Biotechnology

The biotech industry includes bio-pharma, bio-services, bio-agri, bio-industrials and bioinformatics. Biopharma is a rapidly growing segment that accounts for a dominant share in this sector. Advancements in biotechnology have enabled researchers to evaluate and identify target biomarkers/cell receptors to develop targeted and personalized therapies. Scientific research and technological advancements have resulted in the emergence of various personalized medicines that are undergoing research. According to research conducted by the Personalized Medicine Coalition, 42% of all compounds and 73% of oncology compounds in the pipeline possess the potential to be personalized medicine. Moreover, according to this study, it is expected that companies will increase their investment in R&D of personalized medicines by 1/3rd over the following five years. The study found that over 20% of drugs approved in 2014 were personalized medicines.

The biotechnology sector has witnessed some disruptive innovations such as gene and cell therapies, immunotherapy, and antibody drug conjugates. Advancement in stem cell therapy is resulting in effective treatment therapies for chronic conditions, organ growth and repair and disease prevention.

Key Challenges

Biotech products have extensive application in oncology and autoimmune disease treatment. However, the cost of these drugs is high owing to extensive research and trials that need to be carried out for the same. Therefore, there is constant pressure to reduce price and increase accessibility, especially in emerging economies. In the U.S., companies are facing reimbursement issues with respect to biopharmaceutical products. Besides, there are regulatory and scientific challenges faced by the sector. Scientific research for new molecules and targeted therapies is capital intensive and challenging owing to growing concern for safety of the drug.

Also, there is lack of awareness about personalized medicine among most healthcare providers, which may hamper its adoption. Clinical adoption of biotechnology products is essential for its success. However, it significant scientific evidence and backing is required to ensure its safety.

“Translating genomic discoveries into personalized medicines entails overcoming substantial scientific, regulatory, and economic challenges, including identifying validated biomarkers, as well as developing personalized therapeutics and clinically relevant diagnostic tests.”

  • Tufts Center for the Study of Drug Development

Opportunities

The biopharmaceutical sector offers vast lucrative growth opportunities. High efficacy and safety of biopharmaceutical products has led to a growth in their demand, Furthermore, consumers are willing to pay high prices for biopharmaceutical products compared to other conventional products. Biopharmaceutical brands have set new standards for blockbuster drugs by recording an annual average sale of over US$ 2bn. Drugs such as Humira have generated sales revenue of over US$ 10bn.

Governments in emerging economies are endorsing biosimilars as cost-effective alternatives to biotech products, which is expected to create significant growth opportunities for manufacturers of generic drugs. Therefore, cost-effectiveness and high quality are prime parameters that need to be considered while developing biosimilars. Recent and upcoming biologic patent expirations include the following:

  • Erbitux (cetuximab) - February 2016
  • Rituxan (rituximab) - September 2016
  • Herceptin (trastuzumab) - June 2019
  • Avastin (bevacizumab) - July 2019
  • Aranesp (darbepoetin alfa) - May 2024
  • Enbrel (etanercept) - November 2028

Companies such as Teva Pharmaceuticals, Hospira, Sandoz, and Amgen are focusing on development of biosimilars and vaccines as preventive measures in addition to treatment. For instance, in 2015, Zarxio TM became the first biosimilar to be approved in the U.S. market. The EMA approved Mosquirix, a malaria vaccine, in the same year. Extensive research is currently underway to develop a dengue vaccine, which could be another breakthrough pharmaceutical product in the near future.

Conclusion

The increasing research in the biotechnology sector is expected to result in higher number of biopharmaceutical products seeking FDA approvals. Biopharmaceuticals are positioned to be promising treatment solutions that would improve patient outcomes and help with reduction of the cost of drug development.

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Biotechnology Published Insights

Coherent Market Insights Tissue Engineering Market

Published Date : Aug 2022

Tissue engineering is a scientific field majorly focused on the development of tissue and organ substitutes by controlling biophysical, biological, and/or biomechanical parameters in the laboratory. Tissue engineering has emerged as a rapidly expanding approach to add... View more

Coherent Market Insights Pneumococcal Vaccines Market

Published Date : Aug 2022

Pneumococcal disease is a common and often mild infection that includes conditions such as middle ear infection, a blood infection, pneumonia, and bacterial meningitis. However, the disease can sometimes result in severe and fatal health problems. Pneumococcal vaccine... View more

Coherent Market Insights Human Recombinant Insulin Market

Published Date : Jul 2022

Recombinant human insulin is the synthetic insulin, developed using recombinant DNA technology by growing insulin proteins within Escherichia coli. Recombinant human insulin has a faster onset of action and lower immunogenicity than other types of insulin such as pork... View more

Coherent Market Insights Stem Cell Banking Market

Published Date : Jul 2022

Stem cells are building blocks of the immune system and blood, and they have the ability to develop into other cell types, in order to help in repairing tissues, organs, and blood vessels. They are also used in the treatment of various disease. The ability of stem cel... View more

Coherent Market Insights Genome Engineering Market

Published Date : Jul 2022

Genome engineering is a process of insertion, deletion, modification or replacement of Deoxyribonucleic acid (DNA) bases in an organism. There are two types of gene therapy, Ex-Vivo gene therapy and In-Vivo gene therapy. Ex-vivo gene therapy involves the transfer of g... View more

Coherent Market Insights Cell Lysis Market

Published Date : Jul 2022

Cells contain biomolecules such as proteins or nucleic acids present in the cytoplasm and enclosed within a membrane. Cell lysis is a process in which a cell membrane is ruptured due to some external forces or conditions such as viral infection or osmosis, resulting i... View more

Coherent Market Insights Recombinant Dna Technology Market

Published Date : Jul 2022

Recombinant DNA (rDNA) technology is a novel technique that has led to advances in a number of different fields such as drug development, agriculture, and research. Recombinant DNA technology has introduced new classes of organisms namely genetically modified organism... View more

Coherent Market Insights Bio Pharmaceuticals And Biomedicine Market

Published Date : Jun 2022

A biopharmaceutical (biological or biologic), which consists of sugars, proteins, nucleic acids, living cells, or tissues, is a medicinal product semi-synthesized from biological sources such as humans, animals, or microorganisms. Biopharmaceuticals has emerged as one... View more

Coherent Market Insights Recombinant Vaccine Market

Published Date : Jun 2022

Recombinant vaccines are products of genetic engineering, in which a harmless agent, such as yeast, is programmed to produce antigens of diseases. A small piece of DNA is extracted from the virus or bacteria against which protection is required and inserted into the m... View more

Coherent Market Insights Asia Pacific Wound Care Biologics Market

Published Date : Jun 2022

Wound care biologics are bioengineered products used for non-healing wounds of the lower extremity. Wound care biologic dressings are increasingly used in post surgeries and severe trauma cases, as they provide a moist healing environment aiding heat, protein, and ele... View more

Coherent Market Insights Rhu Albumin Market

Published Date : Jun 2022

A biopharmaceutical is a medicinal product that is derived from biological sources such as animals, humans, and microorganisms using biotechnology. They are manufactured using stem cells, mammalian cells, etc., through tissue culture methods. ... View more

Coherent Market Insights Bone Marrow Transplant Market

Published Date : Jun 2022

A bone marrow transplant is a medical procedure that replaces the bone marrow with healthy cells. Replacement cells might come from either one’s own body or from a donor. A stem cell transplant, or more specifically, a hematopoietic stem cell transplant, is... View more

Coherent Market Insights Pharmacogenomics Market

Published Date : May 2022

Pharmacogenomics is a branch of pharmacology that studies the influence of genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug efficacy or toxicity. It seeks to develop rational methods for optimiz... View more

Coherent Market Insights Middle East And Asia Pacific Cell And Gene Therapy Market

Published Date : Mar 2022

Cell therapy is the administration of living cells in patients for the treatment of a disease such as oncology, Immunology and others. The source of a cell can be autologous or allogeneic, which can be derived from stem cells such as bone marrow. Stem cells therapy is... View more

Coherent Market Insights Covid 19 Sample Collection Kits Market

Published Date : Mar 2022

Coronavirus disease is a contagious disease caused by severe acute respiratory syndrome (SARS-CoV-2). COVID-19 sample collection kits are the kits that consist of reagents and consumables for facilitating the detection and diagnosis of SARS-Cov2 infection from nasal, ... View more

Coherent Market Insights Blood Based Biomarker Market

Published Date : Feb 2022

The term biomarker, or biological marker, refers to a broad range of measures that capture what is happening in a cell or organism at a given moment. Blood-based biomarkers can be effective in formulating new diagnostic and treatment proposals. Blood-based biomarkers ... View more

Coherent Market Insights Middle East And Asia Pacific Biotechnology Market

Published Date : Feb 2022

Biotechnology is a broad field that deals with the use of living organisms to create products that are beneficial to long-term development. It uses cellular and molecular processes to create products and technologies that may improve human life on Earth. It has a numb... View more

Coherent Market Insights Vaccines Market

Published Date : Feb 2022

Vaccination is a way to prevent infectious diseases such as polio, measles, pneumonia, and others. Vaccines contain severely weakened forms of viruses or bacteria, dead viruses or bacteria, or purified comp... View more

Coherent Market Insights Mr Vaccines Market

Published Date : Feb 2022

Measles and rubella is a live virus vaccine that protects against infection with the measles and rubella viruses. It works by causing the body to produce its antiviral defenses (antibodies). Measles (also known as coughing measles, hard measles, morbilli, red measles,... View more

Coherent Market Insights Uk Cell And Gene Therapy Research Challenges Market

Published Date : Jan 2022

Cell therapy can be defined as the transfer of new cells into a patient’s body to repair or replace damaged tissue or cells to treat a disease. The introduced cells can be from patient’s own body or from the donor. Different types of cells can be utilized ... View more

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