  • Key companies covered as a part of this study include Pfizer Inc., CSL Behring, Grifols, S.A., Abbott, ADMA Biologics, Inc., AstraZeneca, Baxter, Bayer AG, Biocon, Bristol-Myers Squibb Company, BDI Pharma, Inc., Bharat Serums and Vaccines Ltd., Eli Lilly and Company, GlaxoSmithKline plc., Lupin Pharmaceuticals Inc., Novartis AG, Octapharma AG, Sanofi, and Takeda Pharmaceutical Company Limited
  • Insights from this report would allow marketers and the management authorities of the companies to make informed decision regarding their future product launch, technology up-gradation, market expansion, and marketing tactics
  • The global immunodeficiency therapeutics market report caters to various stakeholders in this industry including investors, suppliers, manufacturers, distributors, new entrants, and financial analysts
  • Stakeholders would have ease in decision making through various strategy matrices used in analyzing the global immunodeficiency therapeutics market

Detailed Segmentation:

  • Global Immunodeficiency Therapeutics Market, By Therapy Type:
    • Immunoglobulin Therapy
    • Antibiotics Therapy
    • Stem Cell and Gene Therapy
    • Others
  • Global Immunodeficiency Therapeutics Market, By Test Type:
    • Blood Test
    • Prenatal Testing
  • Global Immunodeficiency Therapeutics Market, By Disease Type:
    • Antibody Deficiency
    • Cellular Immunodeficiency
    • Innate Immune Disorders
    • Others
  • Global Immunodeficiency Therapeutics Market, By Distribution Channel:
    • Hospital Pharmacy
    • Retail Pharmacy
    • Online Pharmacy
  • Global Immunodeficiency Therapeutics Market, By Region:
    • North America
      • By Therapy Type:
        • Immunoglobulin Therapy
        • Antibiotics Therapy
        • Stem Cell and Gene Therapy
        • Others
      • By Test Type:
        • Blood Test
        • Prenatal Testing
      • By Disease Type:
        • Antibody Deficiency
        • Cellular Immunodeficiency
        • Innate Immune Disorders
        • Others
      • By Distribution Channel:
        • Hospital Pharmacy
        • Retail Pharmacy
        • Online Pharmacy
      • By Country:
        • U.S.
        • Canada
    • Latin America
      • By Therapy Type:
        • Immunoglobulin Therapy
        • Antibiotics Therapy
        • Stem Cell and Gene Therapy
        • Others
      • By Test Type:
        • Blood Test
        • Prenatal Testing
      • By Disease Type:
        • Antibody Deficiency
        • Cellular Immunodeficiency
        • Innate Immune Disorders
        • Others
      • By Distribution Channel:
        • Hospital Pharmacy
        • Retail Pharmacy
        • Online Pharmacy
      • By Country:
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
    • Europe
      • By Therapy Type:
        • Immunoglobulin Therapy
        • Antibiotics Therapy
        • Stem Cell and Gene Therapy
        • Others
      • By Test Type:
        • Blood Test
        • Prenatal Testing
      • By Disease Type:
        • Antibody Deficiency
        • Cellular Immunodeficiency
        • Innate Immune Disorders
        • Others
      • By Distribution Channel:
        • Hospital Pharmacy
        • Retail Pharmacy
        • Online Pharmacy
      • By Country:
        • U.K.
        • Germany
        • Italy
        • Spain
        • France
        • Russia
        • Rest of Europe
    • Asia Pacific
      • By Therapy Type:
        • Immunoglobulin Therapy
        • Antibiotics Therapy
        • Stem Cell and Gene Therapy
        • Others
      • By Test Type:
        • Blood Test
        • Prenatal Testing
      • By Disease Type:
        • Antibody Deficiency
        • Cellular Immunodeficiency
        • Innate Immune Disorders
        • Others
      • By Distribution Channel:
        • Hospital Pharmacy
        • Retail Pharmacy
        • Online Pharmacy
      • By Country
        • China
        • India
        • Japan
        • Australia
        • South Korea
        • ASEAN
        • Rest of Asia Pacific
    • Middle East
      • By Therapy Type:
        • Immunoglobulin Therapy
        • Antibiotics Therapy
        • Stem Cell and Gene Therapy
        • Others
      • By Test Type:
        • Blood Test
        • Prenatal Testing
      • By Disease Type:
        • Antibody Deficiency
        • Cellular Immunodeficiency
        • Innate Immune Disorders
        • Others
      • By Distribution Channel:
        • Hospital Pharmacy
        • Retail Pharmacy
        • Online Pharmacy
      • By Country:
        • GCC
        • Israel
        • Rest of Middle East
    • Africa
      • By Therapy Type:
        • Immunoglobulin Therapy
        • Antibiotics Therapy
        • Stem Cell and Gene Therapy
        • Others
      • By Test Type:
        • Blood Test
        • Prenatal Testing
      • By Disease Type:
        • Antibody Deficiency
        • Cellular Immunodeficiency
        • Innate Immune Disorders
        • Others
      • By Distribution Channel:
        • Hospital Pharmacy
        • Retail Pharmacy
        • Online Pharmacy
      • By Country/Region:
        • South Africa
        • Central Africa
        • North Africa
  • Company Profiles
    • Pfizer Inc.*
      • Company Overview
      • Product Portfolio
      • Financial Performance
      • Recent Highlights
      • Strategies
    • CSL Behring
    • Grifols, S.A.
    • Abbott
    • ADMA Biologics, Inc.
    • AstraZeneca
    • Baxter
    • Bayer AG
    • Biocon
    • Bristol-Myers Squibb Company
    • BDI Pharma, Inc.
    • Bharat Serums and Vaccines Ltd.
    • Eli Lilly and Company
    • GlaxoSmithKline plc.
    • Lupin Pharmaceuticals Inc.
    • Novartis AG
    • Octapharma AG
    • Sanofi
    • Takeda Pharmaceutical Company Limited

“*” marked represents similar segmentation in other categories in the respective section.

Frequently Asked Questions

The global immunodeficiency therapeutics market is expected to exhibit a CAGR of 6.1% during the forecast period (2021-2028).
The market is estimated to be valued at US$ 6,991.1 Mn in 2021.
Pfizer Inc., CSL Behring, Grifols, S.A., Abbott, ADMA Biologics, Inc., AstraZeneca, Baxter, Bayer AG, Biocon, Bristol-Myers Squibb Company, BDI Pharma, Inc., Bharat Serums and Vaccines Ltd., Eli Lilly and Company, GlaxoSmithKline plc., Lupin Pharmaceuticals Inc., Novartis AG, Octapharma AG, Sanofi, and Takeda Pharmaceutical Company Limited are the prominent players operating in the market.
The market is expected to be valued at US$ 10,581.6 Mn in 2028.
North America is the prominent region in the market.
Increasing number product launches, rising cases of immunodeficiency diseases, increasing research and development activities by the market players, and increasing strategic collaborations among the market players are some of the driving factors, which are expected to drive growth of the market.

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