The biotech industry includes bio-pharma, bio-services, bio-agri, bio-industrials and bioinformatics. Biopharma is a rapidly growing segment that accounts for a dominant share in this sector. Advancements in biotechnology have enabled researchers to evaluate and identify target biomarkers/cell receptors to develop targeted and personalized therapies. Scientific research and technological advancements have resulted in the emergence of various personalized medicines that are undergoing research. According to research conducted by the Personalized Medicine Coalition, 42% of all compounds and 73% of oncology compounds in the pipeline possess the potential to be personalized medicine. Moreover, according to this study, it is expected that companies will increase their investment in R&D of personalized medicines by 1/3rd over the following five years. The study found that over 20% of drugs approved in 2014 were personalized medicines.

The biotechnology sector has witnessed some disruptive innovations such as gene and cell therapies, immunotherapy, and antibody drug conjugates. Advancement in stem cell therapy is resulting in effective treatment therapies for chronic conditions, organ growth and repair and disease prevention.

Key Challenges

Biotech products have extensive application in oncology and autoimmune disease treatment. However, the cost of these drugs is high owing to extensive research and trials that need to be carried out for the same. Therefore, there is constant pressure to reduce price and increase accessibility, especially in emerging economies. In the U.S., companies are facing reimbursement issues with respect to biopharmaceutical products. Besides, there are regulatory and scientific challenges faced by the sector. Scientific research for new molecules and targeted therapies is capital intensive and challenging owing to growing concern for safety of the drug.

Also, there is lack of awareness about personalized medicine among most healthcare providers, which may hamper its adoption. Clinical adoption of biotechnology products is essential for its success. However, it significant scientific evidence and backing is required to ensure its safety.

“Translating genomic discoveries into personalized medicines entails overcoming substantial scientific, regulatory, and economic challenges, including identifying validated biomarkers, as well as developing personalized therapeutics and clinically relevant diagnostic tests.”

  • Tufts Center for the Study of Drug Development


The biopharmaceutical sector offers vast lucrative growth opportunities. High efficacy and safety of biopharmaceutical products has led to a growth in their demand, Furthermore, consumers are willing to pay high prices for biopharmaceutical products compared to other conventional products. Biopharmaceutical brands have set new standards for blockbuster drugs by recording an annual average sale of over US$ 2bn. Drugs such as Humira have generated sales revenue of over US$ 10bn.

Governments in emerging economies are endorsing biosimilars as cost-effective alternatives to biotech products, which is expected to create significant growth opportunities for manufacturers of generic drugs. Therefore, cost-effectiveness and high quality are prime parameters that need to be considered while developing biosimilars. Recent and upcoming biologic patent expirations include the following:

  • Erbitux (cetuximab) - February 2016
  • Rituxan (rituximab) - September 2016
  • Herceptin (trastuzumab) - June 2019
  • Avastin (bevacizumab) - July 2019
  • Aranesp (darbepoetin alfa) - May 2024
  • Enbrel (etanercept) - November 2028

Companies such as Teva Pharmaceuticals, Hospira, Sandoz, and Amgen are focusing on development of biosimilars and vaccines as preventive measures in addition to treatment. For instance, in 2015, Zarxio TM became the first biosimilar to be approved in the U.S. market. The EMA approved Mosquirix, a malaria vaccine, in the same year. Extensive research is currently underway to develop a dengue vaccine, which could be another breakthrough pharmaceutical product in the near future.


The increasing research in the biotechnology sector is expected to result in higher number of biopharmaceutical products seeking FDA approvals. Biopharmaceuticals are positioned to be promising treatment solutions that would improve patient outcomes and help with reduction of the cost of drug development.

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Biotechnology Published Insights

Coherent Market Insights Tissue And Organ Transplantation Market

Published Date : Dec 2020

Transplantation is a complex area of medicine because when organs or tissues are transplanted from one person to another, the recipient’s immune system can reject and destroy the donor organ or tissue and medication would be needed to suppress this immune respon... View more

Coherent Market Insights Plant Based Biologics Market

Published Date : Nov 2020

Plant-based biologics are biologic drugs that are manufactured by using plant molecular farming. They are also known as plant-made biologics (PMB). The applications and advantages of plant-based biologics have stretched beyond the traditional boundaries of vaccines an... View more

Coherent Market Insights Genomics And Proteomics Reagents Research Kits And Analytical Instrumentation Market

Published Date : Aug 2020

Genomics is the study of human genes and chromosomes. It focuses on structure, function, evolution, mapping, and editing of genomes. Genome is the genetic material of organism, which includes the Deoxyribonucleic acid (DNA). DNA consists the information needed to buil... View more

Coherent Market Insights Europe Allogeneic Human Chondrocyte Market

Published Date : Aug 2020

Allogeneic human chondrocyte cell therapy is anticipated to be a good alternative to autologous chondrocyte implantation in the near future. Increasing product approvals by regulatory authorities is expected to fuel the market growth over the forecast period. For inst... View more

Coherent Market Insights Transcriptomics Technologies Market

Published Date : Jul 2020

Transcriptomics the study of structures and functions of transcript molecules. Transcripts comprise all types of ribonucleic acid (RNA) molecules namely, messenger RNA (mRNA), ribosomal RNA (rRNA), transfer RNA (tRNA), and other non-coding RNA molecules. Increasing ap... View more

Coherent Market Insights White Biotechnology Market

Published Date : May 2020

White Biotechnology refers to the adoption of biotechnology in developing methods to replace petroleum-based synthetics. Major application of white biotechnology constitutes in the production of biochemical, biofuels, and biomaterials. Butanediol, lactic acid, succini... View more

Coherent Market Insights Meningococcal Vaccines Market

Published Date : May 2020

Meningitis is an inflammation in the inner lining of the brain and spinal cord that results from infectious (viral, bacterial, and rarely fungal) or non-infectious (drugs, sarcoidosis etc.) factors. The swelling associated with meninges triggers symptoms such as painf... View more

Coherent Market Insights Viral Vectors And Plasmid Dna Manufacturing Market

Published Date : Mar 2020

Viral vectors aids in transferring genetic material into target cells and therefore, used in various therapeutic areas. Viral vectors can be significantly used in vaccines development against pathogens such as Mycobacterium tuberculosis, Plasmodium falciparum, HIV, an... View more

Coherent Market Insights Dengue Vaccines Market

Published Date : Jan 2020

Dengue fever is a mosquito-borne viral infection causing a severe flu-like illness. Dengue vaccine is only recommended in those who have previously had dengue fever. It is given as three injections over a year. Dengue is most likely to affect individual’s tropic... View more

Coherent Market Insights Forensic Technologies And Services Market

Published Date : Jan 2020

Forensic science is an application and techniques usually deployed to investigate criminal cases. According to legal standards of admissible evidence and criminal procedures, forensic technologies are used only during criminal investigation. Forensic experts gather, d... View more

Coherent Market Insights Vocal Bio Markers Market

Published Date : Nov 2019

Voice can serve as a useful tool in identifying the presence or risk of conditions such as depression, Parkinson’s disease, and coronary artery disease. Moreover, Research institutes and companies engaged in voice and speech technology are partnering to identify... View more

Coherent Market Insights Personalized Cell Therapy Market

Published Date : Nov 2019

The patient-tailored therapies for the treatment of various diseases is known as personalized cell therapy. The personalized cell therapy is based on genomic profile, and disease prevalence/severity and the drug developed by this therapy target the patients, who match... View more

Coherent Market Insights Assistive Reproductive Technology Market

Published Date : Sep 2019

Assistive reproductive technology (ART) is an infertility treatment procedure. In this procedure, the sperm and eggs are taken out of the body and oocyte fertilization is done under laboratory environment. The fertilization process carried outside the body is known as... View more

Coherent Market Insights Artificial Pancreas Market

Published Date : Aug 2019

Type 1 diabetes patients require multiple doses of insulin in a day. Advancements in research and technology has led to commercialization of easy-to-use insulin delivery systems such as insulin pens, pumps, inhaled insulin, and injectors. Use of syringes to deliver in... View more

Coherent Market Insights Cervical Cancer Vaccines Market

Published Date : Jul 2019

Cervical cancer is a common type of cancer occurring in women worldwide. A major cause of cervical cancer is infection by human papillomavirus (HPV), which is found in 99% cervical cancer. Human papillomavirus is sexually transmitted. Around 100 types of HPV have been... View more

Coherent Market Insights Lifescience Reagent Market

Published Date : May 2019

Lifescience reagent is an important component, especially in biotechnology industry for identification and analysis of the biological materials. There are different type of reagents such as diagnostic reagents, biochemical reagents, genomic reagents and others, and ar... View more

Coherent Market Insights Mono Vaccines Epstein Barr Virus Market

Published Date : May 2019

Epstein-Barr virus (EBV) infects human B cells and spreads the infection throughout the entire reticuloendothelial system (RES). The virus is known to cause various autoimmune disorders including multiple sclerosis, celiac disease, systemic lupus erythematosus, juveni... View more

Coherent Market Insights Latin America Bone Graft And Substitutes Market

Published Date : May 2019

A bone graft repairs and rebuilds diseased bone and transplants bone tissues of the hips, knees, spine, and various other bones in the body. Moreover, it repairs bone loss caused by fractures and cancers. The body accepts the newly implanted graft and provides a frame... View more

Coherent Market Insights Sterile Filtration Market

Published Date : May 2019

Sterile filtration is the process of removing microorganisms from a fluid stream without adversely affecting product quality. Drug sterility is important requirement in the pharmaceutical industry. Virus inactivation or removal is required for biologically derived the... View more

Coherent Market Insights Biomarker Research Services Market

Published Date : May 2019

Biomarkers are widely used in development of drugs. One of the primary processes through which biomarkers are accepted for use in drug development, is the drug approval process. The biomarker is included in the regulatory submission process for drug approval such as I... View more

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