Biotechnology

The biotech industry includes bio-pharma, bio-services, bio-agri, bio-industrials and bioinformatics. Biopharma is a rapidly growing segment that accounts for a dominant share in this sector. Advancements in biotechnology have enabled researchers to evaluate and identify target biomarkers/cell receptors to develop targeted and personalized therapies. Scientific research and technological advancements have resulted in the emergence of various personalized medicines that are undergoing research. According to research conducted by the Personalized Medicine Coalition, 42% of all compounds and 73% of oncology compounds in the pipeline possess the potential to be personalized medicine. Moreover, according to this study, it is expected that companies will increase their investment in R&D of personalized medicines by 1/3rd over the following five years. The study found that over 20% of drugs approved in 2014 were personalized medicines.

The biotechnology sector has witnessed some disruptive innovations such as gene and cell therapies, immunotherapy, and antibody drug conjugates. Advancement in stem cell therapy is resulting in effective treatment therapies for chronic conditions, organ growth and repair and disease prevention.

Key Challenges

Biotech products have extensive application in oncology and autoimmune disease treatment. However, the cost of these drugs is high owing to extensive research and trials that need to be carried out for the same. Therefore, there is constant pressure to reduce price and increase accessibility, especially in emerging economies. In the U.S., companies are facing reimbursement issues with respect to biopharmaceutical products. Besides, there are regulatory and scientific challenges faced by the sector. Scientific research for new molecules and targeted therapies is capital intensive and challenging owing to growing concern for safety of the drug.

Also, there is lack of awareness about personalized medicine among most healthcare providers, which may hamper its adoption. Clinical adoption of biotechnology products is essential for its success. However, it significant scientific evidence and backing is required to ensure its safety.

“Translating genomic discoveries into personalized medicines entails overcoming substantial scientific, regulatory, and economic challenges, including identifying validated biomarkers, as well as developing personalized therapeutics and clinically relevant diagnostic tests.”

  • Tufts Center for the Study of Drug Development

Opportunities

The biopharmaceutical sector offers vast lucrative growth opportunities. High efficacy and safety of biopharmaceutical products has led to a growth in their demand, Furthermore, consumers are willing to pay high prices for biopharmaceutical products compared to other conventional products. Biopharmaceutical brands have set new standards for blockbuster drugs by recording an annual average sale of over US$ 2bn. Drugs such as Humira have generated sales revenue of over US$ 10bn.

Governments in emerging economies are endorsing biosimilars as cost-effective alternatives to biotech products, which is expected to create significant growth opportunities for manufacturers of generic drugs. Therefore, cost-effectiveness and high quality are prime parameters that need to be considered while developing biosimilars. Recent and upcoming biologic patent expirations include the following:

  • Erbitux (cetuximab) - February 2016
  • Rituxan (rituximab) - September 2016
  • Herceptin (trastuzumab) - June 2019
  • Avastin (bevacizumab) - July 2019
  • Aranesp (darbepoetin alfa) - May 2024
  • Enbrel (etanercept) - November 2028

Companies such as Teva Pharmaceuticals, Hospira, Sandoz, and Amgen are focusing on development of biosimilars and vaccines as preventive measures in addition to treatment. For instance, in 2015, Zarxio TM became the first biosimilar to be approved in the U.S. market. The EMA approved Mosquirix, a malaria vaccine, in the same year. Extensive research is currently underway to develop a dengue vaccine, which could be another breakthrough pharmaceutical product in the near future.

Conclusion

The increasing research in the biotechnology sector is expected to result in higher number of biopharmaceutical products seeking FDA approvals. Biopharmaceuticals are positioned to be promising treatment solutions that would improve patient outcomes and help with reduction of the cost of drug development.

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Biotechnology Published Insights

Coherent Market Insights Crispr And Cas Gene Market

Published Date : Sep 2023

The global crispr and cas gene market is estimated to be valued at US$ 1.54 Billion in 2023 and is expected to exhibit a CAGR of 22.8 %  during the forecast period (2023-2030).... View more

Coherent Market Insights Plasmid Dna Manufacturing Market

Published Date : Jan 2023

Plasmids are small circular molecules of DNA found in bacteria and other microscopic organisms. Plasmids are physically separated from the chromosomal DNA and replicate independently. They usually have a small number of genes, especially those associated with antibiot... View more

Coherent Market Insights U S Non Oncology Biopharmaceuticals Market

Published Date : Apr 2019

U.S. Non-oncology Biopharmaceuticals Market- Insights Biologics can be defined as molecules derived from living cells such as microorganisms, plants or animal cells and used in the treatment, diagnosis or pre... View more

Coherent Market Insights Immune Checkpoint Inhibitors Market

Published Date : Aug 2022

Immune checkpoint inhibitor products come under biologic therapeutic products. Biologic manufacturers require similar kind of approvals such as drugs from the U.S. Food & Drug Administration prior to bringing the product into market. However, unlike drugs, biologi... View more

Coherent Market Insights Typhoid Fever Vaccines Market

Published Date : Aug 2022

Typhoid fever, also simply called as typhoid is a bacterial infection caused by Salmonella typhi, also known as Salmonella enterica serotype Typhi. The typhoid fever is usually caused due to ingestion of contaminated food or water. Typhoid vaccine prevents typhoid fev... View more

Coherent Market Insights Cell Processing Market

Published Date : Nov 2023

Cell processing includes a series of activities from collection of cells from donor, extraction of cell till the storage, and distribution of cells to receiver for cell therapy. Cell processing involves distinct processes of cell collection, cell isolation, cell analy... View more

Coherent Market Insights Proteomics Market

Published Date : Nov 2023

Proteomics is a study of large scale proteomes. Proteomes are entire complements of protein expressed by a tissue, cell or organism. Proteomics aims to interpret the roles of large number of proteins made from combining 22 genetically-encoded amino acids. It helps to ... View more

Coherent Market Insights Molecular Cytogenetics Market

Published Date : Apr 2023

The global molecular cytogenetics market is estimated to be valued at US$  4,211.4 million in 2023 and is expected to exhibit a CAGR of 24.5% during the forecast period (2023-2030). ... View more

Coherent Market Insights Cell And Gene Therapy Market

Published Date : Jul 2023

The global cell and gene therapy market is estimated to be valued at US$ 22.7 billion in 2023 and is expected to exhibit a CAGR of 28.7% during the forecast period (2023-2030). ... View more

Coherent Market Insights Tissue Plasminogen Activator Market

Published Date : Sep 2023

Global tissue plasminogen activator market is estimated to be valued at US$ 2.58 Bn in 2023, and is expected to exhibit a CAGR of 5.2% during the forecast period (2023-2030). ... View more

Coherent Market Insights Stem Cell Cartilage Regeneration Market

Published Date : Apr 2023

The  global stem cell cartilage regeneration market is estimated to be valued at US$  403.5 million in 2023 and is expected to exhibit a CAGR of 9.2% during the forecast period (2023... View more

Coherent Market Insights Bovine Blood Plasma Derivatives Market

Published Date : Nov 2023

Bovine blood plasma derivatives are products containing proteins that are obtained from the blood plasma of bovine animals using physico-chemical or other fractionation processes. Bovine blood plasma include, Factor VIII and IX Concentrate, Anti-Inhibitor Coagulation ... View more

Coherent Market Insights Nucleic Acid Isolation And Purification Market

Published Date : Nov 2023

High quality DNA and RNA are important for a wide variety of research and clinical applications. Purification or isolation of nucleic acids is the first step in most molecular biological studies and in all recombinant DNA techniques. The extraction of nucleic aci... View more

Coherent Market Insights Plant Based Biologics Market

Published Date : Nov 2020

Rising demand for human biologics cannot be fulfilled by currently used mammalian cell culture production platforms, as these platforms are highly expensive and have limited scalability. However, recent developments in plant expression vectors, downstream processing, ... View more

Coherent Market Insights Protein Expression Systems Market

Published Date : Dec 2018

Protein Expression Systems Market – Insights Protein expression has become an important laboratory technology in biochemistry, molecular biology, and protein research as well as other scientific researc... View more

Coherent Market Insights Dual Specificity Protein Kinase Ttk Market

Published Date : Sep 2023

The global dual specificity protein kinase Ttk inhibitor market is estimated to be valued at US$ 76.6 million in 2023 and is expected to exhibit a CAGR of 22.3% during the forecast period (202... View more

Coherent Market Insights Clostridium Vaccine Market

Published Date : Oct 2023

Clostridium difficile infections are the most widely recognized cause of hospital acquired infectious diarrhea. There is a critical need for development of prevention vaccine for this disease. ... View more

Coherent Market Insights Adipose Derived Stem Cell Therapy Market

Published Date : Nov 2023

Adipose derived stem cells (ADSCs) are stem cells derived from adipocytes, and can differentiate into variety of cell types. ADSCs have multipotency similar to bone marrow mesenchymal stem cells, thus ADSCs substitute for bone marrow as a source of stem cells. Numerou... View more

Coherent Market Insights Gene Therapy For Rare Disease Market

Published Date : Nov 2018

 Gene Therapy for Rare Disease Market - Insights Gene therapy involves insertion of genetic material into cells of the patients to provide new function or to restore missing or inappropriate functioning ... View more

Coherent Market Insights Pneumococcal Vaccines Market

Published Date : Aug 2022

Pneumococcal vaccine is used to prevent infection caused by streptococcus pneumoniae bacteria. There are two types of pneumococcal vaccines: pneumococcal conjugate vaccine and pneumococcal polysaccharide vaccine. The Centers for Di... View more

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